GLEN ARTHUR LAINE - Texas A&M College of Veterinary · PDF fileGLEN ARTHUR LAINE. PRESENT...
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4/22/2015 GLEN ARTHUR LAINE PRESENT TITLE Vice President for Research Chief Research Officer Director, Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices Regents Professor, Department of Physiology and Pharmacology and Cardiovascular Research Institute, College of Medicine ENDOWMENT Wiseman-Lewie-Worth Chair in Cardiology CURRENT POSITIONS HELD Institutional Official for Human Subjects Research Institutional Official for Animal Research Institutional Official for Biosafety Institutional Official for Good Laboratory Practices Empowered Official for Export Controls Designated Officer for Scientific Misconduct Conflict of Interest Official ADDRESS Office of the Vice President for Research Division of Research Texas A&M University College Station, Texas 77843-1112 Office: 979-845-8585 FAX: 979-845-1855 E-mail: [email protected] CITIZENSHIP United States of America MILITARY SERVICE United States Army (RA) – 1967-1969 Honorable Discharge CURRENT SECURITY CLEARANCES AND RELATED RESPONSIBILITIES See optional insert
Transcript of GLEN ARTHUR LAINE - Texas A&M College of Veterinary · PDF fileGLEN ARTHUR LAINE. PRESENT...
4/22/2015
GLEN ARTHUR LAINE PRESENT TITLE Vice President for Research Chief Research Officer
Director, Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices
Regents Professor, Department of Physiology and Pharmacology and Cardiovascular Research Institute, College of Medicine
ENDOWMENT Wiseman-Lewie-Worth Chair in Cardiology CURRENT POSITIONS HELD Institutional Official for Human Subjects Research Institutional Official for Animal Research Institutional Official for Biosafety Institutional Official for Good Laboratory Practices Empowered Official for Export Controls Designated Officer for Scientific Misconduct Conflict of Interest Official ADDRESS Office of the Vice President for Research Division of Research
Texas A&M University College Station, Texas 77843-1112 Office: 979-845-8585 FAX: 979-845-1855 E-mail: [email protected]
CITIZENSHIP United States of America MILITARY SERVICE United States Army (RA) – 1967-1969
Honorable Discharge CURRENT SECURITY CLEARANCES AND RELATED RESPONSIBILITIES
See optional insert
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UNDERGRADUATE EDUCATION
1970-1974 B.S. in Microbiology -Minor in Chemistry University of Louisiana
GRADUATE EDUCATION
1974-1976 M.S. Work in Physics – Minor in Microbiology University of Louisiana
1976-1979 Ph.D. in Physiology and Biophysics
Minor in Biomedical Engineering Texas A&M University College of Medicine
POSTGRADUATE TRAINING
1980-1983 Post Doctoral Fellow in Biophysics of Microvascular Transport Microcirculation Research Institute College Station, Texas
1983-1985 Research Fellow, Critical Care Medicine
Hermann Hospital Houston, Texas
2009-2012 National Trauma Institute Fort Sam Houston, Texas ACADEMIC APPOINTMENTS
1974-1976 Graduate Teaching Assistant Department of Physics University of Louisiana Lafayette, Louisiana
1976-1980 Graduate Research Assistant
Department of Medical Physiology Texas A&M University-College of Medicine College Station, Texas
1980-1983 Research Fellow - Biophysics
Microcirculation Research Institute College Station, Texas
1980-Present Graduate Faculty Member Texas A&M University College Station, Texas
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Academic Appointments cont. 1983-1985 Research Fellow - Critical Care Medicine
Department of Anesthesiology University of Texas Medical School Houston, Texas
1983-2014 Graduate Faculty Member
University of Texas Medical School Houston, Texas
1985-1988 Assistant Professor
Department of Anesthesiology University of Texas Medical School Houston, Texas
1985-2001 Director, Center for Microvascular and Lymphatic Studies
University of Texas Medical School Houston, Texas
1988-1991 Associate Professor
Departments of Anesthesiology and Pharmacology University of Texas Medical School Houston, Texas
1992-2013 Professor and Department Head
Department of Physiology and Pharmacology Director, Cardiovascular Physiology and Applied Physics - Texas Engineering Experiment Station Texas A&M University College Station, Texas
1999-Present Director, Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices
Texas A&M University College Station, Texas
2005-2010 Associate Dean for Graduate Studies College of Veterinary Medicine & Biomedical Sciences
Texas A&M University College Station, Texas
2013-Present Regents Professor Department of Physiology and Pharmacology Texas A&M University College Station, Texas
2013-Present Vice President for Research Texas A&M University College Station, Texas
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CURRENT ADMINISTRATIVE RESPONSIBILITIES Senior Research Officer, Association of American Universities (AAU)
Research Vice President, Association of Public and Land-grant Universities (APLU)
Board of Trustees, Southeastern Universities Research Association (SURA)
University Councilor, Oak Ridge Associated Universities (ORAU)
Chief Research Officer, Southeastern Conference (SEC)
Member Representative, University Industry Demonstration Partnership (UIDP)
Board of Advisors, Houston Technology Center (HTC)
Houston Advanced Research Center (HARC)
Board of Directors, Research Valley Partnership (RVP)
Member Representative, National Academy of Inventors (NAI)
University-Industry Partner, Government-University-Industry Research Roundtable (GUIRR)
Board of Directors, National Space Biomedical Research Institute (NSBRI)
Council of Presidents, Universities Research Association (URA)
Institute for National Security Education and Research (INSER)
National Center for Therapeutics Manufacturing (NCTM)
High Performance Research Computing (HPRC)
President’s Executive Staff Member
President’s Academic Reps and Direct Reports
Provost’s Academic Leadership Team
Council on the Built Environment
University Research Council
Council of Principal Investigators
Advancement of Women in Science and Engineering Careers (ADVANCE) Internal Advisory Board
Council of Deans
Research Park Advisory Committee
Texas A&M Institute for Advanced Study (TIAS) Administrative Council Co-Chair
Intellectual Property Constituent Committee
PROFESSIONAL ORGANIZATIONS American Physiological Society
Microcirculatory Society
American Heart Association (Gold Member)
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Professional Organizations cont. Circulation Council
Cardiopulmonary and Critical Care Council
Biomedical Engineering Society
North American and International Society of Lymphology
International Society for Heart Research
Association of Chairmen of Departments of Physiology
Association of Former Intelligence Officers
National Association of Combat Medics
HONORS Regents Professor Award, Texas A&M University
Wiseman-Lewie-Worth Endowed Chair in Cardiology
Resident Fellow-Texas Higher Education Coordinating Board
Distinguished Achievement Award in Research, Texas A&M University
Director, Center for Microvascular and Lymphatic Studies Texas Medical Center
Fellow, Cardiovascular Section, American Physiological Society
Coordinator of Research, Halboughty Endowment for Cardiovascular Science, Texas A&M University
Established Investigator of the American Heart Association
Research Career Development Award, National Heart, Lung and Blood Institute
Upjohn Cardiovascular Investigator Award, International Society for Heart Research
Lamport Microvascular Investigator Award, Microcirculatory Society
Faculty Teaching Recognition Award, University of Texas Medical School-Houston
Diversity Award, Texas A&M University College Level
Department of Defense - Pro Patria Award
Association of Academic Department Chairs (Section Chair)
Gordon Conference - Invited Speaker
Phi Eta Sigma - National Honor Society
Pi Mu Epsilon - National Mathematics Honor Society
Phi Zeta - National Veterinary Medical Honor Society
Phi Kappa Phi – Collegiate Honor Society
Sigma Xi – National Scientific Research Society
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GRANTS 1975-1976 National Science Foundation, Bioremediation of a Southern Louisiana Freshwater Lake,
Co-Investigator, $5,000. 1974-1976 National Aeronautics and Space Administration, Interplanetary Transport of Spores by
Micrometeorites, Principal Investigator, $14,000. 1976-1979 Texas A&M University, University Starter Grant, Principal Investigator, $10,000 1979-1980 Multidisciplinary Approach to Peripheral Vascular Disease. Office of University
Research, Texas A&M University, Co-Investigator, $25,000. 1979-1982 Pathobiology of Hypertensive Microvessels. NIH-NHLBI Research Grant, Co-
Investigator, $366,920. 1979-1984 Pathophysiology of Edema. NIH-NHLBI Research Grant, Co-Investigator, $420,000. 1980-1981 Pathophysiology of the Ventricular Microcirculation Resulting from Chronic Coronary
Insufficiency. NIH Biomedical Research Support Grant, Principal Investigator, $15,000. 1980-1983 Pathophysiology of Ascites. NIH-NHLBI National Research Service Award, Principal
Investigator, $156,000. 1984-1985 Basic Determinants of Pulmonary Lymph Flow. NIH-NHLBI Research Grant, Co-
Investigator, $79,934. 1984-1985 Pathophysiology of the Coronary Microvasculature in Chronic Arterial Hypertension.
NIH-Biomedical Research Support Grant, Principal Investigator, $16,000. 1985-1987 Cardiac Lymph and Capillary Changes in Chronic Hypertension. American Heart
Association, Principal Investigator, $48,399. 1984-1988 Pulmonary Edema, Mechanisms and Therapy. NIH-NHLBI Research Grant, $420,088. 1986-1987 National Institutes of Health Small Instrumentation Grant, Co-Principal Investigator,
$17,000. 1986-1987 Criticare Corporation, Meeting Seed Money Grant, Principal Investigator, $2,000. 1986-1989 Fluid Exchange in Edematous Lungs. NIH-NHLBI Research Grant, Co-Investigator,
$258,562. 1986-2002 Basic Determinants of Lymph Flow in Edema. NIH NHLBI R01-36115 Grant, Principal
Investigator, $1,760,000
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Grants cont. 1988-1989 Lymphology Meeting Grant, Principal Investigator Merrell Dow; Merck Sharp & Dohme;
Princeton Pharm.; C.R. Bard; Smith, Kline, Beckman; Marion Lab; DuPont Critical Care, $20,000.
1989-1994 Myocardial Lymph Flow and Edema Formation. NIH-NHLBI, RCDA, Principal
Investigator, $200,000, Returned due to overlap with AHA Grant. 1989-1994 Myocardial Lymph Flow and the Interstitial Matrix. American Heart Association,
Established Investigator Award, Principal Investigator, $220,000. 1990-1995 Basic and Clinical Implications of Myocardial Edema. UT Medical Practice Plan
Research Award, $250,000. 1991-1995 PMN Adherence Reactions: Role in Cardiopulmonary Bypass. NIH - NHLBI Research
Grant, Co-Investigator, $950,000. 1994-1997 Continuous endotracheal tube cleaning device. THECB-Advanced Technology Program
(Research). $226,111. 1994-1995 National Institutes of Health Small Instrumentation Grant, Co-Principal Investigator,
$37,000. 1995-2000 Basic and Clinical Implications of Myocardial Edema. UT Medical Practice Plan
Research Award, $500,000. 1997-1998 NASA-National Space Biomedical Research Institute, Johnson Space Center, Co-
Investigator, $175,000. 1999-2002 Signature Program Comparative Cardiovascular Research Grant, College of Veterinary
Medicine, Principal Investigator, $120,000. 1993-2007 Deutsche Forschungsgemeinschaft Fellowships, Mentor, $1,200,000. 2000-2007 Basic and Clinical Implications of Myocardial Edema. UT Medical Practice Plan
Research Award, $700,000. 2001-2006 Reducing Morbidity and Mortality in patients with Cardiovascular Disease DHHS-
Centers for Disease Control and Prevention, Principal Investigator, $1,800,000
2001-2004 Anti-edema mechanisms: Nitric oxide and thromboxane in the regulation of lymphatic function. Advanced Research Program, Co-Principal Investigator $131,125
2002-2005 Vascular Biomechanics and Mechanobiology. The Whitaker Foundation, Co-Principal
Investigator, $3,000,000-(20%)
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Grants cont. 2003-2006 Mechanisms of Edema Resolution: Implications for Treatment of Cardiovascular
Disease. Life Sciences Task Force (PI Glen A. Laine), $500,000 2006-2011 Mechanisms of Reperfusion – Induced Endothelial Injury. NIH – RO1-NHLBI-077566,
Co-Investigator, $1,775,625
2006-2011 Biologists and Engineers Advancing Research. NIH-R25 NHLBI-084667, Co-Principal Investigator, $473,270
2007-2010 Bioengineering, Bioinformatics Institute. NSF-EEC-0609395. Co-Investigator,
$600,000 2007-2012 Role of Cytokine-Induced Inflammation in Endothelial Dysfunction in Diabetes. NIH –
RO1-NHLBI-085119. Co- Investigator, $1, 620,440 2009-2012 Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema. NIH-
RO1-NHLBI-092916. Co-Investigator, $695,000 2010-2012 Batwing as a Novel Model for Cardiovascular Radiobiology: Vascular contribution to
Radiation-Induced Edema. AHA 10-GRNT-4320043. $140,000 2011-2014 Adjustable Pediatric Systemic to Pulmonary Artery Shunt, NIH-R21HL104476-01.
Principal Investigator, $432,500 2013-2018 Center for Cell and Organ Biotechnology, Texas Engineering Technology Fund,
08/09/13. Principal Investigator, $14,000,000 2015-2018 Intestinal Lymphatic Insufficiency Caused by Paralytic Ileus Induces Intestinal Interstitial
Edema, NIH-R21 11328077. Principal Investigator, $363,750.00 (Pending) MENTORED TRAINING GRANTS
1987-1992 Pleural Effusion and Pulmonary Edema Formation. (Steven J. Allen, M.D.), NIH - K08-NHLBI-01999, $266,534
2000-2004 Microvascular Injury During Extracoporeal Life Support. (Charles S. Cox, M.D.), NIH -
K08 NIGM-00675, $477,144 2002-2007 Pulsatile Hemodynamics and Carotid Stenting. (Christopher Quick, Ph.D.), NIH - K25-
NHLBI 70608, $636,779 2003-2006 Edema and Volume Resuscitation. (Stacey D. Moore-Olufemi, M.D.), NIH - T32-GM-
08792, $350,000. 2004-2007 Vascular biology: Aging and Endothelial Dysfunction. (Christopher R. Woodman, Ph.D.),
NIH –K01-AG00988, $350,000.
