HCV/HIV 2013: Management of HCV in patients co-infected with HIV | PowerPoint Presentation

7/27/2019 HCV/HIV 2013: Management of HCV in patients co-infected with HIV | PowerPoint Presentation

1/31

Ohihkòìt cg MBW di phtdìtsbc-dig`bt`j wdtm MDW

^cn`rt Kdsm OJ

Rìdcr O`jdbhe Jdr`btcr, Rt Fcs`pms O`jdbhe Bìt`r \mcìdx

Bedidbhe \rcg`sscr cg O`jdbdi`, Pidv`rsdty cg I`vhjh, Ehs W`khs\rdibdphe, ^cn`rt K Kdsm Bcisuethits EEB


2/31

>

MDW/MBW bcdig`btdci6 h pr`vhe`it bmhee`ik`

MBW bc-dig`btdci ds bcooci hocik MDW dig`bt`j dijdvdjuhes

Hocik MDW-dig`bt`j dijdvdjuhes di tm` PR

>0% hr` bc-dig`bt`j wdtm MBW

=:


3/31

Bcophrdsci cg vdrhe bmhrhbt`rdstdbs6

MNW, MBW hij MDW dig`btdci

8. Ehu`r K & [hea`r N. I @ike F O`j > M`phtdtds B vdrus8,2 Muohi doouic-j`gdbdìby vdrus2

Zyp` cg vdrus M`phjihvdrus (JIH) Gehvdvdrus (ssÎH) ^`trcvdrus (ssÎH)

Kche cgtm`rhpy

Wdrhe `rhjdbhtdci Wdrhe `rhjdbhtdci Wdrhe suppr`ssdci

O`bmhidso cgp`rsdstìb`

Hbtdv` r`pedbhtdci uitdemcst dooui` r`spcis`be`hrs dig`bt`j bèes

Bcitdiucus hbtdv`r`pedbhtdci

Ehtìby

\rcpmyehxds ^`bcondihit vhbbdi`1dooui` kecnuedi (pcst-`xpcsur`)

Pihvhdehne` Pihvhdehne`

Hitdncjy r`spcis` Whrdhne` Di`gg`btdv` ju` tcvdrhe `sbhp`

Di`gg`btdv` ju` tcvdrhe `sbhp`

Wdrhe outhtdci rht` \mhs`-j`pìjìt 88


4/31

[crejwdj` pr`vheìb` cg MBW

di phtdìts wdtm MDW dig`btdci

8. Rm`rohi A, `t he. Bedi Dig`bt Jds >. Rtrhsgèj E, `t he. F Hbqudr Dooui` J`gdb Ryijr >


5/31

Edv`r jds`hs` ds tm` e`hjdik bhus` cg j`htm

hocik mcspdtheds`j HDJR phtdìts

MDW hbbè`rht`s tm` bedidbhe bcurs` cg MBW-rèht`j edv`rjds`hs`6

Ghst`r tdo` tc bdrrmcsds8>

Ghst`r tdo` tc MBB2

Ocr` phtdìts j`vècp bdrrmcsds wdtmdi h kdvì tdo` grho`8

Hebcmce mhs hi hjjdtdcihe hkkrhvhtdik `gg`bt

MBW bc-dig`btdci6

Dibr`hs`s tm` rdsa cg hitdr`trcvdrhe jruk-hsscbdht`jm`phtctcxdbdty

Jhopìs tm` BJ: r`spcis` tc hitdr`trcvdrhe tm`rhpy jurdiktr`htoìt:

