Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society...

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Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington Sea urchin larvae

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Transcript of Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society...

Page 1: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Grand Challenge IV

Understanding how genomes produce organisms

David RaibleBoard Member, Society for

Developmental BiologyProfessor, University of Washington

Sea urchin larvae

Page 2: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Grand Challenge IV

Understanding how genomes produce organismsGeneration of organismal diversity

Heliconius

Page 3: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Grand Challenge IV

Understanding how genomes produce organismsGeneration of organismal diversity

Geospiza

Page 4: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Grand Challenge IV

Understanding how genomes produce organismsEnvironmental influences on growth

Arabidopsis

Page 5: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Drosophila

Page 6: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Carollia

Page 7: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

The challenges in developmental biology

• Generation of cellular diversity• Generation of shape: morphogenesis• Growth, repair, regeneration

Cnemidophorus

Page 8: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Progress at the interface

• Convergence of genetics and development – Defining components

• Integration of Cell Biology– Cell shape to tissue architecture

• Systems biology – the future?– Moving beyond the descriptive

Page 9: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Systematic analysis of development

• Gene regulatory networks

Page 10: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Systematic analysis of development

• In toto imaging

Kane and Karlstrom, 1995

Page 11: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Systematic analysis of development

• In toto imaging– xyzgt

http://www.embl.de/digitalembryo/

Page 12: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Moving forward• Instrumentation – ways to measure• Centralized databases (GCOB #11)

– Access, analyze, manipulate large data sets– Standardization

• New model organisms– Genomes– Genetics– Lab culture– Transgenics

• Quantitative training

Page 13: Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington.

Moving forward • Distribution of effort• Centralized resources• Distribution of data• Recognition


© SSER Ltd.. The genomes of eukaryotic organisms are enormous and contain millions of nucleotide sequences that form their genes Finding a specific gene.

© SSER Ltd.. The genomes of eukaryotic organisms are enormous and contain millions of nucleotide sequences that form their genes Finding a specific gene.

BB30055: Genes and genomes Genomes - Dr. MV Hejmadi (bssmvh)

BB30055: Genes and genomes Genomes - Dr. MV Hejmadi (bssmvh)

FEATURE The Difference Makers - Science News › wp-content › uploads › ...how jumping genes have influenced fruit fly evolution. Genomes of most organisms are littered with the

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Refreshing Your UI with HTML5, Bootstrap and CSS3 - Raible Designs

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Chapter 11: cell signals Without cell signaling, no multicellular organisms could exist. Cells would use their genomes equivalently. Cell signals allow.

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Transcriptomic Signatures of Tacaribe Virus-Infected ... filenon-model organisms, virtually nothing is known about bat immune responses. Al-though bats appear to have small genomes

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Igor Ulitsky. “the branch of genetics that studies organisms in terms of their genomes (their full DNA sequences)” Computational genomics in TAU ◦

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Fungi-The Rotten World About Us. What are the Fungi? Simple eukaryotic organisms with small genomes Reproduce asexually and sexually by spores Heterotrophs:

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1 Gene Finding Charles Yan. 2 Gene Finding Genomes of many organisms have been sequenced. We need to translate the raw sequences into knowledge. Where.

1 Gene Finding Charles Yan. 2 Gene Finding Genomes of many organisms have been sequenced. We need to translate the raw sequences into knowledge. Where.

Selecting Genomes for Reconstruction of A ncestral Genomes

Selecting Genomes for Reconstruction of A ncestral Genomes

Genomes and Their Evolution - MyTeacherSite.org...– Comparisons of genomes among organisms provide information about the evolutionary history of genes and taxonomic groups • Genomics

Genomes and Their Evolution - MyTeacherSite.org...– Comparisons of genomes among organisms provide information about the evolutionary history of genes and taxonomic groups • Genomics

MySQL and AppFuse - Raible DesignsWho is Matt Raible? Developing websites since 1994 (before Netscape 1.0) - Developing in Java since 1999 Committer on several open source projects:

MySQL and AppFuse - Raible DesignsWho is Matt Raible? Developing websites since 1994 (before Netscape 1.0) - Developing in Java since 1999 Committer on several open source projects:

TRANSGENIC ANIMALS - Worcester Polytechnic InstituteTransgenic animals are genetically modified organisms whose genomes have been integrated with foreign DNA to provide a new phenotype.

TRANSGENIC ANIMALS - Worcester Polytechnic InstituteTransgenic animals are genetically modified organisms whose genomes have been integrated with foreign DNA to provide a new phenotype.

Web Frameworks of the Future - Raible Designs :: Static Resources

Web Frameworks of the Future - Raible Designs :: Static Resources

Christoph Raible (1) M. Yoshimori (1,2), T. Stocker (1), C. Casty (1)

Christoph Raible (1) M. Yoshimori (1,2), T. Stocker (1), C. Casty (1)

Genome Annotation Assessment in Drosophila melanogastermartinr/papers/Reeseetal.GASP.GenomeRes.2000.pdf · automated feature prediction tools in the genomes of higher organisms, we

Genome Annotation Assessment in Drosophila melanogastermartinr/papers/Reeseetal.GASP.GenomeRes.2000.pdf · automated feature prediction tools in the genomes of higher organisms, we

Choosing a JVM W eb Framew ork - Raible Designsstatic.raibledesigns.com/.../presentations/ChoosingAJVMWebFrame… · Choosing a JVM W eb Framew ork Matt Raible matt@raibledesigns.com

Choosing a JVM W eb Framew ork - Raible Designsstatic.raibledesigns.com/.../presentations/ChoosingAJVMWebFrame… · Choosing a JVM W eb Framew ork Matt Raible [email protected]

Microbiology Introduction to Virology & Immunology...Introduction to Virology & Immunology What is a virus? • Viruses may be defined as acellular organisms whose genomes consist

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Transposon Mutagenesis of Mycobacterium marinum Identifies … · ner transposons are able to insert into diverse genomes of distantly related organisms, including both eukaryotes

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S TANDARD : DESCRIBE TECHNIQUES OF SUCH AS CHROMOSOMAL ANALYSIS TO STUDY GENOMES OF ORGANISMS (B.6H) E SSENTIAL Q UESTION : HOW CAN A KARYOTYPE BENEFIT.

S TANDARD : DESCRIBE TECHNIQUES OF SUCH AS CHROMOSOMAL ANALYSIS TO STUDY GENOMES OF ORGANISMS (B.6H) E SSENTIAL Q UESTION : HOW CAN A KARYOTYPE BENEFIT.