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Mentored Training Grants cont. 2007-2011 Effects of edema on cadherins in small intestine. (Karen S. Uray, PhD). NIH
K01DK070758. $500,000. 2008-2013 Preclinical Development of the Adjustable Pediatric Systemic – Pulmonary Artery Shunt
(M. W. Mohiuddin, Ph.D.) AHA 825211F. $78,000
2010-2013 Lymphatic Adaptation Due to Partial Lymphatic Obstruction (Ranjeet Dongaonkar, PhD) AHA 10POST3870014, $140,000
Texas A&M University Vice President for Research Grants 2010-2013 ARRA – Texas A&M University Interdisciplinary Life Sciences Building Build-Out. NIH
1C06RR028658. Principal Investigator, $3,529,612 2012-2017 CONACYT – National Council of Science and Technology (Mexico). Agreement of
Cooperation in Research. Principal Investigator, 02-465451 $389,000.00 Michael E. DeBakey Institute Private Funding
Wiseman-Lewie-Worth Endowed Chair in Cardiology-$1,000,000 Read Endowed Chair in Cardiothoacic Surgery-$1,000,000 Sid Richardson Foundation-$300,000 Cardiovascular Building Addition-$2,150,000
Microcirculatory Society Excellence in Lymphatic Research Award Winners from Laboratory Randolph Stewart, DVM, PhD Charles Cox, MD Christopher Quick, PhD Ranjeet Dongaonkar, PhD CURRENT EDITORIAL POSITIONS Associate Editor, Lymphology Reviewer, American Journal of Physiology Heart and Circulatory Section Reviewer, American Journal of Physiology (Gastrointestinal and Liver, Regulatory and Integrative) Reviewer, Circulation Research Reviewer, Hypertension Reviewer, Circulation Reviewer, Journal of Applied Physiology
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Current Editorial Positions cont. Reviewer, Microvascular Research Reviewer, Anesthesiology Reviewer, Critical Care Medicine Reviewer, Laboratory Animal Science Reviewer, American Journal of Pathology Reviewer, Hepatology Reviewer, Canadian Journal of Physiology Reviewer, Institute for Laboratory Animal Research (National Academy of Sciences) Reviewer, Journal of Vascular Research Reviewer, The American Journal of the Medical Sciences SERVICE ON GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES: (PAST 7 YEARS) NIH Study Section (Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and
Pulmonary Systems), Center for Scientific Review (2014 - Present) NIH Study Section (Biochemistry, Physiology, and Medicine), Research Centers Special Review
Committee NIH - Institute for Comparative Medicine (Ad Hoc - Reviewer) NIH - Expedited AIDS Review Study Section (Ad Hoc) NIH - Alcohol and Immunologic Disorders (Site Visit Team) NIH - Child Health and Human Development (Site Visit Team and Study Section) Veterans Administration - Central Grant Review Committee American Heart Association Grant Review Panel (State and National) Medical Research Council of Canada Natural Sciences and Engineering Research Council of Canada LINK Equine Advisory Board Arizona Disease Control Research Commission Texas Higher Education Coordinating Board – Minority Health Grant Program American Society of Lymphology a) Executive Committee, Member
b) Membership Committee, Chairman c) Program Committee, Chairman d) Drinker Lectureship Committee, Chairman
e) Treasurer f) Vice President
g) President Microcirculatory Society
a) Awards Committee b) Development Committee American Heart Association Bio. Eng. Study Section (2010-2014)
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TEACHING EXPERIENCE (expanded teaching portfolio available upon request) Undergraduate Microbiology Microbial Physiology Virology Parasitology Labs Physics Radiation Biophysics Medical Physics Introduction to Classical Physics Graduate Physiology and Biophysics Cardiovascular Lymphatic Fluid balance Gastrointestinal Comparative Theory of Research Professional Medical Physiology Physiology Pharmacology Anesthesiology Pre-entry Physics, Chemistry Trauma and Intensive Care SERVICE ON UNIVERSITY COMMITTEES University of Texas Medical School at Houston 1984 - 1991 Admissions - Faculty Interviewer 1984 - 1991 Computer Resources Committee 1984 - 1991 Visiting Professor and Research Seminar Committee 1985 - 1991 Biohazards Committee (Vice Chairman, 1987-1990; Chairman 1990-1991) 1988 - 1993 Departmental Promotions and Tenure Committee (Chairman, 1990-1992) 1988 - 1991 Medical Student Summer Research Program Grant Reviewer 1988 - 1991 Medical Student Pre-entry Summer Program (Instruction in Basic Sciences)
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Service cont. 1989 - 1991 Faculty Senate 1989 - 1991 Medical Student Mentor Program 1989 - 1990 Grants and Contracts Task Force 1991 - 1991 Department of Anesthesiology Steering Committee 1991 - 1991 Radiation Safety Committee Texas A&M University 1991 - 1993 College of Veterinary Medicine Graduate Instruction Committee 1991 - 1995 Departmental Director of Graduate Studies 1991 - 1996 Departmental Teaching Contingency Committee 1991 - 1996 College of Medicine Graduate Instruction Committee 1991 - 1996 Co-Director of the Veterinary School/Medical School Cardiovascular Forum 1991 - 1995 College of Veterinary Medicine Representative to the Faculty Senate 1991 - 1995 Faculty Senate Research Committee 1991 - 2004 University Graduate College Representative 1991 - 2010 Medical Division of the Texas Engineering Experiment Station 1991 - Present Council of Principal Investigators 1991 - 1998 Cardiovascular Faculty Bylaws Committee 1993 - 1997 Course Coordinator, Medical Physiology 606 and Veterinary Physiology 656 1993 - 2013 Acting Dean (During Deans Absence) 1993 - 2013 Designated Department Head-Interdisciplinary Faculty of Toxicology 1993 - 2013 Executive Committee, College of Veterinary Medicine 1993 - 1996 College Council, College of Veterinary Medicine 1993 - Present President's Administrative Advisory Council 1993 - 1997 Center for Animal Biotechnology (IBT) 1995 - 2009 New Faculty Orientation Promotion and Tenure Presentation 1995 - 2005 Diversity Education Program for Faculty 1995 - 2013 Executive Committee, Biomedical Sciences 1996 - 1997 Howard Hughes Medical Institute Undergraduate Intern Program 1996 - 2005 Unit Ethics Education Coordinator 1996 - 2005 Hospital Executive Advisory Board 1997 - 1998 State Employee Charitable Campaign, Area Coordinator 1997 - 2007 Science and Technology Committee, Office of the Vice President for Research 1997 - 1998 Committee on Research Foundation Indirect Costs Distribution, Office of the
Provost 1997 - 1999 School of Rural Public Health, Steering Committee 1998 - 1999 Research Task Force Committee of Vision 2020 –Texas A&M University Long-
Range Plan, Office of the President
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Service cont. 1998 - 1999 Chairman, Faculty of Toxicology External Review, Office of the Provost 1999 - 2001 Rewarding Teaching/Enhancing Student Learning Project Texas A&M University System 2001 - 2002 Life Sciences Initiative Integrative Biology Task Force 2002 - 2003 Texas Agricultural Experiment Station, Distribution of Indirect Cost Return
Committee 2002 - 2003 Provost Committee for Establishment of Research Metrics 2002 - 2004 Interdisciplinary Faculty of Reproductive Biology Internal Advisory Board 2004 - 2010 College of Veterinary Medicine Research Space Advisory Committee 2004 - 2006 Texas Agricultural Experiment Station Long Range Planning Committee 2005 - 2007 Life Science Building Advisory Committee (Office of the President) 2005 - 2007 Chancellor’s Medical Instrumentation Committee 2005 - 2013 Department Heads Council (Dean of Faculties and Provost) 2005 - 2014 Regents’ Scholars Presentations 2005 - 2008 Mid-Range Planning Committee (Division of Student Affairs) 2008 - 2009 Digital Communications and Publishing 2008 - 2013 Convener, Department Heads Council (Lead Department Head, 66 departments) 2008 - 2010 Academic Master Plan Committee (Office of the Provost) 2009 - 2010 Faculty Governance Panel 2009 - Present Research Valley Partnership 2009 - 2010 Association of Former Students Funding Task Force 2009 - 2013 Council on Climate and Diversity (Office of the Vice President for Diversity) 2010 - 2011 Deferred Maintenance Task Force (Vice President for Administration) 2010 - 2013 Interdisciplinary Research Groups and Interdisciplinary Research Programs
Working Committee (Division of Research and Graduate Studies) 2011 - 2013 Research Administration Shared Services Committee (Division of Research and
Graduate Studies) 2011 - 2013 Incivility Workshop Planning Committee (Dean of Faculties) 2010 - 2011 Fy12-13 Budget Planning Committee (Office of the President) 2010 - 2011 Budget Reallocation Working Group (Office of the President) 2011 - 2013 Interdisciplinary Research Faculty Incentives (Office of the Provost) 2012 - 2013 Texas A&M University - Health Science Center merger (Office of the Provost) 2012 - 2013 Strategic Reallocation Sub-Council (Office of the Provost) 2013 – Present Continuity and Recovery Group
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Select Administrative Search Committees (From 50 Total Search Committees): Dean, College of Science Mayborn Chair in Cardiovascular Sciences Dean, College of Medicine Vice President for Research Director, Biomedical Sciences
Curator, Corps of Cadets Museum Dean of Faculties and Associate Provost (2002, 2009 and 2012) Department Head, Biomedical Engineering (Committee Chair)
Department Head, Small Animal Medicine and Surgery Associate Dean for Research and Graduate Studies (Committee Chair) Director, Texas AgriLife Research Department Head, Pathobiology (Committee Chair) ADMINISTRATIVE TRAINING
Texas A&M University Administrative Training (Office of the Associate Provost and Dean of Faculties)
1) Academic Administrators Development Program 2) Higher Education Administrator Developmental Workshop 3) Higher Education Law Symposium 4) Academic Administrators Seminar Series 5) Search Advisory Committee Training
Mays Graduate School of Business - Executive Development Program
Texas Higher Education Coordinating Board – Resident Fellow
Department of Defense - Industrial College of the Armed Forces National Security Series
Various leadership schools (civilian and military), academic course work (administration and policy) and focused programs (i.e., ADA, EEOC, Strategic Planning, Law ....), Boy Scouts of America, Assistant Scoutmaster High Adventure Troop, Troop Committee Chairman
ADMINISTRATIVE EXPERIENCE Department of Anesthesiology, UT Medical School, Houston, Steering Committee-Group, functioned
as department head for two years during Anesthesiology Head Search process. Director, Center of Microvascular and Lymphatic Studies, University of Texas Medical School,
Houston.
Director of the Medical Inreach Division of the Texas Engineering Experiment Station.
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Administrative Experience cont. Director of Graduate Studies, Department of Physiology and Pharmacology.
Director, Cardiovascular Physiology and Applied Physics Laboratory, Texas Engineering Experiment
Station.
President - various local, state and national organizations, both academic and nonacademic.
Executive Committee, Biomedical Sciences
Executive Committee, College of Veterinary Medicine and Biomedical Sciences.
Acting Dean, during Dean’s absence.
Academic Department Head, Physiology, Pharmacology and Toxicology.
Association of Chairmen of Departments of Physiology
Director, Michael E. DeBakey Institute
Endowed Chairholder
Designated Department Head-Interdisciplinary Faculty of Toxicology
Vice President for Research
CLINICAL/PATIENT CARE 1966 - 1967 Civil Defense Medic
1967 - 1969 Combat Medic-US Army
1970 - 1972 EMT-Ambulance-Acadian Ambulance
1972 - 1976 EMT-Paramedic-Acadian Ambulance
1976 - 1980 TAMU Medical School (Student) (City of College Station Ambulance Committee)
1980 - Present UT Medical School-Herman Hospital Department of Anesthesiology (Faculty)
1999 - Present Director, Michael E. DeBakey Institute
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FELLOWS – UNDERGRADUATE, GRADUATE AND POSTDOCTORAL UNDERGRADUATE FELLOWS
Over 100 – names available upon request GRADUATE FELLOWS
CHAIR OR CO-CHAIR
1980 - 1982 Jan First, M.S. in Bioengineering 1985 - 1986 Ayele Workenesh, M.S. in Pharmacy 1988 - 1991 Julie Poorman, Ph.D., Pharmacology 1988 - 1991 Robert Scott III, M.D., Ph.D., Pharmacology 1991 - 1993 Kristen Norton, M.S., Cardiovascular Physiology 1991 - 1997 Karen Davis, Ph.D., Physiology and Biophysics 1992 - 1997 Randolph Stewart, D.V.M., Ph.D., Cardiovascular Physiology 1994 - 2000 Doug Rohn, D.V.M., Ph.D., Cardiovascular Physiology 2006 - 2008 Rachel Boyle, Ph.D., Cardiovascular Physiology 2006 - 2008 Wonjun Hwang, Ph.D., Cardiovascular Physiology 2004 - 2007 Robert Jay Widmer, Ph.D., Physiology 2004 - 2008 Ketaki V. Desai, Ph.D., Physiology 2004 - 2008 Ranjeet Dongaonkar, Ph.D., Physiology 2004 - 2008 Mohammed Waqar Mohiuddin, Ph.D., Physiology 2004 - 2008 Arun Venugopal, Ph.D., Physiology 2007 - 2009 Bryon Jennings, M.S., Cardiovascular Physiology 2008 - 2010 Olivia Masters, M.S., Cardiovascular Physiology 2009 - 2012 Julia Buck, Ph.D., Cardiovascular Physiology 2006 - 2013 Phuc Nguyen, Ph.D., Cardiovascular Physiology 2008 - 2013 Tam Nguyen, Ph.D., Cardiovascular Physiology 2009 - Present Sara Knesek, Ph.D., Cardiovascular Physiology
MEMBER 1991 - 1993 John Schackleford, Ph.D., Animal Science 1991 - 1993 Lisa Butler, D.V.M., Ph.D., Physiology 1991 - 1994 Kate Meurs, D.V.M., Ph.D., Cardiovascular Physiology 1991 - 1995 Jon Lengefeld, Ph.D., Exercise Physiology 1993 - 1995 Kyland Burden, M.S., Veterinary Physiology 1992 - 1997 Zeng Jian Chen, Ph.D., Genetics 1992 - 1997 David Nelligan, D.V.M., Ph.D., Veterinary Physiology 2002 - 2004 Kristina Aghassibake, M.S., Biomedical Engineering 2004 - 2007 Bruce Ngo, Ph.D., Physiology 2006 - 2008 Ashton Charles, M.S., Genetics
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POSTDOCTORAL FELLOWS 1984 - 1986 Frank G. Zavisca, M.D. 1985 - 1988 Steven J. Allen, M.D. 1986 - 1987 Jeffrey Katz, M.D. 1986 - 1989 John P. Williams, M.D. 1986 - 1989 Burdett S. Dunbar, M.D. 1987 - 1990 J. Rael Elk, M.D. 1990 - 1992 Andreas Hoeft, M.D., Ph.D. 1993 - 1996 Uwe Mehlhorn, M.D. 1994 - 1998 David Warters, M.D. 1995 - 1998 Hans Geisler, M.D. 1998 - 2000 Henning Sauer, M.D. 1998 - 2001 Randolph Stewart, D.V.M., Ph.D. 2001 - 2003 Uwe Fischer, M.D. 2001 - 2004 Charles Cox, M.D. 2002 - 2005 Stacey Moore, M.D. 2004 - 2008 Karen Davis, Ph.D. 2005 - 2008 Ravi Radhakrishnan, M.D. 2007 - 2008 Werner Monzon-Posateas, M.D. 2007 - 2009 Alonzo Guedes, D.V.M, Ph.D. 2009 - 2011 Shinil Shah, M.D. 2008 - 2013 Ranjeet Dongaonkar, Ph.D. 2008 - 2013 Mohammed Waqar Mohiuddin, Ph.D. 2010 - 2013 Ji Chu, Ph.D.