8. Rctc N, `t he. F M`phtce 844;1 >76 8>. Ocmsì H. Kut >ij DHR Bcig`rìb` ci MDW \htmckì`sds hij Zr`htoìt >


6/31

MDWMBW bc-dig`btdci ohihkòìt dssu`s

MDWMBWbc-dig`btdciohihkòìt

dssu`s

Zdodik cg MBWtr`htoìt wdtm MDW

tr`htoìt Zdodik hij jurhtdcicg MBW tr`htoìt

hbbcrjdiktc kìctyp`

Cptdohe jcs` hijjurhtdci cgtm`rhpd`s

Edv`r

trhispehithtdci

Ohihkòìt cghjv`rs` `gg`bts

Hjjdbtdci-rèht`jprcneòs hij

scbdc`bcicodbdssu`s

Bcuisèedik hncutMBW sthtus hijMDW rdsa ghbtcrs

Bcuisèedik gcrtrhisodssdci rdsa

hij hebcmcehnstdiìb`


7/31

[ceg` OD, 4tm B^CD.

Bhus`s cg J`htm

\cst- vs. \r`-MHH^Z

ZN

ici-ZN Oybcnhbt`rdh

\i`uocbystds

Zcxcpehsocsds

Edv`r Jds`hs`

Ici-Mcjkadis eyopmcoh

Bhbm`xdh/[hstdik

Adji`y Jds`hs`

M`hrt Jds`hs`

Cjjs ^htdc

< 8 > 2 :


8/31Rheoci-B`rci `t he. F M`phtce >


9/31

@tdceckd`s cg Edv`r Difury

MDW MBW & MNW

Rt`htcsdsDooui`

^`hbtdvhtdci

MDWHebcmceCr ctm`rJruks

OdtcbmcijrdheDifury

H^Z


10/31

MBW Cutnr`has di ORO9 bmhik` di

n`mhvdcur

\hrds, I?>4 Khoncttd E `t he., @urc Rurv`dee, Ohy >


11/3188

^`jub`j r`spcis` tc H^Ws di phtdìts

bcdig`bt`j wdtm MDW/MBW hij MNW6 ZHMCJ

Cns`rvhtdcihe jhthnhs`6 ;,:00 MDW-pcsdtdv` phtdìts (>> mcspdthes, 88 bcuitrd`s)

Bcdig`btdci6 80% wdtm MBW, 88% wdtm MNW

ZHMCJ, Z^@HZ Hsdh MDW Cns`rvhtdcihe Jhthnhs`.

Bmì T.-O.H. `t he. DHR >


12/31

@gg`bt cg MBW ci MDW

Z-b`ee ^`ncuij wdtm H^Z

Odee`r OG `t. he., BDJ, >


13/31

82

Dibr`hs`j rdsa cg m`phtdb j`bcop`ishtdci

di phtd`its bc-dig`bt`j wdtm MDW/MBW

WHBR bcmcrt (844;->


14/31

M`phtctcxdbdty cg hitdr`trcvdrhe hkìts6

pr`jdbtdv` ghbtcrs di bc-dig`btdci

>. jì Nrdia`r O, `t he. HDJR >46 :82. I`z O, `t he. F HDJR >

0. Rhvs O, `t he. Hitdodbrcn Hkìts Bmòctm`r >>

82>0

> I^ZDs

H^Z

H^Z

8;

8

>

Rhvs0

[dt; 07< 2: 7.2 MBW, MNW, HEZ*, IW\,^ZW, RXW, gdrst MHH^Zr`kdoì

\D-nhs`j

* Nhsèdi` HEZ

\D-nhs`j

II^ZD-

nhs`jH^Z


15/31

80

MDW bcdig`btdci hbbè`rht`s MBW-hsscbdht`j

edv`r gdnrcsds ny heocst 8< y`hrs

HEDW@ bcmcrt6 88;7 burrìt hij gcro`r DJPs wdtm MBW hitdncjd`s, 2:% bc-dig`bt`j wdtm MDW

Kr`ht`r pr`vheìb` hocik MBW/MDW bc-dig`bt`j phtdìts tmhi MBW ocic-dig`bt`j phtdìts

cg6

Bedidbheey sdkidgdbhit gdnrcsds wdtmcut bdrrmcsds (8>.4% vs. 4.0%)

Bdrrmcsds (84.0% vs. 88.


