Graham Tipples - University of Calgary...Dr. Graham Tipples, Summary CV January 2018 3 Awards April...

Dr. Graham Tipples, Summary CV January 2018

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Graham Tipples

14008 78th Ave

Edmonton, AB, T5R 3C1

Canada

Education / Certification

BSc (Honors) Biochemistry

1989

University of Manitoba

PhD Medical Microbiology

1994


FCCM (Fellow of the Canadian College of Microbiologists)

2006

Clinical microbiology training 2003-6 coordinated through the Department of Medical

Microbiology, University of Manitoba

D(ABMM) (Diplomate of the American Board of Medical Microbiology)

2007

FCCM-ABMM reciprocity agreement

Management Experience

July 2012 - ongoing

Medical / Scientific Director

Provincial Public Health Laboratory, Alberta Health Services

March 2012 – May 2012

Acting Scientific Director General

National Microbiology Laboratory, Public Health Agency of Canada

May 2010 – June 2012

Executive Director


May 2009 – April 2010

Acting Executive Director


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October 2003 – April 2012

Director, Surveillance and Reference Services

National Microbiology Laboratory, Health Canada / Public Health Agency of Canada

Academic Affiliations

Adjunct Professor (1998-2007); Assistant Professor (2007-2017)

Department of Medical Microbiology, University of Manitoba

Associate Adjunct Professor (2012-2020)

Department of Medical Microbiology and Immunology, University of Alberta

Associate Investigator (2012-ongoing)

Li Ka Shing Institute of Virology, University of Alberta

Research Experience

March 1997 – February 2010

Research Scientist

Chief, Viral Exanthemata Section

National Microbiology Laboratory, Health Canada / Public Health Agency of Canada

Research, surveillance and diagnostics of measles, rubella, human herpes viruses-6/7, and

varicella-zoster viruses

August 1994 - February 1997

Post-doctoral Fellow (Dr DLJ Tyrrell)

Department of Medical Microbiology and Immunology

University of Alberta

Molecular biological studies of hepatitis B virus

July 1989 - July 1994

PhD Student (Dr GA McClarty)

Department of Medical Microbiology


Biochemical and molecular biological studies of nucleotide metabolism in Chlamydia

trachomatis


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Awards

April 2015, “Canadian College of Microbiologists Distinguished Microbiologist Award, 2015, in

recognition of his outstanding professional contributions to the field of microbiology in the areas

of research, teaching and leadership in furthering microbiology at the national and international

levels.”

June 2005, Deputy Minister’s Award of Team Excellence for implementation of a lab

information management system, Health Canada.

June 2003, Assistant Deputy Minister’s Special Team Excellence Award as part of the Health

Canada response to the 2003 outbreak of SARS, Health Canada.

May 2001, Most Promising Scientist Award, Office of the Chief Scientist, Health Canada.

February 1995 - February 1997, Alberta Heritage Foundation for Medical Research Fellowship

June 1995, Apotex Fermentation Inc Award for Molecular Biology

University of Manitoba Faculty of Medicine Student Research Award

July 1990 - June 1994, Manitoba Health Research Council Studentships

International Activities

"Meeting of experts to discuss the essential data elements for the regional protocol for

documenting and verifying the interruption of endemic measles and rubella transmission in the

Americas", 27-29 August 2008, Washington, DC.

Meetings of the Global Measles/Rubella Laboratory Network, 25-26 August 2005, 28-30 August

2006, 26-28 September 2007, 24-26 September 2008, Geneva, Switzerland.

Steering Committee Member for the "2004 Michigan-Ontario Border Health Conference:

enhancing early warning infectious disease surveillance", 9-10 September 2004, Detroit,

Michigan, USA.

WHO Temporary Advisor for "Standardization of the nomenclature for genetic characteristics of

wild-type rubella viruses" meeting, 2-3 Sepember 2004, Geneva Switzerland.

WHO Temporary Advisor for the "5th Meeting of the WHO Product Development Group for

Measles Aerosol Vaccine", 5-6 April 2004, and the "Consultation on Vaccination Against

Rubella by Aerosol", 7-8 April 2004, Geneva, Switzerland.

PAHO Temporary Advisor for the "Panel of Experts on Rubella Elimination and Measles

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Eradication in Latin America and the Caribbean", 3-4 March 2004, Washington, DC, USA.

WHO Temporary Advisor for the "4th Meeting of the WHO Product Development Group for

Aerosol Measles Vaccine", Baltimore, USA, June 19, 2003.

Collaboration on WHO measles aerosolized vaccine study, 2003 - 2004.

Collaboration on rubella in pregnancy study in Rio de Janeiro, Brazil, January 2003 - 2005.

Collaboration on measles molecular epidemiology studies in Kenya, Kenyan Medical Research

Institute and WHO/EPI, January 2002 to March 2003.

WHO short-term consultant, measles serology workshop, Laos, May 22-June 2, 2001.

WHO short-term consultant, measles serology workshop, Cambodia, September 8-22, 2000.

WHO Temporary Advisor and Canadian Reference Laboratory Representative for a "Meeting on

preventing congenital rubella syndrome: immunization strategies, surveillance needs", Geneva,

Switzerland, January 12-14, 2000.

WHO short-term consultant to assess measles laboratory surveillance in Pakistan (October 7-16,

1999) and Iran (October 17-24, 1999).

WHO Temporary Advisor for the global measles elimination program meeting -

"Standardization of the nomenclature for the genetic characteristics of wild-type measles",

Geneva, Switzerland, May 26-27, 1998.

Canadian Measles Reference Laboratory Representative for the Pan-American Health

Organization Technical Advisory Group on Vaccine Preventable Diseases Meetings.

Guatemala City, Guatemala, September 8-12, 1997; Ottawa, Canada, April 12-16, 1999;

Iguasu Falls, Brazil, October 2-5, 2000; Mexico City, November 2-6, 2004; Guatemala City,

Guatemala, July 24-27, 2006.

Canadian Measles Reference Laboratory Representative for the 3rd Meeting on Advances in

Measles Control and Elimination. Atlanta, U.S.A., August 27-29, 1997.

Professional Activities

Member of the Alberta Provincial Pediatric Enteric Infection Team (APPETITE) Strategic

Advisory Committee. Multi-disciplinary collaborative (University of Calgary, University of

Alberta, Provincial Laboratory for Public Health (Alberta Health Services)) research project

funded by Alberta Innovates. 2014 – present.

Member of the Association of Public Health Laboratories (APHL) Workforce Development


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Committee, July 2016 to June 2017.

Member of the Association of Public Health Laboratories (APHL) subcommittee for the

development of a Doctorate of Public Health (DrPH) course through the University of South

Florida, 2017.

Provincial Co-chair of the Canadian Public Health Laboratory Network (CPHLN), May 2016 –

May 2018.

Team Lead for College of American Pathologists (CAP) assessment of Oregon State Public

Health Laboratory, May 6, 2014.

Lead organizer for the "Severe H1N1 Disease: Preventing Cases, Reducing Mortality"

symposium, Winnipeg, Canada, September 2-3, 2009.

Scientists as Leaders Program

January 2008 - May 2011

Science ADM Advisory Committee in partnership with the Leadership Network of the Public

Service Human Resources Management Agency of Canada (executive management training

includes Direxion program) – Direxion, Gatineau, Quebec, November 17-28, 2008.

ISO17025 Lead Auditor Training Course (RABQSA Certified Quality Management System

Lead Auditor Course with Specific Reference to ISO/IEC 17025), Washington, D.C., November

13-17, 2006.

