GREEN GOLD A portfolio of 10 Commercially Successful Southern African Herbs

“60 % of worlds plant species are in Sub Saharan Africa... less than 8% of the 1,100 commercialised medicinal plants are from Africa” - AFRHP (2010)

SEARCHING FOR GREEN GOLDOur research has highlighted 10 p l an t s w i t h se r i ous commercial potential, based on these factors: 1 . P ro v e n c o m m e rc i a l success records.2. Stable, long-term supply 3. Well researched and efficacy proven.

This is our introduction to the most promising herbs from Sub Saharan Africa. This is the Green Gold Portfolio

Common names: Aloe ferox Mi l l , Cape Aloe, Aloe ferox bi t ter crysta ls Lat in Name: Aloe ferox Quick Facts : A loe ferox is one of the key commercia l p lant species t raded in Southern Afr ica. I ts been used for centur ies as a natura l laxat ive and has a strong history of internat ional t rade. I ts a natura l laxat ive and bi t ter tonic for improving digest ion, wound heal ing propert ies . Pharmacological propert ies : - Laxat ive - st imulates per is ta ls is and mucous secret ion - Ant i- inf lamatory !

Active ingredients : A lo in Commercial Success: Aloe ferox has been used in the popular remedies “Swedish B i t ters” and “Lewensessens” - Used in many commercia l laxat ive medic ines wor ldwide. - A pure extract of Aloe bi t ters known as Aloes in which is sold by Afr iget ics has appl icat ions in the sk in l ightening industry , especia l ly in Japan. Products Offered: Aloe ferox bi t ter crysta l NLT 12% Aloin amd Aloe ferox bi t ter crysta l wi th NLT 18% Aloin

1. Aloe ferox bitter sap NLT 12% AND NLT 18% Aloin

Common names: Aloe arborescencs powder, a loe whole leaf powder Latin Name: A loe arborescencs. Quick Facts : A loe leaf powder has been used traded to As ia for many centur ies and is t radi t ional ly used in sk incare and weight loss products , a lso ant i-cancer t reatment. Propert ies : A Natural Laxat ive and bi t ter tonic for improving digest ion, wound heal ing propert ies . Immune modulatory propert ies .

Pharmacological propert ies : - Laxat ive - st imulates per is ta ls is and mucous secret ion - Ant i- inf lamatory - ant i-tumorgenic - phytotherapeut ic !Active ingredients : A lo in Commercial Success: Approved in Korea as a natura l supplement for weight loss . Recent studies conducted by the Palat in in Sa lzano Venezia Inst i tute in I ta ly d iscovered that a loe arborescens is 200% r icher in phythorapeut ic compounds than a loe vera.

2. Aloe arborescens leaf powder 1% and 3% Aloin

Common names: Buchu Lat in Name: Agathosma betul ina Quick Facts : Buchu has been used for centur ies by the San Bushmen as a tea. I t has many heal th propert ies and is considered as a general tonic . Recent research highl ights is use as a sports supplement and in weight loss . The leaf powder is used as Ant i- inf lamatory in sports supplements , the oi l i s used in topica l appl icat ions for pain re l ief and ant i-inf lamatory. F lavor and fragrance industry uses the oi l in soft dr inks and perfumes. !

Pharmacologica l propert ies : Diuret ic , Analges ic Act ive Ingredients : Flavonoids, buchu camphor (d iosphenol ) . !Commercia l Success : Commercia l ly used in perfumes and soft dr inks, most ly by European f i rms. The oi ls help enhance frui t f lavours , part icular ly b lackcurrant , making them ideal for soft dr inks and i t ’ s used by the fragrance houses in upmarket perfumes. Coca-Cola recent ly explored i t for their d iet soft-dr inks. Buchu is: FDA-Approved (FDA No: 172.510) and Proven Safe (GRAS No: 2169) Products Offered: Mil led leaf powder

3. Buchu 4. Bulbine natalensisCommon names: Bulbine, Rooiworte l Latin Name: Bulbine nata lens is Quick Facts : Bulbine has been used by Zulu men for centur ies as a natura l aphrodis iac probably due to i ts testosterone boost ing propert ies . Late ly i ts become an increas ingly popular ingredient in the sports supplement industry due to i ts pro-testosterone propert ies . Most of the hype was caused by a study publ ished in South Afr ica showed a 350% r ise in testosterone in rats us ing extracts of Bulbine.

