HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L....
-
Upload
peregrine-pierce -
Category
Documents
-
view
216 -
download
0
Transcript of HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L....
![Page 1: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/1.jpg)
HCV in Addicted Patients:HCV in Addicted Patients:Overcoming the Barriers to Overcoming the Barriers to Education, Treatment, and Education, Treatment, and
OutcomesOutcomes
Diana L. Sylvestre, MDDiana L. Sylvestre, MDExecutive Director, OASISExecutive Director, OASIS
Presented by: Amy Smith, PA-CPresented by: Amy Smith, PA-C
![Page 2: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/2.jpg)
OASISOASIS
Organization to Organization to Achieve Solutions in Achieve Solutions in
Substance-AbuseSubstance-Abuse
![Page 3: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/3.jpg)
Our situationOur situation
• Poverty, high rates of drug usePoverty, high rates of drug use– Heroin, crack cocaine, Heroin, crack cocaine,
methamphetaminemethamphetamine
• Low rates of health insuranceLow rates of health insurance– Limited access to medical careLimited access to medical care– Limited access to drug treatmentLimited access to drug treatment
• Limited access to healthcareLimited access to healthcare
![Page 4: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/4.jpg)
Our Mission:Our Mission:
Provide high quality Provide high quality medical care to drug users medical care to drug users
(or whoever shows up)(or whoever shows up)
![Page 5: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/5.jpg)
A Small Community A Small Community ClinicClinic
• One doctor One doctor • One physician assistant (Me)One physician assistant (Me)• 3 peer educators3 peer educators• No nurses, social workers, or case No nurses, social workers, or case
managersmanagers• A lot of willing volunteersA lot of willing volunteers
![Page 6: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/6.jpg)
A Small Community Clinic A Small Community Clinic with an Evidence-based with an Evidence-based
ApproachApproach• Addiction is a medical illnessAddiction is a medical illness• Treatments are limited and relapse Treatments are limited and relapse
is characteristicis characteristic• Perfection is an unrealistic Perfection is an unrealistic
expectationexpectation
![Page 7: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/7.jpg)
![Page 8: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/8.jpg)
Treatment options Treatment options for hypertensionfor hypertension
• DiureticsDiuretics– HCTZ, spironolactone, furosemide, amiloride, HCTZ, spironolactone, furosemide, amiloride,
triamterene, etc.triamterene, etc.• ACE InhibitorsACE Inhibitors
– Benazepril, captopril, enalapril, fosinopril, Benazepril, captopril, enalapril, fosinopril, lisinopril, quinapril, ramipril, etc.lisinopril, quinapril, ramipril, etc.
• Beta BlockersBeta Blockers– Propranolol, atenolol, metoprolol, pindolol, labetolo, Propranolol, atenolol, metoprolol, pindolol, labetolo,
carvedilol, timolol, sotalol, nadolol, etccarvedilol, timolol, sotalol, nadolol, etc• ARBsARBs
– Irbesartan, losartan, candesartan, valsartan, Irbesartan, losartan, candesartan, valsartan, olmesartan, telmisartan, etc. olmesartan, telmisartan, etc.
• Calcium Channel Blockers Calcium Channel Blockers – Verapamil, diltiazem, nifedipine, nicardipine, Verapamil, diltiazem, nifedipine, nicardipine,
amlodipine, felodipine, etc.amlodipine, felodipine, etc.
![Page 9: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/9.jpg)
Treatment options Treatment options for diabetesfor diabetes
• InsulinsInsulins– Aspart, Glargine, Lispro, glulisineAspart, Glargine, Lispro, glulisine
• SulfonylureasSulfonylureas– Chlorpropamide, tolbutamide, tolazamideChlorpropamide, tolbutamide, tolazamide– Glipizide, glyburideGlipizide, glyburide– GlimeprirideGlimepriride
• BiguanidesBiguanides– MetforminMetformin
• Alpha-glucosidase inhibitorsAlpha-glucosidase inhibitors– Acarbose, miglitolAcarbose, miglitol
• GlitazonesGlitazones– Pioglitazone, rosiglitazonePioglitazone, rosiglitazone
• Megiltinides Megiltinides – RepaglinideRepaglinide
![Page 10: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/10.jpg)
Treatment options Treatment options for depressionfor depression
• Tricyclics (TCAs)Tricyclics (TCAs)– Amitriptyline, imipramine, nortriptyline, etc.Amitriptyline, imipramine, nortriptyline, etc.
• Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs)– Phenelzine, tranylcypromine, isocarboxazid, Phenelzine, tranylcypromine, isocarboxazid,
etc.etc.
• Selective serotonin reuptake inhibitors (SSRIs)Selective serotonin reuptake inhibitors (SSRIs)– Fluoxetine, sertraline, paroxetine, Fluoxetine, sertraline, paroxetine,
fluvoxamine, citalopram, etc.fluvoxamine, citalopram, etc.
• Serotonin antagonistsSerotonin antagonists– Trazodone, nefazodone Trazodone, nefazodone
• Other agents Other agents – Bupropion, venlafaxine, mirtazapine, Bupropion, venlafaxine, mirtazapine,
reboxetine, etc.reboxetine, etc.
![Page 11: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/11.jpg)
Treatment options for Treatment options for addictionaddiction
• AlcoholAlcohol– Disulfiram, acamprosate, naltrexoneDisulfiram, acamprosate, naltrexone
• OpiateOpiate– Methadone, buprenorphine, Methadone, buprenorphine,
naltrexonenaltrexone• StimulantsStimulants
– ??
![Page 12: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/12.jpg)
Addiction is not a single Addiction is not a single syndrome:syndrome:
Cannabis
Methamphetamine
CocaineHeroin
Regular use
Binge use
Alcohol
Polysubstance use
Intermittent use
![Page 13: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/13.jpg)
The evidence for addiction The evidence for addiction as a brain diseaseas a brain disease
Dopamine release in the Nucleus Dopamine release in the Nucleus Accumbens is a common Accumbens is a common characteristic of virtually every drug of characteristic of virtually every drug of abuse.abuse.
Koob, Trends in Pharm Sci, ,1992
DMT VTA
LC
Frontal Cx
N. Acc
Hippo
AMG
![Page 14: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/14.jpg)
It quickly became It quickly became apparent that our apparent that our
little clinic had a big little clinic had a big problem:problem:
HEPATITIS CHEPATITIS C
![Page 15: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/15.jpg)
Hepatitis C in OaklandHepatitis C in Oakland
• 96% of long-term injectors96% of long-term injectors• Limited access to drug Limited access to drug
treatmenttreatment• Syringe exchange available Syringe exchange available
on a limited basison a limited basis
![Page 16: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/16.jpg)
How we came to How we came to treat hepatitis C:treat hepatitis C:
![Page 17: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/17.jpg)
No one else would No one else would do it.do it.
![Page 18: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/18.jpg)
Relative Importance of Relative Importance of Risk Factors for Risk Factors for
Hepatitis CHepatitis C Remote (>15 yrs ago) Recent (<15 yrs ago)
Transfusion
Sexual
Other*
Unknown
TransfusionInjection Drug Use
Unknown
Other*Sexual
Injection Drug Use
* Nosocomial, occupational, perinatalAdapted from CDC Hepatitis Slide Kit http://www.cdc.gov/ncidod/diseases/hepatitis/slideset
![Page 19: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/19.jpg)
Natural history: Natural history: addictionaddiction
Hser, Y. I., et al. (2001) Arch Gen Psychiatry, 58, 503-8.
![Page 20: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/20.jpg)
No one else would No one else would do it.do it.
![Page 21: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/21.jpg)
We decided to try.We decided to try.
![Page 22: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/22.jpg)
Hepatitis C Hepatitis C Treatment in Drug Treatment in Drug
UsersUsers
![Page 23: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/23.jpg)
No one wants to No one wants to treat drug users for treat drug users for
hepatitis C.hepatitis C.
