Haematological Responses of Clarias Gariepinus Exposed to Anaesthetics

7/29/2019 Haematological Responses of Clarias Gariepinus Exposed to Anaesthetics

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Continental J. Pharmacology and Toxicology Research 4 (1): 18 - 29, 2011 ISSN: 2141 4238

Wilolud Journals, 2011 http://www.wiloludjournal.com

` Printed in Nigeria

HAEMATOLOGICAL RESPONSES OF Clarias gariepinus EXPOSED TO ANAESTHETICS

METOMIDATE

1Gabriel, U.U.,

2Deelae. S.N.

3Akinrotimi, O.A

4Orokotan, O.O.

1,2Department of Fisheries and Aquatic Environment, Faculty of Agriculture, P.M.B. 5080, Rivers State

University of Science and Technology, Port Harcourt, Rivers State,3African Regional Aquaculture

Centre/Nigeria Institute for Oceanography and Marine Research P.M.B. 5122, Port Harcourt, Rivers State,4Gabrovic Agric Nig. Ltd. Fishery Consultancy Service 100 East West Road, Eliozu Junction, Rumuodara,

Port Harcourt, Rivers State, Nigeria.

Corresponding author:Akinrotimi , E-mail:[email protected]

ABSTRACT

Haematological responses ofClarias gariepinus exposed to different levels of anaesthetic metomidatewere investigated, using varying concentrations (0.00 control, 0.25, 0.75, 1.00, 2.00, 4.00, 6.00, 8.00,

10.00 and 12.00 mL-1

) in triplicates. The result obtained from the study indicates that the anaestheticcaused a concentration dependent changes in the blood ofC. gariepinus with significant reduction (P 0.05) in the values of neutrophils, eosinophils, and monocytes under

metomidate agrees with the report of Wey et al. (1996), in gold fish, Carassius auratus exposed to 2-phenoxy

ethanol at different temperatures and concentrations. The increase in number of these differential counts may be

due to recruitment of more cells to resist the stressor.

CONCLUSION

In summary, metomidate anaesthetics was associated with changes in blood parameters of C. gariepinus.

However, the effects of the anaesthetics were different from one another in the measured variables. On the basis

of this experiment, it appears that metomidate effects on the blood parameters is concentration dependent, with

the highest effects observed in the fish exposed to 12.0Ml/L. Hence application of metomidate should not be

too high, not exceeding 8.0m/L-1

in application.

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Received for Publication: 26/06/11

Accepted for Publication: 26/08/11

Akinrotimi, O.A

African Regional Aquaculture Centre/Nigeria Institute for Oceanography and Marine Research P.M.B. 5122,

Port Harcourt, Rivers State, Nigeria.E-mail:[email protected]

Haematological Responses of Clarias Gariepinus Exposed to Anaesthetics

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