HDI oligomers, isocyanurate - Endpoint HDI   HDI oligomers, isocyanurate EC Number: 931-274-8

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Transcript of HDI oligomers, isocyanurate - Endpoint HDI   HDI oligomers, isocyanurate EC Number: 931-274-8

  • HDI oligomers, isocyanurate

    EC Number: 931-274-8 CAS Number: 28182-81-2 IUPAC name: HDI Oligomers, isocyanurate

    IUCLID Endpoint Summary Information The information compiled in this document consists mainly of the IUCLID endpoint summaries regarding environmental and health hazards and the rationale for DNEL and PNEC derivation. This information is included in the REACH registration dossier for HDI Oligomers, isocyanurate but is currently not disseminated on the ECHA website. However, this information is deemed necessary to comprehend the conclusions as derived in the REACH registration dossier for HDI Oligomers, isocyanurate.

  • EC No: 931-274-8 HDI Oligomers, isocyanurate CAS Number:28182-81-2

    December 2011 Endpoint Summary information 2

    Table of Contents 1. PHYSICAL AND CHEMICAL PROPERTIES ................................................................................................... 32. ENVIRONMENTAL FATE PROPERTIES ......................................................................................................... 3

    2.1. Hydrolysis ...................................................................................................................................................... 32.2. Phototransformation in air ............................................................................................................................. 32.3. Biodegradation ............................................................................................................................................... 4

    2.3.1. Biodegradation in water ......................................................................................................................... 42.3.2. Biodegradation in soil ............................................................................................................................ 42.3.3. Summary and discussion of degradation ............................................................................................... 4

    2.4. Bioaccumulation ............................................................................................................................................ 52.5. Adsorption / desorption .................................................................................................................................. 52.6. Volatilisation .................................................................................................................................................. 52.7. Distribution modelling ................................................................................................................................... 52.8. Secondary poisoning ...................................................................................................................................... 5

    3. ENVIRONMENTAL HAZARD ASSESSMENT ................................................................................................ 53.1. Aquatic compartment (including sediment) .................................................................................................. 5

    3.1.1. Toxicity test results ................................................................................................................................ 53.1.2. Short-term toxicity to fish ...................................................................................................................... 63.1.3. Long-term toxicity to fish ...................................................................................................................... 63.1.4. Short-term toxicity to aquatic invertebrates .......................................................................................... 73.1.5. Long-term toxicity to aquatic invertebrates ........................................................................................... 73.1.6. Algae and aquatic plants ........................................................................................................................ 73.1.7. Sediment organisms ............................................................................................................................... 83.1.8. Predicted No Effect Concentration (PNEC) .......................................................................................... 8

    3.1.8.1. PNEC water .................................................................................................................................... 83.1.8.2. PNEC sediment .............................................................................................................................. 8

    3.2. Terrestrial compartment ................................................................................................................................. 93.2.1. Toxicity to soil macro-organisms .......................................................................................................... 93.2.2. Toxicity to terrestrial plants ................................................................................................................... 93.2.3. Toxicity to soil micro-organisms ......................................................................................................... 103.2.4. Toxicity to other terrestrial organisms ................................................................................................. 103.2.5. Predicted No Effect Concentration (PNEC soil) ................................................................................. 10

    3.3. Atmospheric compartment ........................................................................................................................... 103.4. Microbiological activity in sewage treatment systems ............................................................................... 11

    3.4.1. Toxicity to aquatic micro-organisms ................................................................................................... 113.4.2. PNEC for sewage treatment plant ........................................................................................................ 11

    3.5. Non compartment specific effects relevant for the food chain (secondary poisoning) .............................. 113.5.1. Toxicity to birds ................................................................................................................................... 113.5.2. PNECoral (secondary poisoning) ........................................................................................................ 11

    3.6. Conclusion on the environmental classification and labelling .................................................................... 114. HUMAN HEALTH HAZARD ASSESSMENT ................................................................................................. 12

    4.1. Toxicokinetics (absorption, metabolism, distribution and elimination) ..................................................... 124.2. Acute toxicity ............................................................................................................................................... 124.3. Irritation ........................................................................................................................................................ 144.4. Sensitisation ................................................................................................................................................. 144.5. Repeated dose toxicity ................................................................................................................................. 154.6. Mutagenicity ................................................................................................................................................. 154.7. Toxicity for reproduction ............................................................................................................................. 154.8. DNEL(s) / DMEL(s) .................................................................................................................................... 16

    5. HUMAN HEALTH HAZARD ASSESSMENT OF PHYSICO-CHEMICAL PROPERTIES ........................ 185.1. Explosivity.................................................................................................................................................... 185.2. Flammability ................................................................................................................................................ 18

    6. PBT AND vPvB ASSESSMENT ........................................................................................................................ 196.1. Assessment of PBT/vPvB Properties - Comparison with the Criteria of Annex XIII ............................... 19

    6.1.1. Persistence Assessment ........................................................................................................................ 196.1.2. Bioaccumulation Assessment .............................................................................................................. 196.1.3. Toxicity Assessment ............................................................................................................................ 206.1.4. Summary and overall Conclusions on PBT or vPvB Properties ......................................................... 20

    6.2. Emission Characterisation ........................................................................................................................... 207. REFERENCES ..................................................................................................................................................... 21

  • EC No: 931-274-8 HDI Oligomers, isocyanurate CAS Number:28182-81-2

    December 2011 Endpoint Summary information 3

    1. PHYSICAL AND CHEMICAL PROPERTIES Molecular