GLORY LILY

GLORY LILY

Jann Andre H. PaduaRhowell N. Tiozon Jr.

III - BSCT

TAXONOMYTAXONOMY Kingdom : Plantae Kingdom : Plantae Phylum : Magnoliophyta Phylum : Magnoliophyta Class : Liliopsida Class : Liliopsida Order : Liliales Order : Liliales Family : Liliaceae Family : Liliaceae Genus : Gloriosa Genus : Gloriosa Species superbaSpecies superba

VERNACULAR VERNACULAR NAMESNAMES

KKaliharialihari in Hindi in Hindi Kal-lavi in Marathi Kal-lavi in Marathi Manthori khizangu in Malayalam Manthori khizangu in Malayalam Kazhappai kizhangu in TamilKazhappai kizhangu in Tamil Flame Lily, Glory Lily, Tiger Claw in EnglishFlame Lily, Glory Lily, Tiger Claw in English

BOTANY AND BOTANY AND ORIGINORIGIN Gloriosa is a native of tropical Asia and Gloriosa is a native of tropical Asia and

Africa. The genus derives its name from Africa. The genus derives its name from the Latin word gloriosus, referring to the the Latin word gloriosus, referring to the flowers. It is found growing throughout flowers. It is found growing throughout tropical India, from the North -West tropical India, from the North -West Himalayas to Assam and the Deccan Himalayas to Assam and the Deccan peninsula.peninsula.

BOTANY AND BOTANY AND ORIGINORIGIN

It is also found growing in Madagascar, It is also found growing in Madagascar, Sri Lanka, Indo-China, Bangladesh, Sri Lanka, Indo-China, Bangladesh, Malaysia Myanmar, Indonesia and on Malaysia Myanmar, Indonesia and on the adjacent island.the adjacent island.

BOTANICAL BOTANICAL FEATUREFEATURE

It is an herbaceous, climbing perennial, It is an herbaceous, climbing perennial, growing between 3.5 to 6m in length, growing between 3.5 to 6m in length, but usually trained at 1.5m above but usually trained at 1.5m above ground level.ground level.

TOXICOLOGICAL PROFILE

GGLLOORRIIOOSSAA

SSUUPPEERRBBAA

GGLLOORRIIOOSSA A SSUUPPEERRBBAA

CHEMICAL CHEMICAL CONSTITUENTSCONSTITUENTS

CornigerineCornigerine 3-demethyl-N-formyl-N-deacetyl-3-demethyl-N-formyl-N-deacetyl-β-β-

lumicolchicinelumicolchicine 3-demethyl-g-lumicolchicine3-demethyl-g-lumicolchicine 3-demethyl colchicines3-demethyl colchicines colchicocidecolchicocide gloriosinegloriosine


tannins tannins superbinesuperbine β -β -sitosterolsitosterol GlucosideGlucoside a long chain fatty acida long chain fatty acid β β and g-lumiccolchicines and g-lumiccolchicines


LuteolinLuteolin colchicinescolchicines N-formylde N-formylde acetylcolchicines acetylcolchicines glucosides of 3-demethylcolchicineglucosides of 3-demethylcolchicine

CHEMICALS ON EACH CHEMICALS ON EACH PARTPART

COLCHICINE and COLCHICINE and GLORIOSINEGLORIOSINE

They are pale yellow to greenish They are pale yellow to greenish yellow alkaloids.yellow alkaloids.

They are considered as They are considered as phytochemicals which is phytochemicals which is concentrated on the tubers.concentrated on the tubers.

COLCHICINECOLCHICINE

GLORIOSINEGLORIOSINE

MODE OF ACTIONMODE OF ACTION Colchicine has an antimitotic effectColchicine has an antimitotic effect

– – It stops cell division by disrupting the It stops cell division by disrupting the spindle apparatus during the metaphasespindle apparatus during the metaphase

– – Cells with rapid turnover are affected Cells with rapid turnover are affected (bone marrow, intestinal epithelium, hair-(bone marrow, intestinal epithelium, hair-producing cells -> hair loss)producing cells -> hair loss)

– – It can alter neuromuscular functionIt can alter neuromuscular function

CLINICAL FEATURES OF CLINICAL FEATURES OF POISONINGPOISONING

Initial symptoms Initial symptoms develop within 6-12 hours develop within 6-12 hours of ingestionof ingestion

- pain, numbness, itching and tingling around - pain, numbness, itching and tingling around the mouth and throat with thirstthe mouth and throat with thirst

