Have a

Know the risk of cholera.

Please see Important Safety Information on pages 6 and 7 and accompanying full Prescribing Information.

Taste for Travel?

Vaxchora® can help protect you from cholera when you travel abroad.1

Vaxchora® is the only cholera vaccine approved for use in the US.5

Vaxchora® (Cholera Vaccine, Live, Oral) is a vaccine indicated for active immunization against disease caused by Vibrio cholerae serogroup O1 in adults 18 through 64 years of age traveling to cholera-affected areas.1

Limitations of Use: The effectiveness of Vaxchora® has not been established in persons living in cholera-affected areas.1

The effectiveness of Vaxchora® has not been established in persons who have pre-existing immunity due to previous exposure to V. cholerae or receipt of a cholera vaccine.1

Vaxchora® has not been shown to protect against disease caused by V. cholerae serogroup O139 or other non-O1 serogroups.1

Sampling local fare when you travel is one of the bestways to immerse yourself in a culture; however, it'sestimated that cholera is regularly found in 69 countries, primarily in Africa, Asia, and the Caribbean.2 Destinations that may be on your travel list.

That's why it's important to follow good food and water practices when you're abroad, to help protect your health. You can �nd the full recommended guidelines about food and water safety procedures at the CDC website (https://wwwnc.cdc.gov/travel/page/food-water-safety).3,4

Along with safe food and water precautions, and proper hygiene, the CDC recommends Vaxchora® for adults (18-64

years old) traveling to areas of active cholera transmission.6

2

Cholera Facts 4

Cholera is an intestinal infection caused by a bacterium that can be life-threatening.

The most common source of transmission is through ingesting food or water that has been contaminated with fecal matter from cholera-infected persons.

Cholera is most likely to be found in areas where there is inadequate water treatment, poor sanitation, and insuf�cient hygiene.

Symptoms include diarrhea, nausea, vomiting, and dehydration.

Please see Important Safety Information on pages 6 and 7 and accompanying full Prescribing Information.

Ask how Vaxchora® can help protect you while traveling to cholera-a�ected areas.

It's estimated thatcholera is regularly

found in

countries2

Primarily in

Africa, Asia, and theCaribbean269

3

failed to strictly adhere tofood and water precautions

in their �rst 3 daysabroad.*

98%

of travelers

*Based on a 1985 study of 688 international travelers who completed a voluntary follow-up survey.7

Vaxchora® is taken as a single dose.

• Vaxchora® is administered in your healthcare provider’s of�ce.

• Your healthcare provider will prepare your dose of Vaxchora® for you to drink right in the of�ce.

• Be sure not to eat or drink 60 minutes before or after administration.

Vaxchora® is contraindicated in people with a history of severe allergic reaction (e.g., anaphylaxis) to any ingredient of Vaxchora® or to a previous dose of any cholera vaccine.

Vaxchora® is an oral vaccine.

Vaxchora® was shown to be e�ective in clinical trials:

90%

3

of people were protected against cholera at 10 days.1

Approximately:

of people were protected against cholera through 3 months.1

80%

4

The most common side effects of Vaxchora® are: tiredness, headache, abdominal pain, nausea/vomiting, lack of appetite, diarrhea, and fever.1

Did you know?

• Cholera can come on abruptly and potentially lead to serious consequences before you can get the necessary health care.8

• In addition to using bottled, boiled, or treated water for making ice and brushing your teeth, the CDC also recommends it for washing your dishes in areas where cholera regularly occurs.3

Please see Important Safety Information on pages 6 and 7 and accompanying full Prescribing Information.

Vaxchora® can provide protectionin as little as 10 days, so be sure to get vaccinated 10 days before you travel.1

Ask how Vaxchora® can help protect you while traveling to cholera-a�ected areas.

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Important Safety Information

Vaxchora® is contraindicated in people with a history of severe allergic reaction (e.g., anaphylaxis) to any ingredient of Vaxchora® or to a previous dose of any cholera vaccine.

The safety and effectiveness of Vaxchora® have not been established in immunocompromised persons.

Vaxchora® may be shed in the stool of recipients for at least 7 days. There is a potential for transmission of the vaccine strain to non-vaccinated close contacts (e.g., household contacts). Use caution when considering whether to administer Vaxchora® to individuals with immunocompromised close contacts.

The most common adverse reactions (incidence >3%) were tiredness (31%), headache (29%), abdominal pain (19%), nausea/vomiting (18%), lack of appetite (17%), and diarrhea (4%).

For more information about Vaxchora®, please see full Prescribing Information.

6

References:

1. Vaxchora [package insert]. Redwood City, CA: PaxVax, Inc.; 2017.

2. Ali M, Nelson AR, Lopez AL, Sack DA. Updated global burden of cholera in endemic countries. PLoS Negl Trop Dis. 2015;9(6):1-13.

3. CDC. Cholera - Vibrio cholerae infection. Frequently asked questions. CDC website. https://www.cdc.gov/cholera/general/index.html. Last reviewed May 11, 2018. Accessed April 16, 2019.

4. Mayo Clinic. Cholera. Overview. Mayo Clinic website. https://www.mayoclinic.org/diseases-conditions/cholera/symptoms-causes/syc-20355287. Published March 9, 2017. Accessed April 17, 2019.

5. FDA approves vaccine to prevent cholera for travelers [press release]. Silver Spring, MD: U.S. Food and Drug Administration; June 10, 2016. Available at: https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm506305.htm. Accessed April 17, 2019.

6. CDC. Cholera. What is cholera? CDC website. https://wwwnc.cdc.gov/travel/diseases/cholera. Published January 10, 2017. Last reviewed January 10, 2019. Accessed April 4, 2019.

7. Kozicki M, Steffen R, Schär M. ‘Boil it, cook it, peel it or forget it’: does this rule prevent travellers’ diarrhoea? Int J Epidemiol. 1985;14(1):169-172.

8. Loharikar A, Newton AE, Stroika S, et al. Cholera in the United States, 2001-2011: a re�ection of patterns of global epidemiology and travel. Epidemiol Infect. 2015;143(4):695-703.

Ask how Vaxchora® can help protect you while traveling to cholera-a�ected areas.

7

The content in this brochure is for informational purposes only and is not intended to be a substitute for professional travel health or medical advice.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Don’t underestimate the threat of cholera.Ask your healthcare professional about Vaxchora®. Please see Important Safety Information on pages 6 and 7 and accompanying full Prescribing Information.

©2019 Emergent BioSolutions Inc.

All rights reserved. PAX-US-0245 | April 2019