AD-753 300

Hallucinogenic Drugs

Defense Documentation Center

DECEMBER 1972

Distributed By:

National Technical Information ServiceU. S. DEPARTMENT OF COMMERCE

525Pf!Rn Ro"' , S- inyil 2,91

UNCLASSIFIED AD-753 300

HALLUCINOGENIC DRUGS

A DDC BIBLIOGRAPHY

DDC-TAS-72-62

DECEMBER 1972

Approved for public releasedistribution unlimited.

NATiCýN"AI. TECHNICALINFORMATION SERVICE

UNCLASSIFIED

4 S

b'N

UNCLA S I ALi - • 1 t . .. __ I I

DOCUMENT CONTROL DATA - R & D(3.c~fnhfr I ~L... lt .,l,o.'" ,[ . b~e ; ci *h" { f eb:l~ nd ind~ellnl ,,l ,lle,,m ii. , ,.t Ie .~in".d wh.., the ov,,sll tIn,,,l•i . /•~,I ,

I ONIGIN&TI,4 AC IV II% W(C ofltl I* e1IMM) 1. RrrO0 l -I -

DEFENSE DOCUMENTATION CENTER UNCLASSIFIEDCameron SLation W °0"Alexandria, VirginIa 22314

HALLUCINO,'ENIC DRUGS

4 DII[ CPl1 TIvC P-OTEI (7'Yp Orep•.o( e land Wl hitt sle4 )

Bib] iography (,-'"emiber 1955 - March I372 _*• AU Tl-QR(*tl PI..rl f nleel,. miorol, I~tH'ei;. caile namen) •

M CPCON CATIE I.. 70TrL NO 01 P.AGI$ i9" of 0 ts

December 1972 ._ IS'_ _ _I_)_"_-73

-4 CON I (-,)R , RAN, NI i O.IGIN .I'. -t S tf1 N1;•Iflt•,I5

.- CJECT NU DDC-TAS-72--62

C i~~f,. r0 a

SAD-753 300

'0 OrSITN tBUIO0f STATIE U161

Approved for public reiease, d s tr ibu ti on, ni - mi ted.

11 UI-I *pLgtM~NIAq'• NO'f1 2 SPO'NSIOfIlN(. u,.I!A•ll ALTIVl?"

Supersedes AD 339 850

2 -AEETPIACI

This bibliography is composed of 73 references on thephys iol og i cal , psychological , bi o.,: hemi cal , arid chemi cal mechen i s',.!sof certain hallucino';c, c drugs. Drugs i,,cluded are l sergic aci!,mescaline, psilocylien, 'h,ratenin. cannabis and the hallucinogenicseries of amphetamines.

Studies on the chemically active ingredient of marijuana,tetrahydrocannabinal, have beer included.

Corpora Le Author-Moni tori rig Agency, Subject, Title, PersonalAuthor, Contract Number and Report Number Indexes are provided.

DD '2' 1473 ,WLSSII,No ... 'AS I ,D

UNCLASSIFIEDlecurit'y clesiftr|calt ion

KE LINK A LINK LIN__

ROLCI WT mOlG WT mOLE WT

*Bibl iographies*Hal I uci nogensLysergic AcidsCannabisAmphetaminesPsychotropic AgentsCentral Nervous SystemReaction(Psychology)PharmacologyDrug AbuseMarijuanaPsychopharmacol ogy

UNCLASSIFIEDSecurity Classificetion

UNCLASSIFIED

AD-7F3 300

HALLUCINOGENIC DRUGS

A DOC BIBLIOGRAPHY

DDC-TAS.72-62

November 1955 - March 1972

DECEMBER 1972

Approved for public release;distribution unlimited.

a

I

DEFENSE DOCUMENTATION CENTER

DEFENSE SUPPLY AGENCY

CAMERON STATION

ALEXANDRIA, VIRGINIA 22314

UNCLASSIFIED

FOREWORD

This bibliography is a compilation of references on

Hallucinogenic Drugs. Entries were selected from references

processed into the Defense Documentation Center's data bank

from January 1953 to July 1972 and supersedes AD-839 850.

Corporate Author-Monitoring Agency, Subject, Title,

Personal Author, Contract Number and Report Number Indexes

are provided.

BY ORDER OF THE DIRECTOR, DEFENSE SUPPLY AGENCY

OFFICIAL

AdministratorB.SEM

Defense Documentation Center

iii

CONTENTS -

Page

FOREWORD .............................................. iii

AD BIBLIOGRAPHIC REFERENCES .........................

INDEXES

CORPORATE AUTHOR-MONITORING AGENCY .............. 0-1

SUBJECT ......................................... D-1

TITLE ........................................... T-1

PERSONAL AUTHOR ................................. P-1

CONTRACT .......................................... C-1

REPORT NUMBER .................................... R-I

Preceding page blank

UNCLASS~ 1I1 O

ZFPQ~ 'P i t'L I1J I i PHY ý,t C H CO0N T qO0L NOIZAML2

CAý. rl~qNIA 'U'l LO)S ANGLLE5

1IJTLqU,1 PROGREqi REPaT, 1 JCTORFR 60-)l MARCHi1961 4 u

APR 61 IV ALLES GnRDON AoIFAtRCNILDoM, DAVIDt

rONTRACT: DAIQ 1OB '4U4C4L7;)5

UNCLASqlrIEU RFPORT

nESCRIPTORS: *HALLUC INOGENS, 01-MARmACOLOGY,_AMPHLTAMINES, AIIHALONIUM ALKALOIDS, ANIMALS,RARRI'IJRATES, ArHAVIUR, CEREBRAL CORTEX", DRUGS,ELF CTRICAL. PROPrRTIES, FLECTRODFS,ELECTROENCEPHAL'-GRAPMyt FREQUENCY ANALYZERS; TESTME THUDS )

THIý> 'REPORT TNICLUU.ES! MET'iYLENEDIOXY-AMPHETAMINE

I4ALLIICINUGFNTC SERILS OF COMPOUNDS. PART Is APR 6i,

l0P. iCiNTRAtT DA Ld1845CL75CO)NUIIIONED REWAVIOtR AND ELECTROENCEPHALOGRAPHIC TESTMETHODS. PART TI. APR 61, IUP. (CONTRACT DA Is-1 OA-qQ5-CML- 73 U I

UNCLASSIFIED /?AML2

II

UNCLASS rIEQ

•)b 4EPOT QImLIjGRAPHY SEAqCw CONTROL NO, /ZAML2

A•-26• 11V

CALIFORNIA U'NII' LOS ANGELES

MtThYLENET IOXY-AHPHETAMINE HALLUCINOGENIC SERIES OFCtMI'MUND (I1) CONOITIONED BEHAVIOR AND

.LELTf~rNCEPHALOGRAPHIC TEST METHODS (IT1 (U)

urT 61 IV ALLES;GORDON A.IFAIRCHILD,M, DAVIDICONTrACT: OAIA 108 4USCML735

UNCLASqIrIEO REPORT

MESCRIPTORS: *Dý,HALONIUM ALKALOIDS. OBRAIN, *CONDITIONEDREFLLX, OHALLIfCTNOt.ENS, AMPHETAMINES, DOSAGE, ELECTRICPOTENTIAL, EL7CTROENCEPHALOGRAPwY, LABORATORY ANIMALS,PHARMACOLOGY, P"YSIOLOGY, PRODUCTION (U)

AePhOXIMATFLY 10 GRAMS OF EACH OF THE SALTS OF FOUR3.I-ý;zTHYLEN!O1OXY-AMPHETAMINE DERIVATIVES *ERESUIAmTTED FOP rURTHLR TESTING IN ANIMALS AND POSSIBLEEVALUATION OF THEIR RELATIVE HALLUCINOGENICACTIVITIES IN "AAN, NO ORGANIZED REPORT AS TO WORKPRO64ES, ON THFSE COMPOUNDS IS YET AVAILABLE. THE

BEHAVIORAL ST:J'IES INVOLVING AVOIDANCE-ESCAPETRAINJING IN S4TSS ALBINO MICE WAS BEEN COMPLETED.ALL eIX TEST CnMPOUNDS HAVE BErN INJECTED INTO ATLEA•T FIVE MTCr IN AT LEAST TWO DOSE LEVELS, THEEFFLTr OF THE mRUuS ON THE EXTINCTION OF THECONDITION•F QEqPONSL IN ReLATIONSHIP TO A CONTROLGr)OuP RECEIVINr 1SOTONIC SALINE IS PRESENTED. WORKON THE EEG TES METHODS DURING THIS PAST SIX MONTHSHAS CONSISTE" LARGELY OF THE CONSTRUCTION OF AN EIGHTCHANNEL FREQUEnCY ANALYZER. DETAILS OF THISINSTPUMENT APE PRtSENTED IN THF BODY Or THIS REPORT*

(AU THOR U

2

UNCLASS I FIED /ZAMLZ

L.

UNCLASSIrIOD

OL" RP.qT QLkLGRlFPH4Y SEaQCH CONTROL NO, OZAML2

JOiNR HUPKINI '-NIV JALTIMORE M" SCHOOL OF MEDICINE

T'IF PHARMAOt.LOrICAL PROPERTIES OF AN EVOKED POTENTI$L

IN )HE MIDBR ýI,' RLTICULAR FORMATION (U)

MESCRIPTIVL NOTE k&EPT. FOR JUL 98-DEC 99AiUG 61 'lP LANGFITT,THOMAS *,I

CONTRACT: 'lA-Im. 10-CML-6'425

MONITuR: CRDL SP-2-4)

tINCLASRIrIE) HEPORT

nESCRIPTORS: SAIBITURATES, 8RAINI DRUGS; ELECTRICPOTENTIAL, ELFCTRICAL. PROPERTIES,

ELLCIROENCEPHALmGRAPHY, LYSERGIC ACIDS; SPINAL CORD (U)

THIS STU Y o m 0 0 TERM! ER BRAT ST

EVOKF POT NT! t. CUULD BE ALTERED BY A VARIETY OF PH

RM LOLOGICAL AnENTS, EVOKED POTENTIALS IN THEMIDOPAIN RETIC1ILAR FORMATION AND IN T E POSTERIOR

LATERAL VENTPA,. NUCLEUS OF THE THALAMUS (VPL' WERE;TULtTED IN ý! PATS. THE RESULTS SHO* THAT THERE WAS

NL) LONISTENTAI.TERATION IN THE EVOKED POTEN IALS

FULLON;I U THF iD INIS o TIO OF Y DRUG C PT P

itA KPI AL. P F OB ROITAL DEPRESSES HE EVOK DPOTENTIAL IN THE MIORRAIN RETICULAR FORMATION OF THE

CAT. THE LOCUS OF ACTION OF LYgERGIC ACID

OIETHYLAMIDE (L 0) CHLORPROMAZINE, PHYSOSTIGMINE,

ATPUPINE, ADOE'ALINEo GAMMA AMINOBUTYRIC ACID

(GAvA), SUCCINVLCHOLI , MECHOLYL, AND QESERPINEEITHFR IS NOT AT THE RECORDING sITES INVESTIGATED IN

T IS STUDY (MI'BRAIN RETICULAR FORMATIMN ANDPOSTFRIOR LATE"AL VL0TQAL NUCLFUS OF THE T LAMUS),

Uk IWE ALlERATION5 IN ELECTRICAL ACTIVITY PRODUCED BY

THE DRUGS ARr TOO SOJkTLE TO 5E DETECTED BY THEMEThODS USED. (AUTHOR) (U)

3

UINCLASSIFIED /ZAML2

UNCLASSIeIED

DOC REPUOT mICLIOGRAPMY SEARCm CONTROL NO* IZAML2

AD-2e> 261KENT STATr UNIt' OMHI

THF FFFECT Or ^RUGS ON PHYSICAL PERFORMANCE INAN I mALe q UI

OCT 62 IV *ILBER;CHARLES G.,CONTRACT: DA'9 19)M0d2|6

UNC' ASeTrIEO REPORT

DESCRIPTORS: *RrHAVIwR, *DOSAGE; *HALLUCINOGENS;*MATEMEATICAL AmALYSIS, oPHARMACOLOGY, *TIME, *TOXICITY,AQUATIC ANIMALS, CANCER; CANNABINOLSo CHLORPROMAZINE,DRUGS, FwUATIONq, LABORAIORY ANIMALS, LYSERGIC ACIDS,MAN, eNIMMING, TEMPERATURE (U)

THIS REPORT TNrLUUES: THE BIOLOGY OF WATERTOXICANTS IN SUBLETHAL CONCENTRATIONS; BY CHARLESG, ,iILREN* 1967, 28P, INCL, ILLUS. TABLES. SOMETHnUGHTS ON PSYCHOTOUENIC URUGS, BY CHARLES G#'1ILvFR* 1962, lUOP THE EFFECT OF LYSERGIC ACIDD[IETHYLAMIOE O'J S 1IMMING TIME IN ALBINO MICE, BYCHAmLES G. WtLmER AND Ji A* BURKE. 1962, lOP*INCL, TABLES* CONTENTS! THE EFFECTS OF DRUGS ONPHYSICAL PERFOPMANCE IN ANIMAL"; THE BIOLOGY OFWATER TUXICANT5 IN SUBLETHAL CONCENTRATIONS; SOMETHOUGHTS ON PSYCHOTOGENIC DRUGS; AND THE EFFECT OFLYSLRGIC ACIn [IETHYLAMIDE ON qRIMMING TIME IN ALBINOM IC E (U)

4

UNCLASS I rED /ZAML2

IN C LA SS ~ro

4ENPuPT li:"LIUGtIAPNY SCAQCH CONT9O0OL IZAL

AASHTNGTQN u'k't' SEATTLE

SO4L RIOCHEMTCAL SjTUDIES ON PSILOCYBIN ANDPSj LOC IN (UI

UCT 62 IV HoRITAv,A.CON7RqACT: nAjA l0BCML6)169

UNCLASSIF1EV REPORT

nESCRIPTcR5: OHALLUC INOGENS, ANTIMETABOLITES, CYTOCHROMEO"!flAS-E1 DISTQIflUTION, INTbSTIN!. KIDNEYS, LABORATORYANTMALS, OX!DrIRrDUCTASES, PHARMACOLOGY, PHOSPHORICMONULýSTER HYOPOLASES, SEROTONIN (u)

UNCLASSIFIlED ,ZANLZ

UNCLASSIFIED

DOC REPORT QIQLIoGRAPHY SEAPCH CONTROL NO, /ZAML2

AD-294 9568CALIFORNIA UO•,lt LOS ANGELES

I. MFTHYLENEDIMXY-AMPHETAMINE HALLUCINOGENIC SERIESOF (OMPUUNf. IIe CONDITIONED REHAVIOR ANDFLF(TROENCEPHALOGRAPHIC TEST METHODS tUl

kJFC 62 IV ALLESGORDON A**FAIRCHILDMo DAVIDICONTRACT: OAIA 108 HUSCML7)5

UNCLASqIrIED REPORT

OESCRIPTORS: *HALLUCINOGENS, ALKOXY RADICALS, AMIDES,ANHALONIUM ALKALOILq; 9FNZEDRINF SULFATE, CATS,CONDITIONED RFFLEX, )IOXIDES, ELECTRIC POTENTIAL*ELF'CTROENCEPHALMGRAPHY, MAN, METHANES it C), MICE,PHARMACOLOGY, PwENYL RADICALS, PROPYL RADICALS,STIMuLATION, TE•T LQUIPMENT, TEST METHODS, TOXICITY 4U)

FOUR METHOXY ANM MLTHYLENEDIOXY DERIVATIVES OFAMPHLTAMINE, AMPHETAMINE, AND MESCALINE HAVEBEEN TESTED FOR THEIR EFFECT ON THETRAN3CALLOSAL EVOKED POTENTIAL; ON A DISTINCTIVE WAVEFORM IN TmE EEG ANESTHETIZED AN'i UNANESTHETIZED CATSAND UN THE CONDTTIONLD AVOIDANCF RESPONSE IN MICE INAN ATTEMPT TO FIND A TEST METHOO GIVING RESULTS THATCORRLLATE WITH THE HALLUCINOGENIC ACTIVITY IN MAN*

6

UNCLASSIFIED /ZAML2

UNCLASSIF IECPi Q jT I Q G rýAP HY SEARCH4 IO~O O ZAmL2

'.j~~CNTO NTNO* 'I\ ~

SL.ii. fFFLCTS Of t rnJPTENIlJE ON OHYSICAL PERFORMANCE IN

M I C L I(UI

OPC 63 IV *!L9RlrrHARLES G.;roNTRACr: OA40 19)MD2216

g1 C L AS I rI UL, li rP 0 K

R *4L L U CI N 0 G Et 1 .(1 A tIC COMPOUNDS,ALKA;,F S , LI'A'IF ( Njo:,dERM I rJAL ,ALK~ANES ( POLY USAGE,

ALKAiirl cTFRM?tfL), A!rAIPLS, 3F~N7ENE (FUSED), BENZENE( f 0-4u S U il TI T U?'r %) , F ( 14A NE S ( 2 C), ExERCtSE, HYDROXYL(OH), HYDRIXYL, MENCAPTrn RADICALS*, 1NHI$3ITIOA. METHANES(I (.), MIC% tiTTR~OGFN HETEROCYCLICS (I Nj), NITROGEN

HETCKOCYCLICS (a m), NITROGEN HrTEROCYCLICS (FUSED),-

PFRF~rmmtNCr TrSPS, PHARMACOLOGY, qTIMULATION, SWIMMING,

TER~TIARY AMINFS (-N~ 4U)

7

UNCLASSIrIED /ZAML2

UNCL ASS Ir IED

D,.~ REPO3ýT *ILj~jGRAPHY SEARCH CONTROL NO. IZAML2

AD-3I42 112C~-EmICAL RESFArCH AND4r lEvELOPMFNT LAOS EDGEOOOD ARSENAL

SUM~MARY REPORT ON EA 1'476 AND FA 223:1 lU)

A11G 63 45* DEPTo NJOo CRDL-cPECIAL PUB-1-'44* ~~PRoj: DA-N-C-fl'2O2'49 DA-'4C-08OIU16

T ASK: 9-C-OA07n)4O), 4--83061

UNCLASqIFIED REPORT

flESCRIPTORS: (*CHEMICAL WARFARE AGENTS,CANNAS.IS)t (*P5vCMuTROPIC AGENTS, EFFECTIVENEhSS, (*PHARMACOLOGY, CANNABIS),

(*PHYSIOLOGY, CANNABIS), 19CANNAB!S,

EFFECT IVENESSi. (U)

IDEriTIFIFRS: i9A), EA 1'476s EA 2231. (U)I

THiF ACTIONS 'IF EA 1476 AND EA 22:12 ARE_

GENLP'ALLY SIMI! AR TO MHPPSYCHOTROPIC COMPOUNDS OFI MILITARY INTvrST; I.E., THEY YIELD VARYING DEGREES

OF INCAPACITATION, UOTH PHYSICAL AND MENTAL. BOTH

COHi'nUNDS, HtVACVERg AREJ UNIQUE IN ELICITING AN

0INEUIVOCAL (,RTHOSTATIC HYPOTEmISION AT DOSE LEVELS

F~AR RELO* TH('Sr REQUTRFD TO PRO DUCE MILD MENTAL

IN~CAPACITATION. ND HUJMAN STUDIFS HAVE YET BEEN MADE

O:-, iSOMEuRS 2 ANDI 4- PRIMATE DATA DO INDICATE,

HONfLVFR, THAT THESE SPFCIFIC STEPEOISOMERS POSSESS A

DEGiiFF' OF PHAIIRACULUGIC POTENCY, AT LEAST E:QUIVALENT

To II4AT OF T'wE RACEMIC MIXTURES STUDIED IN HUMAN

SU~3jFCTS. SECOýJDLY, NO HUMAN OR ANIMAL DATA ARE

AVALLA3LL ON TwE EFFECTS OF THr ALROSOLIZED AGENTS.

IT IS; fELIFVrn THAT DATA SHOULD YET BE OBTAINEDF,0Ori THE FOLLO-ING !)TUDIFS, (1I FXPOSURE OF

A~itMAL AND HUJMAN SUdJECTS TO TH~E AEROSOL? ZEDRACt.MATt~. 12) rXpOSURE OF HUMAN SUF.JECT TO

ORAL DOSES OF cýTEREOISOMERS 2 AND '4. iAUTHOR)

8

,)NCLASSIFIEO /ZAML2

'JNCLASSIr I D

J)(. RE -• !IgGRAPHY SEAQCH CONTROL NO, /ZAML2

Co.ENICAL RESrA-CH AN) DEVELOPMENT LABS LOGENOOD ARSENALL4 L

THE INCAPACITATINU LFFECTS OF CERTAIN COMPOUNDS,MEA:,lRrO nY THC RESPONSES Oý FLY LARVAe, (Ul

MESLRIPTIVE NOTE! REPT. FOR JAN-OCT 61,JI.\JN 13P SNYDERqF H. [HASSETTC, C.

REPT. 'Oe CRDL-1200

PROJ: DA4Cn~22T ASK: '4-C-OfIU201ý30

UNCLASqlrIEU RFPORT

DESCRIPTORS: (*1NCAPACITATING AGENTS# LARVAE)) TESTS$ANALYSIS, DIPTEDA, MLASUREMENT, CHEMICAL COMPOUNDS, VAGLNrs, STATISTICAL ANALYSIS, RFCOVERY (U) BIOLOGICALASSAY, ATROPIME (U "

IDENTIFIERS: TETRAHYDROCANNABINnL, ATROPINE SULFATE,BZ A(aFNTS, SAPCnPHAGA BULLATA, V9 AGENTS, PROPYLENEGLYCul (U)

THE METHOD OF PIOAS5AY USING LARVAE OF THE FLESHFLY, SARCOPHAGA BULLATA, DESCRIaED IN THIS REPORT,CAN DISCLOSE 8nTti THE KNOCK-DOWN EFFECT OF A CHEMICALAND THE DURATIlN OF THE EFFECT. IT SHOULD BECUNSIDERED AS A POSSIBLE ROUTINE SCREENING METHODFOR TOXIC OR IKICAPACITATING COM POUNDS, THEFOLIOWIN•j ANr THE RELATIVE POTrNCIES OF THE COMPOUNDSTLSTFD: VX, lInO; EA 1476(TETQAHYUROCANkA;3 NJL); S3; LSD. !O; 8Z, 16;AND ATROPINE S''LFATc, 4. LSD, RZ, AND ATROPINESuLFATE hERE J"DGED TO HAVE SIMILAR ACTIONS, WHICHDIFFER FROM THrSE OF VX AND EA 1476. (AUTHOR)

(U)

9

UNCLASSfrI ED /ZAML2

UNCLASSIFIED

DOC REPORT SIOLIOGRAPHY SEARCH CONTROL NO, /ZAML2

AD-)66 91'

CHEMICAL RESF.nCH AN" nEVELOPMENT LASS EOGEwOOD ARSENALrio

TETHAHYDROCANNABINOLS I1. SYNTHESIS OF EIGHT ISOMERSOF A SYNTHETIC TETRAHYnROCANNARINOL, (Ul

nESCRIPTIVE NOTE: rECHNICAL REPT, SEP 5A-FES 62,

SFP 65 19P FERGUSON ,C. PARKER IAARON,HEROFRT So ;

REPT. NO. CRDLR-3)I.PROJ: DAIC522'1IA0O0

TASK: 4CO 03 016 07

UNCLASqIFIED REPnRT

MEScRIPTORS: (OM-HLTEROCYCLIC COMPOUNDS,STERLOCHEMISTPY), (*MOLECULAR ISOMERISM, 0-HETENOCYCLIC COMPOUNDS); SYNTHESIS(CHEMISTRY),HYDRuXIDES, AROMATIC COMPOUNDS, POLYCYCLICCOMPOUNDS, SPECTRAMINFRARED), NUCLEAR MAGNETICREbONANCE, CHROMATOGRAPHIC ANALYSIS, MOLECULARROTATION, PHYSICAL PROPERTIES, MELTING, OPTICALPROPLRTIES, PHARMACOLOGY (U) (eCHEMICAL WARFARE

AGENTS) (UiIDENTIFIERS: CAMINABINOLS, EA 1476, EA 2223,

TETRAHYnROCANNAPINOL (U)

EIGHT INDIVIDUAL ISQMEQS OF A SYNTHETICTETkAHYDROCANNABINOL WERE PREPARED FORPHAHMACOLOGICAL EVALUATION. FOUR THREO ISOMERSWLRL OBTAINEn mPTICALLY PURE, WHEREAS FOUR ERYTHROISOMERS WERE OnTAINLO AS PARTIALLY RESOLVED MATERIALSOF UNCERTAIN OPTICAL PURITY. (AUTHOR) (U)

10

UNCLASSIFIED /ZAML2

UNCLASS Ir~IED

('-I(. 9'UEP -T a I'L IvGNA PH Y SEARCH CONTROL NO, *ZAML2

AD-41 I )RSCHEM'ICAL RESF4V)CH ANO DLVELOPmFNT LABS EDGEOOOD ARSENALm p

SYNTHESIS nF AN IhOM1ER OF TETRAHYDRUCANNABINOL"'UI

PiAP 63 ft]P HIVELY,41CHARO LoISTECLE',ROGLR &HOFFmh-p,F.Wo;

REPTo "'0. CRDL-ePECIAL PUB-1-41PROj: OA-'s-C-mrm3O) 6TASK.: H-C-'3RO1Q1607

IJNCLASq I lEo REPORT

SUPPLLME14TARY PNIO7E: 6ORK STARTEf) JAN 61 AND COMPLETED

flESCRzPTORS: aroRGANIC COMPOUNDR, SYNTHESIS(CHEMISTRY)), leMOLECULAR ISOMERISM, MOLECULARsTMUL.TJPE), MnLFCULAIR STRUCTURE; SPECTRA(IN4FRARED), SPEtcTRA (VISIBLE.+

ULTRAVIOLLT), N-ICLEAk MAGNETIC RESONANCE, 0-HETFCOCYLIC CIM POUNLIS, STEREOCHEMISTRY. uIDENTIFIERS: TERAHYDqOCANNABINOLo 196). U

STRUCTURL OF TPTRAH~r'ROCANNABINOL DERIVED FROMNATURAL SOURCE-I I-s KNOWN EXCEPT rOR THE POSITION OFTHE ISOLATED ALICYCLIC DOUBLE ROND AND THE

CONFIGURATIONI ABOUT THE 6 00 IDA-CARBON ATOMS. THEFINAL RESOLUTIMN OF THE STRUCTURE OF NATURAL.TETFRAHYDROCANNABINOL DEPENDS ON THE SYNTHESIS OF THESEVERAL POSSIBLE ISOMERS. AN ATTEMPT TO FIND AMETmOD FUR THE PREPARATION OF THE ThO PAIRS OF

DIAbTEREOMERTC CIS)- AND TRANS-I-HYDROXY-3-N-AMYL 6,6, 9-TRIMETHYL-6Ao 7s 10, IOA-TETRAHYDRO-6n149ý!ZOPYRANS MY A DIELS-ALDER CONDENSATION OFISIPRENE WITH AN APPROPRIATELY SUBSTITUTED COU MARIN

15 HFPOR~TED9 qrFSULT5 OF THE CONDENSATION OFISOPPENE kvITH I-CARaOXYCOUMARIN, 51-ACETYLCOLJMARIN@ I-CAR OXY-!),-HYnqOXY-7-AMYLCOUMARIN; AND 3-CARBOXY ~HYRX--A~TOY7AYCUAI AND THE PRE

PARATION OF TRANS-1-HYflROXY-1-N..AMYL-6, 6, 9TRIU1ETHYL-6A,7:10, lOA-TETRAHYD90-6-DIBENZOPYRAN ARE

nESCP IBED. TQAK'S-1 -HYOROXY-3)-N.AMYL-6 ,6,9

TRIrFTHYL-6A,7:1,IOIA-TETRAHYDRO-6-DIBENZOPYRAN ISI NOT IDENTICAL -ITH A TETPAHYORnCANNABINOL ISO LATEDFROM HASHIS3H. *ORK 1S IN PROGRESS ON THE SYNTHESISAND OPTICAL PEcOLuTION OF THE CIS- AND TRANS-I-HY H X - - -M L 0 , -R M T V -A 7 10, IOA-TLTRAt4YDRO-6-DTBENZUPYRANS. (AUTHOR) (U)

11

UNCLASSIFIEU /ZAML2

UNCLASSIFIED

DOC. FPORT RIOLIOG.APHY SEARCH CONTROL NO. /ZAML2

ISTITUTO SUIPERIORE 0O SANITA RVME lITALYi

EFFLCT OF PRI,Gc ON CENTRAL NERVOUS SYSTEM NEURONES,iUI

MESCR1rTIVE NOTE: FINAL TECHNICAL REPTs,JUL 63 16P LONGOVINCENZO Got

CONTRACT: AF 61g(UO2)-!99MONITWR: AFOSR 5107

UNCLAS';IFIED REPORT

"nESCRIPTORS: (s'.ERVOU9 SYSTEM; CNS DEPRESSANTb, SCOPOLAý'INE, AMPHETAMINES, LYSERGICACID:, PHYSIOLOnY, CEREBRAL CORTEX,ELECTROENCEPHALmGRAPHY* (U)

IDENTIFIERS: FLFCTRICAL ACTIVITY, ESERINE,TRYPTAMINE, 1961, qU)

THE PRESENT QEPORT LXPOSES THE RESULTS OBTAINED

DURING AN INVESTIGATION ON THE EFFECTS OF DRUGS ON

THE FLýCTRICAL ACTIVITY OF SINGLE CORTICAL NEURONES.

DURING THE COUqE OF THIS INVESTIGATION THE

FOLLOAING DR"'Ge AERE INJECTED! ESERINE; SCOPOLAMINE.