Invited expert for assessment and consultation of the Newfoundland Provincial Public Health

Laboratory quality system (ISO15189), June 2006.

Invited expert for assessment of the Winnipeg Health Sciences Centre Clinical Microbiology

Laboratory quality system (CAP and ISO15189), June 2005.

Invited laboratory expert for rubella and VZV, Goals and Objectives Consensus Conference for

Vaccine Preventable Diseases, Public Health Agency of Canada, Quebec City, 12-14 June 2005.

Numerous Public Health Agency of Canada committees

NML Director responsible for:

Implementation and maintenance of the ISO17025 and ISO9001 quality systems.

Development, implementation and maintenance of the NML Laboratory Information

Management System (LIMS).

Development and implementation of the Laboratory Liaison Technical Officer program

(LLTO) - PHAC technical staff located in provincial public health labs.

Reference services provided by national external reference centres.

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Federal Co-chair of the Canadian Public Health Laboratory Network Reference Centre Advisory

Subcommittee, October 2004 - present.

Federal Co-chair of the Canadian Public Health Laboratory Network Laboratory Standardization

Subcommittee, June 2004 - present.

Member of the National Microbiology Laboratory SARS investigation team (March-June 2003)

and the H1N1 swine influenza laboratory response team (April – present 2009).

Member of the Editorial Board of the Journal of Clinical Microbiology, 2001-2009.

Ad hoc reviewer for the Journal of Virological Methods, Journal of Clinical Virology, Journal of

General Virology and Clinical Infectious Diseases.

Ad hoc grant reviewer for the “CIHR Grand Challenges Canada Transition to Scale”, February

2017.

Board member of the Canadian Association for Clinical Microbiology and Infectious Diseases:

Past-President 2008-2010, President 2006 - 2008, Vice-President 2004-2006, Councillor 2002-

2004. Member of the Scientific Planning and Central Planning Committees for the CACMID-

AMMI conjoint conferences 2006-2010. Member of the CACMID Awards and Nominations

Committee, 2017-2019.

Department of Medical Microbiology, University of Manitoba.

Medical Microbiology Visiting Professors Committee (2001-2005).

Chair of the organizing committee for the herpesvirus mini-symposium, Nov’05

Medical Microbiology Residency Training Program Committee (2004-2012)

Acting Director General, National Microbiology Laboratory. January 26 - February 11, 2001;

June 26, 2007; extensively during 2009.

Acting Chief, Division of Viral Diagnostics, National Microbiology Laboratory. Alternating

months beginning October 2000 to June 2001.

Member of the Working Group on Measles Elimination in Canada (WGMEC) and chair of the

WGMEC lab issues subgroup, 1997 to 2000.

Organizer and co-chair of the "Expert Working Group on HHV-6 and 7 Laboratory Diagnosis

and Testing" meeting, Winnipeg, March 7-8, 2000. Coordinated the publication of the meeting

proceedings in the Can Commun Dis Rep 2000;26S4:1-27.

Organizer and chair of the “Expert Working Group on Rubella in Canada” meeting, Winnipeg,

November 22, 2001.

Co-chair of the Occupational Safety and Health Committee for the Virus Building (December


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1997 - May 1998) and the Candian Science Centre for Human and Animal Health (June 1998 -

Decmember 1999).

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Supervision of Graduate Students

David Safronetz, MSc (graduated), Sept 2000 to December 2002. Now working as a Research

Scientist and Section Chief, National Microbiology Laboratory, Public Health Agency of

Canada.

Joanne Hiebert, MSc (graduated), May 2001 to December 2003. Now working as a Biologist,

National Microbiology Laboratory, Public Health Agency of Canada.

Tracie EisBrenner, PhD (graduated), July 2005 – October 2013. Now working as a Biologist,

National Microbiology Laboratory, Public Health Agency of Canada.

Chris Hoban, MSc (graduated), Sept 2006 - May 2008. Entered medical school after completion

of MSc.

Graduate Student Committee Member

Claire Sevenhuysen, MSc candidate (Medical Microbiology), 2002 to 2006.

Lena Shah, MSc candidate (Community Health Sciences), 2004 to 2006.

Publications

Published peer-reviewed manuscripts

Hasing ME, BE Lee, Y Qiu, M Xia, G Tipples, X Jiang, XL Pang. Changes in norovirus

genotype diversity in gastroenteritis outbreaks in Alberta, Canada - an augury? (Submitted to

Journal of Infectious Diseases)

Stang A, M Trudeau, OG Vanderkooi, BE Lee, L Chui, XLi Pang, V Allen, CAD Burnham, DM

Goldfarb, J MacDonald, B Parsons, A Petrich, F Pollari, PI Tarr, G Tipples, R Zhou, SB

Freedman. Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: a Modified

Delphi Consensus Process. (submitted to BMC Infectious Diseases)

German GJ, M Gilmour, G Tipples, HJ Adam, H Almohri, J Bullard, T Dingle, D Farrell,

G Girouard, D Haldane, L Hoang, PN Levett, R Melano, J Minion, R Needle, SN Patel, R

Rennie, RC Reyes, J Longtin, MR Mulvey. Canadian recommendations for laboratory

interpretation of multiple or extensive drug resistance in clinical isolates of Enterobacteriaceae,

Acinetobacter species and Pseudomonas aeruginosa. Can Commun Dis Rep. 2018;44(1):29-34.

Sikora C, G Tipples, X-L Pang, A Andonov. Hepatitis A virus infection associated with

cannabis use. Can Commun Dis Rep. 2017;43(11):245-6.


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Pabbaraju K, S Wong K Gill, K Fonseca, GA Tipples and R Tellier. Simultaneous detection of

Zika, Chikungunya and Dengue viruses by a multiplex real-time RT-PCR assay. J Clin Virol

83:66-7 (2016).

Pabbaraju K, S Wong, SJ Drews, G Tipples and R Tellier. Full genome analysis of enterovirus

D-68 strains circulating in Alberta, Canada. J Med Virol 88:1194-203 (2016).

Hatchette TF, SJ Drews, E Grudeski, T Booth, C Martineau, K Dust, R Garceau, J Gubbay, T

Karnauchow, M Krajden, P Levett, T Mazzulli, R McDonald, A McNabb, S Mubareka, R

Needle, A Petrich, S Richardson, C Rutherford, M Smieja, R Tellier, G Tipples and JJ Leblanc.

Detection of enterovirus D68 in Canadian Laboratories. J Clin Microbiol 53:1748-51 (2015).

Drews SJ, K Simmonds, HR Usman, K Yee, S Fathima, G Tipples, R Tellier, K Pabbaraju, S

Wong, and J Talbot. Characterization of enterovirus activity, including enterovirus D68 in

pediatric patients in Alberta, Canada, in 2014. J Clin Microbiol 53:1042-5 (2015).

Lai FY, DC Dover, B Lee, K Fonseca, N Solomon, SS Plitt, J Jaipaul, GA Tipples, CL Charlton.

Determining rubella immunity in pregnant Alberta women 2009–2012. Vaccine 33:635–641

(2015).

Adachi D, JW Tang, R Lundeberg, G Tipples, CL Charlton and SJ Drews. Comparison of the

IMDx influenza A, influenza B, and respiratory syncytial virus A/B assay on the m2000 platform

with real-time reverse transcriptase PCR assays. J Clin Microbiol 52:4441-2 (2014).