16/31

Edv`r jds`hs`6 h ohfcr bhus` cg j`htm di tm`

MHH^Z `rh

8. ^cs`itmhe @, `t he. HDJR > Rphdi (Ohjrdj)2,: PRH (Ncstci)0

82%

20%

0%

8>%

:0%0


17/31

8;

MNW dibr`hs`s rdsa cg j`htm di phtd`its

bcdig`bt`j wdtm MBW hij MDW

Rphidsm WHBM bcmcrt6 72;4 MBW/MDW bcdig`bt`j phtd`its

200 (7%) hesc dig`bt`j wdtm MNW

0:2 j`htms hbrcss >7,;6=:0-=.


18/31

8=

MBW tr`htoìt r`jub`s tm` rdsa cg bdrrmcsds

di MDW/MBW-bc-dig`bt`j phtdìts

\rcsp`btdv` bcmcrt6 877 MDW/MBW bcdig`bt`j phtdìts wdtm bcopìsht`j bdrrmcsds

Zr`ht`j wdtm p`k-DGI peus rdnhvdrdi

Ghbtcrs dij`pìjìtey hsscbdht`j wdtm edv`r j`bcopìshtdci

Ici-RW^ (M^ =.8, BD 8.-;.>, p ?


19/31

84

MBW tr`htoìt r`jub`s tm` rdsa cg bdrrmcsds

di MDW/MBW-bc-dig`bt`j phtdìts

\rcsp`btdv` bcmcrt6 877 MDW/MBW bcdig`bt`j phtdìts wdtm bcopìsht`j bdrrmcsds tr`ht`j

wdtm p`k-DGI peus rdnhvdrdi

Odrh FH, `t he. Bedi dig Jds >


20/31

>7 (24%)

*Hjfust`j gcr hk`, s`x, MDW trhisodssdci bht`kcry, BJ: ihjdr, hjvhib`j gdnrcsds,

MDW ÎH 50< b/oE hij hitdr`trcvdrhe tm`rhpy.

M^, mhzhrj rhtdc1 RW^, susthdi`j vdrceckdb r`spcis`.

N`rìku`r F, `t he. Bedi Dig Jds. >1006;>=-27 .

Cv`rhee Edv`r-rèht`j

Ici-edv`r rèht`j Ici-edv`r, ici-HDJR

AO burv`s gcr j`htms

Hjfust`j M^ (40% BD) gcr ici-r`spcij`rs

vs r`spcij`rs*

I`w HDJR-j`gdidik

`vìts

8.4< (


21/31

\@KHRTRpeus BC\@KPR6 sup`rdcr `ggdbhby

r`khrje`ss cg nhs`edi` vdrhe echj

>>%

2:%

80%

22%

78%

RW^(%)

:

MBW edg`bybe`

hij jdr`bt hbtdik hitdvdrhe (JHH) thrk`ts

Hjhpt`j grco Ohiis O\, `t he. Iht ^`v Jruk Jdsbcv. >


25/31

>0

Cv`rvd`w cg JHHs

hpprcv`j cr di pmhs` 2

\`k-DGI, p`kueht`j dit`rg`rci hegh1 ^NW, rdnhvdrdi.

Hkìts \rct`hs`

dimdndtcrs

Iube`cs(t)dj`

pceyo`rhs`

dimdndtcrs

Ici-iube`cs(t)dj`

pceyo`rhs`

dimdndtcrs

IR0H

dimdndtcrs

Hpprcv`j Zèhpr`vdrNcb`pr`vdr

\mhs` 2 Rdo`pr`vdr

Ghejhpr`vdr

Hsuihpr`vdr

HNZ-:07;

^`kdoì

8 JHH + p`k-DGI/^NW

> JHH + p`k-DGI/^NW

DGI-gr`` wdtm > cr ocr` JHH +/- ^NW


26/31

>7

Cv`rvd`w cg bedidbhe stujd`s wdtm DGI-gr``

JHH bcondihtdcis

G^CO [ye`s OJ, ht Htehith KH6 Hprde 8< >. Ruzuad G. #8: @HRE >. @v`rsci K. HHREJ >. Khi` @F HHREJ >. Kde`hj pr`ss r`e`hs` G`n >. Khi` @F.