FACULTY MENTORED Blue, Alice, D.V.M. Boothe, Dawn, D.V.M., Ph.D. Conover, Gloria, Ph.D. Cox, Charles, M.D. Cudd, Timothy, D.V.M., Ph.D. Davis, Karen, Ph.D. Dunbar,Burdett S., M.D. Elk,J. Rael, M.D. Fajt, Virginia, D.V.M., Ph.D. Fischer, Uwe, M.D. Geisler, Hans, M.D. Golding, Michael, Ph.D. Guedes,Alonzo, D.V.M, Ph.D. Han, Guichun, M.D., Ph D. Heaps, Cristine, Ph.D. Herman, James, D.V.M.. Ph.D. Hinrichs, Katrin, D.V.M., Ph.D. Hoeft, Andreas M.D., Ph.D. Ivanov, Ivan, Ph.D. Katz,Jeffrey, M.D. Kochevar, Deborah, D.V.M., Ph.D.
Long, Charles, Ph.D. Mehlhorn,Uwe, M.D. Quick, Christopher, Ph.D. Ramos, Kenneth, Ph.D. Rucker, Edmund, Ph.D. Sayes, Christie, Ph.D. Scott, Maya, D.V.M., Ph.D. Stallone, John , Ph.D. Steven J. Allen, M.D. Stewart, Randolph, D.V.M., Ph.D. Tian, Yanan, Ph.D. Warters,David, M.D. Wasser, Jeremy, Ph.D. Westhusin, Mark, Ph.D. Williams,John P., M.D. Wilson, Shannon, DVM, Ph.D. Woodman, Christopher, Ph.D. Zavisca,Frank G., M.D., Ph.D. Zhang, Cuihua, Ph.D. Zhou, Beiyan, M.D., Ph.D.
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VISITING PROFESSORSHIPS AND CONSULTANTSHIPS: (PAST 7 YEARS)
National California Institute of Technology University of Arizona College of Medicine University of Texas Medical School at Dallas University of Missouri College of Medicine Walter Reed Army Hospital Scott and White Hospital University of Texas Medical School, Houston The University of Chicago Medical School University of South Alabama College of Medicine Baylor College of Medicine Texas Heart Institute University of California College of Medicine, Los Angeles The Ohio State University College of Medicine National Aeronautics and Space Administration Johnson Space Center University of Alabama at Birmingham School of Medicine
International Department of Chemical Engineering University of British Columbia, Canada Center for Microcirculation, Beijing, China Department of Physiology, Oxford, England Department of Medicine, Bergen, Norway Department of Medicine, Keio University School of Medicine, Tokyo, Japan Department of Physiology, University of Glasgow, Scotland Department of Surgery, Trauma Research Program, Univ. of Toronto, Canada Department of Physiology and Pharmacology, University of NSW, Australia Department of Internal Medicine, University of Otago, New Zealand Department of Cardiothoracic Surgery, University of Köln, Germany World Innovation Summit for Health, Qatar Foundation, Doha, Qatar International Livestock Research Institute, Nairobi, Kenya, Africa Center for Disease Control and Prevention (CDC), Kenya Medical Research Institute (KMRI),
Nairobi, Kenya, Africa Weizmann Institute of Science, Rehovot, Israel Yucatan University, Agriculture and Life Science, Merida, Yucatan, Mexico
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PUBLICATIONS Abstracts Laine, G.A., Hall, J.T., and Granger, H.J.: Starling forces and lymphatic dynamics in canine liver during venous hypertension. Fed. Proc. 38:1304, 1979. Laine, G.A., Hall, J.T., and Granger, H.J.: Pathophysiology of ascites formation. National Student Research Forum. 25,1979. Laine, S.H., Laine, G.A., and Granger, H.J.: Osmotic pressure of solutions containing entangled polysaccharide chains. Microvas. Res. 17:S32, 1979. Laine, G.A., Hall, J.T., Laine, S.H., and Granger, H.J.: Interstitial and lymphatic fluid dynamics in canine liver during venous hypertension. Microvas. Res. 17:S33, 1979. Laine, G.A., Smyers, D.D., and Granger, H.J.: Transcapillary fluid dynamics in canine myocardium. National Student Research Forum 10,1980. Laine G.A., and Granger, H.J.: Myocardial starling forces and lymphatic dynamics during venous hypertension. Microvas. Res. 20:116, 1980. Laine, G.A., and Granger, H.J.: Permeability of intestinal capillaries in chronic arterial hypertension. Microvas. Res. 21:248,1981. Laine, G.A., and Granger, H.J.: Transcapillary fluid balance in exercising skeletal muscle. Fed. Proc. 40:406, 1981. Hansen, T., Drake, R., Geissler, M., Gabel, J., and Laine, G.: Effect of outflow pressure on lung lymph flow in sheep. Fed. Proc. 43:1030, 1984. Drake, R., Fallon, K, Laine G., and Gabel, J.: Edema formation and lung lymph flow during volume infusions. Fed. Proc. 43:640, 1984. Zavisca, F., Laine, G., Abouleish, E., Drake, R., Smith, B., and Gabel, J.: Effect of endotoxin and ritodrine on lung capillary permeability in unanesthetized sheep. Fed. Proc. 43:1030, 1984. Laine, G.A., Drake, R., and Gabel, J.: Effect of differences between lymph flow rate (QL) and transmicrovascular fluid flux (Jv) on permeability estimations. Microvas. Res. 27:250, 1984. Laine, G.A., Drake, R., Zavisca, F., and Gabel, J.: Effect of lymphatic cannula outflow height on lung permeability estimations. Fed. Proc. 43:1029, 1984.
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Abstracts cont. Granger, H.J., Laine, G.A., and Macken, E.R.: Exchange of fluid and proteins across hepatic sinusoids and Glisson's capsule in chronic caval hypertension. Fed. Proc. 43:417, 1984. Laine, G.A., Butler, B., Drake, R., and Gabel, J.: Effect of air embolism on lung fluid balance. Microcirc. Endo. Lymphatics. 2(1):15,1985. Laine, G.A.: Myocardial microvascular fluid exchange in chronic arterial hypertension. Microvas. Res. 29:232,1985. Gabel, J., Fallon, K., Laine, G., and Drake, R.: Intravenous volume infusions cause lung edema by elevating systemic venous pressure (SVP). Fed. Proc. 44:1907, 1985. Allen, S., Drake, R., Gabel, J., and Laine, G.: Effect of raised intracranial pressure (ICP) on lung fluid balance in dogs. Fed. Proc. 44:1907,1985. Laine, G., Drake, R., and Gabel, J.: Lymphatic outflow reduction resulting from elevated systemic venous pressure: Effect on pulmonary edema formation. Fed. Proc. 44:1906, 1985. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Raised central venous pressure enhances the formation of pulmonary edema. Anesthesiology 63:A126, 1985. Allen, S.J., Tonnesen, A.S., Stanley, T., Laine, G.A., and Miner, M.E.: The effects of high frequency jet ventilation on elevated intracranial pressure and hemodynamic function in patients with acute closed head injuries. Anesthesiology 63:A529, 1985. Laine, G.A.: Myocardial edema and lymph flow in chronic arterial hypertension. Journal of Molecular and Cellular Cardiology. 17(12):32,1985. Drake, R.E., Laine, G.A., Allen, S.J., and Gabel, J.C.: Effect of lymph vessel cannulation on lymph flow rate measurements. Fed. Proc. 45(3):1148, 1986. Laine, G.A.: dp2/dt2 as an index of myocardial microvascular permeability in chronic preparations. Fed. Proc. 45(3):1149,1986. Drake, R.E., Allen, S.J., Laine, G.A., and Gabel, J.C.: Error in estimation of sheep lung lymph contamination. Fed. Proc. 45(3):285,1986. Allen, S.J., Laine, G.A., Drake, R.E., and Gabel, J.C.: Reduction of pulmonary artery pressure and systemic venous pressure decreases pulmonary edema formation in endotoxemia. Fed. Proc. 45(3):283,1986.
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Abstracts cont. Giezentanner, A.L., Cronau, L.H., Laine, G.A., and Allen, S.J.: Effect of whole body hyperthermia on cerebral blood flow during general anesthesia. Fed. Proc. 45(3):415, 1986. Laine, G.A., Drake, R.E., Allen, S.J., and Gabel, J.C.: Mechanics of lymph flow in cannulated vessels. Fed. Proc. 45(3):412, 1986. Laine, G., Butler, B., Allen, S., Drake, R., and Gabel, J.: Intravenous air embolism does not alter pulmonary microvascular permeability. 30th IUPS Proceedings. 16:96, 1986. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Nitroprusside reduces pulmonary edema in endotoxemia. Critical Care Med. 14:373, 1986. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Elevated central venous pressure enhances the formation of pulmonary edema. Critical Care Med. 14:322, 1986. Allen, S.J., Giezentanner, A., Cronau, L.H., Bull, J.M., and Laine, G.A.: Whole body hyperthermia increases cerebral blood flow and impairs cerebral autoregulation. Anesthesiology 65:A321, 1986. Allen, S., Drake, R., Williams, J., Gabel, J., Elk, R., and Laine G.: Superior vena caval pressure elevation increases extravascular lung water following endotoxemia. Fed. Proc. 46(4):1099, 1987. Laine, G.A., Allen, S.J., Elk, R., Gabel, J.C., and Drake, R.E.: A model of the interstitial-lymphatic system in the lung. Fed. Proc. 46(3):329,1987. Gabel, J., Williams, J., Allen, S., Laine, G., and Drake, R.: Preparation for chronic left atrial pressure elevation in sheep. Fed. Proc. 46(4):1422,1987. Drake, R., Allen, S., Katz, J., Laine, G., and Gabel J.: Diaphragm lymph response to endotoxin in sheep. Fed. Proc. 46(4):1099, 1987. Williams, J., Drake, R., Allen, S., Gabel, J., and Laine, G.: Myocardial edema and lymph flow. Fed. Proc. 46(4):1545,1987. Laine, G.A., Williams, J.P., Allen, S.J., Gabel, J.C., and Drake, R.E.: Regulation of transmicrovascular fluid and protein flux by interstitial fluid pressure. Fed. Proc. 46(4):1532, 1987. Drake, R., Allen, S., Williams, J., Elk, R., Gabel, J., and Laine, G.: Lymph flow from edematous dog lungs. Fed. Proc. 46(4):1526,1987.
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Abstracts cont. Elk, R., Drake, R., Williams, J., Allen, S., Gabel J., and Laine, G.: Effect of outflow pressure on hepatic lymph flow. Fed. Proc. 46(4):1527, 1987. Allen, S., Laine, G., Gabel, J., Williams, J., Elk, R., and Drake, R.: Elevated superior vena caval pressure causes pleural effusion in sheep. Fed. Proc. 46(4):1520,1987. Katz, J., Warters, R.D., Leiman, B.C., Laine, G.A., Kurusz, M., and Butler, B.D.: Distribution of arterial air emboli: effect of the trendelenberg position in dogs. Anesth. Analg. 66:S93, 1987. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Central venous hypertension worsens pulmonary edema formation following endotoxemia in sheep. Anesthesiology 67(3A):A125, 1987. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: General anesthesia reduces lymph flow rate. Anesthesiology 67(3A):A137, 1987. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Pleural effusions can be caused by superior vena caval hypertension. Anesthesiology 67(3A):A138, 1987. Laine, G.A., Allen, S.J., Gabel, J.C., and Drake, R.E.: Microvascular changes in the heart during chronic arterial hypertension. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College. Suppl. 2(2):57, 1987. Drake, R.E., Allen, S.J., Laine, G.A., and Gabel, J.C.: Lung lymph vessel pressure and flow in sheep. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College. Suppl. 2(2):81,1987. Allen, S.J., Drake, R.E., Williams, J.P., Gabel, J.C., Elk, J.R., and Laine, G.A.: Elevation of superior vena caval pressure increases pulmonary edema following endotoxemia. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College. Suppl. 2(2):110,1987. Laine, G.A., Drake, R.E., Allen, S.J., and Gabel, J.C.: Lymphatic function and interstitial dynamics in various tissues. Microcirc. Endoth. Lymphatics 3:314, 1987. Drake, R.E., Laine, G.A., Allen, S.J., and Gabel, J.C.: A model of the pulmonary interstitial-lymphatic system. Microcirc. Endoth. Lymphatics, 3:313,1987. Drake, R., Allen, S., Laine, G., Dunbar, B., and Gabel, J.: Lung lymph flow and protein with 7 days of elevated left atrial pressure in unanesthetized sheep. The Physiologist 30(4):145, 1987.