Tang JW, D Adachi, H Gunning, C Marian-Dyer, S Hume, S Taylor, S Haase, L Vicen, M

Benedet, A Chow, M Somerville, M Hicks, and G Tipples. Discrepant HIV results resolved by

human DNA Testing. J Clin Virol 61:311-2 (2014).

Pabbaraju K, R Tellier, S Wong, Y Li, N Bastien, JW Tang, SJ Drews, Y Jang, CT Davis, K

Fonseca and GA Tipples. Full-genome analysis of avian influenza A(H5N1) virus from human,

North America, 2013. Emerg Infect Dis 20;887-891 (2014).

Chow VT, GA Tipples, C Grose. Bioinformatics of varicella-zoster virus: single nucleotide

polymorphisms define clades and attenuated vaccine genotypes. Infect Genet Evol 18:351-6

(2013).

Kruk T, S Ratnam, J Preiksaitis, A Lau, T Hatchette, G Horsman, P Van Caeseele, B Timmons,

and G Tipples. Continuous Monitoring of the Performance of Rubella IgG and Hepatitis B

Surface Antibody Assays Using Trueness Controls: Results of a Multicentre Trial. Clin Vaccine

Immunol 19:1624-1632 (2012).

Wielders CC, RS van Binnendijk, BE Snijders, GA Tipples, J Cremer, E Fanoy, S Dolman, WL

Ruijs, HJ Boot, HE de Melker, SJ Hahné. Mumps epidemic in orthodox religious low-

vaccination communities in the Netherlands and Canada, 2007 to 2009.

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EuroSurveillance 16(41) (2011).

Tipples GA. Rubella diagnostic issues in Canada. J Infect Dis 204:S659–S663 (2011).

Macey JF, T Tam, T Lipskie, G Tipples, T EisBrenner. Rubella Elimination, the Canadian

Experience. J Infect Dis 204:S585–S592 (2011).

Breuer J, C Grose, P Norberg, G Tipples, Schmid DS. A proposal for a common nomenclature

for viral clades that form the species varicella-zoster virus: summary of VZV Nomenclature

Meeting 2008, Barts and the London School of Medicine and Dentistry, 24-25 July 2008.

J Gen Virol 91:821-8 (2010).

Dallaire F, G De Serres, FW Tremblay, F Markowski, G Tipples. Long-lasting measles outbreak

affecting several unrelated networks of unvaccinated persons. J Infect Dis 200:1602-5 (2009).

Angelini P, F Kavadas, N Sharma, SE Richardson, G Tipples, C Roifman, Y Dror, Y Nofech-

Mozes. Aplastic anemia following varicella vaccine. Pediatr Infect Dis J 28:746-8 (2009).

Bastien N, Bowness D, Burton L, Bontovics E, Winter AL, Tipples G, Minielly D, Gregg B,

Cramer C, Schincariol C, Li Y. Parotitis in a child infected with triple-reassortant influenza A

virus in Canada in 2007. J Clin Microbiol 47:1896-8 (2009).

Hahné, S, J Macey, R van Binnendijk,, R Kohl, S Dolman, Y van der Veen, G Tipples, H Ruijs,

T Mazzulli, A Timen, A van Loon, H de Melker. Rubella outbreak in the Netherlands, 2004-

2005: high burden of congenital infection and spread to Canada. Pediatr Infect Dis J 28:795-800

(2009).

Ota K, V Kim, S Lavi, L Ford-Jones, G Tipples, R Tellier. Vaccine-strain varicella zoster virus

causing recurrent herpes zoster in an immunocompetent 2-year-old. Pediatr Infect Dis J 27:847-

8 (2008).

Leblanc JJ, J Pettipas, RJ Davidson, GA Tipples, J Hiebert, TF Hatchette. Detection of mumps

virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform. J

Clin Microbiol 46:4049–4051 (2008).

Hatchette T, GA Tipples, G Peters, J Zhou, Alsuwaidi, T Mailman. Foscarnet salvage therapy

for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of

the literature. Pediatr Infect Dis J 27(1):75-7 (2008).

Humar A, D Kumar, M Gray, G Moussa, R Kumar, B Welsh and GA Tipples. A Prospective

Assessment of Cytomegalovirus Immune Evasion Gene Transcription Profiles in Transplant

Patients With Cytomegalovirus Infection. Transplantation 83:1200-6 (2007).

Mubareka S, H Richards, M Gray, GA Tipples. Evaluation of Commercial Rubella IgG Avidity

Assays. J Clin Microbiol 45:231-3 (2007).


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Tyler SD, GA Peters, C Grose, A Severini, MJ Gray, C Upton, GA Tipples. Genomic

cartography of varicella-zoster virus: a complete genome based analysis of strain variability

with implications for attenuation and phenotypic differences. Virology 359:447-58 (2007).

Peters GA, SD Tyler, C Grose, A Severini, M Gray, C Upton, GA Tipples. A full-genome

phylogenetic analysis of varicella-zoster virus reveals a novel origin of replication-based

genotyping scheme and evidence of recombination between major circulating clades. J Virol

80:9850-60 (2006).

Rota J, L Lowe, P Rota, W Bellini, S Redd, G Dayan, R van Binnendijk, S Hahné, G Tipples, J

Macey, R Espinoza, D Posey, A Plummer, J Bateman, J Gudiño, E Cruz-Ramirez, I Lopez-

Martinez, L Anaya-Lopez, TH Akwar, S Giffin, V Carrión, AM Bispo de Filippis, A Vicari, C

Tan, B Wolf, K Wytovich, P Borus, F Mbugua, P Chege, J Kombich, C Akoua-Koffi, S Smit, H

Bukenya, J Bwogi, FN Baliraine, J Kremer, C Muller, S Santibanez. Identical genotype B3

sequences from measles patients in 4 countries, 2005. Emerg Infect Dis 12:1779-81 (2006).

Robinson JL, BE Lee, JK Preiksaitis, S Plitt and GA Tipples. Prevention of congenital rubella

syndrome – what makes sense on 2006? Epidemiol Rev 28:81-7 (2006).

Coates AL, G Tipples, K Leung, M Gray, E Louca. How many infective viral particles are

necessary for successful mass measles immunization by aerosol? Vaccine 24:1578-15885 (2006).

Hahné S, J Macey, G Tipples, P Varughese, A King, R van Binnendiijk, H Ruijs, J van

Steenbergen, A Timen, AM van Loon and H de Melker. Rubella outbreak in an unvaccinated

religious community in the Netherlands spreads to Canada. Eurosurveillance Weekly 10(20)

(2005).

Leung K, E Louca, M Gray, G Tipples, AL Coates. Use of the next generation pharmaceutical

impactor for particle size distribution measurements of live viral aerosol vaccines. J Aerosol Med

18(4):414-26 (2005).

Grose C, S Tyler, G Peters, J Hiebert, GW Stephens, WT Ruyechan, W Jackson, J Storlie and

GA Tipples. Complete DNA sequence analyses of the first two varicella-zoster virus

glycoprotein E (D150N) mutant viruses found in North America: Evolution of genotypes with an

accelerated cell spread phenotype. J Virol 78:6799-807 (2004).

Loparev VN, A Gonzalez, M Deleon-Carnes, GA Tipples, H Fickenscher, EG Torfason and DS

Schmid. Global Identification of Three Major Genotypes of Varicella-Zoster Virus: Longitudinal

Clustering and Strategies for Genotyping. J Virol 78:8349-58 (2004).

Tipples GA, M Garbutt, M Gray, PA Rota, and the Canadian Measles Surveillance Program.

