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Fig 2S Effects of foretinib on tumor growth of patient-derived xenograft line 5-1318. 5-1318 tumors were s.c implanted in SCID mice as described in Materials and Methods. Mice bearing tumor xenografts were treated with vehicle (30% Captisol) or 2 doses of foretinib: 15 mg/kg (daily) and 30 mg/kg (every other day) for 14 days as described in Materials and Methods. Each treatment arm involved 14 independent tumor-bearing mice. Mean of tumor volume ± SE at given time points (A), representative vehicle- and foretinib-treated tumors (B) and the corresponding tumor weight and statistical analysis (C) for 5-1318 xenografts are shown. Different asterisks (*) indicate significantly different from one another at P <0.05. Experiments were repeated twice with similar results.

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