Hair Growth Promoter
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Transcript of Hair Growth Promoter
Nattaya Lourith, Ph.D. 1
Anti-hairloss and Hair growth promoter
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Hair growth cycle
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Hair cycle of head hair shaft
Stage of the hair cycleAnagen : the growing phaseCatagen: the intermediate phaseTelogen : the shedding phase 4
Hair growth cycle
Exp. Gerontol. 2002;37:981-90.
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Hair follicle gradually terminated Terminal hair changes to vellus hair
Vellus hair : Terminal hair = 6-8 : 1 NormalVellus hair : Terminal hair = 0.1-3.9 : 1 Bald
Hair Loss
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Causes of hair loss
Reduction in hair follicle function due to male hormones
Reduction in metabolic functions of hair follicles and hair bulbsReduction in scalp physiological functions
Local impairment of circulation due to tension in the scalp
Nattaya Lourith, Ph.D. 2
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Physical stressEmotional stressDiet considerationsHormonal causesEndocrinopathyOral medications:
Blood thinning agentsRetinoidsAntihypertensive agentsMiscellaneous
Hair Loss
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Overall causes
AndrogenGenetic Age
Testosterone 5α-Dihydrotestosterone
Androgenic alopecia
9Semin. Cutan. Med. Surg. 1998;17:276-283. 10Semin. Cutan. Med. Surg. 1998;17:276-283.
11J. Am. Acad. Dermatol. 2001;45(suppl):S70-80.
Regions of scalp potentially involved in pattern hair loss12
A. Regional scalp hair density scale
B. Regional scalp zones F : Frontal
M : Mid
T : Temporal
V : Vertex
J. Am. Acad. Dermatol. 2003;48:253-62.
Nattaya Lourith, Ph.D. 3
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Hair loss patterns in male
J. Am. Acad. Dermatol. 1985;13:185-92.
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Male Pattern Diffuse Frontal Accentuation
(Hamilton/Norwood) (Ludwig) (Olsen)
Hair loss patterns in female
J. Am. Acad. Dermatol. 2003;48:253-62.
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Graduation of hair loss in Ludwig pattern
J. Am. Acad. Dermatol. 2003;48:253-62. 16
Graduation of hair loss in frontal accentuation pattern
J. Am. Acad. Dermatol. 2003;48:253-62.
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Savin patterns of hair loss
J. Am. Acad. Dermatol. 1999;40:106-9. 18
Big head? Bald head?
Med. Hypo. 2009; 72: 23-28.
Nattaya Lourith, Ph.D. 4
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Hair care products
Hair cleansing productsHair growth promotersHair grooming cosmeticsHair waving and straightening productsHair coloring products
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Basic ingredient and functionDetergent : removes dirt, styling products, sebum and skin scale from hair and scalpFoaming agent: allows shampoo to foamConditioner : soften and smoothen hair after sebum removalThickener : thicken shampooOpacifier : makes shampoo opaque
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Basic ingredient and functionSequestering agent : prevent soap scum from forming on hair and scalp in hard water
pH adjusters or neutralizer : minimize hair damage from baseFragrance : give acceptable smell
Preservative : prevent microbial and fungal contaminations
Specialty additive : treatment ingredient or marketing aid to impart other benefit to shampoo
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Basic shampoo categoriesNormal hair shampooDry hair shampooDamaged hair shampooOily hair shampooEveryday shampooDeep cleaning shampooBaby shampooMedicated shampooConditioning shampooHair dyeing shampooEthnic shampoo
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Active ingredients : Hair loss
Finasteride : 5α-reductase Type II inhibitorMinoxidil : vasodilator (long lasting anagen)Dutasteride or GI198745 : 5α-reductase inhibitorIamin or prezatide copper : 5α-reductase inhibitorFolligen or copper chloride : 5α-reductase inhibitorZinc : hair growth, 5α-reductase Type I inhibitorPolysorbate 80 : hair growing improvement
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MK-386 or β-dimethyl-4-aza-5-cholestan-3-one: 5α-reductase inhibitorWO9704002 : 5α-reductase inhibitorFCE28260 : 5α-reductase inhibitor
FCE26073 or Turosteride : 5α-reductase Type II inhibitorKetoconazole : Androgenetic blocker
Active ingredients : Hair loss
Nattaya Lourith, Ph.D. 5
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Canrenone 2%Spironolactone 3%DexamethasonePrednisone Cyclosporin ACyproterone acetateFlutamideDrospirenoneBromocriptine
Active ingredients : Hair loss