Genotyping of measles virus in Canada: 1979 to 2002. J Infect Dis 189 (Suppl. 1):S171-S176

(2004).

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King A, P Varughese, G DeSerres, G Tipples, J Waters and Members of the Working Group on

Measles Elimination. Measles elimination in Canada. J Inf Dis 189 (Suppl. 1):S236-S242 (2004).

Tipples GA, R Hamkar T Mohktari-Azad, M Gray, G Parkyn and S Ratnam. Evaluation of

rubella IgM serology assays. J Clin Virol 30:233-238 (2004).

Tipples GA, D Safronetz and M Gray. A real-time PCR assay for the detection of varicella-

zoster virus DNA and differentiation of vaccine, wild-type and control strains. J Virol Meth

113:113-6 (2003).

Mbugua F, F Okoth, M Gray, T Kamau, A Kalu, R Eggers, P Borus, J Kombich, A Langat, P

Maritim, J Lesiamon and GA Tipples. Molecular epidemiology of measles virus in Kenya. J

Med Virol 71:599-604 (2003).

Tipples GA, R Hamkar, T Mohktari-Azad, M Gray, G Parkyn, C Head and S Ratnam.

Assessment of measles IgM serology assays. J Clin Microbiol 41:4790-2 (2003).

Safronetz D, M Petric, R Tellier, B Parvez and GA Tipples. Mapping ganciclovir resistance in

human herpesvirus 6 U69 protein kinase. J Med Virol 71:434-9 (2003).

Severini A, C Sevenhuysen, M Garbutt, and G Tipples. Structure of replicating intermediates of

human herpesvirus type 6. Virology 314:443-50 (2003).

Safronetz D, A Humar and GA Tipples. Differentiation and quantification of human herpesvirus

6A, 6B and 7 by real-time PCR. J Virol Methods 112:99-105 (2003).

Walters KA, GA Tipples, MI Allen, LD Condreay, WR Addison and L Tyrrell. Generation of

stable cell lines expressing lamivudine-resistant hepatitis B virus for antiviral-compound

screening. Antimicrob Agents and Chemother 47:1936-42 (2003).

Mehta A, B Conyers, DLJ Tyrrell, KA Walters, GA Tipples, RA Dwek, TM Block. Structure

activity relationship of a new class of anti-hepatitis B virus agents. Antimicrob Agents

Chemother 46:4004-6 (2002).

Tipples GA, GM Stephens, C Sherlock, M Bowler, B Hoy, D Cook and C Grose. A new variant

of varicella-zoster virus. Emerg Infect Dis 8:1504-5 (2002).

Best JM, S O’Shea, G Tipples, N Davies, S Al-Khusaiby, A Krause, L Hesketh, L Jin, G Enders.

Interpretation of rubella serology in pregnancy - pitfalls and problems. BMJ 325:147-8 (2002).

Booth SA, Drebot MA, Tipples GA, Ng LK. Application of DNA Array Technology for

Diagnostic Microbiology. Can J Infect Dis 11:291-294 (2000).

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Ratnam S, GA Tipples, C Head, M Fauvel, M Fearon, and BJ Ward. Performance of indirect

IgM serology tests and IgM capture assays for laboratory diagnosis of measles. J Clin Microbiol

38:99-104 (2000).

Tipples GA. The public health role for measles surveillance in Canada. Paediatrics and Child

Health 4:43-45 (1999).

Allen MI, M Deslauriers, CW Andrews, GA Tipples, KA Walters, DLJ Tyrrell, N Brown, and

LD Condreay. Identification and characterization of mutations in HBV resistant to lamivudine.

Hepatology 27:1670-1677 (1998).

Drebot MA, and GA Tipples. Application of molecular diagnostics for the surveillance of

hantavirus and measles virus in Canada. Can J Infect Dis 9:71-75 (1998).

Bain VG, NM Kneteman, MM Ma, K Gutfreund, JA Shapiro, KP Fischer, GA Tipples, H Lee,

LD Jewell, and DLJ Tyrrell. Efficacy of lamivudine in chronic hepatitis B patients with active

viral replication and decompensated cirrhosis undergoing liver transplantation. Transplantation

62:1456-1462 (1996).

Tipples GA, MM Ma, KP Fischer, VG Bain, NM Kneteman, and DLJ Tyrrell. Mutation in HBV

RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 24:714-

717 (1996).

Wylie JL, LL Wang, GA Tipples, and GA McClarty. A single point mutation in CTP synthetase

of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine. J Biol Chem 271:15393-

15400 (1996).

Tipples GA, and GA McClarty. Cloning and expression of the Chlamydia trachomatis gene for

CTP synthetase. J Biol Chem 270:7908-7914 (1995).

Tipples GA, and GA McClarty. The obligate intracellular bacterium Chlamydia trachomatis is

auxotrophic for three of the four ribonucleoside triphosphates. Mol Microbiol 8:1105-1114

(1993).

Tipples GA, and GA McClarty. Isolation and initial characterization of a series of Chlamydia

trachomatis selected for hydroxyurea resistance by a stepwise procedure. J Bacteriol 173:4932-

4940 (1991).

McClarty GA, and GA Tipples. In situ studies on the incorporation of nucleic acid precursors

into Chlamydia trachomatis DNA. J Bacteriol 173:4922-4931 (1991).

McKinnon DM, P Spevak, and GA Tipples. Conversion of some azaheterocyclic-acetic esters

and acetonitriles into fused heterocycles. Can J Chem 66:2339-2344 (1988).

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Book Chapters

Pellett P and GA Tipples. Human herpesviruses 6, 7 and 8. In Manual of Clinical Microbiology,

8th, 9th, 10th and 11th editions. American Society for Microbiology Press, 2003, 2007, 2011 and

2015.

Tipples GA, J Hiebert. Detection of measles, mumps and rubella viruses. In JR Stephenson and

A Warnes (Eds.), Diagnostic Virology Protocols, 2nd edition. Springer Science and Business

Media, 2011. Methods Mol Biol. 2011;665:183-93.

Ma MM, GA Tipples, KP Fischer, and DLJ Tyrrell. Viral Hepatitis. In VL Yu, TC Merigan and

S Barriere (Eds.), Antimicrobial Therapy and Vaccines. Baltimore: Williams and Wilkins, 1999.

Publication as a member of the NML SARS investigation team

Poutanen SM, DE Low, B Henry, et al, the National Microbiology Laboratory and the Canadian

SARS Study Team. Identification of severe acute respiratory syndrome in Canada. N Engl J Med

348:1995-2005 (2003).

Marra MA, SJM Jones, CR Astell, et al. The genome sequence of the SARS-associated

coronavirus. Science 300:1399-1404 (2003).

Abstracts

Ko F, G Tipples, SJ Drews. Identifying optimal turnaround time indicators for respiratory viral

and Bordetella batched testing. Canadian Association of Clinical Microbiology and Infectious

Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting,

Vancouver, BC, Canada, May 2 – 5, 2018.

Hasing E, R Zhuo, G Tipples, S Freedman, B Lee, X Pang. Emergence of a novel norovirus

GII.P16/GII.2 strain in Alberta, Canada in 2016. Alberta Virology Conference, University of

Alberta, Edmonton, Alberta, June 1-2, 2017.

Hasing E, B Lee, Y Qiu, M Xia, G Tipples, X Jiang, X Pang. Molecular epidemiology of

Norovirus Outbreaks in Alberta, Canada: 2012-2016. DRIvE Day in Laboratory Services &

Pathology, University of Alberta, April 21-22, 2017.