AMPhETAMINE, TOYPTAMINE AND LYSERGIC ACID

DIV ITHYLAMIDE (L.SD|, ALTHOUGH IT IS NOT POSSIBLEWITm THE PREc;EPT LIMITED DATA TO ARRIVE AT ANY CLEAR-

CUT CONCLUcsI0N, SOME COM MENTS AND INDICATIONS IN

REGARD TO FUTUDE DEVELOPMENT OF THE RESEARCH ARE THE

FGLL'OWING: (1) IN THE SENSORIMOTOR CORTEX THERE

SLErh TO BE SOME LAYERS THAT HAVE MANY CELLSRESPONDING WtTw INCREASED FIRING RATE AFTER

APPLTCATION nF EXTERNAL STIMULI;o (2) BOTH

ESERINE AND AMPHE TAMINE PROVOKE AN INCREASE IN

FIRING OF SINGLE NFURONESi AND (3) THE''FLATTENING Or THE EEG TRACING PROVOKED BY

TRYPTAMINE AND LSD SEEMS TO BE RELAT IT LEAST WHERE

IT IS CONCERNEn *ITH THE LIMBIC CORTEX, WITH A

DIMINUTION OF (ELLULAR ACTIVITY. (AUTHOR) (U)

12

UNCLASSIjIED /ZAML2

uNCLAk5 IF 1(

00%. 4FF~qT AlnLIJGHAPNY SEARCH4 C'JNTROL NO. oZAML2

JLFF~RqeN "E'EIrAL COLL PHILADELPHIA PA

NLUI.nrPHARMACrnLrGIL PROFILE OF PSYCI4OTOMIr4ETICACT IVITY * (U)

D~ESCRIPTIVE NOTE: CUMULATIVE PROGRESS REPT* I APR 62-110

SEP 6),bFP 63 IV BAKER,WALTER We

CONTRA(T: flAIl tOeCML.7069

IINCLAS'-,IIED REPORT

!nESCRIPTORS: (owALLUCINOGENS, PHYSIOLOGY); STIMULATION;

PHARMIACOLOGY$ FrHAVTOR, MOTOR~ RFACTIONS, AUTONOMICNFRVu(IS SYSTEM, EXCITATION. STRYCHNOS ALKALOIDS,

REFLL XES (U)

IDENTIFIER5: CLrCTROPHYSIOLOGY, RAGE, 196) (U)

UNCLASSIFIED /ZAML2

UNCLASSIFIED

ODL REPORT RIOLJuGRAPHY SEARCH CONTROL NO. #ZAML2

40-44b 700

CHEMlICAL RESEADCH AND DEVELOPMENT LAOS EDGE100t ARSENALMD

ACUTE TOXICITY OF TETRAHYDROCANNABINOL TO MICE INALTERED ENVIROMMENTS, (U)

iFP 64 HP FROCHLICHIHARRY Le IREPT. NO. )2ý7TASK: IC522301AM7901

UNCLASRIFIED REPORT

DESCRIPTORS: temRutjSp TOXICITY); ENVIRONMENTAL TESTS,SURVIVAL, HYPOTHERMIA, MICE, PHYSIOLOGY; PHARMACOLOGY,LETHAL DOSAGE; gTRESS (PHYSIOLOGY), ABDOMEN; INJECTION(MEDICINE), BIOrHEMISTRY, TEMPERATURE (U)

IDENTIFIERS: TETRAHVDROCANNABINOL (U)

A DoSE RANGE STUDY AND AN ACUTE INTRAPERITONEALTOXICITY STUnY WERE PERFORMED WITHTETHAHYDROCANNABINOL, THE PURPOSE WAS TO DETERMINEWHETHER ANY nMIFERENCES IN PHYSIOLOGICAL ACTIVITY ORACUTF INTRAPERITONEAL TOXICITY (LDSO) COULD BEOBSERVED IN mIcE HOUSED AT ROOM TEMPERATURES OF 70DEGHEES AND 40 DEGREES Fe MICE RECEIVINGTETRAHYDROCANNABINOL AT A ROOM TEMPERATURE OF go FEXHIBITED THF SAME PHYSIOLOGICAL EFFECTS AS MICERECiIVING TETRAHYDRUCANNABINOL AT A ROOM TEMPERATUREOF 70 DEGREES Fe THE ACUTE INTRAPERITONEAL LD5O

OF TFTRAHYDROCANNABINOL IN MICE AT 70 F WAS 129a37 MG/KG. THE ACUTE INTRAPERITONEAL LD9O OFTETHAHYDROCANNSBINOL IN MICE AT 40 F WAS l'$2MG/KG. TETRAHYDROCANNABINOL IS NINE TIMES MORE TOXICIN HICE SUBJRCTED TO THE ADDED STRESS OF COLDU(AUTHOR) MUD

14

UNCLASSIFIED /ZAML2

UNCLASSIFIED

'OC REPURT PInLIUGRAPHY SEARCH CONTROL NO. IZAML2

AD-481 812 6/1; 6F20OFFICE OF NAVAl RESEARCH LONDON fENGLANDI

SYMPOSIUM ON D0UGS AND SENSORY FUNCTIONS, (U)

DESCRIPTIvE NOTE: TECHNICAL REPT.,APR 66 5P MILLERCHARLES H. I

REPT. NO. ONRL-r-6-66

UNCLASIrVIEU REPORT

OESCRIPTORS: (ogYMPOSIA, *DRUGS), 40SENSORYPERCLPTION, DPUS)S, TOXICITY, SENSORY MECHANISMS,PSYCHOPHYSIOLOGY, SMELL; TASTE, AMPHETAMINES,APPETITE, EAR, AUDITORY PERCEPTION, NYSTAGMUS,SENSORY DEPRIVATION, ANOXIA, LYSERGIC ACIDS; CNSSTIMULANTS, LIGmT, OXYGEN, COLOR VISION,MEMONY, PERCEPTION, PHARMACOLOGY; CODING,GREAT BRITAIN; CTRESS(PHYSIOLOGY) (U)

IDENTIFIERS: KAKlAMYCIN (UI

TH15 REPORT REVIEWS PRESENTATIONS AT THE SYMPOSIUMON DRUGS AND SFNSORY FUNCTIONS; HELD 22-2qMAR 1966 AT THF ROYAL COLLEGE OF PHYSICIANS,

LONUON, WHICH "'AS SUPPORTED BY SIA BRITISH ANDTWO INTERNATIONAL SCIENTIFIC ORGANIZATIONS*APPROXIMATELY 7$0 ATTENDED, MOSTLY FROM FIELDS OFPHARMACOLOGY$ PHYSIOLOGY, AND PSYCHOLOGY. (Ul

15

UNCLASSIFIED /ZAML2

UNCLASSIFIED

COC REPORT RIALIUGRAPHY SEARCH CONTROL NO, fZAML2

AD-48e 326 7/3

FDGEAOOD ARSFNAL MD

SYNTHE';IS ANfs ISOLATfON OF TETRAHYDROCANNABINOLISOMFRSI (U)

MESCRIPTIVE NOTE: TECHNICAL REPT, JAN 6)-MAR 65.

JUL 66 119P HIVELY ;RICHARD L. IHOFFMANN*FRIFnRICH he I

REPT. NO. EA-TR-qOU2"PROJ: DA-IC52231fIAb6U

UNCLASSIFIED REPORT

nESCRIPTORS! (o.ANNABINOLStSYNTHESIS(CHEMITRY))o PLASTICS, DIENESYNThFSISo HYnRnLYSIS, PHENOLS, ULTRAVIOLETSPLC1ROSCOPY, MmLECULAR ISOMERIemv TEST METHODS;NLICLLAR MAGNETIC RESONANCE, CHEMICAL BONDS* THIN

LAYER CHROMATIGMAPHYo DEGRADATIONS AROMATICCOMPuUNDS, MELTING POINT, PROTONS$ OXIDATION$ABSORPTIONo HYDOOCARUONS fUl

IDENTIFIERS! MAPIJUANA (U)

IN ADDITION TO CANNASINOLo CANNASIDIOL; AND TRANS-1-HYDROXY-3-N-AMYL-69 6, 9 TRIMETHYL-6A, 7, 8, IOA-TETHAHYDRO-6-DTBENZO0 YRAN 4TETRAHYDROCANNABINOLA), A NEW MARIJUANA CONSTITUENT, TRANS=I-HYDROXY-)-N-AMYL-6o 6, 9.TRIMETHYL-6As 7, ID, IOA-TETRAHYDRO 6-DIBENZOPYRAN (TETRAHYDROCANNABINOL 8); WASISOLATED FROM UARYLAND AND MEXICAN MARIJUANA,TRACES OF TETRAHYDROCANNABINOL B WERE ALSO FOUNDIN EGYPTIAN HAqHISHq WEST VIRGINIA MARIJUANA

CONTAINED ONLY CANNASIDIOLIC ACID* A SECOND SAMPLE

OF MEXICAN MARIJUANA FURNISHED ONLYTETkAHYDROCANNABINOL A AND CANNABINOL, WHILE ASPANISH SAMPLE CONTAINED AN ADDITIONAL AMOUNT OF

CANNABIDIOLs THE STRUCTURE OF TETRAHYDROCANNABINOLB WAS ELUCIDATFD BY CHEMICAL AND SPECTRAL EVIDENCE.

THE PARTIAL SYKJTHESES OF FOUR ISOMERICTETRAHYDROCANNABINOLS (A, BS AND THEIR CIS-ISOMERS) AND TwE TOTAL SYNTHESIS OF THE RACEMIC

CIS-ISOMER OF TETRAHYOROCANNABINOL B ARE ALSOOESCRIBELo (AUTHOR) (U)

16

UNCLASSIFIED /ZAML2

~ -2A' LIOGR4PHY SEASCH CO)NTROL NO* *ZAHL2

RA% .. COiRP SANTA MONICA CALIF

HALLUCINOGENIC DRUGS: A PERSPECTIVE WITH4 SPECIALRELF~RENCE TO PrYOTE AND CANNABIS; (U)

JULL 644 AqP MCGLOTHLINWILLIAM He IREPT. NO. -2917

'JNCLASSIrIED REPORT

DEScRIPTORS: toli.ALLUCINOGENSo ANHALONIUM ALKALOIOSs(OANhALONIUM ALKALOIDS, ADDICTION), (OADDICTION,ANmA1 .ONIUM ALKALOIDS), (sCANNABIS, TOLERANCES('Rmz1Y.OLOGY)j DRUGS, PSyCHOPHYSIOLOGY, RELIGION;CL'LTk.iRE, LYSEPGC ACJMS, PSYCHOTRCIPIC AGENTS,BI OiL G RAPH~I E ý (U)

IDENTIFIERS: PEVOTISM (U)

THF rxTLNSIVF LITLRATURE ON PEYOTE AND CANNABISSATIVA (MARUHUhNA), 41TH PARTICULAR EMPHASIS ONRýDUCrING THE tJwICERTAINTY ABOUT THE BENEFITS OR PERILSINHLRENT IN THr USE OF LSD AND OTHER RECENTAL)DLT1ONS TO TwE HALLUCINOGEN FAMILY I'S REvIEWED:(11 INTRODUCTIIMN, (2) ADDICTION ANDHABITUATIONO (1) PEYOVE, I'4) CANNABIS; AND.5) THE LSD CONTROVERSY. (U)

17

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DDL REPORT AIRLIOGRAPHY SEARCH CONTROL NO, #ZANL2

AD-604 802RANL CORP SANTA MONICA CALIF

LONu-LASTING EFFECTS OF LSD ON CERTAIN ATTITUDES INNORMALS; AN FXPERIMENTAL PROPOSAL, IUl

MAY 62 66P MCGLOTHLINoWILLIAM He IREPT. NO. P'257•

UNCLASSIFIED REPORT

OESCRIPTORS: l.tYSERGIC ACIDS, REACYION (PSYCHOLOGY)),(*REACTION (PSYrHOLOGY); LYSERGIC ACIDS), DRUGS, DOSAGE;CHEM;ITHERAPY, P1YCHOMETRICSI PERSONALITY, EMOTIONS,

ATTITUDES, REHAVIOR, MEMORY, SOCIAL COMMUNICATION,PSYCIIMPHYSIOLOGv, PSYCHIATRY, ABNORMAL PSYCHOLOGY,PSYCHOSES, NEURMSES9 ADJUSTMENT (PSYCHOLOGY), PERCEPTION

IPSYCHOLOGY2, TMLERANCES (PHYSIOLOGYI, CENTRAL NERVOUSSYSTEM (U)

RESEARCH INTM THE LONG-LASTING EFFECTS OFADMINISTERING N-LySERGIC ACID nIrTHYLAMIDE (LSD) TONORMALS IS DITSUSSEO* IN ADDITION TO ITS USE IN

PSYCHOTHERAPY, THLRL WERE SOME REPORTS OFEXPERIMENTAL 51BJECTS WHO CLAIM LASTING BENEFICIALEFFECTS ATTRIBUTABLE TO THE LSD EXPERIENCE* INPARTICULAR, TWn FOLLOO-UP QUESTIONNAIRE STUDIESINDICATED THAT NORMAL SUBJECTS FREQUENTLY CLAIM

CHANGES IN PFRqONALjTY RESULTING FROM ONLY ONE OR TWO

ADMINISTRATIONq OF LSD: AND THESE CLAIMS WEREMAINTAINED AFTrR PERIODS OF A YEAR OR MORE, THESE

RESULTS ARE SUAJECT TO THE WEAKNESSES OF THEQUESTIONNAIRF METHODI BUT, WHEN CONSIDEPED ALONG WITH

SOME OF THE LITERATURE ON THE USE OF LSD INPSYCHOTHERAPY, THEY APPEAR TO RE SUFFICIENTLYSUGGFSTIVE TO WARRANT MORE CONTROLLED EXPERIMENTS IN

THIS AREA. AN rXPERIMENT IS SUGGESTED WHICH WOULDATTLMPT TO MEASURE ANY LONGLASTING CHANGES INATTITUDES, VALOES, AND COMMUNICATIVE ABILITYRESULTING FROM THE ADMINISTRATION OF LSD. IN

PARTICULAR, THr MEASURES WOULD CONCENTRATE ON CHANGESIN CLOSED-MINDNIESS AS REFLECTED BY SCALES OFDOCGMATISM, OPIN'IONATION, AND ETHNOCENTRICITY, (U)

1I8

UNCLASSIFIED fZAML2

UNCLAbSIrlE0

R rEPOOT q;LIOGRAPHY SEARCH CONTROL NO, IZAML2

AD-607 16?

CORN4FLL UNIV I7HACA N y

SLRt.,TONIN BINtIING TO PREPARATIONS FROM RAT BRAIN,(U)

nESCRIPTIVL NOTE: TECHNICAL REPT., NO, 61AUG 64 I0.P MARCHBANKSRs M, 1

CONTRACT: NOf;P-.OUI(O), NSF-GP-971

UNCLASSIrIED REPORT

IUPPLLMENTARY NOTE: REPTe ON COGNITIVE SYSTEMSRESEARCH PROGRAM', uOCTORAL THEStS.

DESCRIPTORS: .*qEROTONINp REACTIJN KINETICS), (*NERVECELLS; SERITONIM)$ (9RRAIN, SEROTONINI, NERVE IMPULSES,ENZYMES, OXIDORFDUCTASESs NERVOUS SYSTEM, LYSERGIC

ACIOS, RESERPINF, INHIBITION, CHLORPROMAZ!NE,ACETYLCHLOLINF, FATTY ACIDS, LEVARTERENOL, LEARNING,MEMOKY, PERMEABILITY, MEMBRANES (BIOLOGY), MITOCHONDRIA;MORPHOLOGY (BIOLOGY), CENTRAL NERVOUS SYSTEM, DRUG,CHEMICAL BONDr, EQUATIONS, BIOCHEMISTRY: PHYS:OLOGY (U)

IDENTIFIERS: ELECTROPHYSIOLOGY (U)

THE BINDING OF SEROIONIN TO ELEMENTS FROM THE

SYNAPSE HAS AErN INVESTIGATED IN AN ATTEMPT TO

OEVLLOP METHeng FOR TH7 INVESTIGATION OF SYNAPTICEVENTS tlY 8IOCwEMICAL METHODS* CHEMICALINTLOACTLONS APE KNOWN TO BE IMPORTANT FOR THETRANSMISSION Or IMPULSES ACROSS THE SYNAPSE; THEIMPORTANCE OF THESE INTERACTIONS IN CONNECTION WITHBRAIN MECHANISMS IS DISCUSSED. THE PHYSIOLOGY OFTHE NEUROHUMORAL AGENT, SEROTONIN, I5 DISCUSSED; ITHAS A ROLE IN ARAIN FUNCTION, BUT ITS EXACT FUNCTIONREMAINS OBSCUR7, METHODS OF EVALUATING THE AMOUNT

OF A PARTICULAP BINuING COMPONENT AND ITS EQUILIBRIUMCONSTANT ARE DISCUSSEDI THESE INVO'.VE THE MEASUREMENTOF THE AMOUNT QOUND AS A FUNCTION OF SEROTONINCONCENTRATION. BINDING COMPONENTS AREDISTINGUISHED RY THE ASSOCIATION CONSTANT OF THEBINUING REACTIAN. FUNCTIONAL SIGNIFICANCE ISASSIGNED TO THr BINDING COMPONENTS BY INVESTIGATIONOF THEIR PROPEOTIES, AND PARTICULARLY; BY EXAMINATIONOF THE EFFECTS OF INHIBITORS ON THE BINDINGCOMPONENT. THE AMOUNT BOUND BY A HOMOGENATE ISDETERMINED BY rQUILIBRIUM DIALYSIS, CENTRIFUGALSEPARATION Or THE MACROMOLECULE PHASE, AND A METHODINVOLVIN6 THF mACROMOLFCULAR EXCLUSION PROPERTIES OFSEPhADEX,

(U)

UNCL.ASSIPIEU /ZAML2

UNCLASSIFIED

DOC REPORT RIDLIQGRAPHY SEARCH CONTROL NO* tZAMLI

DUKL ONIV DURHAM N C SCHOOL OF NrDIC?NC

PSYLHOPHYSIOLOr|CAL MECHANISMS OF STRESSRESPONSIVITY (U)

DESCRIPTIVE NOTC! ANNUAL REPT.oUN 61 &46P COMENSANFORD I* ;SILVERMAN,

ALBERT jo

CONTRACT: AF49 A48 354MON!TuR: AFOSP , 1515

UNCLASSIFIED REPORT

DESCRIPTORS: (oqTRESS (PHYSIOLOGY), REACTION(PSYCHOLOGY)), (*PSYCHOPHYSIOLOGY, STRESS (PSYCHOLOGY)l;CENTRAL NERVOUS SYSTLHM SENSORY PERCEPTION, ANXIETY,SENSORY DEPRIVATION, CONFINEMENT (PSYCHOLOGY)$PERSONALITY, PSYCHUCHEMICAL AGENTS, LYSERGIC ACIDS,

DRUGS, ENOOCRINF GLANDSI PERCEPTION (PSYCHOLOGY)#THREbHOLDS (PNYcIOLOGY), TOLERANCES 4PHYSIOLOGY,

ELECTROENCEPHALMGRAPHYP PAIN, PROJECTIVE TECHNIQUES,GALVANIC SKIN RFSPONSEs PSYCHOMETRICS lU)

RESARCH Is SUMMARIZED ON WORK IN THE FOLLOWING

FOUR AREAS: 1i' CENTRAL NERVOUS SYSTEM,PERIPHERAL PHYCIOLOG! CAL ENDOCRINOLOGICAL ANDPSYCHOLOGICAL PESPONSES OF BODY AND FIELD ORIENTED

SUBJECTS TO EX"ERIMENTAL SITUATIONS CHARACTERIZED BYUNCLRTAINTY, SMCIAL AND SENSORY ISOLATION ANDLIMITATION OF MOVEMENT; (2) ANALYSIS OF

PE!fONALITY, PHYSIOLOGICAL AND CENTRAL NERVOUS SYSTEMCORRELATES OF PODY AND FIELD PERCEPTUAL MODES AND THEEXPLORATION OF OTHER INDIVIDUAL DETERMINANTS OF THE

RESPONSE TO LOW SENSORY INPUT EXPERIMENTS; (2) A

STUDY OF THE INFLUENCE OF DRUGS ACTING ON CENTRALNERVOUS SYSTFM IN BODY AND FIELD ORIENTED SUBJECTS INLOW SENSORY INPUT EXPERIMENTS; AND 14) ANEXPLORATORY STHDY OF THE INFLUENCE OF APSYCHOCHEMICAL (LSD) ON RESPONSE TO TWO HOUR LOWSENSORY INPUT rXPERIMENTAL CONDITIONS* 4U)

20

UNCLASSIFIED /ZAML2

UNCLASSIFIED

C%. REPOQT AIaLIjGRAPMY SEARCH CONTROL NO, OZAHL2

40-61) 76.4AAL1FR RLFD AR,,Y INT OF RESEARCM WASHINGTON D C

DIFFFRENTIAL EFFECT OF LSD UPON HABITUATING ANDExTINGUISHINn rVOKED RFSPONSES, (U)

APR 64 BP SMEATZAUY C. tBGGDANSKI,DONALD Ft

UNCLASqIrIED REPORT

1UPPLEMENTARY NOTE: PUB, IN JOURNAL OF NEUROPSYCHIATRY

(U. S.) V5 NS P485-92 NOV-DEC 196q (COPIES NOTAVAILABLE TO DOC OR CLEARINGHOUSE CUSTOMERS)@

DESCRIPTORS: (oLYSERGIC ACIDS; CONDITIONED REFLEX),

(OCON•ITIONED RrFLEXI LYSERGIC ACIDS), 6EHAVIOR,ELECTROENCEPHALmGRAPHYs AUDITORY PERCEPTION;

OSCILLATION; RADBITURATES, CENTRAL NERVOUS SYSTEM,DRUG5, DOSAGE; NoERVOUS SYSTEM, PHYSIOLOGY (Ul

LSO, IN SMALL MOSLS 410 MICROGRAMS/KG) WHICHAFFLCT BEHAVIOR ONLY IN THE ABSENCE OF AN ACTIVEENVIRONMENT AHn' 4HICH ONLY MINIMALLY ALTER THE

SPONTANEOUS FE9, DRAWS A CLEAR DISTINCTION BETWEEN

BABITUATING ANm EXTINGUISHING FVOKED AUDITORYRESPONSES BY POEFLRLNTIALLY FACILITATING THE LATTER.

IT ALSO ESTARLTSHES A CONDITION FAVORABLE TO

PROLONGATION 00 OSCILLATION OF THE RESPONSE,RESPONSC COMPOVENTS MAY BE VISIBLE AS LONG AS 5SEC, FOLLOWINIG THE CLICK. LSD PoTENTIATEDRESPONSES DO NmT FOLLOW THE USUAL FAST EXTINCTION

CURVF, BUT TwEY ARE EASILY REDUCED BY DISTRACTION AND

BY bMALL DOSES OF NL9BUTAL. (ALITHOR) (U)

21

UNCLASSIFIED /ZAML2

UNCLASSIrIED

DOC REPORT RItLI4GKAPHY SEARCH CONTROL NO, #ZAML2

AD-615 698

TUF1' LINIV MFDrORD MASS

VISUAL IMAGEoy PRODUCED BY RHYTHMIC PHOTICSTIMULATION: PrRSONALITY CORRELATES ANDPHENOMENULOGYI 4U)

NOV 63 laP FREEDMAN,SANFORD J, ;MARKS,

PATkTCIA A. ICONTRACT: AF AFOSR62 11MONITOR: AFOSz , 65-0711

UNCLASSIrIED REPORT

SUPPLLMENTARY mOTE: PUB, IN BRITISH JOURNAL OFPSYCHOLOGY V56 NI P95-112 1965 (COPIES AVAILABLE ONLY TODOC USERS),

MESCRIPTORS: toPSYCHOPHYSIOLOGY: OPTICAL IMAGES!,(OPF4SONALITY, 4ENSORY PERCEPTIbN), (eVISION,STIMULATION)o PrRCEPTION (PSYCHOLOGY), REACTION(PSYCHOLOGY), POOJECTIVE TECHNIqUES, SENSORYDEPRIVATION, ANHALONIUM ALKALOIDS,ELECTROENCEPHALMGRAPHY, MOTIVATION. EMOTIONS, GEOMETRIC

FORMS, COLORS; LIGHT, CORRELATION TECHNIQUES (U)IDENTIFIERS: HALLUCINATIONS$ HYPNOSIS,

IMAGINATION (U)

THIS STUDY I1 CONCERNED WITH RELATIONSHIPS BETWEENDESCRIPTIONS O3 VISUAL IMAGERY PRODUCED BY RHYTHMICPHOTIC STIMULATION AND A NUMBER OF PERSONALITY 'TESTS*INDIVInUALS WHn MANIFESTED THE ABILITY TO SUSPENDTHEIR GENERALITED REALITY-OR!ENTATION DESCRIBED MOREIMAGERY; IMAGINATION AND SUGGESTIBILITY ALSO SEEMED

TO jE IMPORTANT. SUBJECTS' EXPFCTATIONS ABOUT WHATTHEy wOULD SPE INFLUENCED THEIR REPORTS, ALTHOUGHCOMPREHENSION PF THE EXPERIMENTAL DESIGN, FATIGUE ANDMOTIVATION WFRF NOT RELEVANT* THE CORRELATED

PERSONALITY VAqIABLES INDICATE A CLOSE RELATIONSHIPWITH OTHER TYPFS OF VISUAL IMAGERY| THE PHENOMENOLOGYFITS A SYNTHESIZED DESCRIPTION OF SENSORYDEPRIVATION, MrSCALINE; AND HYPNAGOGIC IMAGERY.(AUTHOR) (U)

22

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DC REPORT RImLIOGRAPHY SEARCH CONTROL NO. /ZAML2

AD-618 802TEXAS UNIV GALVESTON MEDICAL BRANCH

EFFLCT OF A CHEMICALLY DEPRESSED AMYGOALA ON THE

REHAVIORAL mANIFESTATIONS PRODUCED IN CATS BY LSD-295Ul

DEC 64 6P BARRATTERNEST S, |PRAY,SIONFY Le ;

CONTRACT: NON199806

UNCLASSIrIEU REPORT

SUPPLEMENTARY N0OE: PUB, IN EXPERIMENTAL NEUROLOGY VI2

N2 P177-8 JUN 1Q65 (COPIES NOT AVAILABLE TO ODC OR

CLEAkINGHOUSE CUSTOMERS).

DESCRIPTORS: (*LYSLRGIC ACIDS1 INHIBITION,,SKELETAL MUSCLE RELAXANTS, CEREBELLUM,THRESHOLDStPHYSIOLOGY)o DOSAGE, NERVOUS SYSTEM;PHYSIOLOGYs CONVULSIVE DISORDERS, CENTRAL NERVOUSSYSTLM, BEHAVIOR, CATS (U)

IDENTIFIERS: AMYGDATLA (U)

THE DRUG, SQ Ino,96, AN EXPERIMENTAL

ANTInPEPRESSANiT; RAISFD THE THRESHOLD FOR ELECTRICALLYINDUCED AMYGOAI.OID sEIZURE5 IT ALSO BLOCKED OR

DIMINISHED THE BEHAVIORAL EFFECTS OF LSD-29, THE

BLOCKING EFFECT OF 5Q 10o496 IS RELATED TONEUHOPHYSIOLnGICAL MECHANISMS ¶HICH ARE POSSIBLE THE

BASES FOR THE MEHAVIORAL EFFECTS OBTAINED WITH LSD-

25. (AUTHOR) (U)

23

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DLt REP IPT RILIOGRAPHY SEARCH CONTROL NO, /ZAML2

AD-622 8'4q

CALIFORNIA UNt" LOS ANGELES BRAIN RESEARCH INST

PROLONGED EFFECTS OF LSD ON EEG RECORDS DURIN(QDISCRIMINATIVE PERFORMANCE IN CAT: EVALUATION OYCOMPUTER ANALYSIS, (U)

MAY 6 q I lP ADEYsW. Re IPORTERRo ;WALTER,Do OU ;BROWN,To So ;

CONTRACT: AF AFMSR246 6) ,NSG203 62MONITOR: AFOSP , 65-0940

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: PUB, IN ELECTROCEPHALOGRAPHY ANDCLINICAL NEURnPwYSIOLOGY VI8 P25-35 1965 (COPIESAVAILABLE ONLY TO DOC USERS), PREPARED IN COOPERATIONWITH VETERANS AMMINISTRATION HOSPITALS, LONG BEACHAND LOS ANGELES; CALIF.

DESLRIPTORS: (otYSERGIC ACIDS, REHAVIORc)(OELLCTROENCEPHALOGRAPHy, LYSERGIC ACIDS);TOLERANCES(PHYSTOLOGY), BRAIN,TISSuES(BIOLOGYi, PSYCHOTROPIC AGENTS, CEREBRALCORTEX, 7RAINING, DATA PROCESSING SYSTEMS, CATS (U)

THE FFFECTS OF LSD WERE STUDIED IN RELATION TOCHANGES INDUCEn IN COMPUTED AVERAGES CF EPOCHS OFEEG RECORDS DUPING A DISCRIM!NATIVE TASKPERFORMANCE IN A SERIES OF SIX CATS REPEATEDLYEXPUSED TO LSD OVER A PERIOD OF MANY MONTHS*CCMPUTED AVERAnES WERE PREPARED FROM DAILY TRAININGTESTS OF 20 AN(% i4td TRIALS, LSD (75 MICROGRAMS/KG) WAS GIVEK' TN SINGLE DOSES RY INTRAPERITONEALINJECTIONq AT IkITERVALS OF NOT LESS THAN 2 WEEKS.THE FINDINGS I,-IDICATE PERSISTENTELELTROPHYSInLnGICAL EFFECTS OF LSD BEYOND THEPERInD OF ACUTF DRUG ACTION. HOWEVER, THESECHANGES RAN A RHORTER COURSE THAN THE TOLERANCE TOLSD EXHIBITED MY MAN AND ANIMALS* THEY SHOWED ADIFFERFNTIAL DISTRIBUTION IN DIFFERENT BRAIN REGIONS,WITH MAXIMAL CWANGES IN THE HIPPOCAMPUSt AND SMALLEREFFECTS IN THE ENTORHINAL CORTEX AND THE ROSTRALMIOBPATN RETICIPLAR FORMATION@ EVIDENCE IS PRESENTEDOF HIGHLY FOCAtL DIFFERENCES IN LATE •ESPONSES WITHINTHE HIPPOCAMPuq. DIFFERENTIAL SUSCEPTIRILITY OFHIPPOCAMPAL TIcSUL IS DISCUSSED IN RELATION TO ASIMILAR SENSITIVITY TO THE ACUTE EFFECTS OF BOTHLSD AND PSYCHOTOMIMLTIC CYCLOHFXAMINES, AND TO THEPATTERN OF PROOAGATION OF HIPPOCAMPAL AFTER-

S;5CHARGES. AiiTHOR) (Us24

UNCLASSIFIED /ZAML2

UNCLASSIV1ED

DO( REPOT 7vLjIQGRAPHY SEARCH CONTIROL 4O0 /ZAML2

AD-62J 0613

CALIFORNIA uNIv LJS ANGELES BRAIN RESEARCH INST

HIPPOCAMPAL mErHANISMS IN PROCrSSES OF MEMORY:THOUGHTS ON A mODEL OF CEREBRAL ORGANIZATION IN

LEAt \NINGI (U)

"64 "6P AOEYo* ROSSCONTRACT: AF-AFMSR-61-61

PROJ: AF-7164T ASK: 7lt4O 2

MONITOR: AFOSP , 65-1502

UNCLASSIPIEU REPORT

"CUPPLLMENTARY NOTE: PROCEEDINGS OF CONFERENCE 12NOI

LOS ANGELES, CAt IF. 1962 UNIV. CALIF. PRESS

BRAZIFR M A 8 V? P2:)-76 UCLA FORUM MED SCI N2.

(COPIFS NOT AVAYLABLE TO DOC OR CLEARINGHOUSE

CUSTUMERS)s

DESCRIPTORS: ienRAINo LEARNING); (*MEMORY,

BRAIN), (#LEAPN!NG, bRAIN). PERFORMANCE TESTS,

HALLUCINOGENS, nRuGS, COMPUTERS; ANALYSIS,

REACTION(PSYCHOLOGY), TRAINING, ELECTRICAL

IMPEDANCE, ELFCTROENCEPHALOGRAPHY (U)

IDENTIFIERS: HIOPOCAMPUS fU)

A DISCUSSION Ic PRES!NTED OF THE ABLATION AND MRUG

STUUIES OF TWE SYSTEM ORGANIZATION OF THE HIPPICAMPUS

IN ANIMALS. THrSE STUDIES SUPPORT THE IDEA THAT

THE HIPPOCAMPA1 SYSTEM IS VITALLY CONCERNED IN THE

CONTINUED CAOAGILITY To MAKE A DISCRIMINATIVE

PERFORMANCE INVOLVING THE INTEGRITY OF BOTH RECENT

AND LONG-TERM vEMORY FUNCTIONS. COMPUTER ANALYSES

OF VARIOUS AqPrCTS OF WAVE PROCESSES DURING

DISCRIMINATIVE LEARNING INDICATED STRONG SUPPORT OF

THE HYPOTHFSIS OF CUNVEYANCE OF INFORMATIOkJ ON THE

BASIS OF GRAMEM ANALOG *AVE PROCESSES.