Pharmacological propert ies : Pro-hormone ( testosterone) !Active ingredients : Poss ib ly anthraquinones and sapnonins. Commercial Success: Bulbine products are new to the market of sports supplements but they are r is ing in number quickly . Some successful brands: Prolens is , Testabol . Products offered Mil led stem powder 5:1 Extract (Cold-water soaked, u l t rasonic extract , f reeze-dr ied) .

5. Devils Claw 6.HoodiaCommon names: Devi ls Claw Latin Name: Harpagophytum procumbens Quick Facts : Devi ls Claw is a very popular ingredient in herbal medic ines for arthr i t i s and pain re l ief associated with jo ints and injur ies . !Pharmacological propert ies : Anti-arthr i t ic , Ant ioxidant , Analges ic , Ant i- inf lamatory. Active Ingredients : I r idoid glycos ides, harpagocide, f lavonoids !

Commercial Success: Devi ls Claw has a long history of use in Europe and USA as herbal medic inal products for arthr i t i s and back pain - export volumes are est imated at 600-800 tonnes annual ly . I ts been sold in many products around the wor ld s ince the 1960’s . Products Offered: Mil led powder or f reeze-dr ied extract s tandardized for act ive ingredient Harpagocide.

Common names: Hoodia, Latin Name: Hoodia gordoni i Quick Facts : Hoodia rose to fame when Pf izer chose to use i t as an appet i te suppressant in their S l imFast product . A major r ise in demand from 2004-2006 led to a shortage in supply and fake Hoodia inf i l t rated the market and col lapsed the industry . The cool ing off per iod has been 6 years now and some companies are start ing to re-launch weight loss products containing Hoodia in countr ies other than the USA. !

Pharmacological propert ies : Appet i te suppressant , ant i-diabet ic . Active Ingredients : P57, s teroidal g lycos ides !Commercial Success: The legi t imate Hoodia market was est imated to be worth $100 mi l l ion in 2005, the counterfe i t market was est imated to be many t imes larger than this . Tr imSpa and H-57 were two notable brands on the US market . Products Offered: Mil led leaf powder and freeze-dr ied powder - standardized for NLT 0.25%P57

7. Pelargonium 8.RooibosCommon names: Pelargonium, Umckaloabo Latin Name: Pe largonium s idoides Quick Facts : Cold and f lu remedies - especia l ly chi ldrens cough syrups. Extracts of Pelargonium have been proven to reduce the durat ion and sever i ty of colds, especia l ly re lat ing to bronchia l infect ions of the lungs. Pharmacological propert ies : Anti-microbia l and immunomodulary !Active Ingredients : Umckal in, polyphenols , epi t ichin. !

Commercial Success: In 2006, German pharma company Schwabe sold more than EUR80 mi l l ion of their Pe largonium based product “Umckaloabo”. Other companies across the wor ld are fo l lowing in their footsteps now, us ing Pelargonium based formulat ions for cold care products . F lora in the USA se l ls Pe largonium s idoides preparat ions as “Umcka Cold Care” . Products Offered: Mil led leaf powder and freeze-dr ied extract , s tandardized to: - Umckal in 100 and 300 ppm. - Polyphenols NLT 10%, 20%

Common names: Red Tea, Rooibos Tea Latin Name: Aspalathus l inear is Quick Facts : Rooibos tea is a popular export product in South Afr ica and is a considered a legi t imate a l ternat ive to B lack tea. In the USA i t i s known as “Red Tea” and sold in severa l d i f ferent commercia l teas , and dr inks. The ant ioxidant propert ies of rooibos are used to market i t in sk incare products . !Pharmacological propert ies : Anti-oxidant , antiradicalActive Ingredients : Polyphenols , Aspalathin !