Why?Why?
![Page 24: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/24.jpg)
Barriers: Barriers: perceived vs. realperceived vs. real
• Adherence is badAdherence is bad• Reinfection Reinfection • Interferon can exacerbate Interferon can exacerbate
psychiatric symptomspsychiatric symptoms• Interferon is an injectable Interferon is an injectable
medication and may increase the medication and may increase the risk for relapserisk for relapse
![Page 25: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/25.jpg)
Most HCV treatment Most HCV treatment barriers are perceived barriers are perceived
or relative.or relative.
The real barrier is The real barrier is prejudiceprejudice..
![Page 26: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/26.jpg)
Bridging Active Heroin Bridging Active Heroin Users to HCV Users to HCV
Treatment with Treatment with BuprenorphineBuprenorphine
1 R01 DA015629-01
![Page 27: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/27.jpg)
HypothesisHypothesis
• Active, street-recruited heroin users Active, street-recruited heroin users can be safely and successfully can be safely and successfully treated for hepatitis C after 12-24 treated for hepatitis C after 12-24 weeks of buprenorphine weeks of buprenorphine stabilization.stabilization.
![Page 28: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/28.jpg)
Study DesignStudy DesignStreet-recruited
Heroin Users
Hepatitis C Viral Testing
Active: 12-24 weeks buprenorphine
Inactive: Ineligible
HCV Treatment, n=50Buprenorphine Maintenance
Not Interested in HCV Treatment: 12 wk buprenorphine taper
24 week buprenorphine taper
![Page 29: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/29.jpg)
![Page 30: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/30.jpg)
![Page 31: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/31.jpg)
EnrollmentEnrollment
• All screened = 415All screened = 415
• Eligible = 275Eligible = 275– Ineligible = 140 (33%)Ineligible = 140 (33%)
• Not viremic = 94 (23%)Not viremic = 94 (23%)• On methadone = 29 (7%)On methadone = 29 (7%)• No opioid addiction = 17 (4%)No opioid addiction = 17 (4%)
![Page 32: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/32.jpg)
RelevanceRelevanceAll Screened: n=415All Screened: n=415
68
53
0
10
20
30
40
50
60
70
80
90
100
Eligible Enrolled Start Bupe
% P
atie
nts
n = 275 n = 188 n = 146
![Page 33: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/33.jpg)
ScreenedScreened EligibleEligible EnrollEnroll Start Start Study Study MedsMeds
P ValueP Value
nn 415415 275275 188188 146146AgeAge 46 46
(20-(20-69)69)
46 46
(24-(24-69)69)
46 46
(24-(24-64)64)
46 46
(24-(24-64)64)
NSNS
MaleMale 70.4%70.4% 74.9%74.9% 73.9%73.9% 71.2%71.2% NSNSWhitWhitee
34.5%34.5% 32.0%32.0% 31.9%31.9% 33.6%33.6% NSNS
BlackBlack 37.3%37.3% 40.0%40.0% 39.4%39.4% 41.8%41.8% NSNSLatinLatinoo
23.9%23.9% 23.6%23.6% 23.4%23.4% 19.2%19.2% NSNS
The study sample is The study sample is representativerepresentative
![Page 34: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/34.jpg)
ScreenedScreened EligibleEligible EnrollEnroll Start Start BupeBupe
P ValueP Value
Yr. Yr. exposedexposed
2424 2525 2525 2525
ALTALT 46 46 5353 5555 5454 <0.001<0.001**
% Cocaine% Cocaine 47.547.5 50.650.6 48.648.6 50.050.0 NSNS% Meth% Meth 15.615.6 14.914.9 13.513.5 13.213.2 NSNS% Alcohol% Alcohol 58.058.0 50.350.3 60.160.1 55.555.5 NSNSGenotype Genotype 11
76%76% 76%76% 78%78% 77%77% NSNS*Significant for the difference between screened and eligible cohorts
The study sample is The study sample is representativerepresentative
![Page 35: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/35.jpg)
Other Other CharacteristicsCharacteristics
• 33% homeless33% homeless• Median education < high schoolMedian education < high school• Median monthly income ~$550 USDMedian monthly income ~$550 USD• 40% on probation or parole, median 40% on probation or parole, median
weeks of prior incarceration = 156weeks of prior incarceration = 156• 64% with history of “serious depression”, 64% with history of “serious depression”,
75% with history of “serious anxiety,” 75% with history of “serious anxiety,” 22% had prior suicide attempt. 14% had 22% had prior suicide attempt. 14% had been prescribed a psychiatric medication.been prescribed a psychiatric medication.