PHYSTCOCHEMIHAL CHANGES IN LEARNING WERE DIRECTLY

MONITORED BY APPLICATION OF IMPEDANCE MEASURING

TECHNIQUES TO THE LLARNING PROCESS. (AUTHOR) (U)

25

UNCLASSIFIED /ZAML2

UNCLASSIFIEO

DDC REPURT PIqLIOGRAPHY SEAqCH CONTROL NO. /ZAMI.2

AD-625 )67BUENOS AIRES UIJV (ARGENTINAl INSTITUTO DE ANATOMIA

GENERAL Y FMRRIOLOGIA

5-HYnROXTRYPTAmINE RECEPTORS AND SYNAPTICTRANSMISSION IP MOLLUSCAN NEUR(INES, cUl

65 lP GERSCHENFELD.!4 Me |STEFANIs

E. iCONTRArT: AV AFmSR656 o4

MONITOR: AFCSR , 65-194:0

UNCLASSIFIED REPORT

SUPPLtMENTARY NOTE: PUB, IN NATURE V205 N4977 P1216-8 20

MAR 1965 ICOPIE9 AVAILARLE ONLY To DDC USERS)o

DESCRIPTORS: (OMOLLUSCA; NERVOUS SYSTEMIt($GAbTROPODA, NFRVOUS SYSTEM), (eNERVE CELLS,

PHYSIOLOGY); (.•EROTONINs NERVE IMPULSES),AMINES, ALCOHOLq, CHEMORECEPTORS,MEMBRANES(BIOLOGY), ALETYLCHOLINE, ENZYMES,

BIOSyNTHESIS, GANGLIA, LYSERGIC ACIDS,ARGENTINA (U)

THE HIGH 5-HYIDOXYTRYPTAMINE (9-HT) MOLLUSC

GANGLIA (WHICH IS HERE CONFIRMFD FOR THE

ARGLNTINE LAND SNAIL CRYPTOMPHALLUS ASPERSA),THE PRESENCE OF ENZYMES FOR THF SYNTHESIS AND

INHIBITION OF R-HT, THE SPECIFIC EFFECTS OF THE

AMINF ON THE MFMBRANE CONDUCTANCE OF CELLS WITH

INHIBITION OF LONG OIRATION (CILDA), AND THE

PREhENCE OF SPFCIFIC 5-HT RECEPTORS ON THE MEMBRANE

OF THE SAMF NEURON TYPE FILL SOME OF THE CRITERIA

REQUIRFU To CONSIDER THE SUBSTANCE AS A SYNAPTIC

TRANSMITTER, TwE BLOCKING OF 5-HT RECEPTOR SITES

BY LYSERGIC ACID DILTHYLAMIDE AND BY BROMOLYSERGIC

ACID WAS CONFIPMED UN THE CELLULAR LEVEL WITH CILDA

NEURONES ADnlITIONAL EVIDENCE INDICATES THAT 5-

HT MAY BE THE NATURAL EXCITATORY TRANSMITTER FOR

THEýE NEURONFS. (U)

26

UNCLASSIFIED /ZAML2

UNCLASSIrIED

DO. REPO0T FI'tLIUGRAPHY SEADCH CONTROL NO, IZAML2

AD-62 )l75OXFORD UNIV (EGLANU) DEPT OF PHARMACOLOGY

HYDROXYINDOLF nXIDASE IN THE CPySTALLINE STYLE OFPINNA NOBILIS, (U)

MAY 65 12P BLASCHKnHELRMANN

CONTRACT: AF EOAR12 64RROJ: 9777

TASKi 977701MONITuR: AFOSR , 65-1549

UNCLASSIrIED REPORT

tUPPLLMENTARY NOTE: PUB, IN RIVISTA DI SIOLOGIA V98PTI P27-36 JAN-mAR 1965 (COPIES AVAILABLE ONLY TODOC ASERS).

')ESCRIPTORb: (*mOLLUSCA; ENZYMES), ('GASTROPODAI

OXIDOREDUC T ASESi, (OUXInOREDUCTASES, GASTROPODA1,DIGESTIVE SYSTE", ORGANIC PIGMENTS, PSILOCIN,OXIDATION, GRFAr BRITAIN (U)

IDENTIrIERSI CRYSTALLINE STYLE; HYDROXYINDOLE

OXIDASE. PINNA MOBILIS (U)

EXPLRIMENTS WErfE CONDUCTED ON THE HYDROXYINDOLEOXIDASE ACTI"ITY OF AN ENZYME PRESENT IN CRYSTALLINE

PINNA NOBILIS. IT I5 SHOWN THAT A HOMOGENATE OFTHE CRYSTALLINr STYLE OXIDIZES PSILOCINE WITH THEFORMATION OF A BLUE PIGMENT, THIS ACTIVITY WAS

ALSO OBSERVEm IN THe GILL PLATES OF MYTILUS EDULISAND IS DESCRIBrD AS AN EXPRESSION OF THE PHENOLOXILASE ACTIVITY IN THESE TISSUES, THIS FINDING IS

DISLUSSED IN RPLATION TO EARLIFR OBSERVATIONS ON ThEPREsFNCE OF A OHENOLOXIDASE IN MOLLUSKS. (AUTHOR)

(U)

27

UNCLASSIFIED /ZAML2

UNCLXSStrttO

DOC REPORT RIqLIuGRAPHY SEA*CH CONTROL NO, tZAML2

40-62) '497CALIFORNIA UNIV LOS ANGELES BRAIN RESEARCH INST

COMPUTFR ANALvYIS OF HIPPOCAMPAL EEG ACTIVITY ANDIMPLDANCL IN APPROACH LEARNING! EFFECTS OFPSYCHOTOMIMETIC AND HALLUCINOGENIC DRUGS, (Ul

61 liP ADEYWo Ro ICONTRACT: AF AFnSR61 81 sPHS B88MONITOR: AFOSP , 65-1972

UNCLASSIFIED REPORT

SUPPLtMENTARY NOTE: PLBs IN PHARMACOLOGY OFCnNDITIONING, LFARNING AND RETENTION. PROCEEDINGSOF THF INTERNATYONAL PHARMACOLOGICAL MEETING(2NDj ORAGUE, 70-2) AUG 1963 tCOPIES AVAILABLEONLY TO DOC USERS)s

nESCRIPTORS: (t.-EARNING: ELECTROENCEPHALOGRAPHY)o(OPSYCHOTROPIC AGENTS, BEHAVIOR), BRAIN,

HALLUCINOGENS, LYSERGIC ACIDS, DATA PROCESSINGSYSTLMS, COMPUTFRS, CATS (U)

REPRINT: COMPUTFR ANALYSIS OF HIPPOCAMPAL EEG ACTIVITYAND IMPEDANCE I" APPROACH LEARNING: EFFCTS OFPSyCHOTOMIMETIC ANL HALLUCINOGENIC DRUGS.

28

UNCLASSIFIED /ZAML2

.. tCý6ASS rItdZ

ZDL REP:-T ".QLIOGRtPHY SEARCH CONTOOL NO, ulAMLZ

AD-62) 601UNIVFRSIDAM DE LA RLPUBLICA MONTEVIDEO (URUGUAY)INSTITLITO DE NPURULOGIA

EFFLCTS OF PgYCHOPHARMACOLOGIC DRUGS UPON SENSORY

INFLfW IN NORMAL SUBJECTS, PSYCHIATRIC PATIENTS ANDIN ANIMALS. (Ul

fESCRIPTIVE NOTE! FINAL TECHNICAL REPT. FOR I OCT 6q.30SEP 65,

SEP e6 16P AUSTTELIO GARCIACONTRACT: DA ARO49 O92 6G'40PROJ: DA2NOI14OIB7ID

UNCLASSIFIED REPORT

DESCRIPTORS: (SPSYCHOTROPIC AGENTS, SENSORYPERCLPTION), (.pSYCHOSES, PSYCHOTROPIC AGENTS),BARBITURATES, LYSERGIC ACIDS., NFURQSES,

NEURuLOGY, PHYSIOLOGY, PSYCHIATRY, DRUGS,ELECTROENCFPHALOGRAPHY, VISUAL PERCEPTION, DATAPROCESSING SYSTrMS, HATS, GUINEA PIGS, CATS (U)

IDENTIFIERS: 5CPIZOPHRENIA, URUGUAY (U)

THE OBJECTIVES OF THE RESEARCH WERE: (f) TO

ESTAPLISH CHAN'ES OuSERVED IN RENSORY EVOKEDPOTENTIAL IN NARMAL SUBJECTS BY BARBITURATES;LYSLRGIC ACIP'. OTHER PSYCHOTROPIC DRUGS IN DIFFERENTATTENTIONAL LEVELS AND DURING HABITUATION ANDCONuITIONING. 12) TO DETERMINE THE CHANGESFVOKED IN PSYCHOTIC PATIENTS, ESPECIALLYSCHIOPHNENICS'. (3) TO OBSERVE THE EFFECT OFTHESE DRUGS IN ATTENTION, HABITUATION, ANDCONGITIONING IN RAT, GUINEA PIG, AND CAT. IN THEFIRST YEAR A BrGINNING WAS MADE ON OBJECTIVES I AND 2ADDING SENSORY INFORqATION ON COMATOSE AND STUPOROUSPATIENTS. THE CAT CUMPUTER SYSTEM WAS MODIFIEDTO AUTOMATE PErORiING PROCEDURES ALLOWINGACCUMULATION FmR PRESENT TIME; READOUT; ERASE ANDRESLT WITHOUT nPERATOR ACTION. STUDY OF DRUGACTION WAS BEGI.,N WITH LSD-2 5 ON VISUAL SENSORYINFLOW. RESULTq: (1) MULTIPLICATION OFWAVLS, PARTICULARLY FIRST COMPONENTS, (2)INCHCASE IN AMbLITUDE, PARTICULARLY LAST COMPONENTS.EXPERIMENTS AITH VRUGS ON NEURMTIC AND PSYCHOTIC

PATIENTS ARE NnT YET DEFINITIVr. CHANGES OF VERlF, CO'IA PATTRQN OF 'ESPUNSE ARt SIMILAR TO THAT OFNEWbORN INFANTt ]iN S T UPOROUS SUBJECT CHANGES WEREOBSEuVFD IND!CATIVE OF CHANGE IN LEVEL OF AWARENESS.(AUTHOR, 29 (UI

tNCLASSIrIED /ZAML2

UNCLASSIFIED

DOC REPORT PIRLIOGHAPHY SEARCH CONTROL NO. /ZAML2

AD-62u 294 6f6 2/1 9 6t1I

AEROSPACE TECHMOLOGY DIV LIBRARY OF CONGRESS WASHINGTON 0

C

CUE FACTORS: MMNTHLY SURVEY NO. to (U)

nESCRIPTIVE NOTE! ATU WORK ASSIGNMENT NO. 90966 IP

REPT. NO. ATO-66-'4MONITUR: TT , 66-60574

UNCLASSIFIED REPORT

SUPPLLMENTARY NOTE: INCLUDES TRANSLATIONS FOR JAN-APR65.

nESCRIPTORS: (*PESTICIDES* ABSTRACTS), (eDISEASEStMICROORGANISMS), (*AGRICULTURE; pESTICIDESPI(.SOIL MECHANTCqo ABSTRACTS)o FUNGICIDES,

HERBICIDES, INSFCTICIDES, FERTILIZERS,HALLUCINOGENS, AEROSOLS; ECOLOGY,MICRUMETEOROLOGY, TOXICITY, VACCINES, VIRUSES;

IMMUNITY, DISEAqE VECTORS (U

THE REPORT IS A SURVEY BY A TEAM OF ANALYSTS

COVERING THE FnLLOWING AREAS: CHEMICAL FACTORS:

PESTICIDES; HEQBICIDES FERTILIZERS;PSYCHOTOMIMETICS; OTHER CHEMICALS, BIOLOGICALFACTORS: PATHOrENSt ENVIRONME'NTAL FACTORS:

AERUSOLS; ECOLnGY; MICROMETEROLOGY; SOIL

SCILNCE, THIS COMBINED REPORT, THE FIRST OF ASERIFS OF MOSITWLY SURVEYS, INCLUDES ITEMS SELECTED

FOR CATCH-UP PiuRPOSESs AS WELL AS CURRENT MATERIALS*THE PROPORTInN OF CuRRFNT MATERIAL NILL TEND TO

INCkEASE IN FUTURL REPORTS. (U)

30

UNCLaSSIfIED /ZAML2

UNCL ASSIFIED

DDL REPUQT SIALIGGNAPHY SEARCH CONTROL NO. 0ZAIAL2

Af-642 973 6.15UNIVFRSIUAD CENTRAL DEL ECUADOO QUITO DEPARTAMENTO DE

FARhACnLOGIA

ESTunIO DE UNA ESPECTE PSICOTOMIMETICA: IPOMOEACARNEA (STUDY nF A PSYCHOTOMIMETIC PLANT: IPOMOEA

CARNEA), (U)

66 TOP NARANJO;PLUTARCO INARANJOI

ENRIqUETA DE ;LASCANOCARMEN I

CONTRACT: AF-AFnSR-845-65PROJ: AF-9777TASK: 977701MONITOR: AFOSR 66-2085

LINCLASSIrIED REPORTAVAILARILITY! PUBLISHED IN ARCHIVOS DE

CRIMINOLOGIA v14 N53 19P JAN-MAP 1966,

SUPPLLMENTARY NOTE: TEXT IN SPANISHI ATTACHED SUMMARY IN

E N G L I S H,

DESCRIPTORS: (*HALLUCINOGENS, OPLANTS(BOTANYH),

SEEDS* FCUADOR? ALKALOIDS, MOTOR REACTIONS,

LYSEkGIC ACIDq, TOXICITY, HYPNOTICS * SEDATIVES;

BARBITURATES, CHROMATOGRAPHIC ANALYSIS (U)

IDENTIFIERS: IPnMOEA CARNEA (U)

IT HAS BEEN FOI|ND THAT THE SEEDS OF THE PLANT

IPOmOEA CARNEA WHICH SPONTANEOUSLY GROWS IN THE

SEMI-ARID ARFAq OF THE COASTAL REGION OF ECUADOR,

CONTAIN SOME ALKALOIDS RELATED TO THE ERGOT GROUP OF

ALKALOIDS* THE EXTRACTS FROM THIS PLANT PRODUCED

ON MICE A RESPMNSE CONSISTING FIRST Or AN INTENSE

PSYCHOMOTOR EXCITATION FOLLOWED BY A SECOND STAGE

CHARACTERIZED PY DEPRESSION WITH FAILURE Or THE

HINDLEGS AND wALKING WITH THE HELP OF THE TAIL.

ANOTHER PERSISTING SIGN IS THE PROTRUSION OF THE

TESTES. THE EXCITATION SYNDROME IS VERY SIMILAR TO

THAT PRODUCED PY LYSERGIC ACID DIETHYLAMIDEO THE

ALKALOIDS FROM I. CARNFA ALSO PRODUCED HYPERTHERMIA

ON RABBITS AND HYPOTHERMIA ON RATS. THE

PSYCwOMOTOR rFrECTS WERE ANTAGMNIZED BY 2-BROM LOS

WHEREAS THE HYPNOTIC AND TOXICEFFECTS OF

PENTORARBITAL e-ERE POTENTIATED. BY PAPER AND THIN

LAYER CHROMATOnRAPHY AT LEAST THREE ALKALOID SPOTS

WERL IDENTIFIEO AND PROBABLY ERGINE IS THE MAIN

ALKALOID OF Is CAHNLA. (AUTHORi (U)

31A D

UNCLASSIFIED /ZAML2

UNCLASSIFIEU

PDO REPOqT AImLIOGRAPHY SEARCH CONTROL NG. PZAML2

AD-64 983 61• 6/5

UNIVrRSIUAD DE LA RV- ICA MONTEVIDEO (URLIGUAY)INSTITUTO DE NFURULOGIA

EFFECTS OF PFYCMOPHARMACOI.OGIC DRUGS UPON SENSORYINFLOW IN NORMAL SUBJECTS, IN PSYCHIATRIC PATIENTSAND IN ANIMALS* (U)

DESCRIPTIVE NOTE! ANNUAL REPT, NO* 2, 1 OCT 60-10 SEP66,

NOV 66 12P AUSTTELIO GARCIACONTRACT: DA-ARf-49-092-66-G100PROj: DA-2JOI'95IB71D-OO-OI7-LA

UNCLASSIFIED REPORT

DESCRIPTORS: (*PSYCHUTROPIC AGENTSt VISUALPERCEPTION) VIRION, HUMANS, ANIMALS, RESPONSES;STIMULATION, CHLORPRUMAZINE, SLEEP, LYSERGIC

ACIDS$ ELECTROE.iCEPHALOGRAPHY (U)IDENTIFIERS: WArEFULNESS, PSYCHOPHARMACOLOGY,

URUGUAY (U)

AVERAGED VISIUA! EVOKED POTENTIALS ARE BEING STUDIEDIN MAN AND ANIMALS BY MEANS OF A COMPUTER OF AVERAGETRANSIENTS (CAT). MUnIFICATIONS INCORPORATED TO

THIS COMPUTER ARE DESCRIBED. EFFECTS OF

PSYCHOTROPIC DOUGS UPON THE AVERAGED VISUAL EVOKEDRESPONSE (VEP) IN NORMAL SUBJECTS ARE STUDIED.LSD 25 GETERMI"ED MULTIPLICATION OF THE WAVES.THE RESPONSE AMPLITUDE INCREASED DURINn CONTINUOUSFLICKER STIMULATION INSTEAD OF OECREASING AS OBSERVEDIN C•,NTROLSo CHLORPXOMAZINE REDUCED VERAMPLITUDE BOTH IN WAKEFULNESS AND SLEEP. STUPOUR

AND COMA VER WhS SIMPLE, LOWER AMPLITUDE THANNORmALSo STUPODOUS SUBJECTS IMPORTANT CHANGES WERE

OBSERVED GENERALLY IN CONJUNCTION WITH MODIFICATIONSIN bACKGROUNn ACTIVITY INDICATIVE OF CHANGES IN THE

LEVEL OF AWAREpES5. EFFECTS OF SAME DRUGS UPONVISUAL INFLO•v ALONG PRIMARY AND SECONDARY VISUALPATmWAYS WERr qTuDILD IN CATS. LSD 25 VERCHANGED IN PATTERN AS WELL AS 'N AMPLITUDE. ANINCXEASE IN LATENCY OF SECONDA Y AAVES WAS EVIDENT.CHLORPROMAZINE PROVUKED AN INCr•EASE OF PRIMARYRESPONSE WITH qMALL DOSES. LARGER DOSES TENDED TO

DECREASE IT AN?) TU REACH NORMAL AMPLITUDE.

(AUTHOR) (U)

32

UNCLASSIFIED /ZAML2

UNCLASSIFIED

ýfl'. REP04T PIRLIO(G.4PHY SEARCH4 CO2NTROL, NO, 11AML1

0D-647 12) 601• siloSTANFORD RESeAOCH INST MENLO PARK CALIr

DISRUPTION OF qIZE DISCRIMINATION IN SQUIRREL MONKEYS

(SAIMIRI SCIUREUS) BY LSD-25, (Ul

66 2P SHARPELAWRENCE G. 1OTIS,LEON S. |SCHUSERMANoRONALD Jo I

CONTRACT: NONR-i990qUO)

UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN PSYCHON SC! V7 N3

PIO.-4 1967.

nESCRIPTORS! (*VISUAL ACUITYs *LYSERGIc ACIDS),(*MONKEYS, VISInN), PSYCHOPHYSIOLOGYýINTERFFRENCE, PrRFURtANCE TESTS, DRUGS (U)

A 'UIFFICULT' SIZE DISCRIMINATION (RATIO1.12:1) WAS nIqRUPTEO IN FOUR OF FIVE SQUIRRELMONKEYS BY in TO 40 MICROGRAM/KG LSD-25 WHEREAS ANEASY' DISCRIMINATION (RATIO 1.96s|) WAS

RELATIVELY UNAFFECTED. DISRUPTION LASTED FROM 4-6MONTHS POSTINJFCTION IN TWO OF THE MONKEYS,NEITHER CHE I'rFICULT NOR THE CASY DISCRIMINATIONWAS AFFECTED IN THREE MONKEYS Ry UP TO 100 MICROGRAN/KG BOL-IN8. (AtTHOR) (U)

33

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DDC REPORT BIRLIOGRAPHY SEARCH CONTROL NO. /ZAML2

AO-647 796 6/5 6/15 5/10MINN4ESOTA UNIV MINNEAPOLIS

CERLBRAL INTeGrATION AND ITS ASSESSMENT BY DRUGS,(U)

67 'P MARRAZZIAMEDEO S. ;MEISCH,RICHARD A. ISCwIELEs8URTRUM Ce I

CONTRACT: AF-AFMSR-764-65PROJ: AF-9777TASK: 977701MONITuR: AFOSP 67-05q7

UNCLASSIFIED REPORT

SUFPLEMENTARY NTOE: PROCEEDINGS OF INTERNATIONALCOLLEGE OF NEuRnPSYCHOPHARMACOLOGy INTERNATIONALCONGRESS i5TH), WASHINGTON, D. Cot MARCH 20,19669

MESCRIPTORS: (*MENTAL DISORDERS: DIAGNOSIS),

('LYSERGIC ACIDS, PSYCHIATRY), CENTRAL NERVOUSSYSTLM, PERCEPTION(PSYCHOLOGY), PSYCHOSESeNEURUSES, BEHAVIOR, VISUAL PERCEPTION,PERSONALITY, PERSONALITY TESTS (U)

NORMAL BEHAVIOP I THE HOMEOSTATIC RESPONSE OF THEORGANISM. IT OPERATES TO PRESERVE LIFE ANDGENERALLY BY PPESERVING EQUILIBRIUM IN RELATION TOITS ENVIRONMENTSo INTERNAL AND EXTERNAL, TO ACHIEVESATISFACTION THROUGH THE REOUCTION OF THE SIGNALOVERLOAD THAT WOULD OTHERWISE RESULT. REGULATORYCONTROL ULTIMATELY REQUIRES CENTRAL REPRESENTATION OFALL EVENTS AND THE RESPONSES TO THEM , PROPOSED ORACTUAL - AS INPUT AND OUTPUT SIGNALS. SUCHMONITORING, !NTERNAL DISPLAY ANO COMMAND SIGNALINGGOES ON IN THE CENTRAL NERVOUS SYSTEM WHERE TOTALHOMEOSTASIS CAP' BE ACHIEVED THROUGH THE INTEGRATIVEINTERACTION OF ITS SIGNALS, THE NEURAL IMPULSES@

THE RECORDING nF SUCH SIGNALS AFFORDS A MEANS OFIDENTIFYING SOME OF THE ELEMENTS OF INTEGRATIVEINTLRACTIONS; AND DRUGS OFFER AN EXTREMELY USEFULTOOL FOR ANALYSIS OF THESE INTERACTIONS, IN THISiVAY IT IS SHOWP' THAT EXOGENOUS PSYCHOTOGENS, LIKELYSLPG;C ACID MIETHYLAMIDE (LSD) TEND TO DISRUPTINTEGRATION AS A CONSEQUENCE OF THE HIGH SENSITIVITYOF cEREBRAL ASqOCIArIONJ AREAS TO THE GENERAL SYNAPTICINHIBITORY ACTION THESE SUBSTANCES EXERCISE@(AUTHOR) (U)

34

UNCLASSIFIED /ZAML2

UNCLASSIF ED

CDC REPORT FIQLIfGkAPHY SEAWCH CONTOOL 40, /IANLU

TEXAS UNIV GALVESTON MEDICAL SPANCH

THE FFFECTS OF THIAZESIMs LSD-25, AND BILATERALLESIONS OF THE AMYGOALAE ON THE RELEASE OF A

SUPPRESSED RESPONSEs (Ul

67 12P BARRATTERNEST S. I

CONTRACT: NONR-I598U36)

UNCLASSIFIED REPORT

AVAILABILITY: PUBLISHED IN RECENT ADVANCES IN

BIOLOGICAL PSYrHIATRY V9 P229-4O 1967,

nESCRIPTORS: (eCONDITIONED REFLEX, *CENTRAL NERVOUS

SYSTLM), BRAIN, PSYCHOTROPIC AGENTS, LYSERGIC

ACIDS, AMPHETAMINES, INHIBITION, CONTROL,REACIION(PSYCHOLOGY), BEHAVIOR, CEREBELLUM,MONKEYS (U)

IDENTIFIERS: THIAZESIM, AMYGDALA (Ul

THE PuRPOSF OF THESE EXPERIMENTS WAS TO TEST THE

HYPOTHESIS THAT THE AMYGDALAE ARE INVOLVED IN THE

RELEASE OF A SlIPPRESSED RESPONSE ON A SCHEDULE

INVOLVING A POSITIVE REWARD (FOOD) AND RESPONSE-

CONTINGEN1 SHOCK. THE FOLLOWING TWO EXPERIMENTAL

TEST CONDITIONS CONSISTENTLY CAUSED RELEASE OF A

SUPPRESSED BAR-PULLING RESPONSE: (1) THE

ADMINISTRATION OF THIAZESIM AND (2) BILATERAL

LESIONS OF THE AMYGDALAE* POSSIBLE MECHANISMS

UNDLRLYING THESE CHANGES ARE DISCUSSED,

(AUTHOR) (U)

35

UNCLASSIFIED /ZAML2

UNCLASSIrIE0

DOC REPORT RIMLIOGRAPHY SEA)CH CONTROL NO, *ZAMLI

AD-693 680 6/Is 6/16CALIFORNIA UNIV LOS ANGELES BRAIN RESEARCH INSTNLUROPHARMACOLOGICAL STUDIES AND POSTULATES ONEXCITATION AND DEPRESSION IN THE CENTRAL NERVOUSSYSTEM,

(U)

67 .SP WINTERS;WALLACE D. 1CONTRACT: AF 49(638)-1)87PROJ: AF-9777TASK: 977701MONITOR: APOSR 67-1116

UNCLASSIFIED REPORTAVAILABIL.TY: PUBLISHC. IN RECENT ADVa4CES INBIOLOrICAL PSYCHIATRY V9 CHAP22 P313-40 1967.

nESCRIPTORS: (*ANESTHESIA,ELECTROENCEPHALMGRAPHY) l (OANýSTHETICS,PHARMACOLOGY), NERVOUS SYSTEM, PHYSIOLOGY# CNSDEPRESSANTS, CNe STIMULANTS, ELECTROPHYSIOLOGY,BRAIN, SLEEP, RFSPONSES, DRUGS; HALLUCINOGENS,ETHERS, EPILEPSy, LYSERGIC ACIDS, PSYCHIATRY (U)

RHOMBENCEPHALIr SLEEP (RPS) IS MORE SIMILAR TOTHE AWAKE DISTmACTED OR HALLUCINATORY STATE THAN TOSLOW-WAVE SLEEP, CNS DEPRESSION OR EXCITATIONCANNOT BE ASSERSED ON LY BY EVALUATING THERESPONSIVENESS OF THE SUBJECT, ImEo, THE LESSRESPONSIVE THE GREATER THE DEPRESSION. THE SUBJECTTHAT IS UNREqPnNSIVE DURING RPS IS NO LESSRESPONSIVE THAN IT IS DURING EPILEPTIC,HALLUCINPTORY; OR ANESTHETIC STATES. LOSS OF THEAROUS'AL RESPONSE IS NOT NECESSARIL'Y CORRELATED WITH ACNS DEPRESSION; SINCE IT CAN AL.SO OCCUR DURINGHYPEREXCITABfLITY. ANY AGENT WHICH CAN INDUCE AREDUCTION IN RPSPONSIVENESS AND LOSS OF MEMORY CAN BECONFUSED WITH, AND CONSIDERED TO BE# AN ANESTHETICAGENT. GHBg THOUGH REPORTED To BE AN ANESTHETICAGENT, HAS PROPERTIES LIKE ALPHA.CHLORALOSE'PHENCYCLIDINE, AND TRICHLORETHYLENEo ALL OP WHICHAPPEAR TO BE HALLUCINATORY AND EPILEPTOID AGENTS.A CUNTINUUM OF INCREASING EXCITABILITY MAY EXISTBEGINNING WITH INCREASED MOTOR ACTIVITY@HALLUCINATORY DEHAVIOR; AND FINALLY GENERALIZEDSEIZURES. THF HALLUCINATORY 'AURA' PRECEDING GRANDHAL SEIZURES It A POSSIBLE EXAMPLE OF THIS CONTINUUM.NITF(OUS OXIDE APPEARS TO BE PURELY AN HALLUCINATORYAGENT, ETHER INDUCES AN INITIAL HALLUCINATORYSTATE FOLLOWFD BY CNS DEPRESSION. THE PROPOSEDMO•L IJNDICATEc THAT SENSORY-INPUT SYSTEMS HAVE ANINCREASED MODULATION DURING EXCITED STATESp (Ut

36UNCLASSIFIED /ztfl,2

UNCLASSIFIED

r0C qLPvRT "IIRLIOGRAPHY SEARCH CONTROL NUs IZAIL2

AU-6bol 447 7/3

IrLA UNIV JERUALEM (ISRAELI DEPT OF ORGAN|C

C04i tI TRY

SYNTHESIS OF ALPHA-HYOROXY-ALPHA-AMINO ACIDS AND

EP'jOT ALKALOIDS* (U)

DESCRIPTIVE NOTE: FINAL TECHNICAL REPT, JUL 69-MAY 67,J jN ol 4'4 p LIWSCHITZ,Ye

CONTRACT: DA-91-591-LUC-1 7 9 9

PROj: DA- 1-52231IA060

MONITOR: ARDG(E) E-99q

UNCLASSIFIED REPORT

DESCRIPTORS: (eAMINO ACIDS,

SYNTHESIS(CHEMISTRY}I) (*ERGOT ALKALOIDS,

SYNTHESIS(CHEMISTRY))o PEPTIDES, ORGANIC

NITROGEN COMPOUNDS, AMINES, ALCOHOLS, CONDENSATIONREACTIONS, HYDROLYSIS, LYSERGIC ACIDS,

PSYCHCTROPIC AGENTS, ISRAEL {U)

IDLNTIFIERS: ERGOTAMINFS, HYOROXY ALANINES (U)

SEVERAL DIFFERENT APPROACHES FOR THE SYNTHESIS OF

THE PEPTIDIC SIDE-CHAIN OF ERGOTAMINE, bASED ON THE

DIRECT USE OF A SUITARLE PROTECTED ALPHA-

HYDROXYALANINE, OID NOT YIELD THE INTENDED RESULTS*

THL ETHYL (1) OR T-BUTYL ESTER OF N-

I EN 7 YLUXYCARRONYL-0-BE NZYL-ALPHA-HYDPOXYALANINEvHEN EXPOSED TO ALKALINE OR ACIDIC HYDROLYSIS,

RESPECTIVELY, UNUER A VARIETY OF CONDITIONS,

UISIr-jTFGRATED INTO tENZYLCARBAMATE AND PYRUVIC ACID

AMOIG OTHER PRODUCTS. ENZYMATIC HYDROLYSIS WAS

ALSO UNSUCCESSFUL, DIRECT CONDENSATION OF I WITH

T-BUTYL GLYCINATE OR L-PHENYLALANYL-L-PROLINE-

LACTAM IN THE PRESENCE OF IrIDAZOLE AND OTHER

CATALYSTS COULD NOT BE REALIZED. THE N-

CAN'OXYANHYDRIDE OF O.BENZYL-ALPHA-HYDROXYALANINE4eA5 PREPARED FROj ETHYL, HYjROGEN O-BENZYL-DL-

MFTHYLTARTRONATE, VIA THE HYDRAZIDE AND THE AZIDE

AHICH FINALLY UNDFROVENT THE CUPTIUS REARRANGEMENT.

SEVERAL REACTIONS CARRIED OuT AITH THIS NCA IN

ORDER TO OBTAIN SUITABLE OERIVATIVES OF ALPHA-

HYDROXYALANINF DID NOT TAKE THE EXPECTED COURSE ANDUfJNDE CERTAIN CONDITIONS THIS SUBSTANCE TRIMERIZED TO

YIELD DEHYDROALANYL-ALPHA-HYDROXYALANYL-DEHYDROALANINEe THE N-T-BUTYLOXYCARBONYL

DERIjATIVE OF ET-YL O.8ENZYL-ALPHA-HYDROXYALANINATL

",•AS SYNTHESIZED, ASSUMING IT TO BE MORE STABLE TOWARD

ALKALINE HYDROLYsIS THAN TH'. BENZYLOXYCARBONYLCo,1-OUNo. 37 (Ul

UNCLASSIF!ED /ZAML2

UNCLASSIFIED

ODC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZAML2

AD- 6 75 719 6/15O'RECTORATE Or SCIENTIFIC INFORMATION SERVICES OTTANA(ONTARIO)

PtfCHOTOM!METIC AGENTS WITH ANTICHOLINERGIC ACTIVITY,(U)

JUL 61 lOP BANSHCHIKOVqV. Me I

!TOLIAROVG. V.REPT. NO. T-OI-R

UNCLASSIFIED REPORT

SUPPL~tlENTARY NOTE: TRANS. OF ZHURNAL NEVROPATOLOGII 1

PSIKHIATRII (USSR) V66 N1 P4614-#68 1966, BY E. Re

HOPL-.

