GREG J SPOONER, PhD 129 Winfield Street, San Francisco, California 94110

mobile: 415 518 5945 gjrspooner@gmail.com

www.linkedin.com/in/gregspooner

CAREER SUMMARY

Developer of lasers, light sources and optics for medical instrumentation. Researcher in fields of ophthalmic and dermatologic photonics-based devices. Focus on clinical applications, product development and market introductions. Strong generalist with excellent problem solving skills. Experienced in medical device regulatory submissions and startup/small company environments. Successful SBIR grant writer. Sixteen issued US patents, twenty+ pending. Accomplishment oriented, working well with all aspects of organizations to achieve goals. Technically expert with effective interpersonal relationship skills.

EDUCATION PhD - Condensed Matter Physics, University of California - Davis

BS - Applied Physics, University of California - Davis

PROFESSIONAL EXPERIENCE

Gain Consulting Services, San Francisco, CA 1998 to present Contractor and consultant for medical device developers

Principal Advise medical device start-up companies, develop intellectual property, assist in fund-raising, perform laser and optical engineering design and analytical tasks, provide regulatory submission advice and technical writing, assist in market introduction and project management for medical laser and medical device products. ClinReg Consulting Services, Irvine, CA 2008 to present Contractor and consultant for medical device developers

Consultant Evaluate prototype clinical devices. Prepare technical and safety documentation for medical device regulation and compliance. Perform laser system characterizations. Manage device development projects. Raydiance, Inc., Petaluma, CA 2007 to 2008 Start-up developer, manufacturer, and distributor of desktop ultra-short pulsed laser systems

Principal Applications Engineer 2007 to 2008 Lead application development efforts for ultra-short laser in medical, manufacturing, scientific and other markets. Create, manage and operate applications laboratory for ultra-short pulsed laser applications development, non-linear optics, material processing, microscopy demonstration, feasibility and system prototyping in collaboration with potential customers and users. Cutera, Inc., Brisbane, CA 2001 to 2007 Developer, manufacturer, and distributor of cosmetic dermatology laser systems

Director of Advanced Development 2005 to 2007 Direct technical team to create new applications and technologies for product pipeline. Develop new laser, photonic and non-photonic technologies for dermatologic therapies. Secure intellectual property for existing medical business and for potential consumer markets. Bring new products to market based on these efforts on a time horizon of 12-18 months. Staff Optical Engineer/Scientist 2001 to 2005 Develop new laser and non-laser light sources for dermatologic therapies. Design optical systems and delivery devices. Construct prototype devices. Assist in development of clinical protocols for IRB investigations using

Greg J Spooner, PhD/ Page 2 prototype devices. Release and transfer new products to market (two successful introductions to date.) Identify new applications and secure appropriate intellectual property. Recruit technical team. Evaluate technical aspects of potential business partnerships. Center for Ultrafast Optical Science, University of Michigan, Ann Arbor 1998 to 2003 NSF funded academic research center for development of femtosecond lasers, science and technology

Assistant Research Scientist Coordinate and lead team of researchers to develop new ophthalmic surgical techniques for refractive surgery, glaucoma intervention and phakic lens surgery. Design and carry out tissue model and animal surgical interventions, including primate models. Explore new femtosecond laser applications including biologic and non-biologic micromachining. Support human clinical ophthalmic evaluations of new femtosecond laser refractive procedures. Intralase Corporation, Irvine, CA ClinReg Consulting Services, Irvine, CA 1998 to 2001 Consultant Evaluate prototype clinical devices. Prepare regulatory and FDA submission technical documentation. Perform laser system characterizations. Coherent Medical, Palo Alto, CA 1993 to 1998 $400M international developer, manufacturer, and distributor of laser systems

Staff Development Engineer Responsible for development of solid state laser systems and delivery devices in surgical laser instruments. Lead projects from conception through market introduction. Work closely with customers, marketing, manufacturing, testing, and regulatory compliance teams. Design, characterization and optimization of flashlamp and diode-pumped solid state resonators and optical systems. Evaluate optical components. Determine material damage thresholds. Investigate laser-tissue interactions. Develop, construct, and debug breadboard prototype and production pilot consoles. University of California, Davis, CA 1987 to 1992

Doctoral Researcher, Department of Physics 1987 to 1992 Responsible for design, modification of novel FTIR spectrometer. study vibrational spectra of MBD GaAs thin films as a function of crystallinity, stoichiometry, thickness, and temperature. Characterized thin GaAs films by XRD, step profilometry, SEM, optical microscopy, IRAS, and X-ray microprobe.

