GLP-1 RECEPTOR AGONISTS - FLAME · 2019. 4. 21. · OBJECTIVES u To understand the mechanism of...
Transcript of GLP-1 RECEPTOR AGONISTS - FLAME · 2019. 4. 21. · OBJECTIVES u To understand the mechanism of...
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GLP-1 RECEPTOR AGONISTSFLAME LECTURE: 6
LAWSON 11.1.18
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OBJECTIVES
u To understand the mechanism of action of GLP-1 Receptor Agonists
u To counsel the patient regarding the benefits, risks, and uses for GLP-1 Receptor Agonists
u Prerequisites:uNONE
u See also – for closely related topicsuFLAMEs on Type 2 DM / Medications for treatment of
DM
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TYPES OF GLP-1-R AGONISTS
u FDA-approved GLP-1 Receptor Agonist Medicationsu Exenatide (Byetta or Bydureon)u Liraglutide (Victoza or Saxenda)u Lixisenatide (Lyxumia)u Albiglutide (Tanzeum)u Dulaglutide (Trulicity)u Semaglutide (Ozempic)
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MECHANISM OF ACTIONu GLP-1 is a peptide hormone
that increases insulin secretion and decreases glucagon secretion from the pancreas in the presence of elevated blood glucose
u These medications delay gastric emptying, decreasing postprandial blood glucose, and increase satiety
u Good for decreasing glucose as well as weight loss
u These medications must be injected subcutaneously
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MEC
HA
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F A
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INDICATIONS / BENEFITS
u Not recommended as first line therapy for blood glucose control
u Recommended for use in type 2 diabetics when blood sugar is not well controlled on oral medication or on insulin
u Clinical trials show a reduction in baseline Hemoglobin A1c ranging from 0.87 to 1.9
u Can be used in combination with metformin or basal insulin
u Not recommended in type 1 diabetes
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ADVERSE EFFECTS
u Most common adverse effects are GI complaints and injection-site reactionsu Nausea, vomiting, diarrhea
u Hypoglycemia may occur when used in combination with insulin secretagogues or insulinu Consider lowering dose of sulfonylurea or insulin when starting
GLP-1 agonist
u Acute renal failure and worsening of chronic renal failure can occur
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CONTRAINDICATIONSu Black Box Warning!!
u Causes thyroid C-cell tumors in rodents; human risk not determined
u Contraindicated in patients with personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)
u Risk of pancreatitis reported; discontinue if pancreatitis suspected and do not restart if confirmed
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REFERENCES
u Dulaglutide (Rx). (2017, September 03). Retrieved October 28, 2018, from https://reference.medscape.com/drug/trulicity-dulaglutide-999965
u Trujillo JM, Nuffer W, Ellis SL. GLP-1 receptor agonists: a review of head-to-head clinical studies. Ther Adv Endocrinol Metab. 2015;6(1):19-28.