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Abstracts cont. Laine, G.A., Elk, J.R., Gabel, J.C., and Drake, R.E. Lymphatic-lymphatic interactions can reduce lymph flow and potentiate organ edema formation. FASEB J. 2(6):A1871, 1988. Drake, R., Allen, S., Laine, G., and Gabel, J.: Lymphatic response to acceleration of edema formation in dog lungs. FASEB J. 2(6):A1864, 1988. Elk, J., Adair, T., Laine, G., Drake, R., and Gabel, J.: Halothane decreases diaphragmatic lymph vessel flow response to endotoxin. FASEB 2(6):A1863, 1988. Laine, G., Elk, J., Dunbar, B., Gabel, J., and Drake, R.: Relationship between central venous pressure and lymph flow. FASEB J. 2(5):A1314, 1988. Drake, R., Allen, S., Butler, B., Laine, G., and Gabel, J.: Critical microvascular pressure after acceleration of edema formation. FASEB J. 2(6):A1701, 1988. Allen, S., Laine, G., Gabel, J., and Drake, R.: Superior vena caval hypertension results in pleural effusions and increasing pleural protein concentrations. FASEB J. 2(6):A1702, 1988. Gabel, J., Allen, S., Laine, G., and Drake, R.: Effect of 1 week elevations in left atrial pressure (LAP) on sheep lung lymph protein concentration. FASEB J. 2(5):A1292, 1988. Dunbar, B., Elk, J., Drake, R., Gabel, J., and Laine, G.: Analysis of gut lymph flow during portal venous hypertension. FASEB J. 2(5):A1314, 1988. Elk, J., Drake, R., Dunbar, B., Gabel, J., and Laine, G.: Elevation of lymphatic outflow pressure alters lymph composition within the thoracic duct. FASEB J. 2(5):A1314, 1988. Laine, G.: Myocardial edema compromises cardiac function. J. Mol. Cell. Card. 20:56, 1988. Williams, J., Laine, G., et. al.: Elevation of superior vena caval pressure increases myocardial edema. Proceedings of the Society of Cardiovascular Anesthesiologist, 11th Annual Meeting, p. 293, 1989. Laine, G.: Interstitial fibrosis in chronic myocardial edema. FASEB J. 3(4):A1392, 1989. Williams, J., Laine, G., Elk, R., and Sweeney, M.: Acute myocardial edema results in decreased cardiac function. Anesthesiology 71 (3A): A478, 1989. Laine, G.: Cardiac function in acute and chronic myocardial edema. FASEB J. 3(3):A272, 1989.
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Abstracts cont. Williams J., Laine, G., Hanley, E., Eberlein, D., and Sweeney, M.: Myocardial interstitial changes in humans with congestive cardiomyopathy. Anesth. and Analg. 70:S435, 1990. Butler, B.D., Allen, S.J., and Laine, G.A.: Pulmonary edema with venous gas emboli: no evidence for microvascular permeability change. Undersea Biomed. Res. 17(S):71, 1990. Steenberg, M.L., Varughese, A., Doursout, M.F., Merin, R.G., Drake, R.E., Laine, G.A., and Chelly, J.E.: Role of the lymphatic circulatory system in drug disposition. FASEB J. 4(3):A463, 1990. Elk, J., Laine, G., and Drake, R.: Effect of outflow pressure on lymphatic flow from dog kidneys. FASEB J. 4(3):A1250, 1990. Laine, G.: Microvascular permeability and interstitial matrix changes in the heart following chronic venous hypertension. FASEB J. 4(3):AS90, 1990. Laine, G.: Physicochemical properties of the myocardial interstitial matrix. FASEB J. 4(3):A1258, 1990. Allen, S.J., Gabel, J.C., Drake, R.E., and Laine, G.A.: Thoracic duct drainage reduces pulmonary edema and pleural effusions. FASEB J. 5(4):A772, 1991. Laine, G.A., and Allen, S.J.: Edema of the heart decreases left ventricular diastolic compliance. FASEB J. 5(6): A1753, 1991. Allen, S.J., and Laine, G.A.: Pulmonary hypertension causes edema of the left ventricle. Crit. Care Med. 19(4): S9, 1991. Laine, G.A., and Allen, S.J.: Changes in the interstitial matrix of the heart induced by chronic venous hypertension. Proceedings of the Fifth World Congress for Microcirculation 56:334, 1991. Allen, S., and Laine, G.: Chronic cardiac edema increases left ventricular end-diastolic compliance. Proceedings of the Fifth World Congress for Microcirculation. 2:9, 1991. Laine, G.A. and Allen, S.J.: Increased cardiac energy consumption accompanies myocardial interstitial edema. FASEB J. 6(5):A2038, 1992. Allen, S.J. and Laine, G.A.: Diastolic heart failure associated with myocardial edema. FASEB J. 6(5):A2069, 1992.
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Abstracts cont. Davis, K., Rohn, D., Warters, D., Dreyer, J., Adams, D., Laine, G., Allen, S.: Myocardial edema compromises left ventricular function following cardiopulmonary bypass. FASEB J. 7:A562, 1993. Davis, K., Stewart, R., Warters, D., Laine, G., Allen, S.: Pulmonary hypertension and left ventricular function. FASEB J. 7:A882, 1993. Dreyer, William J., Michael, Lloyd H., Nguyen, Thinh, Laine, Glen A.: Neutrophil mediated pulmonary injury in a canine model of cardiopulmonary bypass: Evidence for a CD18 dependent mechanism. Circulation 86(4):I629, 1993. Laine, G.A.: Myocardial interstitial edema comprises cardiac function. Circulation 86(4):EI-6, 1993. Rohn, D.A. and Laine, G.A.: D. immitis and cardiopulmonary bypass produce myocardial edema and compromise left ventricular function. Vet. Surg. 22:397, 1993. Laine, G.A., Allen, S.J.: Changes in the interstitial matrix of the heart induced by acute and chronic edema. Lymphology 26:65,1993. Drake, R.E., Allen, S.J., Laine, G.A., Gabel, J.C.: The role of the lymphatic circulation in regulating lung tissue hydration. Proceedings of the International Congress on Microcirculation. (49), 1993. Laine, G.A., Allen, J.A.: Connective tissue and lymphatics of the heart. Proceedings of the 32nd IUPS Congress. (62), 1993. Mehlhorn, U., Adams, E., Davis, K.L., Laine, G.A. and Allen, S.J.: Myocardial edema is enhanced by decreased lymph flow rate during cardioplegic arrest. Thoracic and Cardiovascular Surgery 42(Suppl. 1):94, 1994. Mehlhorn, U., Adams, D., Burke, E.J., Davis, KL., Laine, G.A., de Vivie, E.R., and Allen, S.J.: Myocardial lymph flow rate decreases during cardioplegic arrest. Am. J. Resp. Crit. Care Med. 149:A1059, 1994. Davis, KL., Mehlhorn, U., Laine, G.A. and Allen, S.J.: Pulmonary hypertension and left ventricular dysfunction. Am. J. Resp. Crit. Care Med. 149:A752, 1994. Mehlhorn, U., Davis, K.L., Laine, G.A. and Allen, S.J.: Myocardial edema associated with cardioplegic arrest may be enhanced by decreased cardiac lymph flow. FASEB J. 8:A622, 1994. Davis, K.L., Mehlhorn, U., Laine, G.A. and Allen, S.J.: Left ventricular remodeling and myocardial edema in pulmonary artery hypertension. FASEB J. 8:A795, 1994.
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Abstracts cont. Mehlhorn, U., Davis, K.L., Laine, G.A. and Allen, S.J.: Myocardial microvascular filtration is directly related to arterial blood pressure in anesthetized dogs. FASEB J. 8:A1050, 1994. Allen, S.J., Davis, K.L., Laine, G.A. and Mehlhorn, U.: Hyaluronan removal in ischemic and hydrostatic myocardial edema in dogs. FASEB J. 8:A622, 1994. Mehlhorn, U., Adams, D., Davis, K., Laine, G., de Vivie, E.R., Allen, S.: Myocardial edema is enhanced by decreased lymph flow rate during normothermic continuous antegrade blood cardioplegia in dogs. Cardiovascular Surgery, ESCVS Abstracts: 69,1994. Mehlhorn, U., Adams, D., Davis, K., Gogola, G., Laine, G., Allen, S. ß-blockade results in myocardial edema during biventricular circulatory support. FASEB J. 9:A19, 1995. Davis, K., Mehlhorn, U., Laine, G., Allen, S.: Myocardial edema coincides with alterations in left ventricular collagen, prolyl 4-hydroxylase and TGF-ß. FASEB J. 9:A607, 1995. Gogola, G., Mehlhorn, U., Adams, D., Davis, K., Laine, G., Allen, S.: Warm blood cardioplegia causes myocardial edema and cardiac dysfunction. FASEB J. 9:A19, 1995. Stewart, R., Rohn, D., Mehlhorn, U., Davis, K., Allen, S., Laine, G.: Pericardial effusion and myocardial edema. Microcirculation 2:111, 1995. Mehlhorn, U., Adams, D., Davis, K., Laine, G., de Vivie, E.R., and Allen, S.: Normothermic blood cardioplegia does not prevent myocardial edema and left ventricular dysfunction. Thorac. Cardiovasc. Surgeon 43(Suppl. 1):147, 1995. Mehlhorn, U., Davis, Geissler, H., Laine, G., and Allen, S.: Cardiac interstitial hyaluronan removal increases in non-ischemic myocardial edema. Microcirculation 3:98, 1996. Rohn, D., Stewart, R., Mehlhorn, U., Davis, Allen, S., and Laine, G.: The effects of myocardial edema-induced collagen synthesis on left ventricular function. Microcirculation 3:103, 1996. Geissler, H., Mehlhorn, U., Davis, K., Gogola, G., Laine, G., and Allen, S.: Impact of plasma colloid osmotic pressure on myocardial fluid balance during cardioplegic arrest. FASEB J. 10:A37, 1996.
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Abstracts cont. Mehlhorn, U., Davis, K., Gogola, G., Geissler, H., Laine, G., and Allen, S.: Increased cardiac contractility speeds myocardial edema resolution by improving myocardial lymphatic function. FASEB J. 10:A37, 1996. Davis, K., Mehlhorn, U., Schertel, E., Geissler, H., Laine, G., and Allen, S.: The time constant of left ventricular isovolumic relaxation is dependent on catheter position. FASEB J. 10:A347, 1996. Stewart, R., Rohn, D., Mehlhorn, U., Davis, K., Allen, S., and Laine, G.: Basic determinants of epicardial fluid transudation. FASEB J. 10:A52, 1996. Davis, K., Mehlhorn, U., Geissler, H., Laine, G., and Allen, S.: The effects of myocardial edema on left ventricular fibrosis development. Microcirculation 16 (Suppl 1):60, 1996. Allen, S, Geissler, H., Davis, K., Mehlhorn, U., and Laine, G.: Effects of cardiopulmonary bypass on myocardial Starling forces and lymph flow. Microcirculation 16(Suppl 1):115, 1996. Davis, K., Geissler, H., Mehlhorn, U., Laine, G., and Allen, S.: Decreased left ventricular collagenase activity in pulmonary artery hypertension. FASEB J., 11:A36, 1997. Mehlhorn, U., Davis, K., Geissler, H., Trevas, D., Laine, G., and Allen, S.: Tau along the base-apex ventricular axis: Effects of different calculation methods. FASEB J., 11:A497, 1997. Geissler, H., Davis, K., Mehlhorn, U., Warters, D., Laine, G., and Allen, S.: Impact of high dose β-blockade on myocardial fluid balance and left ventricular function in acute myocardial ischemia. FASEB J., 11:A73, 1997. Geissler, H., Davis, K., Mehlhorn, U., Laine, G., and Allen, S.: Contamination of lymph from the major prenodal cardiac lymphatic in dogs. Microcirculation, 4(4):470, 1997. Rohn, D., Stewart, R., Allen, S., and Laine, G.: Resolution of acute coronary venous hypertension and its impact on myocardial edema and left ventricular function. FASEB J., 11:A500, 1997. Geissler, H.J., Davis, K.L., Allen, S.J., Buja, L.M., Laine, G.A., Melhorn, U., and de Vivie, E.R.: High dose B-blockade during reperfusion only reduces ischemia-reperfusion injury. FASEB J., 12:A711, 1998. Stewart, R., Hooper, N., Allen, S., and Laine, G.: Lymphatic Drainage of Synovial Joints in Sheep. FASEB J., 13:A87, 1999.
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Abstracts cont. Geissler H.J., Allen S.J., Davis K.L., Sauer H., Laine G.A., Huhn-Regnier F., Dapunt O., de Vivie E.R., and Mehlhorn U.: Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial efficiency. Critical Care., 3(2):P10, 1999. Stewart, R., Allen, S., and Laine, G.: Protein Washdown as a Protective Mechanism Against Myocardial Edema. FASEB J. 13:A5,1999. Geissler, H.J., Allen, S.J., Davis, K.L., Buja, L.M., Laine, G.A., Hekmat, K., de Vivie E.R., and Mehlhorn, U.: Infarct size reduction by high dose β-blockade during reperfusion. Thorac Cardiovasc. Surg. 47,(Suppl. 1): S214, 1999. Sauer, H., Cox, C., Laine, G., and Allen, S.: TBC-1269, a novel sialyl Lewis� selectin-antagonist, does not attenuate myocardial ischemia-reperfusion injury. FASEB J., 13:A22, 1999. Geissler, H.J., Allen S.J., Davis, K.L., Sauer, H., Laine, G.A., Kuhn-Regnier, F., Dapunt, O., de Vivie, E.R., Mehlhorn, U.: Impact of Cardiopulmonary Bypass and Cardioplegic Arrest on Myocardial Efficiency. FASEB J., 13:A109, 1999. Sauer, H., Laine, G.A., de Vivie, E.R., and Allen, S.J.: Bretschneider HTK cardioplegia better preserves cardiac function compared to St. Thomas’ solution. FASEB J., 13:A1078, 1999. Geissler, H.J., Allen, S.J., Davis, K.L., Sauer, H., Laine, G.A., Huhn-Regnier, F., de Vivie, E.R., and Mehlhorn, U.: Reduction of myocardial efficiency after cardiopulmonary bypass and cardioplegic arrest. Thorac Cardiovasc. Surg. 47,(Suppl. 1):S216, 1999. Stewart, R., Miller, M., Bonagura, J., Turk, J., and Laine, G.: The Effect of Neutral Endopeptidase Inhibitor (NEPi) and Rapid Pacing on the Myocardium. FASEB J. 14:LB5, 2000. Sauer, H., Allen, S., Beier, N., and Laine, G.: Selective sodium/hydrogen exchange inhibition improves myocardial protection during crystalloid cardioplegia. FASEB J. 14:A422, 2000. Laine, G., Stewart, R., and Allen, S.: The effect of physiologic albumin and hyaluronan concentrations on fluid resistance. FASEB J. 14:LB12, 2000. Stewart, R. and Laine, G.: Flow in Lymphatic Networks: Interaction between Hepatic and Intestinal Lymph Vessels. FASEB J. 15:A46, 2001. Stewart, R., Rohn, D., Fischer, U., Cox, C., Allen, S., Criscione, J., Laine, G.: Alterations in cardiac and vascular function curves following resolution of acute myocardial edema. FASEB J. 16:A1128, 2002.