DESCRIPTORS: (OPSYCHOTROPIC AGENTS, CHOLINESTERASEINHI91TORS), NEUROSES, PSYCHOSES, CHEMOTHERAPY,

DOSAaEs ELECTROENCEPHALOGRAPHY; USSR (U)

IDENTIFIERS: OPSYCHOTOMIMETIC AGENTS,08ENACTYZINE, 9DITRAN, TRANSLATIONS (U)

IN RECENT YEARS THE ATTENTION OF RESEARCH WORKERSHAS REEN DRAAN To A GROUP OF SUBSTANCES THAT AREC.P•ALE OF EVOKING PSYCHIC DISTURBANCES WHEN

AOMINISTERED TO HEALTHY PERSONS AND TO PERSONS WITHMFNTAL ILLNESSES (NEUROSES AND PSYCHOSES).COMMON TO ALL THIS GROUP OF SUBSTANCES IS THEIRMARKED ANTICHOLINERGIC (ATROPINE-LIKE)

ACTIVITY). THE DRUGS CONSIDERED HERE ARE

HENACTYZINE AND DITRAN. (AUTHOR) 1U)

38

UNCLASSIFIED /ZAML2

UNCLASSIFIED

Vt;C 4[EýuRT RIBLIOGRAPMY bEARCM CONTROL NO* /ZAML2

AU-682 5 I 6/5 5/1o'CH.)OL OF AEROSPACE MEDICINE AROOKS AFA TEX

"PRUCIEDINGS OF THE ANNUAL CONFERENCE OF AIR FORCE

15FHAVIORAL SCIENTISTS (15TH), SHEPPARD AIR FORCE

IASE, 41CHITA FALLS. TEXAS$ 31 JANUARY TO 2FEBRuARY 1968 IU)

SEP o 258P MCKENZIERICHARD E. 1

UNCLASSIrIE0 REPORT

SUPPLEMENTARY rjOTE: SEE ALSO CONFERENCE NO, 14, AD'6698H6o

DE¶JCRIPTORS: foPSYCHIATRY, SyMPOSIA), MILITARYPSYCHOLOGY, GROUP DYNAMICS, THERAPY, CHILDREN,EFFICIENCY, AIR FORCE PERSONNEL, MEDICALPERSOIJNEL, MENTAL DISORDERS, TRAINING, BEHAVIOR$PEPCEPTION(PSYC0!OLOGY): LYSEkGIC ACIDS,AVIATION MEDICINE, EVACUATION* NEUROSES,PROJECTIVE TECHNIWUES, INTELLIGENCE TESTS,SuC II. 0GY (U)

IDENTIFIERS: GROUp THERAPY; MENTAL HEALTH$THERAPEUTIC A14ORTION IU)

CONTENTS: SOME COMMENTS ON jEHAVIORALMOUIFICATION; GOALS Or TREATMENT; BEHAVIORTHERAPy IN 1968; THERAPISTSO AWARENESS OF HOW GROUPTHERAPY PATIENTS PERCEIVE THEM; A COMMUNITY MENTAL"HrALTH APPROACH IN A mILITARY SETTING| A CHAP CHILDQUIDANCE CLINIC IN A IJSAF HOSPITAL; IMPROVING THEtlANAGEMENT OF CHILDREfJ BY GMOUP BEHAVIOR THERAPY OFTHEIR PARENTS; THE DEFINITIVE CARE UNIT; A NEWAPPROACH TO AN OLU PROBLEM; THE EFFICIENCY OF GROUPPSYCHOTHERAPY WITH FIRST-TEkM AIRMEN AT AN AIRFORCE TECHNICAL TRAINING CENTER; DEVELOPMENT OF AFAMILY THERAPY PROGRAM AT AN OVERSEAS PSYCHIATRICFACILITY; PSYCHIATRIC PRACTICE AND PSYCHOPATHOLOGYIN A LARGE AIR FORCE CLINIC; A HUMAN RELATIONSTRAINING PROGRAM AT A USAF HOSPITALJ DETERMINISMVERSUS FREE VILL IN HUMAN BEHAVIOR;CONCFPTUALIZATION AS REFLECTED IN SOCIAL PERCEPTIONBEHAVIOR: A PRFLIMINARY REPORT; DIMINISHED MALEORIENTATION IN SUICIDAL BASIC TRAINEESI LSD ANDSOCIALIZATION; THERAPFUTIC ABORTION OF MILITARYDFPENDENTS FOR PSYCHIATRIC REASONS; A DISCUSSION OFSOME PSYCHIATRIC ASPECTS OF THFRAPFUTIC ABORTION;THL PSYCHIATRIST ON TRIAL; MILITARY AEROMEDICALEVACUATION AND P$YCHIIATRIC PATIENTS; THEHkiSCHACH PRnTOCOLS OF TWO CASrS OF TRAUMATICNrUROSIS OF AAPI 39 (UL

UNCLAý,SIFIED /ZAML2

UNCLASSIFIED

ooC RFPORT SIRLIOGRApHY SEARCH CONTROL NO. IZAML2

A!.-66 593 6#15 6/MINNESOTA UNIV M14NEAPOLIS DEPT OF PHARMACOLOGY

CEREBRAL SYNAPTIC TRANSMISSION AIND BEHAVIORALEFFECTS OF DIMETHOXY PHENYLETHYLAMINE: A POTENTIALPSYCHOTOGEN, (U)

68 7P VACCAPLUCIO |FUJIMORI*MASEMOTO IDAVIS;SCOTT H. ;MARRAZZIAMEDEO So

CONTRACT; AF-AFOSR-13ý14-67PRtJ; AF-$777TASr: 977701MONITOR: AFOSR 6 9- 1 0 7 7TR

UNCLASSIFIED REPORTAVAILAbILITY: PUB. IN JNLo SCIENCE; V160 P95-96, 5APR 68,

DESCRIPToRS: (*NERVE IMPULSES, PSYCHOTROPICAGENTSi,_(OPSYCHOTROPIC AGENTS, BEHAVIOR);.(eAMINES, PSYCHOTROPIC AGENTS), INHIBITIONIHALLIJCINOGENS, FRAIN, CATS, CHLORPROMAZINESDOSAGE, PERCEPTION (U)

IDENjTIFIERS: PHENETHYLAMINEUPHENYLETHYLAMINE,*PHiLNYLETHYLAMINE/DIMETHOXYo MESCALINsPHENYLETHYLAMINE/3-..5-TRIMETHOXY, *CEREBRALSYNAPTIC TRANSMISSION, *SYNAPSES,PHENYLETHYLAMINE/3-4-5.TRIMETHIOXY (U)

DIMETHOXYPHENYLETHYLAMINE, LIKE MESCALINE WHICH ITRESEMBLES, IMPAIRS CEREBRAL SYNAPTIC TRANSMISSION ANDBEHAVIOR IN CATS. IT HAS PROPERTIES ASSOCIATEo4ITH HALLUCINOGENS AND, ON THIS SCORE, QUALIFIED AS APOTENTIAL INIUCER OF PSYCHOSIS. THE IDEA OF SUCHAN ENDOGENOUS INDUCER IS THUS REAFFIRMED BY THECANODIDACY OF 0IMETHOXyPHENYLETHYLAMINE&

(AUTHOR) U)I

40

UNCLASSIFIED /ZAML2

UNCLASSIFIED

nDC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* /IAM1.2

AD-686 595 6/15MINNESOTA UNIV MINNEAPOLIS DEPT OF PHARMACOLOGY

P9IMATE CEREBRAL SYNAPTIC INHIBITION BY DRUGS, (Ul

SEP 65 3P TANAKAKUNIO |MARRAZZI,AMEDEO So

CONTRACT: AF-AFOSR-76T-65PROj: AF-9777TASK: 977701MONITOR: AFOSR 69-107BTR

UNCLASSIFIED REPORTAVAILABILITY: PU8. IN SOCIETY FOR EXPERIMENTAL

BIOLOGY AND MEDICINE, V120 P669-670 1965o

DESCRIPTORS: (*NERVE IMPULSES, INHIBITION),(*CHLORPROMAZINE, PROTECTION), LYSERGIC ACIDS;SLRorotJIN, MONKEYS, STIMULATION, CONDUCTIVITY,RESPONSE5o PHARMACOLOGY (Ul

IDENTIFIEKS: SYNAPSES, SPIKE POTENTIAL (U)

CORTICAL EVOKFn POTENTIAL STUDIES SHCA THAT THE'YtqPTIC INHIBITION ey SEFVIONIN AND LY$ERGIC ACIDQILTHYLAMIDE OBSERVED IN THL PAT, (AT AND DOG CANALSO BE OBTAINED IN THE MONKEY- SPFCIFICITY OFACTION IS INDICATED By THE t.ROTECTION AFFORDED BYCHLORPROMAZINE. COMPARISON OF THE SYNAPTIC AND6FHAVIORAL EFFECTS SUGGESTS AN ORDFRLY, PARALLELfRPLATION IN A SERIES THAT PROGRESSES THRDUGH ASUBHUMAN PRIMATE TO MAN. (AUTHOR) (U)

41

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DOC RPORT PIRLIOGRAPHY SEARCH CONTROL NO, tZAML2

AD-686 793 6/5 6/15MINNESOTA UNIV MINNEAPOLIS DEPT OF PHARMACOLOGY

QUANTIFIED LSD EFFECTS ON EGO STRENGTH, IU)

66 2"P MARRAZZIAMEOEO S. ;MEISCHg qRICHARO A. ;PEWWILLIAM L. ;BIETERTHOMAS

CONTRACT: AF-AFOSR-764-.6PRUJ: AF-9777

TASK. 977701MONITOR: AFOSR 69-1070TR

UNCLASSIFIED REPORT

SUPPLEmErITARY NOTE: PRESENTEU AT SOCIETY FORBIOLOGICAL PSYCHIATRY, WASHINGTON, Do C., JUN66.

DESCRIPTORS: 4ELYSERGIC ACIDS, *MENTAL DISOROERS),HALLUCINOGENS, NEUROSES, PSYCHOSES, MEASUREMENT.DIAGNOSIS, THERAPY, PERCEPTION (U)

IDENTIFIERS: EGO (U)

IT VAS FOUND, IN SUPPORT OF THE POSTULATED NATUREOF HALLUCINATION AS AN INADEQUATE INTEGRATION OF NEW

alTr STORED INFORMATION PESULTING IN ABERRANTPERCEPTION. THAT SUBCLINICAL DOSES OF LSD BRING OUTA LATENT OR ACCENTUATE AN EXISTING DIFFICULTY INRFSOLVING THE PERCEPTUAL CONFLICT EXPERIMENTALLYINDUCED IN PSYCHOTICS AS DISTINGUISHED FROM INNEUROTICS AND NORMALS, BUT ADD LITTLE IF THISCONFLICT IS S0 GREAT THAT ACTIVE HALLUCINATIONALREADY EXISTS AT THE TIME OF LSD ADMINISTRATION.IT IS TELT THAT THIS KIND OF DRUG EVALUATION OFCEREfRAL INTEGRATION ýAN HELP IDENTIFY AND MEASUREAnNORMALITY CHARACTERISTIC UF THE FORMS OF MENTALDISTURBANCE IN WHICH A DISSOCIATIVE PROCESS IS AFUINDAMENTAL FEATURE, CONTINGENT ON FURTHERSUBSTANTIATION, THE PROPOSED LSD INDEX HOLDSPROMISE OF SUPPLYING THE 'CLINICAL 'AROSTICK' TO HELPIN DIAGNOSIS AND IN FOLLOWING THE COURSE OF MENTALILLNESS AND THE ErFICACY OF THERAPYo(AUTHOR)

(U)

42

UNCLASSIFIED /ZAML2

UNCLASSIFIED

PVC RPORT EIPLIOGRAPHY SEARCH CONTROL NO* /ZAHL2

AD-691 $)I blis 5/11UNIVERSIDAD CENTRAL DEL ECUADOR QUITO

ETNOFANMACOLOGIA DE LAS PLANTAS PSICOTROPICAS DE

AELRICA tETHNOPHARMACOLOGY OF THE PSYCHOTROPHIC

PLArJTS OF AMERICA); IU)

69 61P NARAfAJO#PLUTARCOCONTRACT: Ar-AFOSR-L436-68PR~j: AF-9777

TASK: 977701MOIITOR: AFOSR 69- 1 913TR

UNCLASSIFIEO REPORTAVAILAbILITY: PUU. IN TERAPIAl V24 P5-631969.

SUPPLEMENTARY NOTE: TEXT IN SPANISH.

DESCRIPTORS! (*PLANTS(BOTANY)i ePSYCHOTROPICAGFNTS), ANTHROPOLOGY, NORTH AMERICA,HALLUCINOGENS, SOUTH AMERICA, PHARMACOLOGY,DRUlGS (u)

IDENTIFIERS: ETHNOLOGY (U)

THIS IS A GENERAL REVIEW OF THE PLANTS IN NORTH

AND SOUTH AMERICA WHICH HAVL BEEN USED FOR THEIRHALUCIGENIC AND RELATED PROPERTIES& SIXTY-ONEPA(3ES WITH ILLUSTRATIONS OF PEOPLE, PLANTS; ANDAPTIFACTS, EIGHTY REFERENCES IN THE BIBLIOGRAPHY,(AUTHOR) (U)

43

UNCLASSIFIED /ZAML2

UNCLAbSIF|ED

DOC RIPORT BIBLIOGRAPHY SEARCH CONTROL NO. iZAML2

AD-696 947 510TrXAS UNIV AUSTIN DEPT OF PSYCHOLOGY

OPINION CHANGE IN THE ADVOCATE AS A FUNCTION OF THE

PFRSUASIBILITY OF HIS AUDIENCE: A CLARIFICATION OFTHE MEANING OF DISSONANCE. (U)

DESCRIPTIVE NOTE: TECHNICAL REPT.,JUN 69 26P NELLLIZABETH IHELMREICH,

ROBERT |ARONSON.ELLIOTREPT, !jO, TR-8

CONTRACT: NODOI 4-67-A-0126PROj: MR-171-804

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: REPORT ON HUMAN REACTIONS TOPSYCHOLOGICAL STRESS,

DESCRIPTORS: (eATTITUDES, TRANSFORMATIONS),-(OSTRESS(PSYCHOLOG'H, eSCIENTIFIC RESEARCH),MOTIVATION, APPLIED PSYCHOLOY, TEST METHODS,CANNABIS, BEHAVIOR, PERFORMANCE(HUMAN) t

CORRELATION TECHNIQUES (U)

IDENTIFIERS: OPINION CHANGE,DISSONANCE(PSYCHOLOGy), SELF ESTEEM;COUNTERATTITUDINAL BEHAVIOR IU)

SUtiJECTS WERE ENTICED TO MAKE A VIDEO RECORDING OF

A STRONGLY COUNTERATTITUDINAL STATEMENT (FAVORING

LEGALIZATION OF MARIJUANA); ONE-HALF OF THE

S511JECTS WERE PAID S.*0 AND ONE-HALF WERE PAID 59FOR THEIR COUNTERATTITUDINAL BEHAVIOR* THESUBJECTS WERE TOLD THAT THEIR VIDEO TAPE WOULD BE

UcED TO ATTEMPT TO CHANGE THE ATITUDES OF (A).AGROUP OPPOSED TO THE LEGALIZATION OF MARIJUANA.

(B) A GROUP IN FAVOR OF THE LEGALIZATION OFMARIJUANA, OR (C) A GROUP WITH NO OPINION ON THE

ISSUE. AS PREDICTED, A SIGNIFICANT DISSONANCEEFFECT (MORE ATTITUDE CHANGE FOR LOW FINANCIALINCENTIVE) WAS FOUND WHEN THE AUDIENCE WAS NOT

COMMITTED ON THE ISSUE, THE RESULTS WEREINTERPRETED AS SUPPORTING A VIEW THAT DISSONANCE isAPOUJSED AS A FUNCTION OF DISCREPANCY BETWEEN SELF-CONCEPT AND THE CONSEQUENCE5 OF BEHAVIORe

(AUTHOR) (U)

44

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DLC REPORT BIPLIOGRAPHY 5EARCH CONTROL NO, AflML2

AU-7U1 170 bf13 6/1EDGE NOD ARSENAL MD

LFFECT OF LYSERGIC ACID DIETXYLAMIDE ON ESCHERICHIACOLI, STRAIN B/R(LAMBDA)o (U)

DESCRIPTIVE NOTE: TECHNICAL kEPT. JAN 68-FEB 69;FES 70 22P DOWLER,MICHAEL Jo .WOLPERT

JACK S. iREPT. NO. EA-TP-'3)9PROj: DA-1-8-562602-AU-19

TASK: I-B-562602-AD-1904

UNCLASSIFIED REPORT

DEscRIPTORS: (*LYSERGIC ACIDS, oESCHERICHIA COLI)'GqONTH, CHROMOSOMES; DAMACE, DOSAGE, PURINE

ALKALOIDS, ULTRAVIOLET RADIATION, DESOXYRIBONUCLEIC

ACIuS, INHIBITION. HALLUCINOGENS, CHEMICAL WARFAREAGENTS, BIOLOGICAL ASSAY (U)

IDENTIFIERS: eLYSERGIC ACID DIETHYLAMIDE (U)

THE EFFECT OF LSD ON Es COLI WAS EXAMINED AS ATEST SYSTEM FOR DAMAGE TO GENETIC MATERIAL. LSD HAD

A DOSE-DEPENDENT EFFECT ON UACTERIAL GROWTH RATE*THIS EFFECT WAS NOT AMPLIFIED BY THE DNA-REPAIR

INHIBITOR CAFFEINE. THE LOMERING OF THE GROWTH RATEBY LSD WAS SHOWN TO 6F COMr-LETELY REVERSIBLE UPONDILUTION. LSD OAS SHOWN TO CAUSE A DOSE DEPENDENTEXTF,'SION OF THE GROWTH RECOVERY LAG DUE TO UV

DAMAGE, CAFFEINE CAUSED A MUCH LARGER EXTENSION OF

THIS LAG TIME. (AUTHiOR) (U)

45

UNCLASSIFIED /ZAML2

IKi,

UNCLASSIFIED

DDC REPORT SIBLInGRAPHY SEARCH CONTROL NO* IZAML2I.

AD-7UI 171 6/1 6/1EDGEAOOD ARSENAL MO

LYSERGIC ACIO DIETHYLAMIDE: PHOTODYNAMICINACTIVATION OF REPAIP DEFICIENT Es COLI AND

TIL BACTERIOPHAGE. (U)

DESCRIPTIVE NOTE: TECHNICAL REPT. MAR-MAY 69t

FEB 70 114P PAPIRMEISTERRRUNO IWOLPERT,JACK S, I

REPT. NO. EA-TR-';00OPROd: DA-1-8-562602-AD-1 9

TASK: I-B-562602-AO-1904

UNCLASSIFIED REPORT

DESCRIPrORS: t*LYSERGIC ACIDS, .ESCHERICHIA COLI),(OBACTERIOPHAGES, LYSERGIC ACIDS),

(OPHOTnSENSITIVITY(BIOLOGICAL' _LYSERGICACID3) DESOXYRIBONUCLEIC ACIDS, INHIBITION,DOSAGE, PURINE ALKALOIDS, DAMAGE, CHROMOSOMES,HALLJCINOGENS, CHEMICAL WARFARE AGENTS, BIOLOGICAL

ASSAY (U)

IDENTIFIERS: *LYSERGIC ACID DIETHYLAMIDE (U)

E. COLL B DERIVATIVES DIFFj:jjING IN ABILITY TO

REPAIR DEOXYRIBONUCLEIC ACID (ONA) DAMAGES PRODUCEDUY ULTRAVIOLET RADIATION SHOWED CORRESPONDING

RESPONSES TO PHOTO EFFECTS SUSTAINED IN LYSERGIC ACID

DIETHYLAMIDE (LSO)-SENSITIZLD ORGANISMS, THE

EXCISION-REPAIR SYSTEM (HCR) WAS A MOST

SIGNIFICANT DETERMINANT FOR ALLOWING RECOVERY OF BOTHTPLATED BACTERIA AND Tfl) BACTERIOPHAGE,

CAFFEINE, A KNOWN INHIBITOR OF THE MCR SYSTEM,PREVENTED THIS RECOVERY* ALTHOUGH THESE FINDINGSSUGGEST AN ASSOCIATION OF LSD WITH DNA IN VIVO,THE RELATIVELY HIGH DOSE OF LSD EMPLOYED FAILED TO

PRODUCE DETECTABLE DNA DAMAGES IN THE ABSENCE OFRADIANT ENERGY, THE RELEVANCE OF THE OBSERVEDPHOTOEFFECTS TO THE REPORTED CHROMOSOME-DAMAGING

PPOPFRTIES OF LSD IS NOT KNUWN. (AUTHOR) (U)

46

UNCLASSIFIED /ZAML2

UNCLASSIFIED

"•UC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. fZAMLJ

AD-7u7 667 6115 6/20MICHIGAN UNIV ANN ARBOR DEPT OF PHARMACOLOGY

THE CHEMISTRY AND PHARMACOLOGY OF CERTAIN COMPOUNDSAFFECTING THE CENTRAL NERVOUS SYSTEM OF ANIMALS ANDMAN. A PHARMACOLOGICAL COMPARISON OF EA 1476(TLTRAHYDROCANNABINOL.) ISOMERSe (U)

DESCRIPTIVE NOTE: PROGRESS REPT.,DEC 56 lOp HARDMANHAROLD F. ;SEEVERS,

MAURICE He ;CONTRACT: DA-18-108-CML-5663

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO AO-707 668 AND AD.707669.

DEbCRIPTORS: (eCANNmBIS, -CENTRAL NERVOUS SYSTEM),MOLECULAR ISOMERISM, BFHAVIOR, TOXICITY; DOSAGE,PATHOLOGY, PHYSIOLOGY, CARDIOVASCULAR SYSTEM,MORTALITY RATES, ANIMALS, HUMANSp PHARMACOLOGY.

DOGS, NERVOUS SYSTEM, SLEEP (U)

EA 1476 (OS) AND EA 1%76 ('(018 PRODUCE A

I5I1LAR BEHAVIORAL RESPONSE IN THE UNANESTHETIZED DOG-VITH COMPARABLE INTRAVENOUS DOSES. EA 1476(44I1) PRODUCED OEATH BY CARDZAC ARREST RESULTING

FROM VENTRICULAR FIBRILLATION "N TWO OUT OF FIVE DOGSOHO RECEIVED INTRAVENOUS nOSES OF 1.0 MGM./KGMs EAIq76 (OS) APPEARS To BE MORE TOXIC NOW THAN WHEN IT4AS FIRST EVALUATED IN THIS LABORATORY TWO YEARS AGO.EA 1N76 (4018) MAY BE SLIGHTLY MORE TOXIC THANEA 11476 (OS) 'NITH INTRAVENOUS DOSES OF 1.0 MGM./KGM (U)

47

UNCLASSIFIED /ZAML2

UNCLASSIFIED

ODC REPORT qIBLIOGRAPHY SEARCH CONTROL NO. IZAML2

A0-707 668 6/15 6/20MICHIGAN UNIV ANN ARBOR DEPT OF PHARMACOLOGY

THE CHEMISTRY AND PHARMACOLOGY OF CERTAIN COMPOUNDSAFFECTING THE CENTRAL NERVOUS SYSTEM OF ANIMALS ANDMAN N 4U)

DESCRIPTIVE NOTE: PROGRESS REPT. NO. I,NOV 9 2p . HARDMANHAROLD F, ;DOMINO,

EDWARD F. ISEEVERSMAURICE H. 1CONJTRACT: DA- 181-R-CML- 5 663

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO AD-707 669 AND AD-.07667,

DEScRIPTORS; (*PSYCHOTROPIC AGENTS,.PHARMACOLOGY) l(*CANNA8IS, CENTRAL NERVOUS 5YSTEM),(oRESERPINEo CENTRAL NERVOUS SYSTEM), TOXICITY,BEHAVIOR, HYPOTENSION, CARDIOVASCULAR SYSTEM,RESPIRATION, ELECTROENCEPHALOGRAPHY, HYPOTHERMIA,DOSAEE, PATHOLOGY, PHYSIOLOGY1 PHARMACOLOGY*ANrrIALSs HUMANS, MORTALITY RATESt DOGS,NERVOUS SYSTEM (U)

EA 1476, EA 1477 AND RESERPINE HAVE NUMEROUS

SIMILAR PHARMACOLOGICAL EFFECTS IN THE DOG WHENAnM[NISTERED BY THE ORAL OR INTRAVENOUS ROUTE. EA1476 AND EA J477 HAVE QUALITATIVELY SIMILAR -FFECTSuPON4 THE CARDIOVASCULAR SYSTEM OF THE DOG* EA 14#760FA 1477 AND RESERPINE PRODUCE A STATE OFTRANOIJ1LIZATION IN THE UNANLSTHETIZED DOG 70L.OWINGINTRAVENOUS ADMINISTRATION. EA 1476 LIKE RESERPINE

CAN PROLONG THE SLEFPING TIME OF WHITE MICE INDUCEDBY THE INTRAPERITON.AL INJECTION OF HEXOBf'8ITALoTHL ELECTROErNCEPHALOGRAPHIC RESPONSE OF TH-UNA'4FSTHETIZED CuRARIZED DOG TO 0.10 MGM,/KGMo OFEA 1476 ADMINISTERED INTRAVENOUSLY IS CHARACTERIZEDBY 'IIGH VOLTAGE SLON NAVES *ITH SOME TENDENCY TOSPINDLING, HYPOTHERMIA IS AN OUTSTANDING SIGNFOLLOWING INTRAVEmOUS ADMINISTRATION OF 1.0 MGMoIKGM*OF CA 14&76o EA 1I476 AS WELL AS RESERPINE

DEPRESSES RESPIPATORY RATF FOLLOWING INTRAVENOUSADMINISTRATICN 10 UNANESTHETIZED 'OGS. (U) t

48

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DOUC REPORT BIBLIOGRAPHY bEARCH CONTROL NO. /ZAHL2

AO-7U7 669 6/I1 6/20

*ILHIGAN UNIv ANN ARBOR DEPT OF PHARMACOLOGY

IHL CHEMISTRY AND PHARMACOLOGY OF CERTAIN COMPOUNDSAFFECTING THE CENTRAL NERVOUS SYSTEM OF ANIMALS ANDMAN. (U)

DESCICIPTIVE NOTE: SUMMARY PROGRESS REPT. NO- 2,JAN !7 544p HARDMANHAROLD Fe IDOMINO,EDAARD Fe ;SEEVERSMAURICE He

CONTH.ýCT: DA-It- IU8-CMLL-66)MONITOR: CWL TM-27-2

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO AD-707 668 AND AD-70 7667.

DESCRIPTORS: (OPSYCHOTROPIC AGENTS, PHARMACGLOGY),,(OCANJNABISo -CENTRAL NERVOUS SYSTEM),(ORESLRPINE, CENTRAL NERVOUS SYSTEM),CARDIOVASCULAR SYSTEMJ BEHAVIOR, TOXICITY.PATHOLOGY, PHYSIOLOGY, PHARMACOLOGY, DOSAGE,ANIMALS, HUMANS, NERVOUS SYSTEM, SLEEP; DOGS IUI

THE EXTENSIVE ACTIOnS OF TETRAHYDROCANNABINOL

UERIVATIVES UPON THE CARDIOVASCULAR SYSTEM SUGGESTTHAT THESE AGENTS ACT BY INHI1ITION OF THE AFFERENTTO EFFERENT AREAS OF THE CENTRAL COMPONENTS OF THESYMPATHETIC iJERVUUS SYSTEM. BEHAVIORAL CHANGESCHARACTERIZED BY CNS DEPRESSION, ATAXIA$ ANALGESIAAND ENHANCED TENDON REFLEXES HAVE BEEN DESCRIBEDOTHE GENERAL TOXICITY OF THE TETRAHYDROCANNABINOLDERIVATIVES IS DISCUSSED AS WELL AS THE EFFECTS OFDRUGS WHICH ANTAGONIZE OR PoTENTIATE THEIRPHARMACOLOGICAL ACTIONS* AN ANALYSIS OF STRUCTUREACTIVITY RELATIONSHIP IS PRESENTED FOR THETETRAHYDROCANNABINOL DERIVATIVES EVALUATED IN THISSTUDY. (U)

49

UNCLASSIFIED /ZAML2

UNCLASSIFICo

DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, #ZAML2

AD-715 :71 6/15 7/1jAINT LOUIS UNIV MO

NEUROTROPIC EFFECTS IN RELATION TO CHEMICAL

STRUCTURE* (U)

DESCRIPTIVE NOTE: SEMI.ANNUAL REPT. NO* 2; 1 OCT 61-11MAR 62,

MAR 62 43P DONAHOEHUGH [C,

CONTRACT: DA-18-108-CML-660!

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NOt 1,A0-715 )77 AND SEMI-ANNUAL REPT. NO. 3, AD-710 379.

DESCRIPTORS: (*ANALGgSICS * ANTIPYRETICS,MOLECULAR STRUCTURE). (OANTISPASMODIC AGENTS,*MOLECULAR STRUCTUpE), (-N-HETEROCYCLIC COMPOUNDS;SYNTHESIS(CHEMISTRY))) (OPIPERIDI.NES,SYNTHESIS(CHEMISTRY)), NARCOTICS, MUSCLERELAXANTSg TROPANE ALKALOIDS, MORPHINE, POLYCYCLICCOMPOUNDSo BIOLOGICAL ASSAY. X-RAY DIFFRACTIONANALYSISI ELECTRON DIFFRACTIQN ANALYSIS, CRYSTALSTRUCTURE, HALLUCINOGENS (U)

IDENTIFIERS: .PHENCYCLIDINE; OQUINOXALINE/TETRAiIYDRO, *EPHEDRINE (U)

THE WORK COVERED BY THE REPORT IS DIVIDED INTO FOURAREAS: CHEMICAL STUDIES WHICH WERE UNDERTAKEN TOPREPARE MODEL COMPOUNDS INCLUDING PHENCYCLIDINE TYPECOMPOUNDS, TETRAHYDROQUINOXALINEStDIAZABIOCYLOALKANES. AND PIPERIDINES1 X-RAY ANDELECTRON DIFFRACTION STUDIES OF SELECTED AND/ORSYNTHESIZED COMPOUNDS WHICH ARE DIRECTED TOWARDS THEELUCIDATION OF STRUCTURE ACTIVITY RELATIONSHIPS INTHE FIELD OF NEUROPHARMACOLOGYi BIOLOGICALEVALUATION OF SPECIFICALLY SELECTED COMPOUNDS BYSPECIAL METHODS; AND CUSTOM SYNTHESIS OFCOMPOUNDS, (U)

I 5O

50

UNCLASSIFIED /ZAML2

I'1

UNCLASSIFIED

DDC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* /ZAHL2

AD-711 379 6115 7/3SAINT LOUIS UNIV 4D

NEUROTROPIC EFFECTS IN RELATION TO CHEMICAL

STRUCTURE, (Ul

DESCRIPTIVE NOTE! SEMI-ANNUAL REPT& NO* 3, 1 APR-30

SEP 62,SEP 62 50p DONAHOEHUGH B.

CONTRACT: DA-I8-1OS-CML- 6 601

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NO. 2,AD-715 378 AND SEMI-ANNUAL REPT. NO. 4, AD-715 380.