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Amino acids : hair growth and healthy, 5α-reductase inhibitorBiotin : hair nutrient and hair growthFolic acid : hair nutrient and hair growthProcyanidin B3 : hair thickener Azelaic acid : strong DHT inhibitorFerritinB7, B12
Active ingredients : Hair loss
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PhytoestrogensIsoflavone
DaizeinGenisteinGlycitein
LignansEnterodiolEnterlactone
BisnapthaquinoneCapsaicin (-)-epoglaaocatechin-3-gallate Soymethide-4
Active ingredients : Hair loss
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5α-reductase inhibitorHair regrowth promoter
Essential fatty acidγ-linolenic acid, α-linolenic acid, palmitoleic acid, oleic acid, myristoleic acidpalmitic acid, stearic acid, oleic acid, linoleic acidEvening primrose oilEmu oil
β-sitosterol
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Saw palmetto : Serenoa repens
- DHT formation inhibitor
- 5α-reductase inhibitor
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Pygeum : Pygeum africanum
- Androgenic blocker
- 5α-reductase inhibitor
Nattaya Lourith, Ph.D. 6
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Holy basil : Ocimum sanctum
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Chillies
- Capsaicin
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Fenugreek : Trigonella foenum
- Multivitamin B
- Hair root strengthen
- DHT formation inhibitor
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False daisy: Eclipta alba
- Hair growth promoter
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False daisy: Eclipta alba
87.5480.4 ± 41.266 ± 7.33.2 mg E.alba
50417.4 ± 35.939 ± 8.41.6 mg E.alba
87.5253.25 ± 6.673 ± 8.22% minoxidil
87.5160.2 ± 1069 ± 3.91% minoxidil
Anagen induction, %Skin thickness, μmFolicle count Treatment
J. Ethanopharmacol. 2009. doi:10.1016/j.jep.2009.05.023
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Fennel : Foeniculum vulgare
- Antiinflammatory
- Androgenic blocker
- 5α-reductase inhibitor
Nattaya Lourith, Ph.D. 7
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Nettle : Urtica dioica
- Androgenic blocker- DHT blocker - 5α-reductase inhibitor- Blood circulator
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Bayberry : Myrica rubra
- 5α-reductase inhibitor- Hair growth stimulant- Anti hair loss
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Arborvitae : Thuja- 5α-reductase Type II inhibitor- sebum reduction
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Arborvitae : Thuja
0.34 μMFinasteride
2.6 μg/mlT. occidentalis
5.55 μg/ml (19.93 μM)γ-Linolenic acid
31.55 μg/ml (112.50 μM)Linoleic acid
5α-reductase Type II inhibitor, IC50 Compounds
J. Dermatol. Sci. 2003; 31: 91-98.
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Gourds
- 5α-reductase inhibitor- Anti hair loss
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Avocado : Persea americana
- 5α-reductase Type I inhibitor- Sebum secretion reduction- Antidandruff- Antiitching
Nattaya Lourith, Ph.D. 8
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Hop : Humulus lupulus
- 5α-reductase inhibitor- Hair growth stimulant- Scalp tonics
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Burdock : Arctium lappa
- Scalp tonics
- Antidandruff
- Antiitching
- Anti hair loss
- Hair sheening
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Pumpkin
- 5α-reductase inhibitor
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Grape seeds
- proanthocyanidins
- in vitro hair follicle proliferation promotion
- in vivo Telogen converts to Anagen
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Willow - Antiinflammatory
- 5α-reductase inhibitor
- Hair loss treatment
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Black cohosh : Cimicifuga racemosa
- 5α-reductase inhibitor
Nattaya Lourith, Ph.D. 9
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Soy bean Flax seed
- 5α-reductase inhibitor- Grey hair treatment
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Ginkgo : Ginkgo biloba
- Hair regrowth promoter- Astringent- Epidermis growth stimulant- Antiinflammatory- Radical scavenger
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Tea : Camellia sinensis
- Antioxidant
- Androgenic blocker
-5α-reductase inhibitor
-Similar activity with saw palmetto
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Sophora : Sophora flavescens
- 5α-reductase Type II inhibitor
- Anagen elongation activity
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Licorice : Glycyrrhiza glabra
- DHT formation inhibitor
- Hair loss treatment
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Breadfruit: Artocarpus incisus
5α-reductase Type II inhibitor
- Chlorophorin IC50 37 μM
- Artocarpin IC50 85 μM
Melanin biosynthesis inhibition
Planta Medica 2000; 66: 16-19.