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Abstracts cont. Fischer, U., Cox, C., Allen, S., Stewart, R., Laine, G. : Impact of acute myocardial edema on left ventricular function. FASEB J. 16:A1128, 2002. Fischer, U., Cox, C., Allen, S., Stewart, R., Laine, G. : Effect of chronic and acute myocardial edema on left ventricular interstitial pressure and chamber compliance. FASEB J. 16:A1128, 2002. Cox, C., Fischer, U., Laine, G., Allen, S.: Is mesenteric lymph toxic to endothelial cells after mesenteric ischemia/reprofusion? FASEB J. 16:A442, 2002. Cox, C., Fischer, U., Allen, S., Laine, G.: Mesenteric lymph diversion prevents myocardial edema and dysfunction after gut ischemia/reperfusion. J Am. Coll. Surg. 195(3), 582, 2002. Cox, C.S., Moore, F.A., Stewart, R.H., Laine, G.A., Fischer, U., and Allen, S.J. Gut Edema Causes Ileus. Crit. Car Med. 30(12), A148, 2002. Quick, C.M., Stewart, R.H., Criscione, J.C., Laine, G.A. Passive flow in edema explains the discrepancy between calculated and measured lymph flow in contracting lymphatic vessels. FASEB J. 17:A129, 2003. Quick, C.M., Stewart, R.H., Criscione, J.C., Cox, C.S. Jr., Allen, S.J., Laine, G.A. Lymphangion “pumping” can decrease lymph flow in edema: preliminary model predictions. FASEB J. 17:A129, 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Rapid Apoptosis Signal Pathway Induction by Cardioplegic Arrest. Thoracic Cardiovascular Surgery. 32: 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Radical Scavenging with N- Acetylcysteine Reduces Oxidative Stress and Improves Cardiac Performance in Dogs Subjected to Cardioplegic Arrest. Thoracic Cardiovascular Surgery. 32: 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Acute Myocardial Edema Does Not Impair Left Ventricular Systolic Function. Thoracic Cardiovascular Surgery. 32: 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Mild Hypothermia Impairs Left Ventricular Diastolic But Not Systolic Function. Thoracic Cardiovascular Surgery. 32: 2003.
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Abstracts cont. Hassoun H., Fischer U., Allen S.J., Moore F.A., Laine G.A., Cox C.S. Regional hypothermia reduces mucosal NFKB DNA binding activity and PMN priming via gut lymph during mesenteric ischemia/reperfusion. J Surg Res 107:316(40), 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Detection of Altered Gene Expression During Cardioplegic Arrest by Means of DNA Microarray. FASEB J. 17:A844, 2003. Fischer, U.M., Cox, C.S. Jr., Laine, G.A. Mehlhorn, U., Allen, S.J. Rapid Apotosis Signal Pathway Induction by Cardioplegic Arrest. FASEB J. 17:A841, 2003. Stewart R.H., Quick C.M., Criscione J.C., Cox C.S., Allen S.J., Laine G.A. The effect of nitric oxide on lymphatic function depends on the axial pressure gradient. FASEB J. 17:A128, 2003. Stewart R.H., Quick C.M., Criscione J.C., Cox C.S., Allen S.J., Laine G.A. Hypothermia inhibits lymphatic pumping. FASEB J 17:A128, 2003. Quick, C.M., Zawieja, D.C., Stewart, R.H., and Laine, G.A. Applying time-varying elastance to lymphatic vessels. 20th Annual Biomedical Engineering Research Conference. HSEMB 20: 53, 2003. Rajagopalan S, Stewart R, Venugopal A, Zawieja D, Laine G, and Quick C. Evaluating the time-varying elastance concept for lymphangions. Proceedings 25th Annual International Meeting of IEEE/EMB Society, Cancun, Mexico, Vol.1: 327-330, 2003. Venugopal A, Stewart R, Rajagopalan S, Zawieja D, Laine G, and Quick C. Applying the time-varying elastance concept to determine optimum coordination in a lymphatic vessel. Proceedings 25th Annual International Meeting of IEEE/EMB Society, Cancun, Mexico, Vol.1: 323, 2003. Venugopal, A.M., Stewart, R.H., Rajagopalan, S., Desai, K.V., Laine, G.A., Quick, C.M. Lymphatic pump efficiency. FASEB J. 18: A657-658, 2004. Mohiuddin, M.W., Quick, C.M., Desai, K.V., Rajagopalan, S., Laine, G.A., Stewart, R.H. Collapsible behavior in non-collapsing vessels: implications for lymph flow. FASEB J. 18: A657, 2004. Quick, C.M, Zawieja, D.C., Gashev, A.A., Stewart, R.H., Laine, G.A. Modeling strategies for optimizing lymph flow. FASEB J. 18: A658, 2004. Moore-Olufemi, S.D., Xue, H., Allen, S.J., Moore, F.A., Stewart, R.H., Laine, G.A. Cox, C.S. Gut edema alters expression of tight junction proteins. Surgical Forum, 199:S39, 2004.
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Abstracts cont. Rajagopalan, S., Venugopal, A.M., Stewart, R.H., Desai, K.V., Laine, G.A., Quick, C.M. Optimal diastolic period for lymphangion contraction. Proceedings of 21st Annual Houston Conference on Biomedical Engineering Research, HSEMB 21: 102, 2004. Moore-Olufemi SD, Kozar RA, Moore FA, Hassoun HT, Sato N, Cox CS, Kone BC. Ischemic preconditioning protects against intestinal ischemia/reperfusion injury. Shock 21, Supplement 2:61, 2004. Veugopal, A.M., Stewart, R.H., Rajagopalan, S., Laine, G.A., Quick, C.M. Optimal Lymphatic vessel structure. Proceedings 26th International Meeting of IEEE/EMB Society, Conf Proc IEEE Eng Med BiolSoc 5: 3700-3703, 2004. Venugopal, A.M., Stewart, R.H., Laine, G.A. Rajagopalan, S., Quick, C.M. Dis-coordination of lymphangion pumping in lymphatic vessels. Proceedings of 21st Annual Houston Conference on Biomedical Engineering Research, HSEMB 21: 101, 2004. Moore-Olufemi S.D., Xue H., Allen S.J., Moore F.A., Stewart R.H., Laine G.A., Cox C.S. Inhibition of intestinal transit by resuscitation induced gut edema is reversed by administration of L-NIL. J. Surg Res, 121:334, 2004. Uray K., Cox C.S., Allen S.J., Laine G.A. Coordinated changes in cadherin expression and contractility due to gut edema development in intestinal smooth muscle. Mol. Biol. Cell, 15: 2329, 2004. Widmer RJ, Stewart RH, Quick CM, Laine GA. Michael E. DeBakey Summer Research Program. Proceedings of 2nd annual TAMUS Pathways Research Symposium, Corpus Christi, TX, 2004. Fischer U., Cox C., Allen S., Bloch W., Mehlhorn U., Laine G. Apoptosis signal pathway induction during cardioplegic arrest depends on cardioplegic solution type. FASEB J. 18:A1245-1246, 2004. Stewart R., Gashev A., Stallone J., Zawieja D., Wilson E., Criscione J., Hardy J., Laine G., Quick C. Lmyphatic vessel contraction impedes flow under high flow conditions. FASEB J. 19:A166, 2005. Uray K., Allen S., Laine G., Stewart R., Radhakrishnan R., Cox C. Intestinal edema decreases intestinal motility through decreased myosin light chain phosphorylation. FASEB J. 19: A744, 2005. Wang W., Gashev A., Stewart R., Hardy J., Greiner S., quick C., Laine G., Zawieja D. Influence of acute experimental edema on pumping of bovine mesenteric prenodal lymphatics. FASEB J. 19: A166, 2005.
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Abstracts cont. Gashev A., Wang W., Stewart R., Greiner S., Quick C., Laine G., Zawieja D. Contractile characteristics of bovine mesenteric prenodal lymphatics. FASEB J. 19: A166, 2005. Ngo B., Hardy J., Zawieja D., Gashev A., Wilson E., Criscione J., Stallone J., Quick C., Laine G., Stewart R. Lymphatic vessel function adapts to high flow conditions. FASEB J. 19: A165, 2005. Ngo B, Hardy J, Zawieja D, Gashev A, Wilson E, Criscione J, Stallone J, Quick CM, Laine GA, Stewart RH. Lymphatic vessel function adapts to high flow conditions. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 95, 2005. Kotiya A., Wilson E., Zawieja D., Gashev A., Stallone J., Hardy J., Quick C., Stewart R., Laine G., Criscione J. Geometric changes in mesenteric lymphatic vessels following intestinal edema. FASEB J. 19: A165, 2005. Quick C., Stewart R., Hardy J., Gashev A., Wilson E., Criscione J., Stallone J., Zawieja D., Laine G. Texas A&M University System Program for Excellence in Life Sciences: A new paradigm for lymphatic vessel research. FASEB J. 19: A167, 2005. Meisner J., Stewart R., Quick C., Laine G. Lymphatic myogenic response decreases pumping. FASEB J. 19: A166, 2005. Meisner JK, Stewart RH, Quick CM, Laine GA. Lymphatic myogenic response can decrease pumping. Third Annual TAMUS Pathways Research Symposium, Kingsville, TX, November 4-5, 2005. TAMUS 3: 57, 2005 Moore-Olufemi S., Padalecki J., Xue H., Radhakrishnan R., Allen S., Stewart R., Laine G., Cox C. Early enteral nutrition improves gut edema associated ileus. Surg Forum, 201:S32, 2005. Venugopal A, Stewart RH, Rajagopalan S, Laine GA, Quick CM. Optimal lymphatic vessel structure. TAMU Student Research Week, College Station, TX, March 28, 2005. TAMU SRW 263-264, 2005. Radhakrishnan R., Xue H., Moore F., Allen S., Cox C. Acute intestinal edema causes a decrease in stiffness and residual stress. Shock 23 (Supplement 3); 85:196, 2005.
Kotiya Akhilesh, Quick Christopher, Stewart Randy, Laine Glen, Criscione John. On Passive Multiaxial Mechanical Response of Lymphatic Vessels. FASEB J 20:A414, 2006.
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Abstracts cont. Wilson Emily, Stewart Randy, Patterson Jan, Auckland Lisa, Bray Jeff, Criscione John, Stallone John, Quick Christopher, Hardy Joanne, Gashev Anatoliy, Laine Glen, Zawieja David. Microarray Analysis of Molecular Adaptation of Lymphatic Vessels to High Flow Conditions, FASEB J 20:A279-280, 2006. Uray, Karen, Laine, Glen, Allen Steven, Cox, Charles. Edema-induced Intestinal dysfunction is mediated by Stat3 activation. FASEB J 20:A1240, 2006. Radhakrishnan R., Xue H., Weisbrodt N., Moore F., Allen S., Laine G., Cox C. Hypertonic saline reverses acute intestinal edema and improves transit through changes in cytoskeletal composition. J Surg Res 130:133, 2006. Moore-Olufemi S., Xue H., Radhakrishnan R., Moore F., Stewart R., Laine G.: Transcriptional analysis of gut edema in rat Intestine following pretreatment with selective iNOS inhibitor L-NIL. Surg Forum, 2006 (In press) Gatson S.N., Stewart R.H., Laine G.A., Quick C.M.: Optimizing efficiency of undergraduate research experiences with research-intensive communities. IEEE/EMB, October 11-14, 2006. Dongaonkar R.M., Quick C.M., Stewart R.H., Laine G.A.: Edemagenic gain and interstitial fluid regulation. FASEB J 21:590.2, 2007. Widmer R.J., Stewart R.H., Young M.F., Laurinec J.E., Laine G.A., Quick C.M.: Capillary recruitment accompanies the biphasic flow response to local heat in a thermoregulatory microvascular network. FASEB J 21:A1313, 2007. Widmer R.J., Laurinec J.E., Young M.F., Mohuiddin M.W., Laine G.A., Quick C.M.: The origin of the biphasic response in the thermoregulatory microcirculation. Proceedings – 24th Houston Conference in Biomedical Research HSEMB 24: 64, 2007. Dongaonkar R.M., Quick C.M., Stewart R.H., Laine G.A.: Edemagenic gain: interstitial fluid balance as feedback system. Proceedings of the 24th Annual Houston Conference in Biomedical Research: 129, 2007. Fischer, Uwe M.; Monzon-Posadas, Werner Otoniel; Fischer, Jürgen H.; Cox, Charles S.; Laine, Glen A.; Bloch, Wilhelm; Mehlhorn, Uwe: Apoptosis inhibition for improved left ventricular function after prolonged cold cardioplegic arrest. FASEB J 21:A1377, 2007. Venugopal, Arun M.; Quick, Christopher M.; Laine, Glen A.; Stewart, Randolph H.: Transmural flow modulates the lymphatic myogenic response in bovine mesenteric lymphatic vessels. FASEB J 21:593.7, 2007.