Pabbaraju K, K Gill, K Fonseca, GA Tipples, R Tellier. Detection of Zika, Chikungunya and

Dengue viruses in returning travelers to Alberta, Canada. ASM Clinical Virology Symposium,

Savannah, Georgia, USA, May 7-10, 2017.

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Pang XL, E Hasing, Y Qiu, G Tipples, BE Lee. Norovirus outbreak in Alberta, Canada – which

strain will win the Indy race?, Canadian Association of Clinical Microbiology and Infectious


Toronto, ON, Canada, May 3 – 6, 2017.

Pang XL, E Hasing, Y Qiu, G Tipples, BE Lee. Norovirus game of thrones in Alberta, Canada.

6th International Calicivirus Conference, Savannah, GA, USA, October 9-13, 2016.

Hinshaw D, R Harrison, K Fonseca, M Joffe, M Lavoie, G Predy, G Tipples, S Tsekrekos.

Follow-up of healthcare workers caring for the first patient diagnosed with avian influenza A

H5N1 in North America. Canadian Public Health Association – Public Health 2016, Toronto,

ON, June 13-16, 2016.

Pang XL, G Tipples, BE Lee. Pre-vaccine group A rotavirus G- and P-genotypes circulating in

Alberta, Canada, from 2004 TO 2015. 32nd Clinical Virology Symposium, Daytona Beach,

USA, May 19-22, 2016.

Harrison R, M Joffe, M Lavoie, K Fonseca, G Tipples, S Tsekrekos, Y Li, D Hinshaw, G Predy,

D Hinshaw. Serologic Follow-up of Healthcare Workers (HCWs) Exposed to Influenza A H5N1.

Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID) /

Association of Medical Microbiologists of Canada (AMMI) Meeting, Vancouver, BC, Canada,

March 30 – April 2, 2016.

Hatchette et al. Detection of Enterovirus D68 in Canadian Laboratories. Canadian Association of

Clinical Microbiology and Infectious Diseases (CACMID) / Association of Medical

Microbiologists of Canada (AMMI) Meeting, Charlottetown, PEI, Canada, April 16 - 18, 2015.

Pabbarajua K, S Wong, SJ Drews, G Tipples, R Tellier. Full genome analysis of Enterovirus D-

68 strains circulating in Alberta, Canada. Canadian Association of Clinical Microbiology and

Infectious Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI)

Meeting, Charlottetown, PEI, Canada, April 16 - 18, 2015.

Pabbaraju K, S Wong, P Gordon, R Pon, K Fonseca, J Tang, G Tipples, R Tellier. Full genome

sequencing of a highly pathogeneic avian influenza A (H5N1) virus directly from the

nasopharyngeal swab, bronchoalveolar lavage and cerebrospinal fluid specimens. 30th Clinical

Virology Symposium, Daytona Beach, USA, April 27-30, 2014.

Pabbaraju K, R Tellier, S Wong, Y Li, N Bastien, JW Tang*, SJ Drews, Y Jang, CT Davis, GA

Tipples. The First Reported Case of Avian A/H5N1 Reported in North America. XVI

International Symposium on Respiratory Viral Infections, March 13-16, 2014, Seoul, Republic

of Korea. (oral session presentation by JWT)

Schulz H, J Hiebert, J Beirnes, L Mendoza, GA Tipples, A Severini. Molecular Evolution of

Measles Virus during the 2011 Outbreak in Quebec. Canadian Student Health Research Forum:

16

Manitoba Student Research Poster Presentation, University of Manitoba, Winnipeg, Canada,

June 4, 2013.

Eisbrenner T, A. Shane, S Desai, YA Li, J Macey, T Lipskie, N Khalil, J Isaac-Renton, M Petric,

M. Krajden, Y Chang, K Macdonald, M Naus, V Sahni, K Fonseca, J May-Hadford, C Grant, T

St Jean, L Lachance, S Nolt, L Robberts, L Gilbert, C O’ Keefe, GA Butler, J Beirnes, J Hiebert,

A Severini, S Mukhi, G Tipples. The MARS Pilot Project: Using Laboratory Data To Estimate

The Performance Of National Measles And Rubella Surveillance. Canadian Association of


Microbiologists of Canada (AMMI) Meeting, Quebec City, Canada, April 4 - 6, 2013.

Hiebert J, J Beirnes, L Mendoza, H Schulz, S Desai, L Sherrard, GA Tipples, A Severini.

Molecular epidemiology of measles virus in Canada: 2003-2012. Clinical Virology Symposium.

Daytona Beach, USA, April 28 – May 1, 2013.

EisBrenner TL, A Shane, S Desai, YA Li, J Macey, T Lipskie, N Khalil, J Isaac-Renton, M

Petric, M Krajden, K Macdonald, M Naus, V Sahni, S David, D Puddicombe, N Lesnikova, K

Fonseca, J May-Hadford, CS Grant, T St. Jean, L Lachance, SL Nolt, L Robberts, L Gilbert, C

O’Keefe, GA Butler, J Beirnes, J Hiebert, A Severini, SN Mukhi, GA Tipples. Real-time,

integrated measles and rubella surveillance in Canada: Implementation of the MARS pilot

project. 10th Canadian Immunization Conference, Vancouver, Canada, December 3-5, 2012.

Wielders CCH, RS van Binnendijk, BEP Snijders, GA Tipples, J Cremer, E Fanoy, HJ Boot, HE

de Melker, SJM Hahné. Mumps epidemic in an orthodox religious low-vaccination community

in the Netherlands 2007-2009: Assessment of the burden of disease, transmission to vaccinated

individuals, and spread to Canada. 29th Annual Meeting of the European Society for Paediatric

Infectious Diseases, The Hague, The Netherlands, June 7-11, 2011.

Naus M, V Sahni, R Gustafson, E Brodkin, R Parker, M Fyfe, W Osei, M Krajden, M Petric, G

Tipples and Measles Outbreak Group. An Outbreak of Measles in British Columbia, Canada: An

Unwelcome Consequence of the 2010 Winter Olympics. 48th Annual Meeting of the Infectious

Diseases Society of America in Vancouver, British Columbia, Canada on October 21-24, 2010.

Gubbay JB, K Ogbulafor, E Lombos, RR Higgins, R Eshaghi, D Alexander, E Kristjanson, S

Racey, J Maregmen, G Lim, S Patel, J Hiebert, G Tipples, DE Low, S Deeks and T Mazzulli. A

Review of Laboratory Testing During a Mumps Outbreak. 26th Clinical Virology Symposium,

Daytona Beach, USA, April 25-28, 2010.

Lau A, T Hatchette, W Dimech, T Kruk, A Chow, H Gunning, F Sidaway, T Dow, M Dawood,

A Dowling, F Stead, M Roy, K Quinn, G Tipples. The Use of External Reference Controls for

Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. Public Health Agency of

Canada Research Forum. Winnipeg, Canada, March 17-18, 2009.



17

Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. Clinical Virology

Symposium. Daytona Beach, USA, April 19-22, 2009.



Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. 26th International Congress

of Chemotherapy and Infection and the Canadian Association of Clinical Microbiology and


Meeting. Toronto, Canada, June 18-21, 2009.

Higgins RR, E Chong-King, J Hiebert, GA Tipples, SJ Drews. Evaluation of real-time RT-PCR

assays, on the ABI 7900HT platform, for the detection of measles directly in clinical specimens

109th General Meeting of the American Society of Microbiology, Philadelphia, Pennsylvania,

May 17-21, 2009.