DESCRIPTORS: (eANALGESICS + ANTIPYRETICS,MOLECULAR STRUCTURE). (*ANTISPASMODIC AGENTS,*MOLECULAR STRUCTURE), (ON-HLTEROCYCLIC COMPOUNDS$

SYNTHESIS(CHEMISTRY)), NARCOTICS, MUSCLERELAXANTS, TROPANE ALKALOIDS, MORPHINE, POLYCYCLICCOMPOUNDS, BIOLOGICAL. ASSAY. X-RAY DIFFRACTIONANALYSIS, ELECTRON DIFFRACTION ANALYSIS, CRYSTAL

STRUCTURE, HALLUCINOGENS (U)

IDENTIFIERS: &PHENCYCLIDINEe *QUINOXALINE/TETRAHYDRO, *BENZODIA7EPINE/TETRAHYDRO,OEPHEDRINE (U)

THE fiORK COVERED BY THIS REPORT IS DIVIDED INTO

THREE AREAS: CHEMICAL STUDIES WHICH WERE

UNDERTAKEN TO PREPARE MODEL COMPOUNDS WHICH ARE OF

INTEREST INCLUDING PHENCYCLIDINE TYPE

COMPOUNDS(SERNYL): TETRAHYDROQUINOXLINES; AND

DIAZABIOCYCLOALKANES, AND PIPERIDINES; X-RAY AND

ELECTRON DIFFRACTION STUDIES OF PHENCYCLIDINE AND

EPHEDRINE HYDROCHLORIDEI BIOLOGICAL EVALUATION OF

SPECIVICALLY SELECTED COMPOUNDS BY SPECIAL METHODS. (U)

1S

UNCLAbSIF !ED /ZANL2

UNCLASSIFIED

DDC REPORT RIBLIOGRAPHY SEARCH CONTROL NO. /ZAHL2

AD-715 380 6/15 7/)SAINT LOUIS UNIV MO

NEUROTROPIC EFFECTS IN RELATION TO CHEMICALSTRUCTURE. (U)

DESCRIPTIVE NOTE: SEMI-ANNUAL REPT. NO', 4; 1 OCT 62-;1MAR 63,

MAR 6) 36P DONAHOEHUGH Oe ICONTRACT: DA-18-IO-CML-6601

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO SEMI-ANNU8L REPT. NO. 3,AD-715 379 AND SEMI-ANNUAL REPT, NO* 5, AD-715 381o

DESCRIPTORS: (eANTISPASMODIC AGENTS; oMOLECULARSTRUCTURE); (OANALGESICS * ANTIPYRETICS;MOLECULAR STRUCTURE) c*(N-HETEROCYCLIC COMPOUNDS,SYNTHESIS(CHEMISTRY)), MUSCLE RELAXANTS,NARCOTICS, POLYCYCLIC COMPOUNDS, X-RAY DIFFRACTIONANALYSIS, CRYSTAL STRUCTURE, ELECTRON DIFFRACTIONANALYSIS, HALLUCIIOGENS (U)

IDEJTIFIERS: *PHENCYCLIDINE, #QUINOXALINE/TETRAHYDRO! *ETHANOQUINOLINE/DIHYDRO-a1-"*EPHEDRINE, OETHAIJONAPHTHALENE DICARBOXYLICANHYORIDE/DIHYDRO.2-3-DIMETHYL-I-' fU)

DURING THE PERIOD COVERED BY THE REPORT, PRIMARY

EMPHASIS HAS BEEN PLACED ON THE INVESTIGATION OF

SYNTHETIC ROUTES TO SELECTED BICYCLOALKANES.STUDIES WERE STARTED DURING THE PERIOD AIMED ATPRLPARING STRUCTURES OF THE 2,3-BENZOQUINUCLIDINE ANDTHE APPROPRIATELY SUBSTITUTEDBONL0(2.2o2)HICYCLOALKANES, THE REACTION OF 2,3-DImETHYLNAPHTHALENE WITH mALEIC ANHYDRIDE WASSTUDIED, AND THE REDUCTION OF THE RESULTING 2,".DIMCTHYL-is4-DIHyORONAPHTHALENE-IR-ENDO- ALPHA, BETA

SUCCINIC ANHYDRIDE To THE DIOL WAS ACCOMPLISHED.IN THE 2o3-BENZOQUINUCLIDINE SERIES* THE SYNTmESISHA5 BEEN CARRIED AS FAR AS THE PREPARATION OF 1,2,•,'4-TETRAHYDRO-L-CARBOMETHOXY-METHYL-4-CARiOMETHOXYQUINOLINIUM BROMIDE@ WORK HASCONTINUED ON THE STUDY OF L-(DIALKYLAMTNOACETYL)-3-KETO- 1 2,3,4-TETRAHYDROQUINOXALINE ANDDERIVATIVES, ALSO STUDIED WAS THE X RAYDIFFRACTION OF PHENCYCLIDINE(SERNYL). fUl

52

UNCLASSIFIED /ZAML2

UNCL IF I I D

AD-7Io 181 6/15•?

SAINT LOUIS UNIV MO

NrUROTROPIC EFFECTS IN RELATION TO CHEMICALSTRUCTUREo (U)

OEbLCIPTIVE NOTE: SEMI-ANNUAL REPT. NO. P; I APR.30SFP 6),

SEP 6; 146P DONAHOEfHUGH B ,CONTRACT: DA-IB-IOS-CML-6601

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NO. '.AD-715 380 AND SEMI-ANNOAL RLPT. NO. 6, AD-715 382.

DESCRIPTORS: (SANTISPASMODIC AGENTS, oMOLECULAR

STRUCTURE), (.ANALGESICS - ANTIPYRETICS,MOLECULAR STRUCTURE| o(eN-HETEROCYCLIC COMPOUNDS;

SYNTHESIS(CHEMISTRY)), MUSCLE RELAXANTS,NARCOTICS, POLYCYCLIC COMPOUNDS, X-RAY DIFFRACTION

ANALYSIS, ELEC T RON DIFFRACTION ANALYSIS,HALLUCINOGENS (U)

IDENTIFIERS: *ETHENOSENZISOINDOLINE/4-9, rOPHENCYCLIDINE. *ETHANOeENZISOINCOLINOL/4-9,*ETHANOANTHRACENE/DIHYDRO-9-10o, ETHANOQUINOLINE/

0IHYDRO-I-'4, eANILINE/N-METHYL,ETHANONAPHTHALENE DARCARBOXIMIDE/DIHYDRO-2-3-DIMETHYL-I-4 (U)

THE REPORT UISCUS5ES THE SYNTHESIS AND BIOLOGICALEFFECTS OF THE FOLLOWING COMPOUNDS: PHENCYCLIDIENTTYPE COMPOUNDSUI-(I-PHENYLCYCLOHEXYLPIPERIDINES); 4-9-ETHENO-IH-

bENZ(Fl ISOINDOLINE; 4-9-ETHANO-|H-BFNZ(F; ISOINDOLIN-1U-OL; ii-AMINOMFTHYL-9-10-DIHYDRO-9-IO-ETHANOANTHRACENE; 1-4-DIHYDRO-1-'-ETHANOUINOLINE. ALSO STUDIED WAS ALKYLATION USINGN-METHYLANILINE AND THE X RAY DIFFRACTION AND

ELECTRON DIFFRACTION ANALYSIS OF PHENCYCLIDINE(SER NYL) (U)

53

UNCLASSIFIED /ZAML2

UNCLASSIFIED

ODC REPORT PIRLIOGRAPHY SEARCH CONTROL NO. **ZAML,2

AD-715 )62 6/15 71)

SAINT LOUIS UNIV MO

N4Fu~oTROPIC EFFECTS IN RELATION, TO CHEMICAL5TRUCTURE. (U)

OL5CR'IPTIVE NOTE: SEMI-ANNUAL. REPT. NO. 6, 1 OCT 63-;lMAR 6'4

MAR 64 68P DONAHOEvHUGH Be

CONTR ACT: OA-l 8-1 Oe-CML- 6 6 0 1

UNCLASSIFIED RF.FORT

SUPPLEMENTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NO. 5,AD-715 )81 AND SEMI-ANNUAL REPT. NO. 7, AD-7101 3183o

DESCHIPTORSI (*ANTISPASMODIC AGENTS* *MOLECULARSTRUCTURE), (*ANALGESICS +ArTIPYRETICS,MULECULAR STRUCTURE) -(N-HETEROCYCLIC COMPOUNDS,SYNTHESIS(CHEMISTRY);, MUSCLE RELAXANTS,POLYCYCLIC COMPOUNDS * X-RAY DIFFRACTION ANALYSIS8

ELFCTRON DIFFRACTION ANALYSIs, CRYSTAL STRUCTURE,FLuORENES, NAPHTHALENES9 PHENOLS, IMIDESt

BIOLOGICAL ASSAY. WALLUCINflGENS (J

IDENT IFIERS! *PHENCYCLIDINE, OQUINOXALINE/TETkAHYDRO, *ETHANOQUINOLI NE/DIHYDRO-1-'41*ETH ANOBENZ ISOl NDOL INEt4-9; *ETHANONAPHMTALENE

DICARBOAIMIDE/DIHyDRO.1-'4' OFLUORENOL/NITRO-2,NITRO COMPOUNDS (U)

THL REPORT DISCUSSES THE SYNTHESIS AND BIOLOGICALEPFECT5 OF THE FOLLOAING COMPOUNDS: '4-9pETHENO-IH-1ENL IF) ISOINDOLINE; 1-4-DIHYDRO-1-R-ETHANONAPHTHALENE DICARBOX IMIDE; 1-'4-DIMYDRO.1-'I-ETHAm'OWjUINOL INE; 1-2,-3-4-TETRAHYOROQUINOXALINE*

ALSO SYNTHESIZED XAb 3-NITRO FLUOREN-2-OL.0FURTHER STUDIES ON THE CRYSTAL STRUCTURZ OF

PHE.NCYCLIDINE (SERNYL) USING x RAY DIFFRACTION

ANALYSIS AND ELECTRON DIFFRACTION ANALYSIS ARE

DI SCU95ED. (U)

54

UNCLA.)SIFIED /ZAML2

UNCL AtSSIF! ED

('CC %ýPORT HPALIOGRAPHY :)EARCM CONTROL NO, /ZANLZ

AD-715 38: 6/15 7/1SAINT LOUIS UNIV MO

UNruRoTNOPIC EFrECIS IN RELATION TO CHEMICAL

ST RU C T RE * (U)

DESCPIPTIvE NOTE: SEMI-ANNUAL REPT. NO. 7; 1 APR-SO

SF& 64,SEP 6'4 614P DONAHOE,HUGH a. ;MUFK-R,

VVTLLIAM j.CONTRkC T: DA- 16-I Oq-CML-6 6fl1

UNCLASSIFIED REPORT

5UPPLFrMENTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NO. 6,

AU-7 15 382 AND SEMI-ANNUAL REPT. NO. 8, AD-715 39q.

CESCRIPToRS: (.ANTTSPASMODIC AGENTS, *MOLECULAR

STRUCTURE), (*ANALGESICS 4ANTIPYRETICS,MOLECULAR STRUCTURE.$ (eN-HETEROCYCLIC COMPOUNDS,

5S"NTHESI5(CHEMISTRY)). MUSCLE RELAXANTS,

POLYCYCLIC COMPOUNDS. X-RAY DIFFRACTION ANALYSIS;ELECTRON DIFFRACTION ANALYSIS, CRYSTAL STRUCTURE,

NAPHTHALENES, ANTHRACENES, IMIDES, ANHYDR*IDES;

HALLUC INOGENS (U)

IDE.NTIF IERS: ePHENCYCL!D1Nr

CLTHENOBENZ ISO! NDOg I rE/4-9 , *BENZOBENZI1501NOOL INE,'

'4-9, *ETHANOANTHRACE:JE D[CARBOXIMIDE/OIHYDRO-91O (U)

THE REPORT DISCUSSES THE SYNTHESIS AND BIOLOGICALEFFECTS OF THE FOLLOWIyNG COMPOUNDS: '4-9-ETHENO-IH-4-ENZ(F)ISO!NDOLINE5; 4-9-0-

DENZENOBENZ(F) ISOINDOLINES; 9-1O-OIHYDRO-9-

1O..ETHANOANTHRACENES111 !2-DICARBOXIMIDr; 9-1O-

UlkiY ORe-9-10 -E THANO AN THR ACEqE-11-12 0 ICARBOX YL IC

UIANHAYDRIDE. ALSO REPORTED IS THE X RAY

DIFFRACTION AND ELECTRON DIFFRACTION ANALYSIS OF THE

HYDROCHLORIDE AND HYDROBROMIDE OF PHENCYCLIDINE

(SERNYL) * (U)

55

UNCLASSIFIED /ZAML2

UNCLASSIFIED

"nDC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* /ZAML2

AD-715 165 6/15 7/1SAINT LOUIS UNIV MO

NEUROTROPIC EFFECTS IN RELATION TO CHEMICALSTkUCTUREO (U)

DESCRIPTIVE NOTE: FINAL REPT, I APR 61-31 MAY 61,MAY 65 76P DONAHOE;HUGH B. ;HUFKER,

AILLIAM Js ;CONTRACT: DA-lB-IOs-CML-660!

UNCLASSIFIED REPORT

SUPPLEr:EtTARY NOTE: SEE ALSO SEMI-ANNUAL REPT. NO. 8,AU-7I,, I814 AND QUARTERLY REPT. NO. Is AD-7195 386.

DESCkIPTORS: (OANTISPASMODIC AGENTS, *MOLECULARSTRuCToRE), (*ANALGESICS + ArTIPYRETICS,MOLECULAR STRUCTURE2, (*N-HETEROCYCLIC COMPOUNDS$SYNTHLSIS(CHEMISTRYI), MUSCLE RELAXANTS;MOPPHINE, NARCOTICS, ANTHRACENESs AMINES,BIOLOGICAL ASSAY, CRYSTAL STRUCTURE,HALLUCINOGENS; ELECTRON DIFFRACTION ANALYSIS, X-RAY DIFFRACTION ANALYSIS, ALCOHOLS (UI

IDLNTIFIERS: aPHENCYCLIDINE,*bENZORENZISOINDOLINE/4-9, OETHANOANTHRACENEMETHYLAMINE/DIHYDRO-9-1O, OETHENOBENZISOINDOLINEI9-

9, .TUINOXALIPIE/TETRAHYDRO, *ETHANOQUINOLINE/DIHY)RO-I-' (U)

THE 4EPORT DESCRIBES A STUDY OF THE RELATIONSHIP

UETNEEN THE STRUCTURE OF CERTAIN BICYCLIC COMPOUNDS$,4HOSF GROSS STRUCTURE RESEMBLES THAT OF MORPHINE, ANDMORPHINE-LIKE AND ANTISPSAMODIC ACTIVITY.APPROXIMATELY TWO HUNDRED AND FIFTY DERIVATIVES OF9-Y-O-BENZOBENZ(F) ISOINDOLINrE, 9-10-DIHYDRO-901O-ETHANOANTHRACENE-11-METHYLAMINE, AND q-9-ETHENO-IH-UENZ(F)ISOINDOLINE.ARE LISTED@ ALSO PREPAREDSE•EE SERIES OF 1,2,3,q-TETRAHYDROQUINOXALINE AND 1,2.;,4-TETRAHYDROQUINOLINE DERIVATIVES. BIOLOGICAL

DATA INCLUDE ACUTE TOXICITIES, ANALGESIC ANDANTISPASMODIC ACTIVITY OF SELECTED TEST COMPOUNDS*AS AN ANALGESIC, 4-9-o-BENZOBENZ(F)ISOINDOLINE`OA5 OBSERVED TO BE STATISTICALLY INDISTINGUISHABLEFPUH DARVON, DERIVATIVES OF 1I-AMINOMEThYL-9910-ITHAIJO-9,IO-DIHYDPOANTHRACENE WERE THE MOST ACTIVEA',TISPASMODIC5, BEING UP TO 30 TIMES AS ACTIVE ASPAPAVERINE A(jAINST HIsTAMINL AND 8.8 TIMES AS ACTIVEAS HEXAMETHONIUM AS A GANGLIONIC BLOCKING AGENT.LVI.dENcE FUR YHL CRYSTAL STRUCTURE OF THEHALLUCINOGEN ;ER-'YL By X-RAY DIFFRACTION STUDIEDIS ALSO PRESENTED. (AUTHO )5 (U)

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DOC kErGRT BIBLIOGRAPHY tEARCH CONTROL NO, /ZAIK.2

AD-716 977 6/15 6/dO 15/2LITTLE (ARTHUR 0) INC CAMBRIDGE MASS

NFO INCAPACITATING AGENTS, SUPPLEMENT isPRECLINICAL PHARMACOLOGY AND TOXICOLOGv OFCANDIDATE AGENT 226,I69. (U1

DE5CHIPTIVE NOTE: QUARTERLY kEPTo 15/16t 1 SEP 66-10J'JL 67.

NOV 67 144PREPT? NO. ADL-C-654O -QR-15/16-SUPPL-1CONTRACT: DA-IB-lUR-AMC-O.3(A)

UNCLASSIFIED REPORT

DESCRIPTORS: (0INCAPACITATING AGENTS,*PHARMACOLOGY), (*CANNABINOLS, PHARMACOLOGY),TOXICITY, N-HETEROCYCLIC COMPOUNDS, O-HETEROCYCLICCOMPOUNUS, CANNABIS, SYNTHESIS(CHEMTSTRY)iALKYNES, PHENOLS; MOLECULAR STRUCTURE,HE"ATOLOGY, bIOLOGICAL ASSAY, PHYSIOLOGY,PSYCHOPHYSIOLOGY, ELECTROPHYS|,LOGY, BEHAVIOR,PATHOLOGY (U)

IDENTIFIERS: OBENZOPyRANOPYRIDINES,OTETRAHYDROCANNABINOL (U)

THE PROPOSED AGENT, 226,169. HAS BEEN VARIOUSLYRFFERRED TO AS A NITROGEN ON ALKALOIDAL ANALOG OFTFTRAHYDROCANNABINOL, AN AZATETRAHYDROCANNABINOL,'THE 39,4-D ISOMER;' OR BY ITS PYRIDINE-DERIVEDCHEMICAL NAME, 5 .5-OIMETHYL-10-HYDROXY-8-(3-METHYL-2-OCTYL)-2-(2-PROPYNYL) -1a,.q4-TETRAHYDRO-5i-( I)BENZOPYRANO(3.'4-D)PYRIDINE. IT WASSYNTHESIZED AS PART OF AN EFFORT TO DETERMINE THEEFrECT OF INTRODUCING A HETEROCYCLIC NITROGEN ATOMINTO THE RING OF A CARBOCYCLIC TETRAHYDROCANNABINOL..,OULD IT RESULT IN AGENTS SIMILAR TO EA 1476 OR,

PnSSIBLY, MORE POTENT ONES. ALTHOUGH BOTH COMPOUNDSHAVE SIMILAR PROFILES: IN WHICH THE PRINCIPALACTIVITY INDICATES DEPRESSION OF THE CFNTRAL NERVOUS

SYSTEM, 226,169 IS MORE POTENT THAN EA 1476 INVIRTUALLY ALL PHARMACOLOGICAL PARAMETERS. THENITROGEN ANALOG IS SOMEWHAT MORE SOLUBLE THAN ITSCAR4UCYCLIC COIJNTERPARTs RUT POLY(ETHYLENEGLYCOL) REMAINS THE VEHICLE OF CHOICE FORPAHENTERAL ADMINISTRATION.

57 (u)

UNCLASSIFIED /ZAML2

-_.

UNCLASSIFIED

ODC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZAML2

AD-719 O83 6/15FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGYBETHESUA MO LIFE SCIENCES RESEARCH OFFICE

A REVIEW OF THE BIOMEDICAL EFFECTS OFMARIHUANA ON MAN IN THE MILITARY

LNVIRONMENT. (U)

DESCRIPTIVE NOTE: TECHNICAL REPT.DEC 70 lOOp

CONTRACT: DAHC19-71-C-0006

UNCLASSIFIED REPORT

DESCKIPTORS: (#CANNABIS .. EVIEWS3s(*IIALLUCINOGENS, REVIEWS), (oDRUGS, *MILITARYPERSONNEL), (eNARCOTICS, MILITARY PERSONNEL),PHARMACOLOGYo PLANTS(BOTANY), CHEMICALPkOPERTIES. ANIMALS, PHYSIOLOGY, PATHOLOGY,CENTRAL NERVOUS SYSTEM, DOSAGE. CANNARINOLS,BEHAVIOR, HUMANS (U)

IDENTIFIERS: *MARIHUANA; CANNABIS SATIVA.*TETRAHYDROCANNABINOL, HASHISH (U)

THE REvIEW DOCUMENTS IN DETAIL THE CURRENT STATE OFK•ONLEoGE OF THE EFFECTS OF MARIHUANA ON MAN. THESTUDY EXAMINES THE RELATIONSHIPS BETWEEN MARIHUANAUSE AND PERFORMANCE Or THE MAN IN A MILITARYENVIRONMENT AND IDENTIFIES OPPORTUNITIES FOR FUTURERESEARCH BY THE ARMY IN THI5 FIELD. THE SCOPE OFTHE STUDY INCLUDES THE BOTANY AND PHYTOCHEMISTRY oFCANNAE5IS SATIVAO ISOLATION, CHARALTERIZATIONo ANDSYNTHESIS OF THE PLANT CONSTITUENTS, THE PHARMOCOLOGYOF THESE COMPOUNDS, ArJt THE NEED FOR QUANTITATIVE

ESTIMATION OF THE TEitAMYDROCANNABINOLS AND THEIR

UERIVATIVES IN BIOLOGICAL SAMPLES* THE REVIEWINCLUDES A DESCRIPTION OF BEHAVIORAL TESTS USED TO

MEASURE MARIHUANA EFFECTS, THE INFLUENCE OF ANINDIVIDUALOS EXPECTATIONS, AND EFFECTS OF

LNVIRONMENTAL SETTING ON HUMAN SUBJECTS. THEANjECDOTAL LITERATURE ON MARIHUANA IS BEING REPLACEDBY REPURTS OF CONTROLLED LABORATORY STUDIES; HOWEVER,INVESTIGATIONS THAT MEASURE PERFORMANCE IN REAL-LIFESITUATIONS ARE REQUIRED TO ANSWER CRUCIAL MILITARY(40L5TIuNS ON MARIHUANA EFFECTS. INFORMATION ON THECHLMISTRY, PHARMACOLOGY, AND BEHAVIORAL EFFECTS OFMAIlHUANA THAT IS NECESSARY FOR THESE FUTURE STUDIESIS REING DEVEL(ýPEn AT THF PRESENT TIME,(AUTHOR) IU)

LI

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DUC ktPORT )ISLIIGRAPHY oEARCH CONTROL NO, /ZAML2

AD-71A 1U6 6/5FRIE'[)S MEDICAL AND SCIENTIFIC RESEARCH INST BALTIMORE MO

LAU OF NEUROLOGICAL SCIENCES

THL ROLE OF THF CENTRAL NERVOUS SYSTEMCHOLINERGIC ECHANISMS IN BLHAVIOR ANDLrARNING. (U)

DESCRIPTIVE NGjE: REPT. NO$ 7 (FINAL),SEP 66 25P BLACKPERRY ;SPYROPOULOS,PFRICLES I

CONTRACT: DA-I8-O5-AMC-253(A)

UNCLASSIFIED REPORT

DESCRIPTURS: (9LYbERGIg ACIDS, NEUROLOGYo,(eREACTION(PSYCHOLOGY), LYSERGIC ACIDS),MONKEYS, TEST METHODS, TIME, DOSAGE, BEHAVIOR,

CORRELATION TECHNIQUESJ TOLERANCES(PHYSIOLOGY) (U)IDENTIFIERS: TASK ANALYSIS, UELAYED RESPONSE (U)

THL PRINCIPAL 'PURPOSE OF THIS STUDY WAS TOINvFSTIGATE THE POSSIPLE DIFFERENTIAL EFFECTS OrLSU AS A FUNCTTON OF PROCEDURAL VARIATIONS INPERFORriANCE OF DELAYED RESPONSE TASKS, IN GENERAL,LSD •A5 FriUN)D TO IMPAIR DELAYED RESPONSE

PFRFOR?.IANCE IN THE MONiKEY* FROM THE STANDPOINT OFDnSE-EFFECT RELATIONSHIPS, THE RESULTS SUGGEST APOSITIVE CORRFLATION RETWEEN MAGNITUDE OF DOSE ANDEXTENT OF FUrnCTIONAL IMPAIRF.IENT. A TENDENCY TOWARDRAPIDLY DEVELOPI;:G TOLERANCE AAS OBSERVED. A'PLACEBO EFFECT' IN RESPONSE TO THE CONTROL AGENT

(STERILE WATER) ,AS ENCOUNTERED IN A SIGNIFICANTJUMBER OF M('jKEY', (U)

59

UNCLASSIFIED /ZAML2

UNCLAbSIFIED

nDC REPORT 81PLIOGRApi.Y SEARCH CONTROL NO* 4ZAML2

AD-720 Z79 6/15 6/5TULANE UNIV NEW ORLEANS LA SCHOOL OF MEDICINE

LFFECTs OF LYSERGIC ACID AND ITSDFRIVATIVES ON RHINENCEPHALIC ELECTROGRAMS. (U)

DESCRIPIiVE NOTE: FINAL REPT, ON PARi is'AY 59 29P MONROE;RIJSSELL R-

CONTRACT: DA-18-IUe-CML- 5 596

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO PART 2, AD-720 280o

DESCRIPTORS: foLYSERGIC ACIDSb eBRAIN);(GELECTROENCEPHALOGRAPHY, LYSERGIC ACIDS)$(OHALLUCINOGENS; gLECTROENCEPHALOGRAPHY)lELECTROpHYSIOLOGY, PHARMACOLOGY, MENTAL D!SORDERS,BEHAVIOR, MONKEYS. HUMANS, NEUROLOGY (U)

IDENTIFIERS: *RHINENCEPHALON IUI

SIX '1ACACA MULATTA MONKEYS HAD CHRONICALLYIMPLANTED ELECTRODES OVERTHE FRONTAL AND OCCIPITALCORTEX, AND IN THE SEPTAL, CAUDATE, AND HIPPOCAMPALRFGIONS, THIRTY-T*O STe'DIES WERE DONE ON LYSERGICACID DERIVATIVES AS D-LSO-25, ALD-B2, MLD-'I,LSM, DAM, LPD, I-LSO02 5 , ROL AND UML TODETERMINE POSSIBLF CORRELATIONS BETWEEN THEPSYCHOTOGENIC EFFECT OF THESE DRUGS AND THE EFFECT ONTHE SUBCORTICAL ELECTROGRAM. NO CORRELATION WASFOUND BETWEEN THE PYRETOGENIC, ANTISEROTCNIN ORPSYCHOTOGENIC EFFECT AS FnUND BY ISBELL STUDYINGTHESE SAME DRUGS ON HUMANS, HOWEVER, THERE DIDAPPEAR TO BE A GOOD CORRELATION BETWEEN THEBEHAVIORAL LFFECT ON MONKEYS AND RHINENCEPHALICPAKuXYSMAL HYPERSYNCHRONOUS ACTIVITY, PARTICULARLY INTHE SEPTAL REGION. FIVE STUUIES WITH MESCALINEALSO REVEALED A SIMILAR CORRELATION. IT WOULD SEEMTHAT EVEN TAKING IN70 ACCOUNT SPECIES DIFFERENCES,RHIr4ENCEPHALIC PAROXYSMAL HYPERSYNCHRONOUSARNORMALITY I A GOOD INDICATION OF PSYCHOTOGENICLFFECTS OF A DRUG. (AUTHOR) IU?

UNCLASSIFIED /ZAML2

UNCLASSIFIED

-DC PEPORT 5IPLIOGRApHY SEARCH CONTROL NO% 11AHL2

AD-72•' 280 6/15 6/20 6/5T!'LANE UNIV NE% ORLEANS LA SCHOOL OF MEDICINE

REPORT ON THE SPECIAL AGENT EA-1476, (U)

DESCRIPTIVE NOTE: FINAL REPT, ON PART 2,MAY 59 22p MONROERUSSELL R. ;

CONTRACT: DA-1-1 o8-CML- 5 596

UNCLASSIFIED REPORT

SUPPLEMENTARY tNOTE: SEE ALSO PART I, AD-720 279o

DESCRIPTURS: (*LYSERGIC ACIDS, *TOXICITY),

(OELECTROENCEPHALoGRAPHY, LYSERIC ACIDS),ELECTROPHYSIOLOGY, PHARMACOLOGY, NEUROLOGY,MENTAL DISORDERS, BEHAVIOR, LABORATORY ANIMALS,

DOSAGE (U

IDENTIFIERS: OPSYCHOPHARMACOLOGY (U)

PRELIMINARY TESTS TO DETERMINE THE TOXICITY OF THE

OPUG LYSERGIC ACID, WERE PERFORMED ON CATS.

DFFINITE CONCLUSIONS COULD NGOT BE DERIVED FROM THE

LIMITED DATA GATHERED. HOWEVER, SEVERAL THINGS WERENOTICED PARTICULARLY AS EXEMPLIFIED BY ONE MONKEY*

THE nRAMATIC IMMEDIATE SLOWING INELECTROENCEPHALOGRAM, THE DEFINITE SPIKE AND SLOW

4AVE THAT APPEARED IN THE SLPTAL REGION WHICH IS MORECHARACTERISTIC OF THE 'SCHIZOPHRENIC SPIKE' THAN

RECORDINGS WITH O-LSD AND MESCALINE, AND PROLONGED

ELECTROENCEPHALO3RAPHIC EFFECTS STILL DRAMATIC 72HOURS AFTER THE DRUG WAS GIVEN. ALSO STRIKING IS

THL CHRnNIC DEBILITATION THE ANIMALS SHOW AFTERMINIMAL DOSES OF THIS DRUG wHICH ULTIMATELY LEAPS TO

THEIR DEATH. PERHAPS k'ITH BETTER 'NURSING' CARE,

THESE ANIMALS MIGHT HAVE SURVIVED, (U)

UIl

UNCLASSIFIED /ZAML2

UNCLASSIFIED

nDC REPORT MILIOGRAPKY SCARCH CONTROL NO. eZAML2

AD-72n 2681 6/1TULANE UNIV NEW( oRLEANS LA SCHOOL Of MEDICINE

PROGRESS REPORT. ARMY CHEMI L CZNTRACT0 A- j - !OS-CML-55 96, U

59 6P MONROERU2SELL Ro I

CONTRACT: DA-18-108-CML- 5 5 9 6

UNCLASSIFIED REPORT

DESCRIPTORS: (*DRUGS' BRAIN), (OLYSERGIC ACIDS;

*BRAIN), (*BEHAVIOR; LYSERGIC ACIDS),PHARMACOLOGY, ELECTROFNCEPHALOGRAPHY,

ELECTROPHYSIOLOGY, Pi.-IOLOGY, RESPONSES.