Nattaya Lourith, Ph.D. 10
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Henna : Lawsonia inermis Linn.
Hair growth accelerator -Leaf extracts have mild antiinflammatory and antiallergic action and analgesic effect
Impart dark red shades : Lawsone
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Aloe : Aloe vera L.
- Traditionally for hair loss
- Improve hair growth following alopecia
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Rhinacanthus nasutus Kurz.
- Hair loss treatment
- Grey hair treatment
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Butterfly pea : Clitoria ternatea
- Antiinflammatory
- Antioxidant
- Hair growth promoter
- Grey hair recover
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Citrus hystrix DC.
- Wound healing
- Antidandruff
- Soft & smooth hair60
Citrus grandis
Skin & scalp tonic
Exfoliation refresh
Nattaya Lourith, Ph.D. 11
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Sapindus rarak A. DC.
Wound healing
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Acacia concinna DC.
- Cleansing
- Shining
- Antidandruff
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Sesame : Sesamum indicum Linn.
- Skin & scalp soother
- Antioxidant
- Natural moisturizer
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Centella asiatica (L.) Urb.Antioxidant Wound healingBlood circulationScalp conditioningEnergy stimulant DetergentAnti hair loss
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Coconut : Cocos nucifera Linn.
- Saturated fatty acid
- Lauric acid
- Myristic acid
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Cymbopogon citratus Stapf
- Oily and grease hair treatment- Antidandruff - Antiseptic
Nattaya Lourith, Ph.D. 12
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Garlic : Allium sativum L.
- Dandruff control- Antiseptic- Tonic- Antioxidant- Antiinflammatory- Antibacterial- Antifungal
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Ginger : Zingiber officinale Roscoe
- Antiinflammatory- Blood circulation stimulant- Muscle relaxation - Hair loss treatment
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Ginseng : Panax ginseng
- Skin & scalp soften- Aniinflammaroty- Blood circulation- Cell regeneration
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Rice: Oryza sativa
- Skin & scalp conditioning- Moisturizer - Emollient - Antioxidant
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Almond: Prunus amygdalus
- Skin conditioning- Moisturizer - Sun protect
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Sage : Salvia officinalis L.
- Hair conditioning- Maintain the sheen of dark curly hair- Strengthen and stimulate hair growth- Antidandruff- Anti hair loss- Greasy hair treatment
Nattaya Lourith, Ph.D. 13
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Rosemary : Rosmarinus officinalis Linn.
- Stimulate hair growth- Antioxidant - Greasy hair conditioner- Gives body and sheen to hair- Daily antidandruff treatment
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Thyme :Thymus vulgaris L.
- Inhibit dandruff
- A scalp rub to prevent hair falling out
- Promote natural hair health
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Swertia japonica Makino
- abdominal pain- skin infection- blood circulation- hair growth stimulant
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- Eczema
- Acne
- Hair loss
- Scalp itching
- Scalp peeling
- Dandruff
- Emollient
- Skin disorder treatment: crack, abrasion, frostbite, chaps
- Sun burn treatment
- Nappy rashes
English Walnut Juglans regia L.
Black walnut : Juglan nigra
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Honey
- Hair growth promoter- Skin & scalp conditioning
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Propolis
- Antifungal - Antibacterial - Similar activity with aloe
Nattaya Lourith, Ph.D. 14
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14Fruit juices Citrus hystrix79Leaves Ixora maerothyra 75Leaves Artocarpus altilis53Leaves Mitragyna hirsuta51Leaves Piper betle47Fruits Passiflora foetida47Leaves Eucalyptus sp.