Tipples GA. Challenges of diagnostic testing for HHV-6. 6th International Conference on HHV-

6/7, Baltimore, USA, June 19-22, 2008 [invited presentation].

Beirnes J, J Hiebert, C Sevenhuysen, GA Tipples. Genotyping of mumps virus in Canada.

Public Health Agency of Canada Research Forum. Ottawa, Canada, March 17-18, 2008.

Beirnes J, J Hiebert, C Sevenhuysen, GA Tipples. Genotyping of mumps virus in Canada. 24th

Clinical Virology Symposium, Daytona Beach, FL, April 27 - 30, 2008.

Hiebert J, J Beirnes, GA Tipples. Genotyping of measles virus in Canada: 2002-2008. 24th

Clinical Virology Symposium, Daytona Beach, FL, April 27 - 30, 2008.

Hiebert J, J Beirnes, G Tipples. Genotyping of measles virus in Canada: 2002-2008. Canadian

Association of Clinical Microbiology and Infectious Diseases (CACMID) / Association of

Medical Microbiologists of Canada (AMMI) Meeting, Vancouver, Canada, February 27 - March

1, 2008.

Hiebert J, C Fung, C Sevenhuysen, J Beirnes, T Hatchette, G Tipples. Validation of RT-PCR

methods for molecular diagnostics and epidemiology of mumps virus. Canadian Association of


Microbiologists of Canada (AMMI) Meeting, Vancouver, Canada, February 27 - March 1, 2008.

Hoban CJ, G Tipples, L Mendoza, B Tan, A McGeer. Presence of varicella-zoster virus and

rubella virus IgG immunoglobulins in WinRho SDF product. Canadian Association of Clinical

Microbiology and Infectious Diseases (CACMID) / Association of Medical Microbiologists of

Canada (AMMI) Meeting, Halifax, Canada, March 14-18, 2007.

Hiebert J, G Tipples. Validation of RT-PCR methods for molecular diagnostics and

epidemiology of measles virus. Canadian Association of Clinical Microbiology and Infectious

18


Halifax, Canada, March 14-18, 2007.

EisBrenner T, GA Tipples, J Beirnes, J Hiebert, GA Peters, SD Tyler, JF Macey. Update on

molecular epidemiology of measles, mumps, rubella and varicella-zoster viruses in Canada. 7th

Immunization Conference, Winnipeg, Canada, December 3-6, 2006. [GT oral presentation]

Humar A, G Tipples, M Gray, G Moussa, B Welsh, S Venkataraman, D Kumar. A prospective

assessment of CMA immune evasion gene expression profiles in transplant patients with CMV

infection. World Transplant Congress. Boston, USA, July 22-27, 2006.

Macey J, S Dolman, GA Tipples. Outbreak of Rubella in southwestern Ontario in 2005;

Challenges for Rubella Elimination in Canada. Pan-American Health Organization Technical

Advisory Group on Vaccine Preventable Diseases Meeting. Guatemala City, Guatemala, July 24-

27, 2006.

Macey J, S Dolman, GA Tipples. Outbreak of Rubella in southwestern Ontario in 2005;

Challenges for Rubella Elimination in Canada. Public Health Agency of Canada Research

Forum. Winnipeg, Canada, March 20-21, 2006.

Peters GA, SD Tyler, C Grose, A Severini, MJ Gray, R Garceau, V Tcherepanov, C Upton, GA

Tipples. Complete genomic analysis of 18 varicella-zoster virus isolates provides insight into

attenuation, recombination and genotyping strategies. Public Health Agency of Canada Research

Forum. Winnipeg, Canada, March 20-21, 2006.

Hahné S, J Macey, Y van der Veen, R van Binnendijk, G Tipples, S Dolman, H Ruijs, A Timen,

AW van Loon, H de Melker. Rubella outbreak in the Netherlands: new rubella genotype spread

to Canada and led to congenital rubella infections. International Conference on

Emerging Infectious Diseases, Atlanta, USA, March 19-22, 2006.

GA Peters, SD Tyler, C Grose, A Severini, MJ Gray, R Garceau, V Tcherepanov, C Upton, GA

Tipples. Complete genomic analysis of 18 varicella-zoster virus isolates: insight into mechanism

of attenuation and genotyping strategies. Canadian Association of Clinical Microbiology and


Meeting, Victoria, Canada, March 15-19, 2006.

Lemos XRMR, MM Siqueira, GRS Sá, M Gray, GA Tipples. Evaluation of rubella IgG avidity

maturation over time in pregnant women. Brazilian Meeting of Virology, Brazil, November 22-

25, 2005.

Peters GA, SD Tyler, M Gray, C Grose, GA Tipples. Complete DNA sequence analysis of 11

varicella-zoster virus isolates provides insight into mechanisms of attenuation. 30th International

Herpesvirus Workshop, Turku, Finland, July 30th to August 5, 2005.

19

Mubareka S, GA Tipples, H Richards, M Gray. Evaluation of commercial rubella IgG avidity

assays. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID) /

Association of Medical Microbiologists of Canada (AMMI) Meeting, in Ottawa, Canada, April

14-17, 2005.

Lemos X, M Siqueira, GRS Sa, M Gray, GA Tipples. Assessment of rubella IgG avidity

maturation in pregnant women. Canadian Association of Clinical Microbiology and Infectious

Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting, in

Ottawa, Canada, April 14-17, 2005. [GT oral presentation]

Mailman T, T Hatchette, G Peters, J Zhou, GA Tipples. VZV acylcovir resistance. Canadian

Association of Clinical Microbiology and Infectious Diseases (CACMID) / Association of

Medical Microbiologists of Canada (AMMI) Meeting, in Ottawa, Canada, April 14-17, 2005.

[GT oral presentation]

Tipples GA, P van Caeseele, V Loparev, M Dawood, W Mar, T Kruk, M Gray, B Wells, P

Carriere, B Cistarelli and P McCusker. Lab Confirmed Reinfection of Varicella: a Case Study.

Canadian Association for Clinical Microbiology and Infectious Diseases, Regina, Saskatchewan,

November 7-10, 2004. [GT oral presentation]

Grose C, S Tyler, G Peters, J Hiebert, GW Stephens, WT Ruyechan, W Jackson, J Storlie and

GA Tipples. Complete DNA sequence analyses of the first two varicella-zoster virus

glycoprotein E (D150N) mutant viruses found in North America: Evolution of genotypes with an

accelerated cell spread phenotype. 29th Annual International Herpesvirus Workshop, Reno,

Nevada, July 25-30, 2004.

Humar A, D Kumar, D Safronetz and G Tipples. An assessment of herpesvirus co-infections in

patients with CMV disease: correlation with clinical and virologic outcomes. American

Transplant Congress, Boston, May 15-19, 2004.

Tipples GA, MA Drebot, N Bastien, Y Li, S Jones, H Feldmann, A Kabani, T. Booth, A.

Andonov, M Fearon, F Jamieson, J Isaac-Renton, M Krajden, A McNabb, M Petric, F Plummer

and the NML SARS investigation team. Analysis of SARS-associated coronavirus laboratory

testing at the National Microbiology Laboratory (NML). Canadian Association for Clinical

Microbiology and Infectious Diseases, Montreal, Quebec, November 2-5, 2003. [GT oral

presentation]

Tipples GA, R Hamkar, T Mohktari-Azad, M Gray, J Ball, C Head and S Ratnam. Performance

of Rubella IgM Enzyme Immunoassays. Canadian Association for Clinical Microbiology and

Infectious Diseases, Montreal, Quebec, November 2-5, 2003.