B^CD >. Adik O. B^CD >: was

88

:2

27 (>>/8 was

>:was

87

87

4:

4: (RW^:)

RCG/^NW IDIhv`

Iuees

8> was>0

8 was

8>/87 was

>02

80/4

42-87/;8)

HNZ-:07;/

222^NW\D/IR0H/IID

Ihv`

Iuees8>

;4

:0

44

42


27/31

\r`bedidbhe

\mhs` D

\mhs` DD

\mhs` DDD

Gde`j

Ncb`pr`vdr

(ORJ)

Zèhpr`vdr

(W`rt`x/FF)

ZOB-:20

(Zdnct`b/FF)OA;;(^cbm`/Dit`roui`)

ND>

(ORJ)

HNZ:07=:

(Hbmdeedci)

NOR ;440

(HVI)

NOR =>:242

(NOR)\\D-8224

(@ihith)

KRA

W`rt`x

Djìdx;84ORJ

Zhrdnhvdrdi

(Whe`hit)

DGI

(Vyockì/Icvhrtds)

J`ndc0/IDO=88

(Icvhrtds)

Idthzcxhodj`

(^cohra)

Rdedndidi`

Wdthodi` J

NOR

ND

^CBM@

Kde`hj

^;8>=

(^cbm`)

KR- ;4;;Kde`hj)

ND

Fhpci Zcinhbbc

^> (^cbm`)

O`jdvdr (Zdnct`b)

KER4242 (KRA)

Ndcbryst

DI] 8=4(Dimdndtr`x)

NOR;482>0

(NOR)Gdednuvdr

(\G@)KR484;(ND)

Wx>>>

(W`rt`x)

HNZ222

HNZ(HNZ)

DJ] 2;0

(Djìdx)

DJ] 8=:

(Djìdx)

RBT-=20

\\D-:78

WNT-2;7

W]-4=0

(W`rt`x)W]-=82

(W`rt`x)

KR4:08

(Kde`hj)

^K;2:=

(^cbm`)

ZOB 7:;4>=

(Hbdeedci)

KR-0==0

W`rt`x

Hnnctt

\mhrohss`t

Iube`csdj`

IR0N

\ceyo`rhs`

Dimdndtcrs

Iube`ctdj` IR0N

\ceyo`rhs`Dimdndtcrs

Ici Iub IR0N

\ceyo`rhs` dimdndtcrs

IR2/:H \rct`hs` dimdndtcrs

IR0H dimdndtcrs

JHH bcondihtdcis

Ctm`rs

Bybecpmdedi. D

DJ]


28/31

Rdo`pr`vdr6 tr`hto`it cg MDW MBW bc-dig`btdci

8:tm @urcp`hi HDJR Bcig`r`ib` (@HBR)

87-84 Cbtcn`r >


29/31

Krhgt RurvdvheMBW-MDW vs MBW Zrhispehit ^`bdpd`its

\?


30/31

24< MDW+ phtd`its

J``n A, `t he. B^CD >1 hnstrhbt


31/31

Zmhia ycu tc6 H\HRE hij

Oy MDW MBW bc-dig`btdci kurus wmc w`r` adij`icukm tc smhr` sedj`s hij tm`dr `xp`rtds`

A`i Rm`rohi Jhvdj [ye`s

Bmdp Rbmcce`y

Rmhrci E`wdi Jhvdj Zmcohs

Ohra Rueacwsad

HCV/HIV 2013: Management of HCV in patients co-infected with HIV | PowerPoint Presentation

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