DOSAGE, LABORATORY ANIMALS (U)

XDENTIFIERS: uPSYCHOPHARMACOLOGY (U)

ONE PHASE OF THE PROJECT WAS TO TEST THE EFFECT OF

D-LSD-25 AND RELATED COMPOUNDS ON THE SUBCORTICAL

ELLCTROGRAMS TO SEE WHETHER THERE COULD BE

OEhONSTRATED CORRELATIONS BETWEEN PAROXYSMAL

HYPERSYNCHRONOUS ACTIVITY IN THE SEPTAL AND/OR

HIPPOCAMPAL REGION AND KNOWN PSYCHOTOMIHETIC

EFFECT, A SECOND PHASE OF THIS STUDY WAS TO TEST

THE EFFECT OF SEROTONIN ON THE ANIMAL BY GIVING A

MONOAMINEOXIOASE INHIBITOR

(PHENYLISOPROPYLHYDROSINE) COMBINED WITH A

SEROTONIN PRECURSOR 5.HYDROXYTRYPTOPHANE WHICH

CROSSES THE BLOOD BRAIN 6ARRIER. THREE STUDIES WERE

ALSO DONE GIVING ANIMALS EA.1476 IN DOSES RANGING

FROM 125 TO 50C GAMMA PER KILO, (U)

62

U2;CLASSIFIED /ZAML2

UNCLAbSIFIEDnUC RPORT eIPLIOGRAPHY SEARCH CONTROL NO* 'ZAiL2

AO-7fl 793 O/15THILANE UNIV NEV. ORLEAtJS LA SCHOOL OF MEDICINE

LYbPRGIC ACID DERIVATIVES, (Ul

OEbcRIPTIVE NOTE: PROGRESS REPT,,JUN 58 4p MONROEIRUSSELL Re ;CONTRACT: DA- I8 - 108-CML- 5 596

UNCLASSIFIEn REPORT

DESCHIPTORS: (*LYSERGIC ACIDS, *BRAIN), DRUGS;PHARkIACOLOGY, PYSIOLOGY, ELLCTROPHYS10LOGY,DOSAGF MENTAL DISORDERS fU)IOENTIFIERS: ORHINENCEPHALON,

PSYCHOPHARMACOLOCY (U)

PPLLIMINARY STUDOES SUGGEST THAT THERE IS ACnk4ELATION BETWEEN PSYCHOTCMIMETIC DRUGS ANDRHINENCEPHALIC PAROXYSMAL ACTIVITY. ONE IMPORTANTOPSERVATION I1 THAT IN TWO OF THE THREE STUDIES OGNETH5U FAR THERE OCCURRED DRAMATIC SEPTAL 'SPIKING'$ ASSFL'J INW SCHIZOPHRENIC PATIENTS AFTER THEY HAVERECEIVED 250 GAMMA PEP KILO EA-1'76.(AUTHOR)

(U)

63

UNCLASSIFIED /ZAML2

UNCLASSIFIED

DLC PEPORT PISLIOGRAPHY •EARCH CONTROL NO, /ZAML2

AD-728 449 ý/loEnGEWOOD ARSENAL MO

STUDlES OF THE EFFECT OF PERSONALITY ONRFACTIVITY TO LSD, (U)

DESCRIPTIVE NOTt: TECHNICAL REPT.. FOR 1962-1966,JuL 71 16P KLAPPERJACK As ;KETCHUM#

JAMES 5. ;MCCOLLOCH.MICHAEL A. ;KYSOR;KRACGPe ;SIMoVAN Me ;

REPT. NO. EA-TR-'4536PRUJ: DA-I-B-662706-AD-25TAbK: I-8-662706-AD-250 3

UNCLASSIFIED REPORT

SUPPLEMErN4TARY NOTE: REPORT ON PROPHYLAXIS AND THERAPYFUR INCAPACIIATING AGENTS.

OESCKIPToRS: (*HALLUCINOGENS. PERSONALITY),(OPER5OjALITY, *LYSERGIC ACIDS),(OPSYCHOPHYSIOLOGY, LYSERGIC ACIDS),REACTION(PSYCHOLOGY}, SENSITIVITY, ARMY.PLRSONNEL, PERFOFMANCEJHUMAN)t CORRELATIONTECHNIQUES (U)

CASE RECORD$ nF 52 ARMY VOLUNTEERS GIVEN FROM I'I

TO 2.0 MICROGRAMS/KG OF LSD ORALLY BETWEEN 1962 AND1966 WERE STUDIED. SINCE 1966 NO FURTHER STUDIESHiVE BLEN PERFORMED. SIGNIFICANT RELATIONSHIPS

"ERE FUUND BETWEEN PERSONALITY (AS MEASURED BY THEPIIN.'FSCTA MULTIPHASIC PERSONALITY INVENTORYAND ARMY GENERAL INTELLIGENCE TEST) ANDPFRFFURMANCE FOLLu.'INý ADMINISTRATION OF LSD.PFSISTANT SUBJECTS AT LO0aR DOSES WERE FOUND TO BE

MORE INTELLIGENT, ENERGETIC, AND OUTGOING#

SENSITIVE SUaJFCTS WERE LESS INTELLIGENT,CONSTRICTED, MORE ANXIOUS, OVER-CONTROLLED, ANDDEPENDENT. AT THE HIGHER DOSES THE PICTURE WAS NOTAr CLEAR, BUT PERSONALITY FACTORS WERE STILL HIGHLYCORRELATED WITH PERFORMANCE, THE PA(PARArOIA) SCALE HAD A HIGHER CORRELATION WITHPERFORMANCE THAN DID rOSE, THE K (POSITIVE TEST-TAKI,iG ATTITUDE), HS (HYPOCHONDRIASIS), AND51 (SOCIAL INTROVERSION) SCALES WERE POSITIVELYCPRR! LATED WITH PERFOuMANCE AT LOOER DOSES ANDNrGATIVELY CORRELATED WITH PERFORMANCE AT HIGHERDOSES* (AUTHOP) (U)

64

UNCLA!SSIFIED /ZAML2

LjNCL AS 171 ED

kiUPU 'LCT I tL I OGR A rY sEARCH CONJTROL NO* iZAMLa

E!,rPiCOD ARSENAL 40

THE EFFECT Or PERSONALITY ON REACTIVITY TO ATFTAH OC0 AINOL. (U

DEbrRIPTIVE NOTE: TECHNICAL REPT. 1961-1968,SEP 61 14P KLAPPERsJACK A,

NCCOLLUCHMICHAEL A. ;SIDELLtF* ReREPT. !ýO# EA-TR-455'4PROj: DA-1I-B-662706-AD..25TASK: I -8-66 2 70 6 -AD-25flJ

uNCLASSIF IED REPORT

DESCR~IPTORS: .*CA~jrJlA~jIS REA(TION(PSYCHOLOGYUs(*PL145OrýALITY, CANqjA-3S)s PSYCHOTROPIC AGENTS,01';AAiFf PERFOkMANCE(HUMAN), DRUGS (U)IDEt!:TIF!ERS: *PSYCHONEt:ROPHARMACOLOGY; DRUG ABUSE;MAP! JLANA (U)

CAS' RECORflS nF ;,'i tiS ARMY v( LtUNTEFRS GIVEN A.'SVtN HET IC TFETRAHYORu'A(NNAR I IOL ( THC ) COMPOUNDSIMILAH IN STRUCTURE AND PHYSIOLOGICAL ACTIVITY TOTHL ACrIVE COMPOPjEJT OF MARI-JUANA V'EP.E REVIEWED,51G,-JiFICANT RELATIONISHIPS hLRE FOUND SFTWEEN THEPFRSU"NALITIEIS OF THESE VOLUJEFERS, AS MEASURED BY THErIrN!JESOTA MULTIPHASIC pERSO:,,ALITY INVENTORY4mMMI) AND THE ARMY GENERAL INTELLIGENCETr iT ( (T) AND PE-RFORMANCE FOLLOININGAflmII.5TRATIorN OF THIS COMP~jUNr) ON COGNITIVE TESTS.THF. HS (r4YPOCHONDRIASIS) ANU PD(PSYC~-4)PATHIC DEVIAT) SCALE SCORES AND THE GTSCLr'(E INERE MORE STRONGLY CORRELATED PITH PERFORMANCETHANJ 1VAS THE DOSE LEVEL.1 MMPI AND GT TESTIltTF.RPRETATIN OF SUBJECTS RESISTANT TO THE COGNIIIVEIMPAIRMENT CAUSED BY THIS COMPOUND SHOVED THEM TO BEMORE INTELLIGENT AND ADVENTuROU3 BUT MORE HOSTILE ANDAGRESSIVE THAN SENSITIVE SUBJECTs. A POSSIBLEEXPLANATION FOR CONTINUED USE OF MARIJUANA BY CERTAINPEkSONALITY TYPES 15 OFFEREu. (AUTHOR) (Ui)

65

UNCLASSIFIED /ZAML2

UNCLASSIFIED

ý'I)C 4EPORT 91BLiOGRAPHY tEARCii CONTROL NO, /ZAML2

AD-734 sU7 6/15 6/16TFXAS UNIV MEDICAL SCHOOL SAN ANTONIO DEPT OF

PHAqrACOLOGY

CNRDIOVASCULAR SYSTe.M. U

OE(R'PTIVE NOTE: FINAN. REPT.,

OCT 71 316P BRIGGS,ARTHUR H.CO'NTACT: F4620-70-C-1059PRUj: AF-9777

MONITOR: AFOSR TR-71-2599

UNCLASSIFIEn REPORT

DESchIPTORS: (OCARDIOvASCULAR SYSTEM,*PHARMACOLOGY), STRESS(PHYSIOLOGY1,PHYSIOLOGY, AUTONOMIC NERVOUS SYSTEM, BLOODPrESSURL, BLOOD CIRCULATION, HYPOXIA, DRUGS,HYPERTENSION, RESERPINE, CERLBELLUM,HALLUCINOGENS, BRAIN, ENZYMES,

ACETYLCHOLINESTERASE, HEART, BARBITURATES,ELrCTROLYTES(PHYSIOLOGY) , TEMPERATURE,'N5ECTICIDES (U!

IDENTIFILRS: PROSTAGLANDINS, BICUCULLINF,PE.NTOBARBITAL, DISULFOTON (U)

THE FOLLOWIN'3 SIGNIFICANT FINDINGS MADE DURING THEPAbT YEAR ARE SUMMARIZED. THE ABILITY OF THE HEARTTr' ý'ApT TO STRESS REf)UIRFS AN INTACT AUTONOMICtFRVOUS SYSTEM, ACUTE INCREASES IN ARTERIALPESSURE MAY CAUSE DETRIMENTAL EFFECTS TO THE SYSTEM1,Y I)IRECT ACTION ON THE HEART, PARTICULARLY IF

UhUýRLYING MYOCARDIAL DISEASE IS PRESENT. THEAgILITy OF THE HEART TO ADAPT TO DIFFERENT HEARTRATES APPEARS TO BE AN IMPORTANT FACTOR IN EXERCISE

OR PROLONGED HYPOXIA. RELAXING SISTEMS AREIFIPORTANT IN THE ACTION OF ANTIHYPERTENSIVE DRUGS ANDF'FRHAPS IN THE ETIOLOGY AND MAINTENANCE OF ABNORMAL

LBL.UOD PRESSURE STATES. RESEkPINE MEDIATEDtLECTROLYTE LOSS FROM VASCULAR TISSUE IS THE RESULTOF URINARY EXCRETION OF SODIUM, POTASSIUM AND CALCIUMAriD CALCIUM EXCRETION INTO THE GUT. A NEW TYPE OFlI!PFRNLNSITIVITY VJAS DISCOVERED AND CHARACTERIZED INVASCULAR SMOOTH Il'JSCLF INITIATED BY COLD TEMPERATURE.PFO'-TACLA4DIrtS AjGMENT MYOCARDIAL CONTRACTILITY BY

INC-REASING IrýTRACELLULAR CALCIUM STORES.CvCr*A-l I AQ I11,I.R TnOY MECH1rA!SM5• RUT NOT RET!CULARuf SPINAL INHIRITORY MECHANISMS, WERE MARKEDLYSl' rF. SEID BY HAII.1-'CINOGENIC DRUGS. BICUCULLINE',.,PPFSSED CERERELLAR INHIBITION, BUT ALSO SUPPRESSED

"("TICULAR AN:) PRESYNAPTIC INHIBITION, 4U)

66UNCLASSIFIED /ZAML2

UNCLASSIFIED

r%[C REPORT iiSLInGRAPHY SEARCH CONTROL NO. /lAM"L

AD-735 1b2 5/10 Sell

NAVAL AEROSPACE MEDICAL RESEARCH LAB PFNSACOLA FLA

IHE RLLATIONSHIP 8ETOEEN PAST BACKGROUND AND

(jRUG USE, (U)

JUN 71 •Bp BUCKY,STEVEN F.

REPT, NO. NAMRL-1135PlOJ: MR-MROII-01-01

MON1T1R: NAVMEO MRO U1.-1-OI-9

UNCLASSIFIEO REPORT

DESCRIPTORS: (aNARCOTICS, oSUCIAL PSYCHOLOGY),

CULTURE, EOUCATIOfj, HISTORY, PERSONALITY,

BEHAVIOR, CORRELATION TECHNIwUES, CANNABIS,ArPHETAMINES, DRUGS U

IOELiTIFIERS; 28DRUG ADDICTION, HEROIN (U)

THE PURPOSE OF THE PRESENT STUDY WAS TO DETERMINE

V-11LTHER SOCIAL-HISTORY VARIABLES DISCRIMINATE AMONG

It~aR- Uc, MARIJUANA, AmPHETAMINE, LS0, AND HEROIN

.ýSL`S. A QUeStIONNAIRE WITH ITEMS ON SPECIFIC DRUG

USE, FAMILY BACKGROUN0, SCHOOL AND MILITARY HISTONY

4,AS A14CNYMOUSLY ADMIN;STERED TO 1508 NAVY ENLISTED

!'Zh, APPROXIMATELY 13.6 PER CENT REFUSED TO FILL

01T TMt FORM, THERE WERE SIGNIFICANT DIFFERENCES

Amo'J4 T'4E GROUPS. ALTHOUGH LITTLE DIFFERENCE

I-FT-EFt, THE SO-DRuG AND MARIJUANA GROUPS WAS

O•Sf•kVED, IN GEt;ERAL THERE kAS A PROGRFSSION FROM THE

:.O-'RUG TO THE MARIJUANA, AMPHETAMINE, LSD, AND

H,'RIN GPOUPS IN Tf<MS OF FAMILY DIFFICULTIES,

TceGJ'5Lh IN :CwrOL, ANO DISCIPLINARY ACTION IN THE

'JAVY. THE VAST rMAJORITY OF THE MARIJUANA GROUP

rev NOT TAKEN OTHER DRUGS, WHEREAS THE MAJORITY 0F

TPi oTHER DRUG GROUPS H;AO T KENl MARIJUANA. MULTIPLE

C0oR FLATIO{iS OF .47 AiD .66 SING NO DRUG AND HEROIN

USE Aý THE CRITERIA SU6GEST i,-AT PREDICTION FOR THESE

Gpt''Jp- IS PO'SIBLE. MULTIPLE C'RRELATIONS RANGING

FROM *2) TO .29 FOR THE MARIJUAN'A, AMPHETAMINE, AND

LSD GROUPS MAKE PPEDICIION OF SUCH DRUG USE

VIkTUALLY IMPOSSIBLE. (AUTHOR) IU)

67

, 5)IF I ED /ZAML2

UNCLASSIFIED

nOC REPORT BIBLIOGRAPHY SEARCN CONTROL NO. IZAML2

AD-737 671 6/1 6/15ARMY ALROMEDICAL RESEARCH LAB FORT RUCKER ALA

5TU')IES F,, FLUOROMETRIC ASSAY PROCEDURES FORLYSERGIC ACID DIETHYLAMIDE, (U)

FEB 72 16P KASVINSKYPETER JsREPT. NO. USAARL-72-9PROJ: DA-3-A-06211n-A-R89

UNCLASSIFIED REPORT

DESCHIPToRS: (*LYSERGIC ACIDS, *BLOOD CHEMISTRY),(OHALLUCINOGENS, ULOOD CHEMISTRY), FLUORESCENCE,IN VITRO ANALYSIS, EXCITATION, BLOOD PLASMA,MICROANALYSIS (U)

IDENTIFIERS: eLYSERGIC ACID DIETHYLAMIDE,*FLUOROMETRIC AMALYSIS. -CLINICAL CHEMISTRY (U)

STUDIES OF THE AVAILABLE FLUOROMETRIC ASSAYPROCEDURES FOR LSD-25 ARE DESCRIBED FOR POSSIBLE

CLIr.IICAL APPLICATION., VARIABILITY OF PLASMAFBLANK' BACKGROUND FLUORESCLNCE VALUES WERE FOUND To

PPOiIIbT THE USE nF STANDARU FLUOROMETRIC PROCEDURES4VITHOUT MODIFICATIOrNo A LITTLE KNOWN FLUOROMETRICPPOCEOURE IS DESCRIBED WHICH MINIMUZES THIS PROBLEMAll) MAINTAINS THE SENSITIVITY OF THE ASSAY AT THEIIAI.OGRAM LEVEL. ;IODIFICATIONS OF THIS METHOD ARESUt(36ESTED WHICH COULD INCREASE THE SENSITIVITY OFTHIS METHOD TO THE 5U8NANOGRAM LEVEL. (AUTHOR) (U)

68

UNCLASSIFIED /ZAML2

UNCLASSIFIED

r[UC KmOqi "ItALIOGRAPHY SEARCH CONTROL NO* IZAML2

AD-7.37 758 6/ 1/ SPIAVY MEDICAL fiEUROPSYCHIATRIC RESEARCH UNIT SAN DIEGOC AL I F

CLINICAL ASPECTS Or MARIJUANA AND AMPHETAMINE

69 26p RuBIr,4ROBERT T,RE•.T. * !O NMNP!J-69-4PRuj: MRIlI.Ul

UNCLASSIFIEn REPORTAVAILABILITY: PUS. IN ANNALS OF INTERNAL

OEDICINE, V70 N3 P591-6144 MAR 69.

DESCRIPTORS: (*CANNA315, ADDICTION),

(OAMPtIETAMINES, AUDIgTION), (-PSYCHOTROPICAQENTS, ADOLESCENTS). (,DRUG5, ADOLESCENTS),MENTAL UISORDERS, THERAPY, PSYCHIATRY, ANXIETY (U)

IDENTIFIERS: OPSYCHONEUROPHARMACOLOGY, *DRUGADD ICTIUN, *MARIJUANA (U)

TWE. MAJOR ROLE OF MARIJUANA AMONG ADOLESCENTS, MANYOr VHO, HAVE LOW SELF-ESTEEil AND FORM INTERPERSONAL

RELATIONSHIPS ONLY ,AITH DIFFICULTY, APPEARS TO BE ASA MEOIUM FOR EASING PEER-GROUP TENSIONS AND AICINGPFER-GROUP InTERACTION, SIMILAR TO THE DRINK-IN-HANDAT A COCKTAIL PARTY. TREATMENT OF THESE PERSON ISPRIMARILY PSYCHOTHERAPEUTIC. THE USE OF HEAVYUSERS OF MARIJUANJA ARE MUCH FEWER IN NUMBER AND

QENERALLY HAVE MORE SEVERE UNDERLYI;4G PSYCHOLOGICALDISTURBANCES, THE PSYCHOPHARMACOLOGICAL SEQUELS OFTHE USE OF REPEATED HIGH DOSES OF MARIJUANA SUCH ASOCCASIONAL AhjXIFTY REACTIONS MAY REQUIREPHLNOTHIAZINE MEDICATION. (AUTHOR) (U)

69

UrJCLASSIFILD /ZAML2

UNCLASSIFIED

ruC REPORT RIRLIOGRApHY SEARCH CONTROL NO, /ZAML2

AD-74o q'O 8/15 5/10MINNFSOTA UNIV MINNEAPOLIS DEPT OF PHARMACOLOGY

HALLUCINOGEN-TRANQU!LIZER INTERACTION: ITSNATURE, (U)

FEB 69 5P HALASZIMICHAEL F, ;FORMANEK,

JAROSLAV ;MARRAZZIAMEDEO S.

CONTRACT: AF-AFOSR-1134-67PROj: AF-9777MONITOR: AFOSR TR-72-0825

UNCLASSIFIEO REPORTAVAILABILITY: PUB. IN SCIENCE, V164 P569-571, 2MAy 69.

SUPPLEMENTARY NOTE: REVISION OF REPORT DATED 20 JUL68.

DESCRIPTORS: (.HALLUCINOGENS. PHARMACOLOGY),

(*TRANQUILIZERS; pHARMACOLOGy)** (OPSYCHOTROPICAGFNTS, INTERACTIONS), CENTRAL NERVOUS SYSTEM,DRUGS, BEHAVIOR, RESPONSES, INHIBITION,OOSAGE, EFFECTIVENESS (U)

IDENTIFIERS: OPSYCHONEUROPHARMACOLOGY (U)

STUDY OF THE COMPETITION BETWEEN HALLUCINOGENS AND7PAN•UILIZERS AT CEREBRAL SYNAPSES AND ON BEHAVIOR INVARIOUS SPECIES OF ANIMALS INDICATES A CONTINUUM OF

EFFECTS FROM PROTECTION TO UOMINANCE OF TRANQUILIZERTOXICITY AS THE DOSE OF TRANQUILIZER INCREASES,

DATA ON CAT AJD MONKEY BEHAVIOR, SUPPLEMENTING THATOti THE RAT, bHOW THAT IT IS POSSIBLE TO ARRIVE AT ATPANrJUILIZER DOSE THAT CAN AGGRAVATE INSTEAD OFPROTECT, IN ACCORD NITH THE COMPETITIVE INHIBITORYNATURE OF THE INTERACTION OF HALLUCINOGEN ANDTRA'JýUiLIZER. (AUTHOR) (U)

70

UNCLASSIFIED /ZAML2

i

UNCLA$SIFIEO

DL C RLPORT r3IFLIOGRAPHY SEARCH CONTROL NO, /ZAML2

AD-7 ,1 14JI 5/10MISSOURI UNIV ST LOUIS INST OF PSYCHIATRY

PERCEPTUAL CHALLENGE TO MEASURE ILLNESS ANDTHLRAPY, (U)

72 8P MARRAZZI,AMFDEO So IAOO:)RUFFSHARON ;KENNEDYOENqIS

CONTRACT; AF-AFOSR-1821-69PROj: AF-9777MONITOR: AFOSR TR-72-0826

UNCLASSIFIED REPORT

AVAILABILITY: PUB. IN AMERICAN JNL. OFPqYCHIATRY, V128 N7 Pe86-R9U ..AN 72.

SUPPLEMENTARY rqOTE: PRESENTED AT THE ANNUAL MEETING OFTHE kMERICAN PSYCHIATRY ASSOCIATION (124TH) HELDIN AASHINGTON, D. C. ON 3-7 MAY 71.

DESCRIPTORS:- (*MEr4TAL DISORDLRS9 *AUDITORYPERCEPTION), DIAGN4OSIS. MEASUREMENT, THERAPY,INSTRUMENTATION, LYSERGIC ACIDS, CHLORpýOMAZINE,DRU ,;, PERCEPTION (U)

THL DISSOCIATION PRODUCED INr THE AUDITORY MODALITYBY A CHALLENGE WITH LSD CAN BE QUANTITATED BY ANINSTRUMENTAL PERCEPTION TEST. CHLORPROMAZINE CANPROTECT AGAINST THIS DISSOCIATION, AND ITS EFFICACYCAN BE MEASURED BY CHANGES IN AUDITORY PERCEPTION*THE AUTHOR DESCRIBFS THIS QUANTITATIVE INSTRUMENTAL

PROCEDURE, 6HICH IS BEING DEVELOPED INTO A 'CLINICALYARDSTICK' TO MEASURE DISSOCIATIVE MENTAL DYSFUNCTIONAhjb ILLNESS, ITS INTENSITY, AND ITS RESPONSE TOTHLRAPy, (AUTHOR) (U)

71

UNCLASSIFIED /ZANL2

UNCLASSIFIED

DOC PEPORT BIBLIOGRAPHY 5EARCH CONTROL NO. /ZAML2

AD-74r] 665 6/5

LETTERmAN GENERAL HOSPITAL SAN FRANCISCO CALIF

PRESENT CONCEPTS IN INTERNAL MEDICINE.

VOLUME IV, NUMBER 9. NEPHROLOGY SYMPOSIUM,(UI

SEP 71 122p CHOJNACKI1RICHARD E# 1

APPLCVHITELOTTIE ;

UNCLASSIFIED REPORT

SUPPLEMENTARY NOTE: SEE ALSO VOLUME 4, NO* 8, AD-740

6844 AN4D VOLUME ,, NO, 1O0 AD-740 686o

DESCRIPTORS: (9KIDNFYS. DISEASES), SYMPOSIA,

PATII)LOtjY, PHYSIOLOGY, DIAGNOSIS, PARENTERAL

INFUSIONS, ELECTROLYTESIPHYSIOLOGY), IMMUNOLOGY,

HYPERTENSION, BLOOD PRESSURE, URINARY SYSTEM,

INFECTIONS, POISONING, DRUGS. LYSERGIC ACIDS,

BARBITURATES, NARCOTICS, THERAPY (U)

IDENTIFIERS: ONEPHROLOGY, IMMUNOLOGIC DISEASES,

GLOMERULONEPHRITIS, DRUG ABUSE, PYELONEPHRITIS,

HE po I iN (U)

THL PAPERS III THIS ISSUE OF PRESENT CONCEPTS

UFFER INSIGHT INTO COTH BROAD AND SPECIALIZED AREAS

OF NEPHROLOGY, IN SLVýRAL PRESENTATIONS,COMPRErENSIVF REvIEVS, NOT LLSEWHERE AVAILABLE; ARE

f'LSENTED. THE FIRST ARTICLE IS ANOTHER APPROACH

Teý THE PROBLEM OF FLUID AND ELECTROLYTE BALANCE

CORRECTION OF PATHOLOGIC OEVIATIONS, THE

PHYSICIAN'S PRESE..JTATION OF HIS EXPERIENCE IN CARING

FOR ACLTE RENAL FAILURE PATIENTS OFF THE COAST OF

VIETrNAM IS BOTH REWARDING AND DISILLUSIONING SINCE

PnST-TRAUMATIC RENAL FAILURE IS ASSOCIATED WITH

ExCESSIVE MORTALITY. THE FXCELLENT REPORT ON THE

PAT-IUGLNESIS OF GLONERULAR DISEASE IS A TIMELY FACT-LALF.N DISSERTATIOU AITH IMMEDIATE VALUE FORUfrIEPSTANDING THE IMMUNOL.OGIC EVENTS OCCURRING IN

PATIENTS WITH GLuMERULONEPHRITIS, LUPUS NEPHRITIS,

ANU GOuDPASTURE'S SYNDROME, AN ARTICLE ON

MALIGNANT HYPERTENSION PROVIDES OBJECTIVE EVIDENCE

",HICH SOLIDIFIFS THE NEED FOR TREATMENT TO

rn1(YILNSIVE LEVELS EVEN IF GLOMERULAR FILTRATION

RATE FALLS, ALBEIT TRANSIENTLY. THE DISCUSSION OF

PYELONEPHRITIS PRESENTS NEW FACETS OF DIAGNOSIS WHICH

SHOULD BE BENEFICIAL TO EVERY CLINICIAN. THE LAST

APTICLL IS A PAPER ON DRUG ABUSE AND IS PUBLISHED AS

A NEEDED AID IN DIAGNOSIS AND TREATMEIT OF THIS

EXTENiSIVE CONTEMPORARY PROBLEM.IU,

72UNCLASSIFIED /ZAML2

UNCLASSIFIED

DDC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZAHL2

AD-741 138 6/15 6/5 6/20ARMY LAND WARFARE LAU ABERDEEN PROVING GROUND MO

DRUG IDENTIFICATION, PROPERTIES ANDCHARACT..RISTICS: NARCOTICS' STIMULANTS,

DEPRESSANTS, MARIJUANA AND HALLUCINOGENS. (U)

DESCRIPTIVE NOTE: FINAL REPT,,"MAP 72 2SOP SANSUNETTICRAIG J. ;REILLY*

HUGH T.

REPT. NO. LWL-TR-72-04

UNCLASSIFIED REPORT

DESC;iIPTORS: (*DRUGS. IDENTIFICATION),

(*NARCOTICS, CHEMICAL ANALYSIS), (OPSYCHOTROPICAGFNTS, CHEMICAL ANALYSIS), (,ADDICTION,

DRU(.,), BIOCHEMISTRY, HALLUCINOGENS$ CNS

DEPRESSANTS, CNS STIMULANTS, CANNABIS, PHYSIOLOGY,

PSYCHOLOGY, PHARMACOLOGY, TOXICITY, THERAPY-BODY FLUIDS, OFTECTICN (U)

IDENTIFIERS *DRUG AaUSE, CLINICAL CHEMISTRY,

PRFSCRIPTION DRUGS (U)

A (aENLHAL SURVEY OF IHE LITERATURE REGARDING DRUG

AHUSE AND DRUG IDENTIFICATION HAS BEEN CONDUCTEDc

ILLICIT DRUGS IN FIVE CATEGuRIES--NARCOTICS,5TIlULANTS, DEPRESSANTS, MANIJUAN,\, ANDHALLUCINOGENS--ARC LISTED AND DESCRIBED. IN EACH

CATEGORY THE HISTORY OF THE DRUG TYPE, ITS CLINICAL

USL, AND THE PHYSICAL AND PSYCHOLOGICAL EFFECTS OFITS ABUSE ARE DISCUSSED. ANALYTICAL DA"4 SUCH ASMFLTINaý POINT, SOLUbILITY, COLOR ANU 'OCRYSTALTESTS, CHROMATOGRAPHY DATA, AND SPECTi "Rl PROVIDED

FOR APPROXIMATELY 125 INDIVIDUAL DRU ýAL

ANALYTICAL TECHNIQUES BOTH FOR PHARMACoi& L

PREPARAIIONS AND FOR DRUGS IN BODY FLUIDS ARE BRIEFLYSUMMARIZED. NUMEROUS REFERENCES ARE PROVIDED FOR

ADDITIONAL DATA. (AUTHOR) (U)

73

UJNCLASSIFIED /ZAML2

I I i

UNCLASSIFIED

CORPORATE AUTHOR - MONITORING AGENCY

oAEROSPACE TECHNOLOGY DIV LIBRARY OF *

CONGRESS NASHINGT4;: D C AFOSR-66-20400 0 0 ESTUDIO DE UNA ESPECIE

ATD.64-4 PSICOTOMIHETICAI IPONOEA CARNEA

CUE FACTORS: MONTHLY SURVEY (STUDY OF A PSYCmOTOMIMETIC PLANT!

NO. I. IPOMOEA CARNEAI,

(TT-66-6007.4 AD-0'2 973AD-620 294••

AFOSR-AV-0047

*AIR FORCE OFFICE OF SCIENTIFIC CEREBRAL INTEGRATION AND ITS

RESEARCH ARLINGTON VA ASSESSMENT BY DRUGS,

* . • AD-6q, 794

AFOSR-60-071 1VISUAL IMAGERY PRODUCED BY AFOSR-67-1

3 1ARHYTHMIC PHOTIC STIMULATION: NEUROPHARMACOLOGICAL STUDIES

PERSONALITY CORREL&TLS AND AND POSTULATES ON EXCITATION AND

PHENOMENOLOGY, DEPRESSION IN THE CENTRAL NERVOUS

AD-619 699 SYSTEM,; 0 • AD-653 4680

AFOSR-6•O9'40 *PROLONGED EFFECTS OF LSD ON EEG AFOSR-69-1070TR

RECORDS DURING DISCRIMINATIVE QUANTIFIED LSD EFFECTS ON EGOPERFORMANCE IN CAT: EVALUATION By STRENGTH.