Tipples GA, D Safronetz, D Kumar, J Ball and A Humar. Diagnostics of Beta-herpesviruses in

Solid Organ Transplant Patients. Canadian Association for Clinical Microbiology and Infectious

Diseases, Montreal, Quebec, November 2-5, 2003.

20

Tipples GA, D Safronetz and M Gray. Detection and Genotypic Analysis of Varicella-Zoster

Virus by Real-time PCR. Canadian Association for Clinical Microbiology and Infectious

Diseases, Montreal, Quebec, November 2-5, 2003.

Mbugua F, F Okoth, M Gray, T Kamau, A Kalu, R Eggers, P Borus, J Kombich, A Langat, P

Maritim, J Lesiamon and GA Tipples. Molecular epidemiology of measles virus in Kenya. 24th

African Health Sciences Congress, Addis Ababa, Ethiopia, September 28 to October 2, 2003.

Safronetz D, M Petric, R Tellier, B Parvez and G Tipples. Human herpesvirus 6 and resistance

to ganciclovir. Health Canada Research Forum, Ottawa, ON, November 18-19, 2002.

Tipples G, G Parkyn, M Gray, R Hamkar, T Mokhtari-Azad and S Ratnam. Laboratory aspects

of the measles elimination program. Health Canada Research Forum, Ottawa, ON, November

18-19, 2002.

Tipples G, J Hiebert, G Parkyn, G Peters, S Tyler and C Grose. Genomic approaches to studying

varicella-zoster virus: implications for diagnostics and surveillance. Health Canada Research

Forum, Ottawa, ON, November 18-19, 2002.

Tipples G, R. Hamkar, T. Mokhtari-Azad, M. Gray, G. Parkyn, C. Head, and S. Ratnam.

Assessment of IgM enzyme immunoassays for the diagnosis of measles. Canadian Association

for Clinical Microbiology and Infectious Diseases, Halifax, NS, November 3-6, 2002.

Parkyn G and G Tipples. Development of a Recombinant Antigen Based ELISA for the

Detection of HHV-6-specific antibodies. Canadian Association for Clinical Microbiology and

Infectious Diseases, Halifax, NS, November 3-6, 2002.

Safronetz D, M Petric, R Tellier, B Parvez and G Tipples. Possible ganciclovir resistant human

herpesvirus 6 in an infant. Canadian Association for Clinical Microbiology and Infectious

Diseases, Halifax, NS, November 3-6, 2002.

GA Tipples, G Peters, S Tyler, JS Hiebert, G Parkyn, C Grose. Sequencing of the first North

American VZV genome. 27th International Herpesvirus Workshop, Cairns, Australia, July 2002.

S Koesters, G Tipples, M Gray, KR Fowke. Active HHV-6 infection does not correlate with

HIV disease progression in a Kenyan commercial sexworker cohort. 11th Annual Conference on

HIV/AIDS Research, Winnipeg, Manitoba, April, 2002.

Tipples GA, J Hiebert, LE Maranan, D Cook and R Garceau. Varicella-zoster virus genotyping.

Canadian Association for Clinical Microbiology and Infectious Diseases, Victoria, BC,

November 4-8, 2001.

Severini A, M Garbutt and GA Tipples. Structure of replicative intermediates of human

herpesvirus 6. 4th International Conference on Human Herpesviruses 6, 7 and 8, Paris, France,

21

May 10-12, 2001.

Tipples GA, GM Stephens, R Reynolds, C Sherlock, M Bowler, B Hoy, D Cook, M Cossitt and

R Garceau. Clinical varicella-zoster virus isolate with a mutation in the 3B3 monoclonal

antibody epitope of glycoprotein E. 4th International Conference on Varicella, Herpes Zoster and

Post-Herpetic Neuralgia, La Jolla, California, March 3-5, 2001.

Tipples GA, M Gray, M Cossitt, M Song, K Makowski, S Forgie, D Cook and R Garceau.

Genotyping of varicella-zoster virus in Canada: 1900-2000. 4th International Conference on

Varicella, Herpes Zoster and Post-Herpetic Neuralgia, La Jolla, California, March 3-5, 2001.

Varughese P, A King, G Tipples, Working Group on Measles Elimination in Canada. Measles in

Canada: 1990-2000. 4th Canadian National Immunization Conference, Halifax, Nova Scotia,

December 3-6, 2000.

Tipples GA. Differentiation of wild-type and vaccine strain viruses: measles, rubella and

varicella-zoster. 4th Canadian National Immunization Conference, Halifax, Nova Scotia,

December 3-6, 2000.

Tipples GA and SHS Lee. Rubella Lab Diagnostics in a Pregnant Woman: Case Report.

Canadian Association for Clinical Microbiology and Infectious Diseases, Ottawa, Ontario,

November 5-9, 2000.

Tipples GA, GM Stephens, R Reynolds, C Sherlock, M Bowler, B Hoy and D Cook. Detection

of a Clinical Varicella-Zoster Virus with a Mutation in the 3B3 Monoclonal Antibody Epitope.

Canadian Association for Clinical Microbiology and Infectious Diseases, Ottawa, Ontario,

November 5-9, 2000.

Tipples G, Gray M and Garbutt M. Genotyping of measles virus in Canada. Canadian

Association for Clinical Microbiology and Infectious Diseases, 67th Conjoint Meeting,

Edmonton, Alberta, October 31 - November 4, 1999. Can J Infect Dis Sept/Oct 1999, volume 10,

supplement D.

Garbutt M, Gray M and Tipples G. Optimization of HHV-6 culture conditions. Canadian

Association for Clinical Microbiology and Infectious Diseases, 67th Conjoint Meeting,

Edmonton, Alberta, October 31 - November 4, 1999. Can J Infect Dis Sept/Oct 1999, volume 10,

supplement D.

Ratnam S, Tipples G, Head C, Fauvel M, Fearon M and Ward BJ. Performance of measles IgM

enzyme immuno-assays. Canadian Association for Clinical Microbiology and Infectious

Diseases, 67th Conjoint Meeting, Edmonton, Alberta, October 31 - November 4, 1999. Can J

Infect Dis Sept/Oct 1999, volume 10, supplement D.

Tipples G. Molecular epidemiology of measles in Canada. 15th Annual Clinical Virology

22

Symposium, Clearwater Beach, Florida, May 9-12, 1999.

Ratnam S, GA Tipples, C Head, M Fauvel, M Fearon, and BJ Ward. Performance of indirect

IgM serology tests and IgM capture assays for laboratory diagnosis of measles. 13th Meeting of

the PAHO Technical Advisory Group on Vaccine Preventable Diseases, Hull, Quebec, April 12-

16, 1999.

Tipples GA. The Role of clinicians and public health professionals in the laboratory surveillance

of measles in Canada. 3rd Canadian National Immunization Conference, Calgary, Alberta,

December 6-9, 1998.

Walters K, Tipples G, Allen MI, Condreay LD, Tyrrell DLJ. Generation of stable lamivudine-

resistant hepatitis B virus cell lines for antiviral screening. 49th Annual Meeting of the American

Association for the Study of Liver Diseases, Chicago, Illinois, November 6-10, 1998.

Fischer KP, Stickney J, Tipples GA, Tyrrell DLJ. Cloning, sequencing and sequence

comparison of a Canadian isolate of duck hepatitis B virus. Submitted to GenBank, February 8,

1998.