• Median number of prior treatment Median number of prior treatment attempts = 7attempts = 7
![Page 36: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/36.jpg)
Criteria for initiating Criteria for initiating HCV treatmentHCV treatment
– Active HCVActive HCV– InterestedInterested– Attendance of >75% of weekly Attendance of >75% of weekly
education sessionseducation sessions
![Page 37: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/37.jpg)
Drug Use Week 0-12Drug Use Week 0-12
0
1020
30
4050
60
70
8090
100
Op Coc Meth MJ
% U
A +
Baseline
Week 4
Week 8
Week 12
`
![Page 38: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/38.jpg)
Treatment Retention Treatment Retention (n=146)(n=146)
108
9383
76 7266
-10
10
30
50
70
90
110
130
150
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Weeks on Buprenorphine
Num
ber o
f Pat
ient
s
58%45%
![Page 39: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/39.jpg)
Interest in HCV Interest in HCV Treatment (n=146)Treatment (n=146)
8155
10
Early Bupe termination
Chose HCV Tx
Chose taper
![Page 40: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/40.jpg)
Drug Use and HCV Drug Use and HCV Treatment RetentionTreatment Retention
0102030405060708090
100
% C
ompl
etin
g H
CV
Tx
None
Any hard drugs
![Page 41: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/41.jpg)
Drug Use and HCV Drug Use and HCV Treatment RetentionTreatment Retention
0
10
20
30
40
50
60
70
80
90
100
% C
om
ple
tin
g H
CV
Tx
None
Any hard drugs
MJ+
![Page 42: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/42.jpg)
Drug Use and HCV Drug Use and HCV Treatment RetentionTreatment Retention
0102030405060708090
100
% C
ompl
etin
g H
CV
Tx
None
Stim+
Any hard drugs
![Page 43: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/43.jpg)
Drug Use and HCV Drug Use and HCV Treatment RetentionTreatment Retention
0102030405060708090
100
% C
om
ple
tin
g H
CV
Tx
None
Any hard drugs
Her+
![Page 44: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/44.jpg)
Drug Use and HCV Drug Use and HCV Treatment RetentionTreatment Retention
0102030405060708090
100
% C
om
ple
ting
HC
V T
x
None
Stim+
Her+
![Page 45: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/45.jpg)
HCV Treatment HCV Treatment OutcomesOutcomes
• Completed treatment, n=38Completed treatment, n=38• Early termination, n=18Early termination, n=18
– 3 incarcerated3 incarcerated– 4 medical4 medical– 10 FTS10 FTS– 1 side effects1 side effects
![Page 46: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/46.jpg)
Outcomes by GenotypeOutcomes by Genotype
6859
40
62
48
32
91100
64
0
10
20
30
40
50
60
70
80
90
100
Completed ETR SVR
%
All Pts
Geno 1
Geno non-1
37 1026 21 13 732 1120
![Page 47: HCV in Addicted Patients: Overcoming the Barriers to Education, Treatment, and Outcomes Diana L. Sylvestre, MD Executive Director, OASIS Presented by:](https://reader036.fdocuments.in/reader036/viewer/2022062423/5697bf7c1a28abf838c83ead/html5/thumbnails/47.jpg)