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Abstracts cont. Yang, Jiyeon; Xu, Xiangbin; Laine, Glen A.; Zhang, Cuihua: Feed-forward signaling of TNFα and NFκB produces endothelial dysfunction in coronary arterioles in type II diabetic mice. Circulation, 116:2-174, 2007. Radhakrishnan, Ravi S.; Villarubia, Lindsey; Xue, Hasen; Laine, Glen A.; Stewart, Randolph H.; Weisbrodt, Norman W.; Cox, Charles S.: Hypertonic saline and its effect on intestinal lymphatic flow in the setting of acute intestinal edema. Gastroenterology 130:A911, 2007. Wright, Zachary W; Uray, Karen S.; Radhakrishnan, Ravi S.; Laine, Glen A.; Cox, Charles S.: The role of nuclear factor-kappa B in edema-induced intestinal dysfunction. Gastroenterology 132:A567, 2007. Wilson, E., Laine, G., Hardy, J., Quick, C., Zaweija, D., Gahev, A., Criscione, J., Ngo, B., Stewart, R.: Functional and structural remodeling of bovine mesenteric lymphatics. FASEB J. 11:392.2, 2008. Fischer, Uwe M.; Harting, Matthew T.; Jimenez, Fernando; Monzon-Posadas, Werner O.; Xue, Hasen; Laine, Glen A.; Cox Jr., Charles S.: Pulmonary passage is a major obstacle for efficient intravenous stem cell delivery. Int. Soc. Of Stem Cell Research, 6:144, 2008. Wilson E, Laine G, Stewart RH. Functional and molecular adaptation of lymphatic vessels. FASEB J 22: 392.2, 2008. Gatson SN, Scott M, Stewart R, Laine GA, Quick CM. A case for centralizing summer research programs: the DeBakey research-intensive community. FASEB J 23: 633.8, 2009. Shah, S., Xue, H., Uray, K., Laine, G., Cox, C.: iNos inhibition increases intestinal contractile frequency in resuscitation induced intestinal edema. Shock, 31(7) Supplement 1: 41, 2009. Quick, C.M., Stewart, R.H., Venugopal, A.M., Dongaonkar, R.M., Moore, J.E. Jr., Laine, G.A.: Multiscale modeling of the lymphatic system relates lymphangion properties to edema formation and resolution. FASEB J 23:764.10, 2009. Dongaonkar, R.M., Laine, G.A., Stewart, R.H., Quick, C.M.: Integrating microvascular, interstitial, and lymphatic function with balance point characterization of interstitial fluid volume and protein regulation. FASEB J 23:951.6, 2009.
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Abstracts cont. Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Estimation of the microvascular filtration coefficient from gravimetric data without neglecting interstitial fluid storage and lymphatic drainage. Frontiers in Microcirculation: Control Processes and Clinical Applications, Columbia, MO, October 16-17, 2009. Mohiuddin, M.W., Laine, G.A., Quick, C.M., Douglass, W.I.: Novel adjustable systemic-to-pulmonary shunt for single ventricle palliation during delayed sternum closure. HSEMB 26, 2009. Shah, S.K., Fogle, L.N., Aroom, K.R., Brijesh, B.S., Uray, K.S., Laine, G.A., Stewart, R.H., Cox, C.S.: Mechanotransduction as a mechanistic explanation for edema induced intestinal dysfunction. J American College of Surgeons 209(3S):S43, 2009. Douglas, W., Mohiuddin, M., Laine, G.: Computational flow dynamics do not predict increased risk of thrombosis in an adjustable systemic-pulmonary artery shunt. Proceedings of the 56th Annual Meeting of Southern Thoracic Surgical Association, 92 ,2009. Shah SK, Jimenez F, Walker PA, Xue H, Aroom KR, Norbury KC, Stewart RH, Laine GA, Cox CS Jr. Peritoneal fluid (PF) from an animal model of abdominal compartment syndrome (ACS) induces priming of naïve polymorphonuclear leukocytes (PMNs). The South Texas Chapter, American College of Surgeons, 2010 Annual Meeting, Austin, TX. February 25-27, 2010. Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine GA, Cox CS Jr. A novel murine model for the study of edema-induced intestinal contractile dysfunction. 2010 Joint International Meeting in Neurogastroenterology and Motility, Boston, MA. August 26-29, 2010. Neurogastroenterology and Motility 22(S1): 28. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Fischer, U.M., Aroom, K.R., Uray, K.S., Laine, G.A., Stewart, R.H., Cox, C.S.: Novel Physiologic Model for the Study of Abdominal Compartment Syndrome. J Surgical Research 158(2):423, 2010. Shah, S.K., Uray, K.S., Xue, H., Velez, N., Moore-Olufemi, S.D., Kots, A.Y., Choi, B.K., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: Signal transduction cascades initiated by intestinal edema: the iNOS/NO pathway. Journal of Surgical Research, 158(2): 295, 2010. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Aroom, K.R., Norbury, K.C., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: Peritoneal fluid induces priming naïve neutrophils in an animal model of abdominal compartment syndrome. Journal of Surgical Research, 158(2): 293, 2010.
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Abstracts cont. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Uray, K.S., Aroom, K.R., Fischer, U.M., Laine, G.A., Stewart, R.H., Norbury, K.C., Cox, C.S., Jr: A novel physiologic model for the study of abdominal compartment syndrome (ACS). Journal of Trauma, 68(3):682-9, 2010. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Aroom, K.R., Norbury, K.C., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: Peritoneal fluid (PF) induces priming of naïve neutrophils in animal model of abdominal compartment syndrome. Medline, 158(2):293, 2010. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Feeley, T.D., Uray, K.S., Norbury, K.C., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: Peritoneal fluid as a novel mechanism for neutrophil priming in a clinically relevant model of intra-abdominal sepsis. Journal of American College of Surgeons, 211(3):S43, 2010. Shah, S.K., Jimenez, F., Walker, P.A., Xue, H., Uray, K.S., Norbury, K.C., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome: a pre-clinical study, Critical Care Medicine, 39(12S):199, 2010. Nguyen T.L., Stewart R.H., Laine G.A., Quick CM. Simple passive device to ensure isotonic contraction of intact tubular or spherical organs. Experimental Biology 2010, FASEB J 24:972.7, 2010. Shah, S., Jimenez, F., Walker, P., Xue, H., Uray, K., Norbury, K., Stewart, R., Laine, G., Cox, C. Jr.: Effect of early negative pressure therapy (NPT) on pro-inflammatory characteristics of peritoneal fluid (PF) and plasma in abdominal compartment syndrome (ACS). Critical Care Medicine; 38(12S):200, 2011. Shah, S.K., Moore-Olufemi, S.D., Uray, K.S., Jimenez, F., Walker, P.A., Xue, H., Stewart, R.H., Laine, G.A., Cox, C.S. Jr.: A novel murine model for the study of edema-induced intestinal contractile dysfunction. Neurogastroenterology and Motility, 22(10):1132-e290, 2010. Dongaonkar, R.M., Quick, C.M., Stewart, R.H., Laine, G.A.: Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient. FASEB Journal, 24:972.6, 2010. Dongaonkar, R, Quick, C., Stewart, R., Laine, G.: Validation of conventional techniques to estimate the microvascular filtration coefficient. 9th World Congress for Microcirculation, 2010. Dongaonkar, R., Vo, J., Quick, C., Stewart, R., Laine, G.: Continuous interstitial fluid pressure-volume (compliance) measurement. Experimental Biology, 2011.
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Abstracts cont. Dongaonkar, R., Nguyen, T., Stewart, R., Wilson, E: Short-Term functional adaptation of bovine mesenteric lymphatic vessels to partial occlusion, Experimental Biology, 2011. Dongaonkar, R., Laine, G., Stewart, R., Quick, C.: Balance-point approach to characterize regulation of microvascular, lymphatic, and interstitial pressure. Annual Fall Meeting of the Biomedical Engineering Society, 2011. Mohiuddin, M., Laine, G., Douglas, W., Quick, C.: Increasing pressure pulse wave velocity does not increase aortic pulse pressure in the elderly. Experimental Biology 2011, FASEB Journal, 25:640.31, 2011. Mohiuddin, M. Laine, G., Quick, C.: Increased pulse wave velocity does not cause increased aortic pulse pressure. Annual Fall Meeting of the Biomedical Engineering Society, 2011. Nguyen, T., Dongaonkar, R., Laine, G., Hardy, J., Quick, C., Stewart, R., Wilson, E.: Short-term functional adaptation of bovine mesenteric lymphatic vessels to altered transmural pressure and flow. FASEB 2011. Dongaonkar, R.M., Laine, G.A., Stewart, R.H., Quick, C.M.: Estimation of the microvascular filtration coefficient from gravimetric data without neglecting interstitial fluid storage and lymphatic drainage. FASEB Journal, 2012.
Dongaonkar, R., Quick, C., Stewart, R., Laine, G: Re-evaluating the interstitial fluid pressure volume (compliance) relationship. FASEB 26:854.2, 2012.
Nguyen TL, Dongaonkar RM, Hardy J, Laine GA, Quick CM, and Stewart RH. Length- tension relationship of bovine mesenteric lymphatic vessels after short-term adaptation to elevated lymph flow. Experimental Biology 2012, San Diego, CA, April 21-25, 2012.
Nguyen TL, Dongaonkar RM, Hardy J, Laine GA, Quick CM, Stewart RH. Sustained high luminal flow in vivo decreases maximal developed tension of bovine mesenteric lymphatic vessels. FASEB J 26:677.3, 2012.
Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Differential sensitivity of the lymphatic system to changes in capillary and central venous pressures prevents edema. Annual Fall meeting of the Biomedical Engineering Society, Atlanta, GA, October 24-27, 2012.
Nguyen TL, Dongaonkar RM, Hardy J, Laine GA, Quick CM, and Stewart RH. Prediction of the behavior of a lymphatic network emerging from complex interactions of lymphangions. Annual Fall meeting of the Biomedical Engineering Society, Atlanta, GA, October 24-27, 2012. (In Press)
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Abstracts cont. Ranjeet M. Dongaonkar, Tam L. Nguyen, Christopher M. Quick, Glen A. Laine, Emily Wilson, Cristine Heaps, Joanne Hardy, Randolph H. Stewart. Post-nodal lymphatic vessels adapt to sustained high flow conditions by becoming weaker pumps. Experimental Biology 2013, Boston, MA, April 20-24, 2013.
Uray KL, Bhattarai D, Laine GA, Cox CS. Intestinal Contractility Decreases in a Model of Post-Operative Ileus Due to Myogenic Factors. Neurogastroenterology and Motility 2013.
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REFEREED MANUSCRIPTS
Laine, G.A., Hall, J.T., Laine, S.H., and Granger, H.J.: Transsinusoidal fluid dynamics in canine liver during venous hypertension. Circ. Res. 45:317-323, 1979. Granger, H.J., and Laine, G.A.: Consecutive barriers to movement of water and solutes across the liver sinusoids. Physiologist 23:83-85, 1980. Granger, H.J., Green, D.M., Laine, G.A., Taber, R.: Transport of water and solutes in the microcirculation. Rheology 347-356, 1981. Laine, G.A., and Granger, H.J.: Permeability of intestinal microvessels in chronic arterial hypertension. Hypertension 5:722-729, 1983. Nyhof, R.A., Laine, G.A., Meininger, G.A., and Granger, H.J.: Splanchnic circulation in hypertension. Fed. Proc. 43:1690-1693, 1983. Laine, G.A., Granger, H.J.: A solid state device for the determination of osmotic and interstitial fluid pressures: Clinical and experimental applications. Biomedical Engineering, 44-46, 1983. Laine, G.A., Drake, R., Zavisca, F., and Gabel, J.: Effect of lymphatic cannula outflow height on lung permeability estimations. J. Appl. Physiol. 57(5):1412-1416, 1984. Granger, H.J., Laine, G.A., Barnes, G.E., Lewis, R.E.: Dynamics and control of transmicrovascular fluid exchange. Edema 189-228, 1984. Drake, R., Geissler, M., Laine, G., Gabel, J., and Hansen, T.: Effect of outflow pressure on lung lymph flow in unanesthetized sheep. J. Appl. Physiol. 58(1):70-76, 1985. Barnes, G.E., Laine, G.A., Smith, E.E., and Granger, H.J.: Cardiovascular responses to elevations in canine intra-abdominal pressure. Am. J. Physiol. 248(17):R208-213, 1985. Laine, G.A., and Granger, H.J.: Microvascular, interstitial and lymphatic interactions in the normal heart. Am. J. Physiol. 249(18):H834-H842, 1985. Fallon, K.D., Drake, R.E., Laine, G.A., and Gabel, J.C.: Effect of cardiac output on extravascular lung water estimates made with the Edwards lung water computer. Anesthesiology 62:505-508, 1985. Granger, H.J., Laine, S.H., and Laine, G.A.: Osmotic pressure of solutions containing entangled polysaccharide chains. Microcirc. Endo. Lymphatics 2:85- 105, 1985.
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Refereed Manuscripts cont. Gabel, J.C., Fallon, K.D., Laine, G.A., and Drake, R.E.: Lung lymph flow during volume infusions. J. Appl. Physiol. 60(2):623-629, 1986. Laine, G.A., and Bryan Brown, C.: Pulmonary capillary pressure. Critical Care Med. 14(1):76-77, 1986. Drake, R.E., Laine, G.A., Allen, S.J., and Gabel, J.C.: Lymph flow rate is not proportional to microvascular filtration rate. Microvas. Res. 31:384-385, 1986. Laine, G.A., Allen, S.J., Gabel, J.C., and Drake, R.E.: A new look at pulmonary edema. Physiological Sciences, 1:150-153, 1986. Drake, R.E., Allen, S.J., Gabel, J.C., and Laine, G.A.: Overestimation of sheep lung lymph contamination. J. Appl. Physiol. 61:1590-1592,1986. Laine, G.A., Drake, R.E., Allen, S.J., and Gabel, J.C.: Effect of systemic venous pressure elevation on lymph flow and lung edema formation. J. Appl. Physiol. 61:1634-1638, 1986. Drake, R.E., Allen, S.J., Katz, J., Gabel, J.C., and Laine, G.A.: Equivalent circuit technique for lymph flow studies. Am. J. Physiol. 251(Heart Circ. Physiol. 20):H1090-H1094, 1986. Drake, R.E., Allen, S.J., Gabel, J.C., and Laine, G.A.: Sheep lung lymph shunting. Lymphology 19:157-160, 1986. Laine, G.A., Allen, S.J., Gabel, J.C., and Drake, R.E.: Outflow pressure reduces lymph flow rate from various tissues. Microvas. Res. 33:135-142, 1987. Drake, R.E., Allen, S.J., Gabel, J.C., and Laine, G.A.: Effect of endotoxin on diaphragm lymph contamination in unanesthetized sheep. J. Appl. Physiol. 62:706-710, 1987. Allen, S.J., Drake, R.E., Gabel, J.C., and Laine, G.A.: Elevation of superior vena caval pressure increases extravascular lung water after endotoxemia. J. Appl. Physiol. 62:10061009, 1987. Drake, R.E., Allen, S.J., Gabel, J.C., and Laine, G.A.: A model of the lung interstitial-lymphatic system. Microvas. Res. 34:96-107,1987. Laine, G.A.: The change in (dp/dt)max as an index of myocardial microvascular permeability. Circ. Res. 61:203-208,1987.