MI Allen, M Deslauriers, CW Andrews, F Baldanti, GA Tipples, KA Walters, DLJ Tyrrell, N

Brown for the lamivudine Development Group, and LD Condreay. Identification and biologic

characterization of mutations in HBV resistant to lamivudine. 48th Annual Meeting of the

American Association for the Study of Liver Diseases, Chicago, Illinois, November, 1997.

MM Ma, GA Tipples, KP Fischer, VG Bain, NM Kneteman, and DLJ Tyrrell. Lamivudine

resistant HBV infection of hepatic allografts: one year follow-up. Canadian Digestive Diseases

Week, Quebec City, Quebec, February 26-March 1, 1997.

Tipples GA, MM Ma, KP Fischer, KS Gutfreund, VG Bain, NM Kneteman, and DLJ Tyrrell.

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo.

47th Annual Meeting of the American Association for the Study of Liver Diseases, Chicago,

Illinois, November 8-12, 1996.

Gutfreund KS, KP Fischer, GA Tipples, MM Ma, NM Kneteman, LD Jewell, DLJ Tyrrell, and

VG Bain. Late breakthrough of HBV viremia with lamivudine as a single agent for prevention of

graft reinfection in liver transplantation for cirrhosis secondary to hepatitis B. 47th Annual

Meeting of the American Association for the study of liver diseases, Chicago, Illinois, November

8-12, 1996.

Gutfreund KS, KP Fischer, GA Tipples, MM Ma, VG Bain, NM Kneteman, and DLJ Tyrrell.

Lamivudine results in a complete and sustained suppression of hepatitis B virus replication in

patients requiring orthotopic liver transplantation for cirrhosis secondary to hepatitis B. 46th

Annual Meeting of the American Association for the study of liver diseases, Chicago, Illinois,

November 3-7, 1995.

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Tipples GA, and GA McClarty. Chlamydia trachomatis are auxotrophic for three of the four

nucleoside triphosphates. Tenth International Meeting of the International Society for STD

Research, Helsinki, Finland, August 29-September 1, 1993.

Tipples GA, and GA McClarty. Chlamydia trachomatis are auxotrophic for three of the four

nucleoside triphosphates. The 92nd General Meeting of the American Society for Microbiology,

New Orleans, Louisiana, May 26-30, 1992.

Tipples GA, and GA McClarty. Deoxynucleotide metabolism in Chlamydia trachomatis. First

European Symposium on Enzymes in Deoxyribonucleotide Synthesis, Les Deux-Alpes, France,

April 6-11, 1991.

McClarty GA, and GA Tipples. Chlamydia trachomatis ribonucleotide reductase: A class I

Enzyme? Eighth Annual Conference on Ribonucleotide Reductase, Uppsala, Sweden, April,

1990.

Reports and Other Publications

Fonseca K, JD Kellner, J Talbot, K Simmonds, M Anselmo, S Kuhn, S Drews, S Fathima, K

Pabbaraju, G Tipples, R Tellier, S Wong. Human Enterovirus 68 - Canada: (Alberta). Promed,

Sept 16, 2014.

Fonseca K, M Lavoie, J Talbot, J Fuller, R Harrison, M Joffe, K Pabbaraju, R Tellier, G Tipples,

S Tsekrekos, S Wong, N Bastien, and Y Li. Avian Influenza, Human (13): Canada ex China

(Beijing, H5N1, Fatal, Case Report. Promed, Jan 11, 2014.

Tipples GA, J Beirnes, J Hiebert, T Hatchette, J Pettipas, J Macey, S Deeks, T Lipskie, W

Bellini, P Rota and J Rota. Laboratory guidelines for the diagnosis of mumps. May 24, 2007

(http://www.nml-lnm.gc.ca/english/mumps.htm).

Tipples GA. Guidelines for Laboratory Diagnosis of Rubella. May 13, 2005.

Tipples GA. Rubella laboratory diagnostics. Can Commun Dis Rep 2002;28S4:14-15.

Tipples GA. (WHO short-term consultant). Mission Report: Measles Laboratory Serology

Workshop, Vientiane, Laos. WHO, Western Pacific Regional Office, May 2001.

Tipples GA. (WHO short-term consultant). Mission Report: Measles Laboratory Serology

Workshop, Phnom Penh, Cambodia. WHO, Western Pacific Regional Office, September 2000.

Tipples GA. Overview of current HHV-6/7 diagnostic methods. Can Commun Dis Rep

2000;26S4:7-8.

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Varughese P, King A, Tipples GA. Progress towards measles eradication: Canada. PAHO EPI

Newsletter 2000;22(4):1-2.

Tipples GA. Laboratory aspects of the measles elimination program in Canada. Can Commun

Dis Rep 1999;25-5:45-46.

Working Group on Measles Elimination in Canada. Measles surveillance: Guidelines for

laboratory support. Can Commun Dis Rep 1999;25-24:201-216.

Duclos P, Gaulin C and Tipples G (WHO short-term consultants). Review of measles

surveillance activities in Pakistan. WHO, Regional Office for the Eastern Mediterranean,

October 1999.

Tipples G and Featherstone D (WHO short-term consultants). Assessment of measles laboratory

surveillance in the Islamic Republic of Iran. WHO, Regional Office for the Eastern

Mediterranean, October 1999.

Working Group on Measles Elimination in Canada. Measles surveillance: guidelines for

laboratory support. Can Commun Dis Rep 1998;24-5:33-44.

Tipples GA. Measles virus: standardization of genotyping nomenclature. Update: Vaccine-

Preventable Diseases 6(4) (1998).

Morris HM, and GA Tipples. Choosing to write the paper format thesis. J Nursing Education

37:173-175 (1998).

Working Group on Measles Elimination in Canada. Measles surveillance: guidelines for

laboratory support - summary. Update: Vaccine-Preventable Diseases 6(2):13-14 (1998).

Tipples GA. Genotyping of Measles Virus. Update: Vaccine-Preventable Diseases 6(1):6

(1998).

Tipples GA. The Viral Exanthema Laboratory at LCDC. Update: Vaccine-Preventable Diseases

5(3):5 (1997).

Research project funding

Health Canada Biotechnology Funds

“The use of novel recombinant DNA/protein reagents for the development of improved

diagnostic tests for viral diseases”

$137,000 per year for 3 years (1999-2001), $411,000 total

co-investigators: Graham Tipples, Michael Drebot, Heinz Feldmann, Yan Li


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“DNA chip technology for enhanced surveillance of human pathogens: genotyping and

identification of antimicrobial resistance genes”

$137,000 per year for 3 years (1999-2001), $411,000 total

co-investigators: Graham Tipples, Michael Drebot, Lai King Ng, Mike Mulvey

Health Canada Office of the Chief Scientist Funds

“Assessment of measles diagnostics tests”

$15,000 (2001-2)

primary investigator: Graham Tipples

Health Canada Office of the Chief Scientist Strategic Science Funds

“Genomic sequencing of measles and herpesviruses”

$35,000 (2002-3)

primary investigator: Graham Tipples


“Genomics of infection and immunity”

Sub-project: “Detection of emerging vaccine-induced immune escape mutants”

$186,000 per year for 3 years (2002-5), $558,000

sub-project co-investigators: Graham Tipples, Raymond Tsang, Anton Andonov, Carla Osiowy

WHO product development group for measles aerosol vaccine, research contract

“Evaluation of the ‘Mexican’ aerosol delivery device for measles vaccination”

primary investigator: Allan Coates (Hospital for Sick Children, Toronto)

virology subcontract: Graham Tipples, $20,000 (2004)

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