- nausea, intense vomitingnausea, intense vomiting- abdominal pain, severe diarrhoea with blood abdominal pain, severe diarrhoea with blood

and mucusand mucus


These lead toThese lead to– – electrolyte imbalanceelectrolyte imbalance- dehydration- dehydration- hypovolaemic shock manifested - hypovolaemic shock manifested - hypotension - hypotension - tachycardia- tachycardia


After 24 hours patients developAfter 24 hours patients develop

– – Muscle weakness, myoglobinuria, Muscle weakness, myoglobinuria, bronchial constriction, leucopenia, bronchial constriction, leucopenia, thrombocytopenia, clotting defects with thrombocytopenia, clotting defects with bleeding, polyneuropathy cardiac bleeding, polyneuropathy cardiac arrhythmias, hepatic insufficiency, acute arrhythmias, hepatic insufficiency, acute renal failure.renal failure.


In severe casesIn severe cases, there may be:, there may be:– – Respiratory depression, Respiratory depression,

confusion, delirium, convulsions, confusion, delirium, convulsions, comacoma

Death Death occurs due to shock or occurs due to shock or respiratory failurerespiratory failure

DIAGNOSISDIAGNOSIS

Toxicological analysis Toxicological analysis Biomedical analysisBiomedical analysisblood gas analysisblood gas analysis hematological analysishematological analysis

TREATMENTTREATMENT

hospitalize the patient immediately hospitalize the patient immediately induce vomiting (ipecac) / gastric induce vomiting (ipecac) / gastric

lavagelavagegive repeated activated charcoalgive repeated activated charcoalsupportive care eg IV fluid, assisted supportive care eg IV fluid, assisted

ventilation may be neededventilation may be needed

ETHNO-MEDICAL ETHNO-MEDICAL IMPORTANCEIMPORTANCE

According to ayurveda, tuber is According to ayurveda, tuber is pungent, bitter, acrid, heating, pungent, bitter, acrid, heating, anthemirtic, laxative, alexiteric, anthemirtic, laxative, alexiteric, abortifacient and useful in ulcers, abortifacient and useful in ulcers, gonorrhea, leprosy, piles, gonorrhea, leprosy, piles, inflammations, abdominal pains, itching inflammations, abdominal pains, itching and thirst. and thirst.


Tubers are also used as antifertility Tubers are also used as antifertility purpose. purpose.

The root paste is used for curing The root paste is used for curing gout, stomach ache, abortion gout, stomach ache, abortion purpose in intermittent fever, purpose in intermittent fever, wounds. wounds.


It can be administered to a delivered It can be administered to a delivered mother along with spirituous drink to mother along with spirituous drink to give relieve to her postnatal complaints give relieve to her postnatal complaints and also if its root paste smeared over and also if its root paste smeared over the palms and feet of a pregnant the palms and feet of a pregnant woman, delivery of child becomes woman, delivery of child becomes easier.easier.


Leaves of Glory lily have more Leaves of Glory lily have more medicinal qualities, namely for medicinal qualities, namely for curing asthma, its juice is effective curing asthma, its juice is effective against lice and also against many against lice and also against many skin disorders and treatment of skin disorders and treatment of various respiratory disorders.various respiratory disorders.

PROMISING PROMISING BENEFITBENEFIT

Analgesic and anti-inflammatory Analgesic and anti-inflammatory potential = gout and rheumatismpotential = gout and rheumatism

Antimicrobial properties – Antimicrobial properties – • antibacterial and antifungal potential. antibacterial and antifungal potential. • Candida albicans and Candida Candida albicans and Candida

glaberata.glaberata.


Larvicidal Potential= larvae of Larvicidal Potential= larvae of malaria vector and cattle tick.malaria vector and cattle tick.

Antithrombotic/Anticoagulent Antithrombotic/Anticoagulent potential = thrombin induced clotpotential = thrombin induced clot

Antitumor potential= cytogenic for P-Antitumor potential= cytogenic for P-388 cell line388 cell line


Enzyme inhibition potential Enzyme inhibition potential • LipoxygenaseLipoxygenase• acetylcholinesterase,acetylcholinesterase,• butyrylcholinesterase butyrylcholinesterase • ureas.ureas.

Treatment of snake bite (neutralize)Treatment of snake bite (neutralize)

TTHANK HANK YYOUOU

““Life is like a Pandora’s Box. There may be Life is like a Pandora’s Box. There may be too many harm it may done to us but it too many harm it may done to us but it depends on us on how we are going to depends on us on how we are going to make this harm for our advantage”make this harm for our advantage”

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GLORY LILY

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