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Refereed Manuscripts cont. Allen, S.J., Drake, R.E., Gabel, J.C. and Laine, G.A.: Lowered pulmonary artery pressure prevents edema after endotoxin in sheep. J. Appl. Physiol. 63:1008-1011,1987. Drake, R.E., Allen, S.J., Williams, J.P., Laine, G.A., and Gabel, J.C.: Lymph flow from edematous dog lungs. J. Appl. Physiol. 62:2416-2420, 1987. Allen, S.J., Drake, R.E., Williams, W.P., Laine, G.A., and Gabel, J.C.: Recent advances in pulmonary edema. Crit. Care Med. 15:963-970,1988. Butler, B., Katz, J., Leiman, B., Warters, D., Kurusz, M., and Laine, G.A.: Effect of trendelenberg position on the distribution of arterial air emboli in dogs. Ann. Thoracic Surg. 45:198-202, 1988. Drake, R.E., and Laine, G.A.: Pulmonary microvascular permeability to fluid and macromolecules. J. Appl. Physiol. 64:487-501,1988. Laine, G.A.: Microvascular changes in the heart during chronic arterial hypertension. Circ. Res. 62:953-960, 1988. Elk, R., Drake, R.E., Williams, J.P., Gabel, J.C., and Laine, G.A.: Lymphatic function in the liver following hepatic venous pressure elevation. Am. J. Physiol. 254:G748-G752, 1988. Allen, S.J., Laine, G.A., Drake, R.E., and Gabel, J.C.: Superior vena caval pressure elevation causes pleural effusion formation in sheep. Am. J. Physiol. 255 (Heart Circ. Physiol. 24):H492-H495, 1988. Gabel, J.C., Allen, S.J., Laine, G.A., and Drake, R.E.: Fluid resuscitation in shock. Acta Anaesthesiol-Belg. 39:147-153, 1988. Dunbar, B.S., Elk, J.R., Drake, R.E., and Laine, G.A.: Intestinal lymphatic flow during portal venous hypertension. Am. J. Physiol. 257:G94-G98, 1989. Elk, J.R., and Laine, G.A.: Pressure within the thoracic duct modulates lymph composition. Microvas. Res. 39:315-321,1990. Laine, G.A., and Allen, S.J.: Left ventricular myocardial edema: lymph flow, interstitial fibrosis and cardiac function. Circ. Res. 68:1713-1721,1991. Allen, S.J., Drake, R.E., Laine, G.A., and Gabel, J.C.: Effects of thoracic duct drainage on hydrostatic pulmonary edema and pleural effusion. J. Appl. Physiol. 71(1):314-316, 1991.
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Refereed Manuscripts cont. Butler Howe, L.M., Boothe Jr., H.W., Boothe, D.M., Laine, G.A., Calvin, J.A.: Effects of vena caval banding in experimentally induced multiple portosystemic shunts in dogs. Am. J. Vet. Res. 54:1774-1783,1993. Stewart, R.H. and Laine, G.A.: Pathophysiology of pulmonary edema. Medical Forum, Washington DC, 11:675-678, 1993. Laine, G.A., Galt. M.A., Langford, J.A., Prout, D. L., Puckett, W. H.: Hospitalwide medication policies and standards. Am J. Hosp Pharm. 51(23):2949-51, 1994. Laine, G. A., Hossain, S. M., Solis, R. T., Adams, S. C.: Polyethylene glocol nephrotoxicity secondary to prolonged high-dose intravenous lorazepan. Ann Pharmacother 29(11):1110-4, 1995. Rohn, D.A., Davis, K., Allen, S.J., Laine, G.A.: D. immitis and cardiopulmonary bypass produce myocardial edema and compromise left ventricular function. Am. J. Vet. Res. 56(2):221-226, 1995. Stewart, R.H. and Laine, G.A.: Pathophysiology of myocardial edema. Medical Forum, 13:285-288, 1995. Davis, K.L., Mehlhorn, U., Laine, G.A., and Allen, S.J.: Myocardial edema, left ventricular function and pulmonary hypertension. J. Appl. Physiol. 78(1):132-137, 1995. Laine, G.A., Mehlhorn, U., Davis, L.K., and Allen, S.J.: Myocardial interstitium and lymphatics: pathophysiology and effects on cardiac function. Interstitium, Connective Tissue and Lymphatics. 271-282, 1995. Mehlhorn U, Davis, K.L, Adams, D., Laine, G.A., and Allen, S.J.: Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Am. J. Physiol. 268 (Heart Circ. Physiol. 37):H178-H183, 1995. Mehlhorn U, Allen, S.J., Adams, D., Davis, K.L., De Vivie, E.R., Laine, G.A.: Normothermic continuous antegrade blood cardioplegia does not prevent myocardial edema and cardiac dysfunction. Circulation 92:1939-1946, 1996. Rohn, D.A., Stewart, R.H., Elk, J.R. Drake, R.E., and Laine, G.A.: Renal lymphatic function following venous pressure elevations. Lymphology 29(2):67-75, 1996. Stewart, R. and Laine, G.: Fluid balance in hypoproteinemic patients. Medical Forum 14:521-523, 1996.
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Refereed Manuscripts cont. Stewart, R.H., Rohn, D.A., Mehlhorn, U., Davis, K.L., Allen, S.J. and Laine, G.A.: Regulation of microvascular filtration in the myocardium by interstitial fluid pressure. Am. J. Physiol. 271 (40):R1465-R1469, 1996. Mehlhorn, U., Davis, K.L., Laine, G.A., and Allen, S.J.: Myocardial fluid balance in acute arterial hypertension. Microcirculation, 3(4):371-378, 1996. Stewart, R., Miller, M., and Laine, G.: Myocardial edema and pericardial effusion. Med. Forum, ACVIM 15:197-198, 1997. Stewart, R., Rohn, D., Allen, S., and Laine, G.: Basic determinants of epicardial transudation. Am. J. Physiol. 273 (42) H1408-H1414, 1997. Mehlhorn, U., Allen, S., Davis, K., Geissler, H., Laine, G., Warters, D., and de Vivie, R.: Increasing the colloid osmotic pressure of cardiopulmonary bypass prime and normothermic blood cardioplegia minimizes myocardial edema and prevents cardiac dysfunction. Cardiovascular Surgery 6: 274-281, 1998. Davis, K., Mehlhorn, U., Schertel, E., Geissler, H., Laine, G., and Allen, S.: Variation in tau, the time constant for isovolumic relaxation, along the left ventricular base-to-apex axis. Basic Research in Cardiology 94(1):41-48, 1999. Geissler, H. J., Davis, K. L., Mehlhorn, U., Laine, G. A., and Allen, S. J.: Contamination of Lymph from the major prenodal cardiac lymphatic in dogs. Am. J. Physiol. 276(45):1795-1800, 1999. Geissler, H. J., Davis, K. L., Laine, G. A., and Allen, S. J.: High dose beta-blockade as an alternative to warm blood cardioplegia in acute myocardial ischemia. Cardiothoracic Surgery 17:63-70, 2000. Davis, K. L., Geissler, H.J., Allen, S.J., and Laine, G.A.: The effects of myocardial edema on the development of myocardial interstitial fibrosis. Microcirculation. 7 (4): 269-280, 2000. Stewart, R.H., Allen, S.J., and Laine, G.A.: Protein washdown as a defense mechanism against myocardial edema. Am. J. Physiol. 279:H1864-H1868, 2000. Stewart, R. and Laine, G.: Flow in lymphatic networks: Interaction between hepatic and intestinal lymph vessels. Microcirculation. 8:221-227, 2001. Geissler, H.J., Mehlhorn, U., Laine, G.A., Allen, S.: The effect of cardiopulmonary lymphatic obstruction on heart and lung function. Thorac. Cardiovasc. Surg. 49:384, 2001.
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Refereed Manuscripts cont. Mehlhorn, U., Geissler, H., Laine, G.A. and Allen, S.J.: Role of the cardiac lymph system in myocardial fluid balance. Cardio-Thoracic Surgery. 20:420-425, 2001. Sauer, H., Allen, S., Cox, C. Jr., and Laine, G.: Effect of Sialyl LewisX selection blockade on myocardial stunning after cardioplegic arrest and reperfusion. Heart Surgery. 4(3): 216-222, 2001. Geissler, H., David, K., Buja, M., Laine, G., Brennan, M., Mehlhorn, U., and Allen, S.: Esmolol and cardiopulmonary bypass during reperfusion reduce infarct size in a dog model of myocardial ischemia and reperfusion. Annals of Thoracic Surgery 72:1964-1969,2001. Geissler, H., Mehlhorn, U., Laine, G.A. and Allen, S.J.: The effect of cardiopulmonary lymphatic obstruction on heart and lung function. Cardio-Thoracic Cardiovascular Surgery. 49:384-385, 2001. Mehlhorn, U., Geissler, H., Laine, G.A. and Allen, S.J.: Myocardial fluid balance. Cardio-Thoracic Surgery. 20:1220-1230, 2001. Cox, C., Sauer, H., Allen, S., Buja, M., and Laine, G.: Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass. Thoracic and Cardiovascular Surgery. 135(5):959-966, 2002. Cox, C., Sauer, H., Allen, S., Allen, S., Laine, G.: Myocardial performance after cardiopulmonary bypass and cardioplegic arrest: Impact of a Na+/H+-exchanger inhibitor. J. Invest. Surg. 15(4): 219-226, 2002. Fischer, U.M., Cox, C.S., Allen, S.J., Stewart, R.H., Mehlhorn, U., Laine, G.A.: The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. J. Thoracic and Cardiovascular Surgery. 126(5):1483-1488, 2003. Cox, C.S., Allen, S.J., Sauer, H. and Laine, G.A.: Improved myocardial function using a Na+/H+-exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass. Chest, 123:187-194, 2003. Geissler, H.J., Mehlhorn, U., Laine, G.A., Allen, S.J. Myocardial protection with esmolol during CABG surgery. Anesthesiology 98(4) 1024-25, 2003. Rajagopalan, S., Stewart, R. H., Venugopal, A.M., Laine, G.A., Zawieja, and Quick, C.M. Evaluating the time-varying elastance concept for lymphangions. IEEE/EMB 1-4, 2003.
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Refereed Manuscripts cont. Venugopal, A.M., Stewart, R.H., Rajagopalan, S., Zawieja, D.C., Laine, G.A., and Quick, C.M. Applying the time-varying elastance concept to determine optimum coordination of lymphangion contraction in a lymphatic vessel. IEEE/EMB 20-24, 2003. Hassoun, H., Fischer, U.M., Allen, S.J., Moore, F.A., Laine, G.A., Cox, C.S. Regional hypothermia reduces mucosal NFKB DNA binding activity and PMN priming via gut lymph during mesenteric ischemia/reperfusion. J. Surg. Res. 115: 121-128, 2003. Cox, C.S., Fischer, U.M., Allen, S.J., Laine, G.A.: Lymphatic diversion prevents myocardial edema following mesenteric ischemia/reperfusion. Microcirculation. 11(1):1-8, 2004. Venogopal, A.M.; Stewart, R.H., Rajagopalan, S., Laine, G.A., Quick, C.M.: Optimal lymphatic vessel structure. IEEE Eng Med Biol 5:3700-3703, 2004. Stewart, S. H., Rohn, D.A., Allen, S.J. and Laine, G.A.: Effect of venous air embolization on pulmonary microvascular protein permeability. Microcirculation 11(5):409-414, 2004. Moore-Olufemi, S.D., Xue, H., Attuwaybi, B.O., Fischer, U.M., Harari, Y., Oliver, D.H., Weisbrodt, N.W., Allen, S.J., Moore, F.A., Stewart, R.H., Laine, G.A., Cox, C.S. Resuscitation-induced gut edema and intestinal dysfunction. J. Trauma 58(2):264-270, 2005. Humphrey, J.D., Coté, G., Walton, J., Meininger, G.A., Laine, G. A New Paradigm for Graduate Research and Training in the Biomedical Sciences and Engineering. Am. J. Physiol. 29(2): 98-102, 2005. Moore-Olufemi, S.D., Xue, H., Allen, S.J., Moore, F.A., Stewart, R., Laine, G.A., Cox, C.S. Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: Implications for the abdominal compartment syndrome. Shock. 23(6): 571-575, 2005. Fischer, U.M., Cox, C.S., Laine, G.A., Mehlhorn, U., Allen, S.J. Mild hypothermia impairs left ventricular diastolic but not systolic function. J. Invest. Surg. 18:291-296, 2005. Moore-Olufemi, S.D., Kozar, R.A., Moore, F.A., Sato, N., Hassoun, H.T., Laine, G.A., Cox, C.S., Kone, B.C. Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock 23:258-263, 2005. Radhakrishnan, R.S., Xue, H., Weisbrodt, N., Moore, F.A., Allen, S.J., Laine, G.A., Cox, C.S. Resuscitation induced intestinal edema decreases the stiffness and residual stress of intestine. Shock 24:165-170, 2005.
