H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg...

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H 2 O

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Transcript of H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg...

Page 1: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.

H2O

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CaCO3

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C2H5OH

Page 4: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.

(C650,000 H4,400,000 O1,800,000

N100,000 Na3 Cl3 S2 K1 Ca0.3

Mg0.3 P0.3 Fe0.1 Zn0.1 Cu0.01

Si0.001 Co0.00001 Se0.0000001….)n

Page 5: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.

Medical Use

Trace Element

Page 6: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.

Human Carbonic Anhydrase II

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Human Carbonic Anhydrase II

Håkansson, K.; Carlsson, M.; Svensson, L. A.; Liljas, A. J. Mol. Biol. 1992, 227(4), 1192.

CO2 + H2O

HCO3– + H+

3 × 108 dm3 mol–1 s–1

Page 8: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.
Page 9: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.
Page 10: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.
Page 11: H2OH2O. CaCO 3 C 2 H 5 OH (C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si 0.001 Co 0.00001.

The Main Challenges

•Understanding

•Biomimetic Chemistry

•New drugs

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0

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801

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Selenium Intake UK / microg d-1

MAFF Food Surveillance Information Sheets 126 and 191

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Biomimetic Chemistry

2H+ + 2e- H2 Hydrogenases

CO2 + H2O HCO3- + H+ Hydrases

6CO2 + 6H2O C6H12O6 + 6O2 Photosystems

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zinc(II)

His-94His-96 His-119

His-200

Glu-106

Thr-199

O(1)O(2)

O(3)

Liljas, A.; Xue, Y.; Vidgren, J.; Anders Svensson, L.; Jonsson, B. H.; Lindskog, S.; Proteins, 1993, 15, 80

M

O

O

O

q = interplanar angle

plane one

plane two

Active Site Structure of HCA II Thr-200 His Complex with HCO3

–

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Complex and Active Site

Zn(1) N(5) = 5.641(2) cf. Zn N(Thr199) = 5.851(4) Å

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New Medicines

O2 + e - O2 -

superoxide

2O2 - + 2H+ H2O2 + O2

Superoxide dismutase

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IC50 value = 3 x 10-6 mol dm-3

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