Commercial Success: Rooibos has now become a wor ldwide name and is gaining considerable momentum in the wor ld market . Germany is the largest importer of Rooibos tea form South Afr ica. Products Offered: Rooibos tea leaf cuts in var ious forms ( fermented, green leaf , mi l led to mesh requirement) .

9. Sceletium 10.SutherlandiaCommon names: Kanna, scelet ium Latin Name: Sce let ium tortuosum Quick Facts : Scelet ium is a natura l ant i-depressant that has a lso been shown to improve cognit ion (concentrat ion, cognit ive funct ions) . Al ternat ive to pharmaceut ica l ant i-depressants and more ef fect ive than St John’s Wort . Research shows i t e levates mood and reduces anxiety , s t ress and tens ion. Pharmacological propert ies : SSRI Active Ingredients : Alkaloids , notably mesembrine. !

Commercial Success: PL Thomas (PLT) and South Afr ican partner HG&H Pharmaceut ica ls launched Zembrin at the 2012 SupplySide West show and is set to focus on market penetrat ion dur ing the year 2013. The company bel ieves that Zembrin is h ighly compet i t ive in re lat ion to other ingredients in the supplement industry that support cognit ion, depress ion and stress . Products Offered: Scelet ium herbal powderand Scelet ium standardized extract NLT1 % Alkalo ids, 0.3% mesembrine.

Common names: Suther landia, Cancer Bush Latin Name: Suther landia f rutescens Quick Facts : Suther landia is poss ib ly the most widely used herb in Southern Afr ica, most famously used in the treatment of wast ing in HIV pat ients . I t i s commonly known as “Cancer Bush” because of i ts cancer prevent ion eff icacy has been tradi t ional ly proven. Pharmacological propert ies : Ant i-carc inogenic , ant ioxidant , ant i-inf lamatory, ant i-HIV, ant id iabet ic , ant i-stress ,

ant i-v i ra l , L-arginine antagonist , immune modulatory, b i t ter tonic . Active Ingredients : Carvanine !Commercial Success: Suther ladia is t raded widely in Southern Afr ica but has not yet been sold into the mainstream in any s igni f icant way. The potent ia l for th is mult i-funct ional herb is yet to be real ized. Products Offered: Mil led leaf powder from selected stra ins of h ighly act ive plant mater ia l .

Afrigetics Botanicals forms part of a joint venture co-operation within the South African agri-processing sector. We work with three specific rural communities in the sourcing of our raw materials and share royalties with the the San people of Southern Africa. Our expertise and skills base include exporting ( incoterms 2010 compliance), fo rmal hor t icu l ture , deta i led k n o w l e d g e o f A f r i c a n pharmacology, agri-processing and, sustainable wild harvesting.

Our processing facility is based in the Western Cape of South Africa and is Euro-GAP compliant. All our herbs are processed for active ingredients and microbial standards a c c o r d i n g t o W H O ( 1 9 9 8 )

regulations in the African Herbal Pharmacopoeia (2010). We are licensed to sell protected species, have a va l id benefit shar ing agreement (Bioprospecting License pending) and are endorsed by the SA San Institute.

The partners involved in Afrigetics Botanicals have been actively involved in the trade of African medicinal plants for over 15 years. We also have the capacity and experience to source beyond Sub-Saharan Africa for our customer requirements.

FACILITIES, KEY MEMBERS,

EXPERIENCE.

Steve Hurt is the owner of Afrigetics Botanicals.

His formal studies include an undergraduate degree in Environmental

Science, postgraduate studies at WITS in Local Economic Development and

informal studies in African pharmacology. Steve was voted Businessman of the Year

2012 as nominated by the George Business Chamber.

www.afrigetics.com Sample requests: bwfqueries@gmail.com

Contact Tel: +27(0)448771696

Postal Address: Postnet Suite 123, Bag X6590, George, W.Cape, 6560.

Physical address: 381 waterside Rd, Wilderness, W.Cape, South Africa, 6560