COMPUTER ANALYSIS, AD-666 793A0-622 e646DR6qIT

* a *AFOSR-69-1077TR

AFOSRo65-I 502 CEREBRAL SYNAPTIC TRANSMISSION

HIPPOCAMPAL MECHANISMS IN AND BEHAVIORAL EFFECTS OF DIMETHOXY

PROCESSES OF MEMORY; THOU 4 HTS ON A PHENYLETHYLAMINE: A POTENTIALMODEL OF CERERRAL ORGANIZATION IN PSYCHOTOGEN,

LEARNING, AD-686 93AD-62, o0o ; ;

; AFOSR-.69-17,TR

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MARIJUANA AND AMPHETAMINE USE. SYNTHESIS OF ALPmA.HYDRDXY-ALPHA-AD-717 758 AMINO ACIDS AND ERGOT ALKALOIDS.,

AD-660 447

OF-AINPROGRESS REPORT. ARMY CHEMICAL *,..?HERICHIA CCLI

CONTRACT Dk-18106. -L-51• .0 LYSERGIC ACIDSAO-720 261 EFFET OF LYSCRGIC ACID

4IETHYLAMIDE IN ESCHERICHIA CDLI,IDENTIFICATION SYPAIN B/RfLAMBDA)*0

DRUG IDENTIFICATION, PRO %'IES AD-701 :%.ANu CHARACTIRISTICS: NARCOD,,.S, LYSERGIC ACID DIETNYLAMIDE;

STImULANTS, 3EPRESSANTS. MARIJUANA PiOTODYNAMIC INACTIVATION OF REPAIR4ND HALLUCIN4OGENS. DEFICIENT E. CO_1 AND T(1)

AD-T'41 38 BAcTERIOPHAGE..AD-7O; ;r

MILITARY PERSONNELA REV'EA OF 'HE bIOMEDICAL OGASTROPODA

EFFECTS jF MAR;.iUANA ON MAN IN THE NERVOUS SYSTEMMILITARY ENVIROr4NMENT.0 EPRINT: 5- "R•RXYTRyPTAKINE

AD-TI8 063 RE.EPTOQS AND 1 -. IC TRANSMISSIONIN POLL .SCAN tEO ,E5

SYMPOSIA AV-623 ;17

SYMPOSIUM ON DRUGS AND SENSORY

FlNCTIONS. OXIDOREtJCTAG

AD-481 8)2 REP' h?: IYDROXNINDC;A OXIDASEIN THE -RYSTALLINE STYLE OF PINNA

TOXICITY NOBILIS.

ACUTE TOXICITY OF AD-62) 375

TETRAHYDROCANNABINUL 7 MICE IN

ALTERED ENVIRONMENTS.* OHALLwCINODGI-S

ADO-48 700 INTEQIM PROGRLSS REPT. I OC'O0FR

60-31l MARCH 1961..ELECTROE CEPMALOGRAPMY AD-256 1 -9

0-4UNCLASSIF;ED

• I I III I I I I I I I I I I III I I I I I I

UNCLASSIFIEDINC-KID

METHYLENEDIOxY-AMPHETAMHNE ELECTROGRAMSteHALLUCINOGENIC SERIES OF COMPOUND AD-720 279III* CONDITIONED BEHAVIOR ANDELECTROENCEPHALOGRAH IC TEST PERSONALITYMETHODS (11)& STUDIES OF THE EFFECT OF

AD-265 110 PER3ONALITY ON REACTIVITY TO LSD.eTHE EFFECTS OF DRUGS ON PHYSICAL AD-728 q49

PERFORMANCE IN ANIMALS: THE BIOLOGYOF WATER TOXICANTS IN SUBLETHAL PHARMACOLOGY

CONCZNTRATIONSI SOME THOUGHTS ON REPRINT: HALLUCINOGEN.PSYCmOTOGENIC DRuGS1 AND THE EFFECT TRANQUILIZER INTERACTION: ITSOF LYSERGIC ACID DIETHYLAMIDE ON NATURE*SWIMMING TIME IN ALBINO MICE. AD-74O 430

AD-285 261SOME BIOCHEMICAL STUDIES ON PHYSIOLOGY

PSILOCYBIN AND PSILOCINe NEUROPHARMACOLOGIC PROFILE OFAD-291 097 PSYCHOTOMIMETIC ACTIVITY.*

FOUR METHOXY AND METHYLENEDIOXY AD-N22 q|3DERIVATIVES OF AMPHE'?AMINE.AMPHETAMINE, AND MESCALINE HAVE P6ANTS(BOTANY)BEEN TESTED FOR THEIR EFFECT ON REPRINT: STUDY uP ATHE TRANSCALLOSAL EVOKED PSyCHOTOMIMETIC PLANT: IPOMOEAPOTENTIAL. ON A DISTINCTIVE WAVE CARNEA-FORM IN THE EEG ANESTHET:ZED AD-642 97)AND UNANESTmETIZED CATS AND ONTHE CONDITIONED AVOIDANCE REVIEWSRESPONSE IN MICE IN AN ATTEMPT TO A REVIEW OF THE IOMEDICALFIND A TEST METHOD GIVING RESULTS EFFECTS OF MARIHUANA ON MAN IN THETHAT CORRELATE *ITw THE MILITARY ENVIRONMENT.*HALLUCINOGENIC ACTIVITY IN AD-71 08)MAN.AD-29' 958 #INCAPACITATING AGENTS

SOME EFFECTS OF BUFOTENINE ON LARVAEPHYSICAL PERFORMANCE IN MICE* THE INCAPACITATING EFFECTS OF

A?-299 879 CERTAIN COMPOUNDS. MEASURED BY THERESPONSES OF PLY LARVAE.

ANHALONIUM ALKALOIDS AD-)5I 911HALLUCINOGENIC DRUGS: A

PERSPECTIVE WITH SPECIAL REFERENCE PHARMACOLOGYTO PEYOTE AND CANNABIS$ NEW INCAPACITATING AGENTS*

AD.602 628 SUPPLEMENT 3. PRECLINICALPHARMACOLOGY AND TOXICOLOGY OF

BLOOD CHEMISTRY CANDIDATE AGENT 226•,169..STUDIES OF FLUOROMETRIC ASSAY AD-TI6 977

PROCEDURES FOR LYSERGIC ACIDDIETHYLAMIDEC, *KIDNEYS

AD-717 671 DISEASESPRESENT CONCEPTS IN INTCRNAL

ELECTROENCEPMALOGRAPMY MEDICINE, VOLUME IV, NUMBER 9.EFFECTS OF LYSERGIC ACID AND ITS NEPHROLOGY SYMPOSIUM,.

DERIVATIVES ON R14INENCEPHALIC AU-740 6B8

P-5

UNCLASSIFIED

UNCLASSIFIEDLEA-LYS

*LEARNING AD-?O0 170

BRAIN LYSERIIC ACID OIfTMYLAMIO(IHIPPOCAMPAL MECHANISMS IN PHOTODYNAMIC INACTIVATION Or RfPAIR

PROCESSES OF MEMORY: THOUGHTS ON A DEFICIENT f. COLI AND TI4IMODEL O CEREBRAL ORGANIZATION IN BAcTERIOPHAOE-6LEARNING, 0-O701 171

AO-623 060INHIBITION

ELECT-IOENCEPmALOGRAPHY REPRINT: EFFECT OF A CHEMICALLYREPRINT: COMPUTER ANALYSIS OF DEPRESSED AMYGOALA ON THE

HIPPOCAMPAL EEG ACTIVITY AND BEHAVIORAL OANIFESTATIONS PRODUCEDIMPEDANCE IN APPROACH LEARNINGI IN CATS BY LSD-25,EFFCTS OF PSYCHoTOMIMETIC AND AD-61B 802HALLUCINOGENIC DRUGS.

AD-623 Q97 MENTAL DISORDERSQUANTIFIED LSD EFFECTS ON EGO

OLYSERGIC ACIDS STRENGTH,*BEHAVIOR AD-6B6 793

REPRINT: PROLONGED EFFECTS OFLSo ON EEG RECORDS DURING NEUROLOGYOISCRIMINATIVE PERFORMANCE IN CAT: THE ROLE OF THE CENTRAL NERVOUSEVALUATION BY COMPUTER ANALYSIS* SYSTEM CHOLINERGIC MECHANISMS IN

AD-622 B46 UEHAvIOR AND LEARNING..AD-718 Ilt

BLOOD CHEMISTRYSTUDIES OF FLUOROMETRIC ASSAY PERSONALITY

PROCEDURES FOR LYSENGIC ACID STUDIES OF THE EFFECT OFDIETHYLAMIDEoe PERSONALITY ON REACTIVITY TO LSD.*

An-717 671 AO-72 1449

BRAIN PSYCHIATRYEFFECTS OF LYSERGIC ACID AND ITS CEREBRAL :NTE4RATION AND ITS

DERIVATIVES ON RH:NENCEPHALIC ASSESSMENT BY DRUGS,.ELECTROGRAMS.0 A0-647 796

AD-720 279

PROGRESS REPORT. ARMY CHEMICAL REACTION (PSYCHOLOGYICONTRACT OA-IR*-11BCML-9596,e LONG-LASTING EFFECTS OF LSD ON

AO-720 281 CERTAIN ATTITUDES IN NORMALS: ANLYSERGIC ACID OERIVATIVWS.e EXPERIMENTAL PROPOSAL-

AD-720 791 AD-604 B02

CONDITIONED REFLEX TOXICITYREPRINT: DIFFERENTIAL EFFECT OF REPORT ON THE SPFCIAL AGENT EA-

LSO UPON HABITUATING AND 1Q76.*EXTINGUISHING EVOKED RESPONSES- AD-72D 280

AD-613 764VISUAL ACUITY

ESCHERICHIA COLI REPRINT: DISRUPTION OF SIZEEFFECT OF LYSERGIC ACID DISCRIH]NATION IN SQJIRREL MONKEYS

DIETHYLAMIDE ON ESCHERICHIA COLIs (SAIMIRI SCIUREUS) RY LSD-29.STRAIN B/RILAMBDA)e. AD-O' 7 12)

D-6

UNCLASSIFIED

UNCLASJIFiEDMAT-NAR

*MATHEMATICAL ANALYSIS AD-266 93M

THE ErFECTS of DRUGS ON PH-SICALPERFORMANCE IN A0'-ALS. THE BIOLOGY *MOLECULAR STRUCTUREOF WATER TOXICANT5 IN SUBLETHAL ANTISPASMODIC AGENTSCONCENTRATIONS: SOME THOUGHTS ON NMEROFROPIC EFFECTS IN RELATIONPSYCHOTOGENIC DRUGSi AND THE EFFECT TO CHEMICAL STRUCTURE-*OF LYSERGIC ACID DIETHYLAMIDE ON AD-713 ]?aSWIMMING TIME IN ALBINO MICE. NEUROTROPIC EFFECTS IN RELATION

AD-JB§ 2&1 TO CHEMICAL STRUCTURE.*AD-715 379

*NEMORY NEUROTROPIC EFFECTS IN RELAIION$RAIN TO CHEMICAL STRUCTURE.*

HIPPOCAMPAL MECHANISMS IN AD-715 18(1PROCESSES OF MEMORY: THOL.,iHTS ON A NEUROTROPIC EFFECTS IN RELATIONMOOEL OF CEREBRAL ORGANIZATION IN TO CHEMICAL STRuCTuRE..

LEARNING. AD-715 381AD-62l 060 NEJROTROPIC EFFECTS IN RELATION

To CHEMICAL STRUCTURE.-@MENTAL DISORDERS AD-7I1 3182

AUDITORY PERCEPTION 14CuROTROPIC EFFECTS IN RELATIONREPRINT; PERCEPTUAL CHALLENGE TO CHEMICAL STRuCTuqE,.

TO MEASURE ILLNESS ANO THERAPY. AD-715 583AD-74O 431 NEUROTROPIC CFFECTS IN RELATION

TO CHEPICAL STRUCTURE.*DIAGNOSIS AD-715 ;85

CEREBRAL INTEGRATION AND ITSASSESSMENT BY DRUGS.. OMOLLUSCA

AD-647 796 ENZYME$

REPR'.TI HYDROXYINDOLE OXIDASELYSERGIC ACIDS IN THE LRYSTALLINE STYLE OF PINNA

QUANTIFIED LSD EFFECTS ON EGO NOSILIS.

STRENGTH,- AD-621 )75A0-686 793

NERVOUS SYSTEM

*MILITARY PERSONNEL REPRINT: S--YDROXYTRYPTAMINEDRUGS RECEPTORS AND SYNAPTIC TRANSMISSION

I REVIEW OF THE BIOMEDICAL IN MOLLUSCAN NEIRONES.EFFECTS OF MARIH',ANA ON MAN IN THE AD- 6 23 l67MILITARY ENVIRON.ENT..

AD-718 O8 *MONKEYSVISION

OMO4ECULAR ISOMERISM REPRINT: DISRUPTION OF SIZEM0ECULAR STRUCTURE UISCRIMINATION IN SUIRREL MONKEYSSYNTHESIS OF AN ISOMER OF (SAIMIRI SCIUREUS) 9Y LSD'-2 "-

TLTRAHYDROCANNABINUL, AD-647 12)ADAD-A1 I lo

*NARCOTICSO-HETEROCYCLIC COMPOUNDS CHEMICAL ANALYSIS

TETRAHYDROCANNABINOLS 11. DRUG IDENTIFICATION, PROPERTIESSYNTHESIS OF EIGHT ISOMERS OF A AND CHARACTERISTICS! NARCOTICS,SYNTHETIC TETRAHYDROCANNABINOL. STIMULANTS, DEPRESSANTS, MARIJUANA

D-7UNCLASSIFIED

UNCLASSIFIED cNCR-PER

AN.) HALLUCINOG•ms.o TO CHEMICAL STRUCTURE,.A; -q7 3)8 AD-715 )79

NEUROTROPIC EFFECTS IN RELATIONMILI'kRY PERSONNEL TO CHEMICAL STRUCTURE..I REVIEW OF THE BIOMEDICAL AD-7I1 380

EFFECTS OF MARIHUANA ON MAN IN THE NEUROTROPIC EFFECTS IN RELATIONMILITARY ENVIRONPIENT~. TO CHEMICAL STRUCTURE.*

AD-TI8 081 AO-719 381NEUROTROPIC EFFECTS IN RELATI-lN

SOCIAL P3YCHOLOGy TO CHEMICAL SIRucTuRECoTHE RELA IONSmIp BETWEEN PAST AD-715 ;82

BACKGROUND AND DRUG USE.* NEuROTROPIC EFFECTS IN RELATIONAD-735 102 To CHEMICAL STRUCTURE..

AD-715 383*NERVE CELLS NEUROTROPIC EFFECTS IN RELATION

PHYSIOLOGY TO CHEMICAL STRUCTURE..REPRINT: 5.HYOROXYTRYPTAMINE AD-715 385

RECEPTORS AND SYNAPTIC TRANSMISSIONIN MOLLUSCAN NEURONES. OORGANIC COMPOUNDS

AD-6J3 167 SOME EFFECTS OF RuFCTLNINE ONPIYSICAL PERFORMANCE IN MICEo

SEROTONIN Aj-29? ;7jSEROTONIN BIND!-;G TC

PREPARATIONS FROM RAT GRAIN- SYN'ISIS (CHEMISTRyIAD-607 167 SYNTHESIS OF AN ISOMER OF

TETRAMYOkOCANNABINOL.PNERVE IMPULSES AD-iI| I35

INHIBITIONRPPRINT: PRIMATE CEREBRAL OOXIDOREDL"-TASES

SYNAPTIC INHIBITION ay DRUGS. GASTROPC.4AD-686 595 REPRINT: HY-ROXYINDOLE OXIDASE

IN THE CRYSTALLINE STYLE OF PINNAPSYCHOTROPIC AGENTS NOBILIS.REPRINT: CEREBRAL SYNAPTIC AD- 6 23 375

TRA2'SMIS9!QN AND BEýAVIORAL EFFECT5OF uImETHOAy PHENYL- TMYLAMINE: A 0O-METEROCYCLIC COMPOUNDSPOTENTIAL PSYCHOTOG,N. STEREOCHEMISTRY

A--686 591 TETRAHYDROCA'-NABINOLS II.

5YNT.-EIS OF FIGHT ISOMERS OF A*NERVOUS SEPSTEm SYNTHETIC TETRAHYOROCANNABINOL.CNS OEPRESSANTS AD-366 932

EFFECT OF ORuis ON CENTRALNLRVOUS NEURONES. *PERSONALITY

AD-414 045 CANNAOISTHE EFFECT OF PERSONALITY ON*N=NETEROCYCLIC COMPOUNDS REACTIVITY TO A

SYNTMESIS(CHEMISTRY) TETRAHYDROCANNABINOL.wNEUROTROPIC EFFECTS IN RELATION AO-730 905

"- CHEMICAL STRUCTURE.*AD-715 178 LYEPG:C ACIDS

NFkJROTROPIC EFrFECTS IN RELATION STUDIES OF THE EFFECT OF

0-BUN.CLASSIFirF

UNCLASSIFIED

"PES-PSY

PERSONALITY ON REACTIVITY TO LSOD* "PHYSIOLOGYAD-720 449 CANNABIS

SUMMARY REPORT ON EA 1476 AND EASENSORY PERCEPTION 223).

REPRINTI VISUAL IMAGERY AO-3V2 322PuODUCED BY RHYTHMIC PHOTICSTIMULATION; PERSONAL|IT? OPIPERIDINESCORRELATES AND PHENOMENOLOGY. SYNTNTSIS(CNEHISYRYI

AD-615 698 NEUROTROPIC EFFECTS IN RELATION

TO CHEMICAL STRUCTURE..*PESTICIDES AD-71P 370

ABSTRACTSREVIEW OF CBE FACTORS RESEARCH. '"PLANTSIBOTANYI

AD-628 294 HALLUCINOGENS

$PHARM4ACOLOGY REPRINT: STUDY OF APPSYCHOTOMIMETIC PLANT: IPOMOEA

INTERIM PROGRESS REPT. I OCTOBER CARNEA.60-31 MARCH 1961. AO-642 973

AO-296 169THE EFFECTS OF DRUGS ON PHYSICAL PSYCHOTROPIC AGENTS

PERFORMANCE IN ANIMALS: THE BIOLOGY RLPRINT: ETHNOPHARMACOLOGY OFOF *ATER TOXICANTS IN SUBLETHAL THE PSYCHOTnOPHIC PLANTS OFCONCENTRATIONS: SOME THOUGHTS ON AMERICA.PSYCHOTOGENIC DRUGS; AND THE EFFECT AD-691 S3lOF LYSERGIC ACID DIETHYLAMIDE ONSWIMMING TIME IN ALBINO MICE. *PSYCHIATRY

AD-289 261 SYMPOSIA

PROCEEDINGS OF THE ANNUALCANNABIS CONFERENCE OF A:R FORCE BEHAVIORALSUMMARY REPORT ON EA 1476 Aro EA SCIENTISTS (1aTH)o SHEPPARD AIR

2213. FORCE BASE; WICHITA FALLS. TEXAS,AD.1%2 132 21 JANUARY TO 2 FEBRUARY 196SeAD-b82 511

CARDIOVASCULAR SYSTEM

CARDIOVASCULAR SYSTEM,* *PSYCHOPHYSIOLOGYAn-/u qO7 LYSERGIC ACIDS

STUDIES OF THE ErFECT OFINCAPACITATING AGENTS PERSONALIiY ON REACTIVITY TO LSD.&INCAPACITATING AGENTS. AD-72j -449

SUPPLEMENT 2. PRECLINICALPHARMACOLOGY ANn TOXICOLOGY OF OPTICAL IMAGESCANDIDAIE AGENT 226,16V.* REPRINT: VISUAL IMAGERY

AD-716 977 PRODUCED BY RHY'MMIC PHOTIC

STIMULATION: PERSONALITy*PMOTOSENSITIVITY(BIOLOGICAL) CORRELATES AND PHENOMENOLOGY.

LYSERGIC ACIDS AD-615 698LYSERGIC ACID DIETlYLA41DE:

PHOTODYNAMIC !NACTIVATIDN OF REPAIR STRESS (PSYCHOLOGY)DEFICIENT E. COLI AND T(c) PSYCHOPHYSIOLOGICAL MECHANISMSBACTERIOPHAGE,* OF STRESS PESPONSIvITY.

AD-701 171 AD-608 4U2

D-9UNCLASSIFIED

PSC-RES LAS31FIED

*PSYCHOSES PHARMACOLOGYPSYCHOTROPIC AGENTS THE CHEMISTRY AND PHARMACOLOGYrFFECTS Or PSYCHOPHARMACOLOGIC OF CERTAIN COMPOUNDS AFFECTING THPDRUGS UPON SENSORY INFLOW IN NORMAL CENTRAL NERVOUS SYSTEM OF ANIMALSSURJECTS, PSYCHIATRIC PATIENTS AND ANU MAN,*

IN ANIMALS. AD-?O? 64gAD-62) 6;1 THE CHEMISTRY AND PHARMACOLOGyOr CERTAIN COMPOUNDS AtFECTING THEOPSYCHOTROPIC A4ENTS CENTRAL NERVOUS SYSTEM OF ANIMALSADOLESCENTS AND MAN.*

REPRINT: CLINICAL ASPECTS OF AD-707 669MARIJUANA AND AMPHETAMINE uSE.

AD-?)? 798 PLANTSIBOTANYIREPRINT| ETHNOPHARMACOLOGY OFBEHAVIOR THE PSYCHOTROPNIC PLANTS OFREPRINT: COMPUTER ANALYSIS OF AMERICA.

HIPPOCAMPAL EEG ACTIVITY AND AD-49i 931IMPEDANCE IN APPROACH LEARNING:EFFCTS Or PSYCHOTOHIMETIC AND SENSORY PERCEPTIONHALLUCINOGENIC ORUGS. EFFECTS OF PSYCHOPHARMACOLOGICAD-62) 497 DRUGS UPON SENSORY INFLOW IN NORMALREPRINT: CEREBRAL SYNAPTIC SUBJECq5S PSYCHIATRIC PATIENTS ANDTRANSMISSI101 AND BEHAVIORAL EFFECTS IN ANIMALS.OF DIMETHOXY PHENYLETHYLAMINE; A AD-o2, 6,jPOTENTIAL PSYCHOTOGEN.AD-696 ,99 VISUAL PERCEPTION

EFFECTSOr PSYCHOPHARMACOLOGICCHEMICAL ANALYSIS DRUGS UPON SENSORY INFLOW IN NORMALDRUG IDENTIFICATION, PROPERTIES SUBJECTS, IN PSYCHIATRIC PATIENTSAND CHARACTERISTICS: NARCOTICS, AND IN ANIMALS.-STIMULANTS, DEPRESSANTS. MARIJUANA AD-6;) 99p

AND MALLUClrJOGENS.,AD-7..Z •), *REACTION (PSYCHOLOGY)

LYSERGIC ACIDSCHOLINESTtRASl INHIBITORS LONG-LASTING EFFECTS OF LSD ONPSYC"OTOHIMETIC AGENTS WITH CERTAIN ATTITUDES IN NORMALS: ANANTICHOLINERGIC ACTIVITY-. EXPERIMENTAL PROPOSAL.

TRANSLATION, AD4604 802AD-679 719

sREACTION(PSYCHOLOGY)EFFECTIVE NESS LYSERGIC ACIDSSUMMARY REPORT ON EA 1476 AND EA THE ROLE OF THE CENTRAL NERVOUS2233. SYSTEM CHOLINERGIC MECHANISMS INAD-342 )32 BEHAVIOR AND LEARNING.e

INTERACTIONS AD-718 136

REPRINT: HALLUCINOGEN- .RESERPINETRANQUILIZER INTERACTION: ITS CENTRAL NERVOUS SYSTEM•AT~URE. THE CHEMISTRY AND PHARMACOLOGYAD-740 q30 Or CERTAIN COMPOUNDS AFFECTING THE

CENTRAL NERVOUS SYSTEM OF ANIMALS

D-10UNCLASSIrIFE

UNCLASSIFIEDSC I-VI S

AND MAN.* *STRESSIPSYCHOLOGY)AD-T07 668 SCIENTIFIC RESEARCH

THE CHEMISTRY 4&,O PHARMACOLOGY OPINION CHANGE IN THE ADVOCATEOF CERTAIN COMPOUNDS AFFECTING THE AS A FUNCTION OF THE 'ERSUASIBILITYCENTRAL NERVOUS SYSTEM OF ANIMALS OF HIS AUDIENCE: A CLARIFICATIONAND MAN.. OF THE MEANING OF DISSONANCE.*

AD-O? 669 AD-&69 947

*SCIENTIFIC RESEARCH *SYNPOSIASTRESS(PSYCHOLOGY, DRUGS

OPINION CHANGC IN THE ADVOCATE SYMPOSIUM ON DRUOS AND SENSORYAS A FUNCTION OF THE PERSUASIBILITY FUNCTIONS.OF HIS AUDIENCE: A CLARIFICATION AD-4i1 8;2OF THE MEANING OF DISSONANCE.e

AD-696 947 *TIME

THE EFFECTS OF DRUGS ON PHYSICAL*SENSORY PERCEPTION PERFORMANCE IN ANIMALS: THE BIOLOGY

DRUGS OF WATER TOXICANTS IN SUBLETHALSYMPOSIUM ON DRUGS AND SENSORY CONCENTRATIONS: SOME THOUGHTS ON

FUNCTIONS. PSYCMOTOGENIC DRUGSI AND THE EFFECTAO-481 832 OF LYSERGIC ACID OIETHYLAKIDE ON

SWIMMING TIME IN ALBINO MICE.*SEROTONIN AD-285 261

NERVE IMPULSESREPRINT: 5-HYOROXYTRYPTAMINE *TOXICITY

REC:PTORS AND SYNAPTIC TRANSMISSION THE EFFECTS OF DRUGS ON PHYSICALIN MOLLUSCAN NEURONES. PERFORMANCE IN ANIMALS: THE BIOLOGY

AD-627 )67 OF WATER TOXICANTS IN SUBLETHALCONCENTRATIONS: SOME THOUGHTS ON

REACTION KINETICS PSYCHOTOGENIC ORUGSI AND THE EFFECT

SEROTONIN BINDING TO OF LYSERGIC ACID DIETHYLAMIDE ONPREPARATIONS FROM RAT BRAIN. SWIMMING TIME IN ALBINO MICE.AD-60? 16? AD-201 261

*SOCIAL PSYCHOLOSY LYSERGIC ACIDSNARCOTICS REPORT ON THE SPECIAL AGENT EA-

THE RELATIONSHIP BETWEEN PASTBACKGROUND AND DRUG USE,* AD-72U 280

AD-725 102

*TRANQUILIZERSOSOIL MECHANICS PHARMACOLOGY

ABSTRACTS RCPRINT: HALLUCINOGEN-REVIEW OF COE FACTORS RESEARCH. TRANQUILIZER INTERACTION: ITS

AD-628 294 NATURE.AD-7qO 470

ITRESS (PHYSIOLOGYiREACTIoN IPSYCHOLOGY) eVISION

PSYCHOPHYSIOLOGICAL MECmANISMS STIMULATIONOF STRESS RESPONSIvITY. REPRINT: VISUAL IMAGERY

AO-4aG 402 PRODUCED BY RHYTHMIC PHOTIC

STIMULATION: PERSONALITY

D-IIUNCLASSIFIED

I"

UNCLASSIFIEOvi S-V 5

CORRELATES AND PHENOMENOLOGY*AD-610 &96

*VISUAL ACUITYLYSERG1C ACIOS

REPRINT: DISRUPTION OF SIZE

DISCRIMINATION IN SQUIRREL MONKEYSISA|MIRI SCIUREUS) BY LSO-2P.

AD-647 123

0-12UNCLASSIFIED

UNCLASSIFIED0

TITLE INDEX

ACUTE TOXICITY OP AD-4q& 700 EFFECTS OF PSYC40TOMIMETIC ANDTErRAMYDROCANNABINOL TO MICE IN HALLUCINOGENIC DAUGS90U)

ALTERED ENVIRONNEI-.:(U) *LEARNINGODRUGS

DIFFERENTIAL EFFECT OF AD%617 164

CARDIOVASCULAR AD0734 qo7 LSO UPON HABITUATING ANDSYSTEM. (U EXTINGUISHING EVOKED RCSPONStSiUl

*CARDIOVASCULAR SYSTEM *LYSERGIC ACIDS

CIE FACTORSI MONTHLY A@0628 29q DISRUPTION OF SIZE AD-647 12P

SURVEY NO. I.(y) DISCRIMINATION IN SQUIRREL MONKEYS*PESTICIDOS (SAIMIRI SCIUREuSl BY LSD-21,IUI

*VISUAL ACUITY

CERESBRAL INT1GRATION AD-i4T 796 *

AND ITS ASSESSMENT By DRUGS,(UI DRUG IDINTIFICATIONt AD-741 $20*MENTAL DISORDERS PROPERTIEq AND CHARACTERISTICSI

NARCOTICS; STIMULANTS, DEPRESSANTSlCEREBRAL SYNAPTIC Al6@&6 099 MARIJUANA AND HALLUCINOGENSefUI

TRANSMISSION AND BEHAVIORAL EFFECTS *DRUGS

OF DIMETHOXY PHENYLETNYLANINEI APOTENTIAL PSYCHOTOGEN*(U) EFFECT OF A CHEMICALLY AP-616 602

*NERVE IMPULSES DEPRESSED AMYGOALA (N THEBEHAVIORAL MANITESTATIONS PRODUCED

THE CHEMISTRY AND ADO707 667 IN CATS BY LSD-29(U)PHARMACOLOGY OF CERTAIN COMPOUNDS oLYSERGIC ACIDSAFFECTING THE CENTRAL NERVOUSSYSTEM OP ANIMALS AND MAN. A EFFECT OF DRUGS ON AQ-qjq 041PHARMACOLOGICAL COMPARISON Of EA CENTRAL NERVOUS SYSTEM NEURONES.1476 (TETRAMYDROCANNABINOLi (U)

ISOMERS.,U) *NERVOUS SYSTEM*CANNABIS

THE EFFECT OF DRUGS ON AD@2lf 261THE CHEMISTRY AND AD-O? 668 PHYSICAL PERFORMANCE IN ANIMALSIUl

PHARMACOLOGY OF CERTAIN COMPOUNDS *BEHAVIORAFFECTING THE CENTRAL NERVOUS

SYSTEM OF ANIMALS AND MAN,(UD EFFECT OF LYSERGIC ACID AD-701 ITO*PSYCHOTROPIC AGENTS DIETHYLANIDE ON ESCHLRICHIA COLI,

STRAIN B/R(LAM9DA),(U)THE CHEMISTRY AND AD-TO7 669 *LYSERGIC ACIDS

PHARMACOLOGY OF CERTAIN COMPOUNDSAFrfECTING THE CENTRAL NERVOUS THE EFFECT OF AD-720 909

SYSTEM Or ANIMALS AND MAN.jUl PERSONALITY ON REACTIVITY TO A*PSYCHOTROPIC AGENTS TETRAHYDROCANNABINOL.(Ul

*CANNABISCLINICAL ASPECTS O A0-737.Th0

MARIJUANA AND AMPHETAMINE USEs(U) EFFECTS OF LYSERGIC AD-720 279

@CANNABIS ACID AND ITS DERIVATIVES ONRHINENCEPHALIC ELECTROGRAMSIUl

COMPUTER ANALYSIS OF AD-o62 497 *LYSERGIC ACIDSHIPPOCAMPAL LEG ACTIVITY AND

IMPEDANCE IN APPROACH LEARNING: EFFECTS OF PSYCHOPHARNAC A@-6q3 981

T-1UNCLASSIFIED

UNCLASSIFIED '.

