Glomerular filtration rate
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Transcript of Glomerular filtration rate
Glomerular Filtration Rate
(GFR) Done By
Budour Alzahrani - Reem Alattas
Under supervise
Amal AlQahtani - Amer Amro
Case Study
Outlines
Nuclear
Medicine
Procedures
Imaging
Procedures
Non-Imaging
Procedures
Imaging procedures
Myocardial perfusion imaging
Thyroid scan
Renogram
Bone scan
Non-Imaging procedures
GFR (in-vitro)
RBC’s (Red Cell Mass)
Schilling Test
Most Common…
Glomerular Filtration
Glomerular filtration rate (GFR) is a commonly accepted
standard measure of renal function.
GFR is calculated from the area under the plasma clearance
curve, which required multiple blood samples to be taken
over a period of several hours.
Glomerular Filtration Rate
Indications Calculation of dose in chemotherapy
Detection of renal failure
Assessment of donors for
transplantation
evaluation of single kidney function
Contraindication
Patients with ascites.
Edema or other expanded body space.
Patient’s Preparation • Excessive intake of drinks containing caffeine including tea, coffee
and Coke should be avoided after 10 pm the night before the
test because of their diuretic effect
• recommended to avoid high protein meals before the study
• Some drugs can reduce renal function, should be stopped e.g.
diuretics.
• Note patient’s height and weight
Radiopharmaceuticals • Cr-51 EDTA
Half Life : 27.7 days
Dose : 2.0 MBq I.V
• Tc-99m DTPA is also used.
Procedure Explain the procedure .
Inject the Cr-51 EDTA .
Ask the patient to come back after 2,3 and 4
hours from the injection time for blood sample .
01
02
03
Procedure 04
05
06
Centrifuge the blood samples.
Dispense 2 ml of plasma.
Count sample tube on Gamma counter.
Case study Case 1
Case 2 Age: 66y.
Gender: female.
Clinical history: Brest cancer.
Reason of study: assess kidney function before chemotherapy.
Age: 65y.
Gender: male.
Clinical history: DM , HTN .
Reason of study: diabetic nephropathy.
Normal Case Result Abnormal Case Result Case 1 Case 2
This sheet is used for calculation of Adult GFR
Conclusion • GFR is the best test to measure kidney function , and to determine
the kidneys filtration rate.
• GFR used to detect renal failure and to assess donors for kidney
transplantation, also help to assess patient kidney function before
chemotherapy.
References • PSMMC Protocol.
• (2016). Bnms.org.uk. Retrieved 11 May 2016, from
http://www.bnms.org.uk/~bnms/images/stories/downloads/documents/gfrguidelin
esv5.2.pdf
• http://www.nuclearmedicine.org.uk/gfr/GFR_autumn2003_web.pdf
Thank You