Head injury
Transcript of Head injury
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Head Trauma
Wayne Triner, DO, MPH, FACEPProfessor, Emergency Medicine
Albany Medical College & State University at Albany
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New Zealand TBI
All TBI 790 / 100,000 py
Mod to Severe 41 / 100,000 py 1.2 x risk Maori 2-5 x risk in rural
the incidence of TBI per 100 000 people per year (790 cases), especially mild TBI (749 cases), in New Zealand was substantially greater than in other high-income countries. in Europe (47–453 cases) and North America (51–618 cases).
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TBI FactoidsUnited States 2007
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Pathophysiology
Primary Direct tissue injury
Secondary Cerebral
perfusion/edema Vasoregulation Tissue ischemia Herniation
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Cerebral Blood Flow
Cerebral Blood FlowCBF ~ CPP – CVP
Cerebral Perfusion PressureCPP = MAP – ICP
CBF ~ (MAP – ICP) - CVP
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The Range of TBI
Mild GCS > 12
Moderate GCS 12-8
Severe GCS < 8
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Head Injury StratificationGlasgow Coma Score
Eye Opening 4=Spontaneous 3=To voice 2=To pain 1=None
Verbal 5=Normal conversation 4=Disoriented conversation 3=Words, but not coherent 2=No words......only sounds 1=None
Motor 6=Normal 5=Localizes to pain
4=Withdraws to pain 3=Decorticate posture 2=Decerebrate 1=None
Mild GCS > 12
Moderate GCS 12-8
Severe GCS < 8
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Mild TBI
GCS 13-15 < 30 minute LOC Non-focal exam
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Mild TBI:Is there a problem?
Short term Mood and cognitive
disturbances Validation Variable rate of CT
abnormalities
Long term Depression Dementia Parkinson’s Cognitive deficits
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Mild TBI:Who to CT
The goal being identification of significant conditions amenable
to intervention
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Critical Questions;Which patients with mild TBI need a head CT?
LEVEL I RECOMMENDATIONA noncontrast head CT is indicated in head trauma patients with loss of consciousness or pos- traumatic amnesia only if one of the following is present: headache, vomiting, age > 60 years, drug or alcohol intoxication, deficits in short-term memory, physical evidence of trauma above the clavicle, posttraumatic seizure, GCS < 15, focal deficit or coagulopathy.
LEVEL II RECOMMENDATIONA noncontrast head CT should be considered in head trauma patients with no loss of consciousness or post-traumatic amnesia if there is focal deficit, vomiting, severe headache, age > 65 years, signs of basilar skull Fx, GCS < 15, coagulopathy or dangerous mechanism (ejection from vehicle, pedestrian struck, fall of more than 3 ft or 5 stairs)
Clinical Policy: Neuroimaging and Decisionmaking in Adult Mild Traumatic Brain Injury in the Acute
SettingACEP 2008
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Understand the Intent and Concepts
Understand the risk factors Age Small brains Inability to fully evaluate Propensity for bleeding Mechanism and evidence of trauma
Recognize neurological abnormalities HA, vomiting, focal deficits
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What works to improve outcomes in minor TBI?
Recommendations “Neuro rest”
Proven ?????
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Concussion and Sports:return to play guidelines(second impact syndrome)
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Moderate to Severe TBI (GCS 3 – 12)
ABCs Limit secondary brain injury Preservation of CBF Issues of coagulation
Reversal of coagulopathies▪ F VIIa▪ Prothrombin complex concentrate▪ Vit K and FFP
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Management of Severe Head Trauma
“Evidence based” Standards, Guidelines and Options• Preserve oxygenation
(at all costs)• Avoidance of hypotension
(SBP < 90)• Euventilation
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Hyperventilation
Rapid reduction in ICP
3 compartment model
Below pCO2 < 23, CBF < 20 ml/100g/min
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Severe TBI;Proven Management Strategies
Preserve oxygenation (at all costs) Issues of airway management▪ Pre-hospital ETT▪ Neuro-protective RSI▪ Laryngeal manipulation▪ Hypotension▪ ICP management
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Severe TBI;Proven Management Strategies
Avoidance of hypotension (SBP < 90) Preserve CBF Control of cerebral edema▪ Brief hyperventilation
Hyperosmolar therapy
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Hyperosmolar Therapy
Recommendations; Level II
▪ Mannitol is effective for the control of raised intracranial pressure at doses of 0.25 to 1 g/kg. Hypotension (SBP < 90) should be avoided
Level III▪ Restrict mannitol use prior to ICP monitoring
to patients with signs of transtentorial herniation or deteriorating mental status not attributable to other causes
Mechanism of Action Blood rheology
▪ immediate plasma volume expansion
Osmotic redistribution Hypertonic Saline
23.4% 50 ml
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Indications for hyperosmolar therapy: impending herniation
Typically uncus herniating across tentorum CN III compression▪ pupillary dilitation▪ 80% ipsilateral to side of structural lesion
Pyramidal tract compression▪ Contralateral weakness▪ 80% contralateral to side of structural lesion
Rapid deterioration of mental status Cushing’s reflex
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Hypothermia
No Level I or II recommendations Level III:
No change in all-cause mortality 46% improved chance of favorable
outcome (GOS 4-5) Some evidence of improved outcome
with > 48 hours of cooling
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Traumatic SAH
Most common CT finding in TBI
Often occurs in concert with other imaging abnormalities
Neuro deficits reflect parenchymal injury and generally not a vascular insult
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Epidural Hematoma
High Mortality Rate Association with Skull Fracture
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Subdural Hematoma
Acute Higher Mortality
Rate Than EDH underlying brain
injury co-morbidity
Chronic Subacute
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Cerebral (Parenchymal) Contusions
Presence of contusion does not independently predict outcome
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Cerebral Edema
• Cisterns• Gray – White
Interface
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Indications For Surgical Intervention
Decompressable lesion with neuro findings SDH, EDH, very few contusions Traumatic SAH is not decompressable
and not an indication for aneurysm screening
Indications of increasing ICP Deteriorating mental status Herniation syndromes
Decompressive craniectomy
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Intracranial Pressure Monitoring
Cerebral edema Monitoring
GCS < 8 and Abnormal Head CT
GCS < 8 and Normal Head CT with... ▪ age > 40▪ posturing▪ hypotension
ICP determination early detection of
mass lesions limit potentially
harmful therapies determination of
prognosis CSF drainage*
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Penetrating Head Trauma
All about GCS GSW injury reflect patterns of
ballistics
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Basilar Skull Fracture
Issues in management Hearing Antibiotics Disposition
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Severe TBI Prognosis
1 Fearnside MR, Cook RJ, McDougall P, et al.: The Westmead Head Injury Project outcome in severe head injury. A comparative analysis of pre-hospital, clinical, and CT variables. Br J Neurosurg 7:267-279, 1993.2 Braakman R: Interactions between factors determining prognosis in populations of patients with severe head injury. In Frowein RA, Wilcke O, Karimi-Nejad A, et al. Advances in Neurosurgery: Head Injuries-Tumors of the Cerebellar Region. Springer-Verlag, Berlin: 12-15, 1978.3 Phuenpathom N, Choomuang M, Ratanalert S: Outcome and outcome prediction in acute subdural hematoma. Surg Neurol 40:22-25, 1993
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Age
Strong factor in determining outcome from severe TBI
This holds true even after correcting for co-morbid conditions.
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The Cutting Edge
TBI Biomarkers Need for imaging Validation Prognostication
Intervention Hypothermia Progesterone Reduction of oxidative stress
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Useful Resources