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Refereed Manuscripts cont. Moore-Olufemi, S.D., Xue, H., Allen, S.J., Moore, F.A., Stewart, R., Laine, G.A., Cox, C.S. Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL. J. Surg. Res. 129:1-5, 2005. Quick, C. M., Mohiuddin, M. W., Laine, G. A., Noordergraaf, A., The arterial system pressure-volume loop, Physiol. Meas. 26:N29-N35, 2005. Quick, C.M., Berger, D.S., Noordergraaf, A., and Laine, G.A.: Resolving the Hemodynamic Inverse Problem. IEEE Trans. Biomed. Eng. 53(3):1-8, 2006. Fischer, U.M., Cox, C.S., Stewart, R., Laine, G.A., and Allen, S.J.: Impact of Acute Myocardial Edema on Left Ventricular Function. J. Invest. Surg. 19:31-38, 2006. Radhakrishnan, R.S., Xue, H., Weisbrodt, N., Moore, F.A., Allen, S.J., Laine, G.A., Cox, C.S. Hypertonic saline resuscitation prevents hydrostatically-induced intestinal edema and ileus. Crit. Care Med. 34:1713-1718, 2006. Uray, K.L., Laine, G.A., Allen, S.J., Cox, C.S. Intestinal edema decreases intestinal contractility by decreasing myosin light chain phosphorylation. Crit. Care Med. 34(10):2630-2637, 2006. Stewart, R.H., Allen, S.J., and Laine, G.A.: Venous air embolization inhibits pulmonary lymph flow by increasing lymphatic outflow pressure. Lymph. Res. 4:18-22, 2006. Widmer, R. J., Laurinec, J.E., Young, M.F., Laine, G.A., Quick, C.M., Local Heat Produces a Shear-Mediated Response in Skin Blood Flow, Am. J. Physiol. 291:R625-R632, 2006. Radhakrishnan, R.S., Xue, H., Weisbrodt, N., Moore, F.A., Allen, S.J., Laine, G., Cox, C.S.: Hypertonic saline reverses stiffness in an acute intestinal edema model leading to improved intestinal function. Crit Care Med 35:538-543, 2007. Fischer, U.M., Cox, C.S. Jr., Laine, G.A., Mehlhorn, U., Bloch, W., Allen, S.J.: Induction of cardioplegic arrest immediately activates myocardial apoptosis signal-pathway. Am. J. Physiol. 292:H1630-H1633, 2007. Meisner, J.K., Stewart, R.H., Laine, G.A., Quick, C.M.: Lymphatic vessels transition to state of summation above a critical contraction frequency. Am. J. Physiol. 293: R200-R208, 2007. Widmer R.J., Laurinec J.E., Young M.F., Mohiuddin M.W., Laine G.A., Quick C.M.: The origin of the biphasic response in a thermoregulatory microvascular network. Am. J. Physiol. 292: R2312-R2317, 2007.
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Refereed Manuscripts cont. Venugopal A.M., Stewart R.H., Laine G.A., Dongoankar R., Quick C.M..: Lymphangion coordination minimally affects flow in lymphatic vessels. Am. J. Physiol. 293: H1181-H1189, 2007. Mohiuddin M.W., Laine G.A., Quick C.M.: Degeneration of the systemic arterial tree into a simple windkessel with increased wavelength. Am. J. Physiol. 293: H1164-H1171, 2007. Uray, K.S., Laine, G. A., Xue, H., Allen. S.J., Cox, C. S., Edema-induced intestinal dysfunction is medicated by Stat3 activation. Shock 28(2):239-244, 2007. Gashev, A.A., Wang, W., Laine, G.A., Stewart, R.H., Zawieja, D.C.: Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics. Lymph Res. 5(2):71-80, 2007. Widmer RJ, Stewart RH, Young MF, Laurinec JE, Laine GA, Quick CM. Application of local heat induces capillary recruitment in the pallid bat wing. Am J Physiol Regul Integra Comp Physiol 292: R2312-R2317, 2007. Laine, G.A., Cox, C.S. Jr.: Hepatic lymph and lymphatics. Hepatology (2) 1.3:84-88, 2007. Stewart, R., Uray, K., Cox, C., Laine, G.: Myocardial fluid balance in dogs with naturally-acquired heartworm infection. American Journal Veterinary Research 69(3):356-361, 2008. Dongoankar R., Quick C.M., Stewart R.H., Laine G.A.: Edemagenic gain and interstitial fluid volume regulation. Am. J. Physiol. 294:R651-R659, 2008. Cox, C.S., Radhakrishnan, R., Villarubia, L., Xue, H., Uray, K., Gill, B.S., Stewart, R.H., Laine, G.A.: Hypertonic saline modulation of intestinal tissue stress and fluid balance. Shock 29(5):598-602, 2008. Widmer R.J., Young M.F., Laurinec J.E., Laine G.A., Quick C.M.: The origin of the biphasic flow response to local heat in skin. Microcirculation 15:349-357, 2008. Desai, K.V.; Laine, G.A.; Stewart, R.H.; Cox, C.S.; Quick, C.M.; Allen, S.J.; Fisher, U.M.: Mechanics of the left ventricular myocardial interstitium: Effects of acute and chronic myocardial edema. Am. J. Physiol. 294:2428-2434, 2008. Desai K., Gatson S.N., Stewart R.H., Laine G.A., Nave F.M., Quick C.M.: Integrating research and education at research-extensive universities with research-intensive communities. Adv Physiol Ed 32:136-141, 2008.
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Refereed Manuscripts cont. Quick, C.M., Venugopal, A.M., Dongoankar R., Laine, G.A., Stewart, R.H.: First-order approximation for the lymphangion pressure-flow relationship. Am. J. Physiol. 294:2144-2149, 2008. Heaps, C.L., Jeffery, E.C., Laine, G.A., Price, E.M., Bowles, D.K.: Effects of exercise training and hypercholesterolemia on adenosine-activation of voltage-dependent K+ channels in coronary arterioles. J. Appl. Physiol., 105:1761-1771, 2008. Yang, J., Park, Y., Zhang, H., Xu, X., Laine, G., Dellsperger, K., and Zhang, C.: Effect of Sodium Salicylate on Insulin Resistance and Endothelial Dysfunction of Coronary Arterioles in Diabetic Mice. Free Radical in Biology and Medicine 69-77, 2008. Fogarty, J. A.; Delp, M. D.; Muller-Delp, J. M.; Laine, G. A.; Parker, J. L.; Heaps, C. L.: Neuropilin-1 enhances VEGF165-mediated vasodilatation: Impact of chronic myocardial ischemia and exercise training. J. Vasc. Res. 46:152-161, 2009. Venugopal, A.M., Stewart, R.H., Laine, G.A., Quick, C.M.: Optimal post-nodal lymphatic network structure that maximizes active propulsion of lymph. American Journal of Physiology-Heart and Circulatory Physiology, 296:303-309, 2009. Yang, J., Park, Y., Zhang, H., Xu, X., Laine, G.A., Dellsperger, K., Zhang, C.: Feed-forward signaling of TNF alpha and NF-KAPPA-B via IKK beta pathway induces insulin resistance and coronary arteriolar dysfunction in Type 2 diabetic mice. American Journal of Physiology-Heart and Circulatory Physiology, 296: H1850-H1858, 2009. Dongaonkar, R.M., Laine, G.A., Stewart, R.H., Quick, C.M.: Balance point characterization interstitial fluid volume Regulation. Am. J. Physiol., 297: R6-R16, 2009. Dongaonkar, R.M., Stewart, R.H., Laine, G.A., Davis, J.J, Zawieja, D.C., Quick, C.M.: Venomotion modulates the lymphatic pumping in the bat wing. Am. J. Physiol. Heart Circ. Physiol., 296: H2015-H2021, 2009. Moore-Olufemi, S.D., Padelecki, J., Olufemi, E., Xue, H., Allen, S.J., Moore, F.A., Stewart, R.H., Laine, G.A., Cox, C.S.: Intestinal edema: Effect of enteral feeding on motility and gene expression. J. Surg. Res.,155:283-292, 2009. Fischer, U.M., Harting, M.T., Jimenez, F., Monzon-Posadas, W.O., Xue, H., Savitz, S.I., Laine, G.A., Cox, C.S. Jr.: Pulmonary passage is a major obstacle for intravenous stem cell delivery: The pulmonary first-pass effect. Stem Cells and Development, 18(5):1-9, 2009.
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Refereed Manuscripts cont. Radhakrishnan RS, Shah SK, Lance SL, Radhakrishnan HR, Xue H, Radhakrishnan GL, Ramaswamy US, Walker PA, Uray KS, Laine GA, Stewart RH, Cox CS Jr: Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation induced intestinal edema. Critical Care Med., 37(11):1-7, 2009. Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Aroom KR, Fischer U, Laine GA, Stewart RH, Norbury K, Cox CS Jr: A novel physiologic model for the study of abdominal compartment syndrome. Journal of Trauma, 68(3):682-689, 2010. Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine GA, Cox CS Jr.: A murine model for the study of edema-induced intestinal contractile dysfunction. Neurogastroenterology and Motility, 22(10):1132-e290, 2010. Vanugopal AM, Stewart RH, Laine GA, Quick CM: Nonlinear lymphangion pressure-volume relationship minimizes edema. Am. J. Physiol. Heart Circ. Physiol., 299(3):H876-H882, 2010. Shah SK, Fogle L, Aroom KR, Gill B, Moore-Olufemi SD, Jimenez F, Uray KS, Stewart RH, Laine GA, Cox CS: Hydrostatic intestinal edema induced signaling pathways: Potential role of mechanical forces. Surgery, 147(6):772-779, 2010. Shah SK, Xue H, Jimenez F, Velez N, Kots A, Choi B, Moore-Olufemi SD, Uray KS, Stewart RH, Laine GA, Cox CS: Evaluating the potential role of iNOS as a mediator of hydrostatic edema mediated intestinal contractile dysfunction. J. Surg. Res., 163(1):102-109, 2010. Dongaonkar RM, Stewart RH, Geissler H, Laine GA: Myocardial microvascular permeability, interstitial edema and compromised cardiac function. Cardiovascular Res., 87(2):331-339, 2010. Shah SK, Jimenez F, Walker PA, Aroom KR, Xue H, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS: A novel mechanism for neutrophil priming in trauma: Potential role of peritoneal fluid. Surgery, 148(2):263-270, 2010. Uray KS, Shah SK, Radhakrishnan R, Laine GA, Stewart RH, Cox CS: Sodium-hydrogen exchanger inhibition reverses edema-induced intestinal dysfunction. Surgery 149(1):114-125, 2011. Dongaonkar RM, Laine GA, Stewart RH, Quick CM: Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient. Am. J. Physiol. Heart Circ. Physiol., 300(6):R1426-R1436, 2011.
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Refereed Manuscripts cont. Shah, SK, Uray, KS, Stewart, RH, Laine, GA, Cox, CS: Resuscitation-induced intestinal edema and related dysfunction: State of the science. J. Surg. Res. 166(1):120-130, 2011. Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS, Jr: Peritoneal fluid: A potential mechanism of systemic neutrophil priming in experimental intra-abdominal sepsis. Am. J. Surgery, 203(2): 211-6 2012.
Hu BY, Laine GA, Wang S, Solis RT: Combined central venous oxygen saturation and lactate as markers of occult hypoperfusion and outcome following cardiac surgery. J. Cardiothorac. Vasc. Anesth., 26(1): 52-57, 2012.
Chu J, Miller CT, Kislitsyna K, Laine GA, Stewart RH, Cox CS Jr, Uray, KS: Decreased myosin phosphatase target subunit (MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle. Neurogastroenterol Motil 24(3): 257-66, 2012.
Shah SK, Jimenez F, Letourneau PA, Walker PA, Moore-Olufemi SD, Stewart RH, Laine GA, Cox CS. Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 20: 25, 2012.
Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr: Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model. European Journal of Trauma and Emergency Surgery 38(1): 65-73, 2012.
Dongaonkar RM, Quick CM, Vo J, Meisner J, Laine GA, Davis M, Stewart RH: Blood Flow Augmentation by Intrinsic Venular contraction in Vivo. American Journal of Physiology, Jun; 302(12):R1436-42, 2012.
Mohiuddin MW, Rihani RJ, Laine GA, Quick CM: Increasing pulse wave velocity in a realistic cardiovascular model does not increase pulse pressure with age. Am J Physiol Heart Circ Physiol. Jul; 303(1):H116-25, 2012.
Dongaonkar RM, Stewart RH (corresponding author), Quick CM, Uray KS, Cox CS, Laine GA: Time course of myocardial interstitial edema resolution and associated left ventricular dysfunction. [Winner of Microcirculatory Society Excellence in Lymphatic Research Award] Microcirculation 19: 714–722, 2012. Mohiuddin MW, Laine GA, Quick, CM, Douglas WI: Computational flow dynamics do not predict increased risk of thrombosis in an adjustable systemic-pulmonary artery shunt. Annals of Thoracic Surgery, 2012.
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Refereed Manuscripts cont. Chu J, Kislitsyna K, Kots A, Stewart RH, Laine GA, Day M-C, LeTourneau PA, Cox CS, Uray K: Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility. Journal of Biologic Chemistry, 288(2):1200-13, 2013.
Dongaonkar RM, Nguyen TL, Quick CM, Hardy J, Laine GA, Wilson E, Stewart RH: Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure. American Journal of Physiology, 305(2): H203-H210, 2013. Quick CM, Criscione JC, Kotiya A, Dongaonkar R, Hardy J, Wilson, E, Gashev, AA, Laine GA, Stewart RH: Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 306(12): R901-907, 2014.
Dongaonkar RM, Nguyen TL, Quick CM, Heaps CL, Hardy J, Laine GA, Wilson E, Stewart RH: Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, DOI: 10.1152, 2014. PROJECTS COMPLETED (MANUSCRIPTS IN PREPARATION) Laine, GA, and Allen, SJ: Physicochemical properties of the myocardial interstitial matrix. Circulation Research (In preparation). Laine, GA and Davies, P: Teaching basic pharmacology in the critical care environment. American Journal of Physiology (In preparation). Nguyen, PH, Knezek, SF, Laine, GA, Kinra, SE, Khatkhatay, MI, Stewart, RH, Quick, CM: Relative resistance of a vessel and the network downstream determines whether vasodilation decreases or increases shear stress (In preparation). Nguyen TL, Dongaonkar RM, Quick CM, Hardy J, Laine GA, Wilson E, Stewart RH: Changes in lymphatic muscle length-tension relationship resulting from adaptation to mesenteric venous hypertension. American Journal of Physiology Heart Circ Physiol (In preparation). Knezek SF, Stewart RH, Laine GA, Quick CM. Characterizing equilibrium structure of an arterial network as a balance point. American Journal of Physiology Heart Circ Physiol (In preparation). Dongaonkar RM, Stewart RH, Cox CS, Uray KS, Quick CM, Laine GA: Chronic venous hypertension and hepatoperitoneal fluid balance. (In preparation).
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Manuscripts in Preparation cont. Nguyen TL, Dongaonkar RM, Laine GA, Stewart RH, Quick CM: Prediction of the behavior of a lymphatic network emerging from complex interactions of lymphangions. American Journal of Physiology Heart Circ Physiol (In preparation). (Non-competitive activities and presentations have been deleted, references available upon request)
