Glycopeptide Analysis (LC-MS) Marker Screening by T-Test, MFC, and ROC Protein and Sugar Chain...
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Transcript of Glycopeptide Analysis (LC-MS) Marker Screening by T-Test, MFC, and ROC Protein and Sugar Chain...
Glycopeptide Analysis (LC-MS)Glycopeptide Analysis (LC-MS)
Marker Screening by T-Test, MFC, and ROCMarker Screening by T-Test, MFC, and ROC
Protein and Sugar Chain IdentificationProtein and Sugar Chain Identification
Glyco Feature AnalysisGlyco Feature Analysis
Serum Glycoproteins Trypsin DigestionGlycopeptide Concentration LC-MS Profiling
A)
B)
C)
Number of glycopeptide peaks
Number of glycopeptide peaks
Number of glycopeptide peaks
AU
C o
f R
OC
p-va
lue
of
t-te
st
mea
n fo
ld c
han
ge
AUC=0.89
HCC vs HBV
HCC HBV HCV Healthy
20
HCC vs HCV
AUC=0.86
HCC vs Healthy
AUC=0.95
MS spectrum
MS/MS spectrum
Outer fucose
Outer fucose
SVQEIQATFFYFTPNKTEDTIFLR
AUC=0.93
HCC vs HBV
HCC HBV HCV Healthy
HCC vs HCV
AUC=0.86
HCC vs Healthy
AUC=0.95
6.5