OLOGIC DRUGS UPON SENSORY INFLOW IN SNOLLUSCANORMAL SUBJECTS: IN PSYCHIATRICPATIENTS AND IN ANI'ALS.(Ul .HYOROXYINDOQL OXIDASE AD-622 317OPSYcHOTROPIC AGENTS IN THE CRYSTALLINE STYLE OF PINNA

NOBILIS,(U)EFFECTS OP PSYCN0PHARNAC A0-621 6311 *MOLLuSCAOLOGIC DRUGS UPON SENSORY INFLOW INNORMAL SUBJECTS; PSYCHIATRIC Is METHYLENEOIOXY- AD-294 906PATIENTS ANO GE ANZTALS.(UI AMPHETAMINE HALLUCINOGENIC SERIES*PSYCNOT•OPlc AG(NTS Or COMPOUND3. It. CONDITIONED

BEHAVIOR AND

THE EFFECTS or 42- ) ELECTPOENCEPHALOGRAPNIc TESTTNIAZESIM, LSO-29, AND BILATERAL METHODS(U)LESIONS OF THE AMYGOALAf ON THE *HALLUCINOGENSRELEASE OF A SUPPRESSEDRESPONSE;(u)

THE INCAPACITATING AD-391 911*CONDITIONED REFLEX EFFECTS oP CERTAIN COMPOUNDS,MEASURED BY THE RESPONSES OF FLYESTUOIO 01 UNA E$PECIC ADo6b2 972 LARVAE- (UJPSICOTOMIMETICA: IPOMOEA CARNEA O*NCAPACITATIN4 AGENTS(STUDY Or A PSY•mOTOMIMEIC PLANTIIPOMOEA CARNEA).(U) INTERIM PROGRESS REPT, iO.2I6 169*HALLUCINOGENS I OCTOBER 6n-A1 MARCH 1961(Up

OHALLUC INOGENSETNOFARMACOLOGIA OE LAS AD-691 031

PLANTAS PSICOTROPICAS DE AMERICA LONG-LASTING EFFECTS OF AD-O60 02(ETHNOPHARMACOLOGY op ?HC LSO ON CERTAIN ATTITUDES INPSYCHOTROPHIC PLANTS Or NORMALS: AN EXPERIMENTALAMERICA)1,U)

PROPOSAL,(U)*PLANTS(BOTANY)

OLYSERGIC ACIDS

HALLUCINOGENIC ORUESI AD-6O2 6;a LYSERGIC ACID AD-720 797A PERSPECTIVE WITH SPECIAL OERIVATIVES.IUlREFERENCE TO PEYOTE AND OLYSERGIC ACIDSCANNA IScUl

*HALLUCINOGENS LYSERGIC ACID AD*701 171DIETHYLAMIDE: PHOTODYNAMICHALLUCINOGEN. AD-.qQ 410 INACTIVATION Or REPAIR DEFICIENT E.TRANQUILIZER INTERACTION: ITS COLI AND Ti(| BACTERIOPHAGE.(U)NATUREjU)

*LYSERGIC ACIDS*HALLUCINOGENS

METHYLENEDIOXY. AD-260 110HIPPQCAMPAL MECHANISMS AD-&27 060 AMPHETAMINE HALlUCINOGENIC SERIESIN PROCESSES OF MEMORY: THOUGHTS OF COMPOUND it), CONDITIONEDON A MODEL OF CEREBRAL ORGANIZATION BEHAVIOR ANDIN LEARNING;gU) ELECTROENCEPHALOGRAPHIC TESTOBRA IN METHODS 411)(U)9ANHALONIUM ALKALOIDS

P-HYDROXTRYPTAMINE AD-Al) 367RECEPTORS AND SYNAPTIV TRANSMISSION NEUROPNARMACOLOGICAL ADo60P 610IN MOLLUSCAN NEURONES,(U) STUDIES AND POSTULATES ON

T-2UNCLASSIFIED

UNCLASSIFIED

EXCITATION AND DEPRESSION IN THE MEASURE ILLNESS AND THERAPYTiUlCENTRAL NEKVOUS S!YTEMs[(JI OMENTAL DISORDERS*ANESTHESIA

THE PHARNACOLOOICAL AG.367 397NEUROPHARNAC*LoE|C AOD-23 41P PROPERTIES OF AN EVOKE9 POTENTIALPROFILE OF PSYCHOTOMIMETtC IN THE MIDBRAIN RETICULARACTIVITY.cuJ FORMATION(UI*HALLUCINOGENS

*BARBITURATES

NCUROTROPIC tFPPCTS IN AO-710 271 PRESENT CONCEPTS IN AO-74o 480RELATION TO CHEMICAL STRUCTURE.IU) INTERNAL NEDICIN[e VOLUME IV,%ANALGESICS s ANTIPYRETICS NUMBER 9. NEPHROLOGY SYNPOSIUMsIU)*KIDNEYSNEUROTROPIC EFFECTs IN AD-710 279RELATION TO CHEMICAL STRuCTURE.euI PRIMATE CEREIRAL AD0066 It$*ANALG$SICS 0 ANTIPYREVICS SYNAPTIC INHIBITION BY ORUGS.IU)*NERVE IMPULSESNEUROTROPIC EFFECTS IN AD-7I1 240RELATION TO CHEMICAL STRUCTURE.(U) PROCEEOING3 OF THE ADO602 Itl*ANTISPASMODIC AGENTS ANNUAL CONFERENCE OF AIR FORCE

BEHAVIORAL SCIENTISTS (ITHji,NEUROTROPIC EFFECTS IN AD&710 391 SHEPPARD AIR FORCE BASE, WICHITARELATION TO CHEMICAL STRUCrURE*IU) FALLS, TEXAS. 31 JANUARY TO 2*ANTISPASMODIC AGENTS FEBRUARY 1968S.Ua

*PSYCHIATRYNEUROTROpIC EFFECTS IN AD-71P 362RELATION TO CME!M!C'L %TRUCTu.:W PROGRESS REPORT* ARMY AD*730 381*ANTISPASMODIC AGENTS CHEMICAL CONTRACT OA.I-.IOI.CML.

999i,(UlNEUROTROPIC EFFECTS IN AD-?[# 28, 'DRUGSRELATION TO CHEMICAL STRUCTURE.(UlOANTISPASFOIC AGENTS PROLONGEO EFFECTS OF AD-622 4q6

LSO ON EEG RECORDS DURINGNEUROTROPIC EFFECTS IN AO-71I )10 DISCRIMINATIVE PERFORMANCE IN CATSRELATION TO CHEMICAL STRuCTURE@(U) EVALUATION BY COMPUTER ANALYSISUIU,*ANTISPASMODIC AGENTS OLYSERGIC ACIDSNCO INCAPACITATING ADo716 977 PSYCHOPHYSIOLOGICAL AD-604 q02AGENTS. SUPPLEMENT 39 PRECLINICAL MECHANISMS OF STRESSPHARMACOLOGY AND TOXICOLOGY OF RESPONSIvITYaIU)

CAV.OIoATC AGENT 226,A69.(U) *STRESS (PHYSIOLOGY)*INCAPACITATING AGENTSPSYCHOTOMIMETIC AGENTS A0-670 719OPINION CHANGE IN THm AD-096 7q? OITH ANTICHOLINERGIC ACTIYITY.(UiADVOCATE AS A FUNCTION OF THE OPSYCHOTROPIC AGENTS

PERSUASIBILITY OF HIS AUDIENCE: ACLARIFICATION OF THE MEANING OF QUANTIFICO LSD EFFECTS AD-8t6 791DISSONANCE.(Ul ON EGO STRENGTHN¢U,*ATTITUDES

*LYSERGIC ACIDS

PERCEPTUAL CHALLENIE TO Ao-74o 43; THE RELATIONSHIP AD-7sp 102

T-3UNCLASSIFIED

UNCLASSIFIEDREP-V IS

SETA[EN PAST BACKGROUND AND DRUG *YNTH[OIU AND ISOLATION AD-6q6 SlaUSE,(U' Of TcTRAHYOROCANNAIINOL ISOMoCRSiu*NARCOTICS *CANNASINOLS

R9PORT ON THE SPECIAL AD-070 210 SYNTNESIS OF ALPHA. A06660 44?AGENT EA.-|7B,(U) MYOROMY-ALPNA.AMINO ACIDS AND ERGOT

OLYSERGIC ACIDS ALKALOIDS, U)*AMINO ACIDSA REVIER OP TIHE AS-?it Og?

BIOMEDICAL EFFECTS OF MARIHUANA ON SYNTHESIS Of AN ISOMER AD-41 3181MAN IN THE MILITARY ENVIRONNENT*Iu) OF TETRAHYDROCANNASNOL,(U,

*CANNAS I OURGANIC COMPOUNDS

THE ROLE Of THE CENTRAL AC-7i1 131 TETRAHYDROCANNASINOLS AD-X6S 921NERVOUS SYSTEM CHO4INERGIC It. SYNTHESIS OF EIGHT ISOMERS OFMECHANISMS IN BEHAVIOR AND A SYNTHETICLEARNING.(U) TETRAMY1ROCANNAB|NOL. U)'LYSERGIC ACIDS *O-NETEROCYCLIC COMPOUNDS

SCROTONIN NINDINI TO AD-OtD 167 VISUAL IMAWERY PRODUCED AD001 696PREPARATIONS FRoM RAT BRAIN,(UI BY RMYTHNMIC PHOTIC STIMU6ATIONI

'SEROTONIN PERSONALITY CORRELATES ANDPHENONENOLOGYo(Ui

SOME 9iOCHRMICAL AO-291 097 OPSYCHOPHYSIOLOGYSTUDIES ON PSILOCYB8N ANDPSILOCINCU)

*HALLUCINOGENS

sONe EFPECTS Or AD-299 479

BUFOTENINE ON PHYSICAL PERFORMANCEIN NICE(U)

*NALLUCINOGENS

STUDIES of PLUOROMCTRIC AD-727 671ASSAY PROCEDURES FOR LYSERGIC ACIDOIETHYLAMIDE.(Uj

*LYSERGIC ACIDS

STUDIES 07 THE EFFECT AO-78 P449OF PERSONALITY ON REACTIVITY TOLSI.9U)

*HALLUCINOGENS

SUMMARY REPORT ON EA AO-2)2 )321476 AND EA 22)) (Ul

*CHEMICAL WARFARE AGENTS

SYMPOSIUM ON DRUGS AND AD-P0I 8)2SENSORY FUNCtIONS.IU)

*SYMPOSIA

T-CUNCLAS31FIED

UNCLASSIFIED

PERSONAL AUTHOR INDEX

*AARON, HERBERT S. PRESENT CONCEPTS IN INTERNALS. * "MEDICINE. VOLU4E IV, NUMBER 9t

TETRA4YDRO:ANNABINLS II NEPHROLOGY SYMPOSIUM,SYNTHESIS OF EIGHT ISOMERS OF A AD-741 661SYNTHETIC TETRAHYDROCANNABINOL,

AD-)&& 913 SARONSON, ELLIOT

vAOEY, we R. OPINION CHANGE IN TME ADVOCATE AS A0 * • FUNCTION OF THE PERSUASISILITY OF

PROLONGED EFFECTS OF LSD ON EEG HIS AUDIENCE: A CLARIFICATION OFRECORDS DURING DISCRIMINATIVE THE MEANING OF DISSONANCE.PERFORMANCE IN CAT: EVALUATION BY AD-696 941COMPUTER ANALYSIS@

AD-622 844 OAUSTT, ELIO GARCIA

COMPUTER ANALYSIS OF HIPPOCAMPAL EFFECTS OF PSYCHOPMARMACOLOGICEEG ACTIVITY AND IMPEDANCE IN DRUGS UPON SENSORY INFLOW IN NORMALAPPROACH LEARNING: EFFECTS OF SUBJECTS, PSYCHIATRIC PATIENTS ANDPSYCHOTOMIMETIC AND HALLUCINOGENIC IN ANIMALS.DRUGS, AD-62) 6)1

AD-623 '497 * 0 0EFFECTS OF PSYCHOPHARMACOLOGIC

0ADEY, We ROSS DRUGS UPON SENSORY INFLOW IN NORMALe . • SUBJECTS, IN PSYCHIATRIC PATIENTS

HIPPOCAMPAL MECHANISMS IN PROCESSES AND IN ANIMALS,OF MEMORY: THOUGHTS ON A MODEL OF AD-64) 989CEREBRAL ORGANIZATION IN LEARNING.

AO-623 060 sBAKER, WALTER W.

CALLES, GORDON A NEUROPHARMACOLOGIC PROFILE OFPSYCHOTOMIMETIC ACTIVITY.

INTFRIM PROGRESS REPT. I OCTOBER 60- A-'422 413)1 MARCH 1961

AD-296 169 *OANSHCNIKOV; V. Me

METHYLENEDIOXY-AMPMETAMINE PSYCHOTOmIMETIC AGrmTS WITH

HALLUCINOGENIC SERIES OF COMPOUND ANTICHOLINERGIC ACTIVITY,(ili CONDITIONED BEHAVIOR AND AD-679 719SELECTROENCEPHALOGRAPHIC TESTMETHODS (Ili *BARRATTo ERNEST So

AD-26S 110* * . EFFECT OF A CHEMICALLY DEPRESSED

I. METNYLENEDIOXY-AMPHETAMINE AMYGDALA ON THE BEHAVIORALHALLUCINOGENIC SERIES OF COMPOUNDS. MANIFESTATIONS PRODUCED IN CATS BYII, CONDITIONED BEHAVIOR AND LSD-20o

ELECTROENCEPHALOGRAPHIC TEST AD-618 802METHODS a ;AD-294 998 THE EFFECTS OF TMIAZES•tM, LSD-2%,

AND BILATERAL LESIONS of THEOAPPLEAHITE, LOTTIE AMYGOALAE ON THE RELEASE OF A

S* . .SUPPRESSED RESPONSE,

P-I

UNCL ASSIFIED

UNCLASSIFIED

l it-DON

AD-6p) '42 NEPHROLOUV SYMPOSIUM,AO-740 61P

OBICTEM, THOMAS Co; 6 a *COHEN; SANFORD 1,

QUANTIFIED LSD EFFECTS ON EGO 0 . *STRENGTH, PSYCHOPHYSIOLOGICAL MECHANISMS OF

AD-656 79) STRESS RESPONSIVITY.AO-608 402

0BLACKI, PERRY000 *DAVIS, SCOTT He

THE ROLE OF THE CENTRAL NERVOUS 0 * 0

SYSTEM CHOLINERGIC MECHANISMS IN CEREBRAL SYNAPTIC TRANRMISSION ANDBEHAVIOR AND LEARNING. BEHAVIORAL EFFECTS OF OIHETHOXY

AD-710 1;6 PHENYLETHYLAMINE; A POTENTIALPSYCMOTOTENo

*BLASCMKOt HERMANN AD-686 9g9

HYIROXYINOOLE OXIDASE IN THE eDOMINg; EOWARD P,

CRySTALLINE STYLE OF PINNA NOBILIS. • . .An-62) ;?f THE CHEMISTRY AND PHARMACOLOGY OF

CERTAIN COMPOUNDS AFFECTING THE*UOGDANSKI. DONALD F, CENTRA. NERVOUS SYSTEM OF ANIMALS

** 0 *AND MANeDIFFERENTIAL EFFECT OF LSD UPON AO-707 666

HASITuATI'4G AND gXTINGUISHINGEVOKED RESPONSES, THE CHEMISTRY AND -HARMACOLOGY OF

AD-613 764 CERTAIN COMPOUNDS APFECTING THE

CENTRAL NERVOUS SYSTEM OF AN1MALS0SRIGGS, ARTHUR Me AND MAN.

S* 0 AD-707 669CARDIOVASCULAR SYSTEM.

AD-7)4 407 ODONAHOC, HUGH Be

.6DOWN, T. S. NEUROTROPIC EFFECTS IN RELATION TOCHEMICAL STRUCTURE,

PROLONGED EFFECTS Or LSD ON EEG AU-7I1 ;78

RECORDS DURING DISCRIMINATIVE * ;

PERFORMANCE IN CAT: EVALUATION BY NEUROTROPIC EFFECTS IN RELATION TOCOMPUTER ANALYSIS, CHEMICAL STRUCTURE,

AD-622 846 AD-715 .79

eBUCKY, STEVEN F. NEUROTROPIC EFFECTS IN RELATION TO* * 0 CHEMICAL STRUCTURE,

THE RELATIONSHIP BETWEEN PAST AD-TI1 ;8O

RACKGROUND AND DRUG USE, * . .AD-739 102 NEUROTROPIC EFFECTS IN RELATION TO

CHEMICAL STRUCTURE*

OCHOJNACKI| RICHARD E. AD-719 )81

PRSN OCPSIN iNT&RNAL NEUROTROPIC EFrECTS IN RELATION TOMEnICINE. VOLUME IV, NUMBER 9. CHEMICAL STRUCTURE.

P-2UNCLASSIFIED

UNCLASSIFIED0OW-NAN

AM-.719 3620** * * VISUAL IMAGERY PRODUCED BY RHYTHMIC

NEUROTROPIC EFFECTS IN AELATION TO PHOTIC STIKU.ATION: PERSONALITY

CHEMICAL STRUCTURE. CORRELATES AND PHENOMENOLOGY,AD-719 )0) AD-&I9 69$

0et

MEUROTROPIC EFrECTs IN RELATION TO *VROCHLICM, HARRY Ie

CHEMICAL STRUCTuRE. * 6

AO-710 )85 ACUTE TOXICITY OFTETRANYDROCANNASINOL TO MICE IN

ODOLER, MICMAEL J, ALTERED ENVIRONMENTS,

* * , AO-'IS8 700IEFFECT OF LYSERGIC ACID

DIETHYLAMIDE ON ESCHERICHIA COLI, ePUJI|ORfI NASINOTOSTRAIN B.ORILAMSDA). 0 0 4

AD-OI 170 CEREBRAL SYNAPTIC TRAN9MISSION AND

SEHAVIORAL EFFECTS OF DIMETHOXY

*fAIRCHIL•O H, DAVID P'IENYLETHYLAMINEI A POTENTIALS111 PSyCNOTOGEN,

INTERIM PRORESS REFT. I OCTOBER 60- A,-6A6 09311 MARCH 1961 .

AO-2%6 169 *SERSCHENFELD; He Me

METHYLENEDIOXY-AMPHETAMINC S9-YDROXTRYPTAMINE RECEPTORS AND

HALLUCINOGENIC SERIES OF COMPOUND SYNAPTIC TRANSMISSION IN MOLLUSCAN(1). CONDITIONED BEHAVIOR AND NEuRONES.ELECTROENCEPHALOGRAPHIC TEST AD-6) W67

-ETHODS Eli)ETO-269 Ito ONALASZ; MICHAEL F,

I. CETHYLENEDIOXY-AMPHETAMINE HALLUCINOGeN-TRANQUILIZERHALLUCINOGENIC SERIES OF COMPOUNDS. INTERACTION: ITS NATURE.II. CONDITIONEO BEHAVIOR AND AD-740 4)0

ELECTROENCEPHALOGRAPHIC TESTMETHODS *HARDMAN. HAROLD P.

AO-294 908 e0 0

THE CHEMISTRY AND PHARMACOLOGY OF*FERGUSON; C. PARKER CERTAIN COMPOUNDS AFrECTING THE

* * . CENTRAL NERVOUS SYSTEM OF ANIMALS

TETRAwYOROCANNABINOLS 11 AND MAN, A PHARMACOLOGICALSYNTHESIS OF EIGHT ISOMERS OF A COMPARISON OF CA 1476SYNTHETIC TETRAHYDROCANNABINOL. (TETRAMYDROCANNABINOL) ISOMERS.

AO-,66 934 AD-707 667

O•ORMANEK, JAROSLAV THE CHEMISTRY AND PHARMACOLOGY Of• * # CERTAIN COMPOUNDS AFFECTING THE

MALLUCINOGEN.TRANQUILIZER CENTRAL NERVOUS SYSTEM OF ANIMALS

INTERACTION: ITS NATURE. AND MAN.AO-7T0 43O AD-7O7 666

OFREEDMAN, SANFORD Jo THE CHEMISTRY AND PmARMACOLOGY OF

UNCLASSIFIED

UNCLASSIFIeOHAS-LAN

CERTAIN COMPOUNDS AFFECTING THE . * *

CENTRAL NERVOUS SYSTEM OF ANIMALS NEUROTROPIC EFFECTS IN RELATION TO

AND MAN. CHEMICAL STRUCTURE,AOD707 669 AD-7i1 $43

geC

*HMASCTT, C. C. NEUROTROPIC EFFECTS IN RELATION TO

* * * CHEMICAL STRUCTURE.THE INCAPACITATING EFFECTS Of AO.II 380

CERTAIN COMPOUNDS, MEASURED BY THERLSPONSES OF FLY LARVAE. *KASVINSKYo PETER 4JAD-91 911 0 0 6

STUDIES OF FLUOROMETRIC ASSAYOMELMREICN; ROSERT PROCEDURES FOR LYSERGIC ACID

* *. DIETMYLAMIDE,

OPINION CHANGE IN THE ADVOCATE AS A AD-777 671FUNCTION OF THE PERSUASISILITY OFHIS AUDIENCE: A CLARIFICATION OF OKENNEDY, DENIS

THE MEANING OF DISSONANCE. * * *Ao-696 947 PERCEPTUAL CHALLENGE TO MEASURE

ILLNESS AND THERAPY,sHIVELYs RICHARD L AL-740 4)1

SYNTHESIS OF AN ISOMER OF *KETCHUM, JAMES S.

TETR•AHYDROCANNASINOL. o q 0

AD-411 389 STUDIES OF THE EFrrCT OF7PERSONALITY ON REACTIVITY TO LS6.

OHIVYLY, RICHARD Le AD-728 449

SYNTHESIS AND IS;OLT;ON OF .KLAPPER, JACK A.TLTRAHYDROCANNABINOL ISOMERS. 0 *AD-N86 326 STUOIES OF THE EFFECT OF

PERSONALITY ON REACTIVITY TO LSO3oMoFFMA.4, F.W AD-72S 4N9

SYNTHESIS OF AN ISOMER OF THE EFFECT OF PERSONALITY ON

TETRAHYDROCANNABINOL, REACTIVITY TO AAD-4il 289 TETRAHYDROCANNABINOL*

AO-730 900*HOFFMANN; FRIEDRICH 0.; ;; KYSORq KRAGG P9

SYNTHESIS AND ISOLATION OF . * .

TLTRAHYDROCANNABINOI, ISOMERS. STUDIES OF THE EFFECT OFAO-486 32& PERSONALITY ON REACTIVITY TO LSD.

AD-728 449*HORITA, A

S* o *LANGFITT, THOMAS WSOME SIOCHEMICAL STUDIES ON * * &

PSILOCYBIN AND PSILOCIN THE PHARMACOLOGICAL PROPERTIES OF

AD-291 097 AN EVOKE) POTENTIAL IN THE MIDBRAINRETICULAR FORMATION

*HUFKIRo WILLIAM Js AD-267 2§7

P-qUNCLASSIFIED

UNCLASSIFIEDLAS-NE[I

*LASCANO, CARMEN AO-•60 79)

ESTUDIO DE UNA EPECOIL HALLUCINOGEN.TRANQUI||cERPSICOTOMIMETICA: IPomOEA CARNtA INTERACTION[ ITS NATURE,(STUDY OF A PSYCmOTOMIMETIC PLANT! AD-74O 400IPOMOEA CARNEAP; 4**

AD-642 972 PERCEPTUAL CHALLENGE TO MEASUREILLNESS AND THERAPY*

OLIWSCMITZ, Y. AO-7'O 4)1SoS

SYNTHESIS Or ALPHA-HYOROXY-ALPHA- 4MCCOLLOCHe MICHAEL A.

AMINO ACIDS AND ERGOT ALKALOIDS. * * 0

AD-660 447 STUDIES OF THE EFFECT OrPERSONALITY ON REACTIVITY TO LSOD

OLON4O, VINCENSO 4 AD-728 q'9

EFFECT OF DRUGS ON CENTRAL NERVOUS THE EFFECT OF PERSONALITY ONSYSTEM NEURONES. REACTIVITY TO A

AO.-qlq o0 TETRAHYDROCANNABSNOL,AD-?!r 90p

6MARCHIANKS, Re NMA-,eYOA A a *RvCLOTHLIN; WILLIAM N,SEROTONIN BINDING TO PREPARATIONS . . .

FROM RAT BRAIN, HAL .UCINOGENIC DRUGS? A :1AD-607 167 PERN'ECTIVE NITH SPECIAL REFERENCE

TO PEYOTE AND CANNABIS,

OMARKS, PATRICIA A. -"O-602 6280* 0 S 0.5

VISUAL IMAGERY PRODUCED BY RHYTHMIC LONG-LASTING EFFECTS OF LSD ON

PHOTIC STIMULATION: PERSONALITY CERTAIN ATTITUDES IN NORMALSI AN

CORRELATES AND PHENOMENOLOGY, EXPERIMENTAL PROPOSAL,AD-61 679 AD-604 002

SMARRAZZI, AMEDEC So *MCKENZIE, RICHARD E,

a a* 0 0 S S 1

CEREBRAL INTEGRATION AND ITS PROCEEDINGS OF THE ANNUALASSESSMENT BY DRUGS, CtOiFERENCE OF AIR FORCE BEHAVIORAL

AD-64? 796 SCIENTISTS (15TH), SHEPPARD AIR* * . FORCE BASE; *ICHITA FALLS, TEXAS,

CEREeMAL SYNAPTIC TRANSMISSION AND 31 JANUARY TO 2 FEBRUARY 1966.BEHAVIORAL EFFECTS OF DIMETNOXY AD-682 5I1PHENYLETHYLAMINE: A POTENTIALPSYCHOTOGEN, eMEISCH; RICHARD A.

AD-686 993 0*AS . *CEREBRAL INTEGRATION AND ITS

PRIMATC CEREBRAL SYNAPTIC ASSESSMENT BY DRUGS.INHIBITION by DRUGS, AD-647 796

AD-686 995 0 0 a. a QUANTIFIED LSD EFFECTS ON EGO

QUANTIFIED LSO E;FFCTS ON EGO STRENGTH,STRENGTH, AD-bQ& 792

P-S

UNCLASSIFIED

UNCLASSIFIfDNI L-RUB

*NILLER, CHARLES H. THE MEANING Or DISSONANCE** • *AD-696 9q7SYMPOSIUM ON DRUGS AND SENSORY

FUNCTIONS. OT|S, LION S.AD-481 832

*LO

fMONROls RUSSELL Ro DISRUpTION OF SIZE OISCRZMINATIONIN SQUIRREL MONKEYS SAIRISCIUREUS) BY LSo-25,EFFECTS OF LYSERGIC ACID AND ITS AD-,4? 123

DERIVATIVES ON RHINENCEPHALIC

ELECTROGRAMs. 0PAPIRMIiSTtR; BRUNOAO-720 279

A 279 LYSERGIC ACID bIETHYLANIOE:

REPORT ON THE SPECIAL AGENT CA- PHOTOOYNANIC ;NACTIVATION OF REPAIRAD-720 280 OEFICIENT E. COLI AND t111

SACTERIOPNAG ,.PROGRESS REPORT ARMy CHEMICAL AO-701 171

CONTRACT UA-It.IOB..CML.596, OPEW; WILLIAM LoAD-720 281*0

D e . 0 QUANTIFIED LSD E;FEC;S ON EGOLYSERGIC ACID Df;I:A IYS. STRENGTH,AD*72n 792

AO-686 79)

ONARANJO; CNRIQUETA DE *PORTZRI R,

ESTUDIO DE UNA ESPECIE PROLONGED EFFECT; OF*LSD ON EEGPSICOTOMIMETICA: IPOMOEA CARNEA HECORDS DURING DISCRIMINATIVE(STUDY OF A PSYCHOTOMINETIC PLANT: PERFORMANCE IN CATI EVALUATION BYIPOMOEA CARNEA), COMPUTER ANALYSIS,

AO-642 971 AO-622 S6q

*NARANJO; PLUTARCO *PRAY; SIONCY L.

ESTuDIo DE UNA EpEC*IE EFFECT OF A CHEMICALLY DEPRESSEDPSICOTOMIMETICA: IPOMOCA CARNEA AMYGDALA ON THE BEHAVIORAL(STUDY OF A PSYqHOTOMIMETIC PLANT: MANIFESTATIONS PRODUCED IN CATS BYIPOMOEA CARNEA).

LSD-209A0-6S2 972

AO-6I8 *02ETNOFARMACOLOGjA DE LAS PLANTAS OREILLY; "Us" T.

PSICOTROPICAS DE AMERICA

(ETHNOPMARMACOLOGY Or THE DRUG IOENTIFICATION, PRO,ý.RTICS ANDPSYCHoTROPHIC PLANTS OF AMERICA), CHARACTERISTICS: NARCOTICS*AD-691 SY) STIMULANTS, DEPRESSANTS, MARIJUANA

AND HALLUCINOGENS,*NEL, ELIZABETH A'q-7M| 338

OPINION CHANGE IN ;HI ADVOCATE AS A *RUBIN, ROgBRT r.FUNCTION OF THE PERSUASIBILITY OF o*.HIS AUDIENCE! A CLA4IVICATION OF CLINICAL ASPECTS OF MARIJUANA AND

P.6

UNCLASSIFIED

W

UNCLASSIFIEO

SAN-STE

AMPHETAMINE USE, AD-447 131AD-?)? 7J6

*SAN$ONtTTI, CRAIG J. *SHEATl, Guy c.

DIFFERENTIAL EFFECT Or LSD UPONORtLG IDENTIFICAT;ON PROPERTIES AND MADITUATING AND EXTINGUISHINGCHARACTERISTICS: NARCOTICS, EVOKED RESPONSES,STIMULANTS, DEPRESSANTS; MARIJUANA AD-6I1 764AND HALLUCINOGENS.

AD-7NI "6e *SIDELL; , no

*SCHIELE; BURTRUM C. THE EFFECT OF PERSONALITT ON* . * REACTIVITY TO ACEREBRAL INTEGRATION AND ITS TETRAHNOROCANNABINOL.

ASSESSMENT BY DRUGSo AO-73O 900AO-6q? 796

*SCMUSTERNANp RONALD JSILVERNAN; ALDER? 4.

• * . PSYCHOPHYSIoLOGICAL MECHANISMS OF rDISRUPTION OF S5ZE O;SCRIMINATION STRESS RESPONSIVITY.IN SQUIRREL MONKEYS tSAIMIRI AD-608 402SCIUREUS) BY LSD-209AD-6q7 12 2 4SI M, VAN M.

*SEEVER3. MAURICE M: STUDIES Or THE EFFEC; OF .* ; * PERSONALITY ON REACTIVITY TO LS,THE CHEMISTRY AND PHARMACOLOGY OF AD-728 '149CERTAIN COMPOUNDS AFFECTING THECENTRAL NERVOUS SYSTEM OF ANIMALS OSNYDERt ; e 14 MAND MAN, A PHARMACOLOGICALCOMPARISON OF EA 1476 THE INCAPACITATING EFFECTS OFITETRAHYDROCANNABINOL) ISOMERS. CERTAIN COMPOUNDS. MEASURED BY THEAD-707 667 RESPONSES OF FLY LARVAE.

THE CHEMISTRY AN; ;H:RMACOLOGY OF AD-i 111CERTAIN COMPOUNDS AFFECTING THE 0SPYROPOULDS0 PERICLESCENTRAL NERVOUS SYSTEM OF ANIMALS * a *ANO MAN. THE ROLE OF THE CENTRAL NERVOUSAD-707 660 SYSTEM CHOLINERGIC MECHANISMS IN

BEHAVIOR AND LEARNING.THE CHEMISTRV AN; ;HARMACOLOGY OF AD-718 1,6CERTAIN COMPOUNDS AFFECTING THECENTRAL NERVOU5 SYSTEM OF ANIMALS sSTEELE, ROotRAND MAN.

An-707 669 SYNTHESIS OF AN ISOMER OF

TETRAMYDROCANNABINOL,01HARPE, LAWRENCE Go AD.qll 3190 0

DISRUPTION OF SIZE DISCRIMINATION OS(EFANI, 9IN SQUIRREL MONKEYSESAIMIRI * 0SCIUREUS, BY LSO.20, 5-HYDROXTRYPTAMINE RECEPTORs AND

P-7UNCLASSIFIED

C!

UNCLASSIPFIESTO-O0O

SYNAPTIC.TRANSMISSION IN MOLLU SCAN 0 *NEURONES, EFFECT OF LYSZRGIC ACID

SAD-62) :07 OIETHYLAIOE ON ESCMERICNIA COLIsSTRAIN GtR(LAMBOAT.

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CEREBRAL SYNAPTIC TRANSMISSION ANDBEHAVIORAL EFFECTS OP'OIMtTHOXYPHENYLETHYLANINEI A POTENTIALPSYCHOTOGEN.

OWALTER, Do 0O

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AD-622 8"6

*WILSER, CHARLES G

THE EFFECT OF DRUGS ON PHYSICALPERFORMANCE IN ANIMALS

AO-289 261

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NEUROPHARMACOLOGICAL STUDIES AND

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