29Flowers Clitoria ternatea
25Fruit peelsCitrus hystrix
25Leaves Leucaena leucocephala
23Leaves Flagellaria indica
21Fruits Acacia concinna
5Leaves Albizia myriophylla
0Leaves Tamarindus indica
0Leaves Alpinia galanga5α-reductase inhibitory activity, %Parts Plants
J. Wood Sci. 2000; 46: 385-389 Conc. 200 μg/ml 80
Provillus
Hair loss treatment example products
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Hair loss treatment example products
- Kigelia africana
- Salvia sclarea
- Gingko biloba
- Cinnamomum zeylanicum
- Panax ginseng
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- Niacin- Biotin- Plant Phytosterols- Saw Palmetto Berry- Macadameia Nut oil- Borage Oil- Evening Primrose oil- Pygeum africana- Green tea extract
Hair loss treatment example products
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Minoxidil 5% w/v for men
Minoxidil 2% for women
Hair loss treatment example products
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- Linolenic acid- Linoleic Acid- Oleic Acid- Azaleic acid- Vitamin B6- Zinc- Saw Palmetto Extract- β-Sitosterol- Procyanidin Oligomers
Hair loss treatment example products
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- Hops extract - Rosemary extract
- Swertia extract
- Si compounds
- Panthenol
Hair loss treatment example products
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- Saw palmetto- zinc- nettles- pumpkin seed extract
Hair loss treatment example products
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Hair loss treatment example products- Soy bean
- Panax ginseng
- Castanea sativa
- Arinca montana
- Hedera helix
- Geranium maculatum
- Inositol, Panthenol
- Cystine, Cysteine, Methionine
- Biotin 88
Hair loss treatment example products
- Swertia extract
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Hair loss treatment example products
- Biotin- Zinc PCA- Panax ginseng, Ginkgo biloba, Swertiajaponica, Palmaria palmata, Soy bean germ,Glycyrrhiza glabra extracts - Simmondsia chinensis Oil,- Benzyl Nicotinate, Inositol, L-Cystine,Cysteine, Choline, Niacin, Methionine
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Hair loss treatment example products
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Mice hair lengthhair growth area
Rabbits hair length and weight
Hamsterssebaceous glands size (in vivo)5α-reductase inhibition (in vitro)DHT receptor inhibition (in vitro)
Monkeyshair growth at head
Animals
Hair growth promoters evaluations
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Hair growth promoters evaluations
hair roots culturehair root cells culture
Tissue culture
photographic evaluationtrichogram method5α-reductase inhibitionhair wash testblood flow measurement
Humans
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Hair growth promoters evaluations : Mice
30 days application of Asiasari radix extract 1% solution in 40% EtOH
J. Dermsci. 2005; 38:89-97. 94
Hair Loss / Hair Growth
Principle- Anti-hair loss efficacy- Anti-hair regrowth products- Videomicroscope visualizationsProtocol design- Long term studies: M0-M1-M2- Up to M0-M3-M6 studies- Female and male volunteers- No age criteria
Biometrological Test
Videotrichogram®
D0 D2
Illustrations : the telogenous hairs
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Selected references Lee OS, Kang HH, Han SH. 1997. Oriental herbs in cosmetics. Cosmet Toiletries 112:57-64.Kameyama S. 1995. Application and consideration of medicinal plants for hair care products. Frag J 23:28-34.Takahashi T, Kamiya T, Yokoo Y. 1998. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venerol 78:428-432.Kim SH, Jeong KS, Ryu SY, Kim TH. 1998. Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice. In vivo 12:219-222.Camacho-Martínez FM. 2009. Hair loss in women. Semi. Cutan. Med. Surg. 28:19-32.Yonenaga M. 2001. Henna leaf extracts and makeup materials containing henna. Jpn Kokai Tokkyo Koho Patent JP2001335496.Bruneton J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. Lavoisier Publishing: Paris.
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