Research Assistant, Departments of Chemical Engineering and Physics 1989 to 1990 Performed spectroscopic measurement and analysis on polymeric thin film gas-separating membranes.

Graduate Researcher, Department of Applied Science 1985 to 1986 Assisted with experiments using gamma ray detection of electron-positron annihilation to map electronic structures of metals at Lawrence Livermore National Laboratory. Assisted with experiments in SHG/frequency doubling of YAG laser light form the Si/Au interface under UHV.

PATENTS (23 issued) US 8,915,906, Method for treatment of post-partum abdominal skin redundancy or laxity, assignee: Cutera, Inc. Inventors: Davenport, Gollnick, Levernier, Spooner; 23 Dec 2014. US 8,911,426, Low-permeability, laser-activated drug delivery device, assignee: OnDemand Therapeutics, Inc. Inventors: Coppeta, Horne, Santini, Scholl, Spooner, Stevenson, Shams, Poutiatine; 16 Dec 2014. US 8,657,804, Visual indication of rupture of drug reservoir, assignee: OnDemand Therapeutics, Inc. Inventors: Horne, Spooner, Scholl, Santini; 25 Feb 2014. US 8,474,463, Methods and devices for non-ablative laser treatment of dermatologic conditions, assignee: Cutera, Inc. Inventors: Levernier, Spooner, Gollnick, MacFarland; 02 Jul 2013.

Greg J Spooner, PhD/ Page 3 US Patent 8,460,280, Localized flashlamp skin treatments, assignee: Cutera, Inc. Inventors: Davenport, Spooner, Gollnick, Christensen; 11 June 2013. US Patent 7,998,181, System and method utilizing guided fluorescence for high intensity applications, assignee: Cutera, Inc. Inventors: Nightingale, Spooner, Gollnick, MacFarland; 16 Aug 2011. AU 2011213616, Low-permeability, laser-activated drug delivery device, assignee: OnDemand Therapeutics; Microchips. Inventors: Coppeta, Horne,.Santini, Scholl, Spooner, Stevenson, Shams, Poutiatine; filed 8 Feb 2011. US Patent 7,780,652, System and method for flexible architecture for dermatologic treatments utilizing multiple light sources, assignee: Cutera, Inc. Inventors: MacFarland, Canant, Gollnick, Spooner, Connors; 24 Aug 2010. US Patents 8870856, 7,722,600, System and method for heating skin using light to provide tissue treatment, assignee: Cutera, Inc. Inventors: Connors, Spooner, Davenport, MacFarland, Gollnick, Levernier; 25 May 2010. US Patent 7,703,458, Methods and devices for non-ablative laser treatment of dermatologic conditions, assignee: Cutera, Inc. Inventors: Levernier, Spooner, Gollnick, MacFarland; 27 Apr 2010. US Patent 7,560,658, Method for forming nanoscale features, assignee: University of Michigan. Inventors: Hunt, Mourou, Joglekar, Meyhofer, Nees, Spooner; 14 Jul 2009. US Patent 7,326,199, System and method for flexible architecture for dermatologic treatments utilizing multiple light sources, assignee: Cutera, Inc. Inventors: MacFarland, Canant, Gollnick, Spooner, Connors; 5 Feb 2008. US Patent 7,291,140, System and method for low average power dermatologic light treatment device, assignee: Cutera, Inc. Inventors: MacFarland, Spooner, Connors, Gollnick; 6 Nov 2007. US Patent 7,208,007, System and method utilizing guided fluorescence for high intensity applications, assignee: Cutera, Inc. Inventors: Nightingale, Spooner, Gollnick, MacFarland; 24 Apr 2007. US Patent 6,995,336, Method for forming nanoscale features, assignee: University of Michigan. Inventors: Hunt, Mourou, Joglekar, Meyhofer, Nees, Spooner; 7 Feb 2006. US Patent 6,991,644, Method and system for controlled spatially-selective epidermal pigmentation phototherapy with UVA LEDs, assignee: Cutera, Inc. Inventors: Spooner, MacFarland, Gollnick; 31 Jan 2006. US Patent 6391020B1, Photodisruptive laser nucleation and ultrasonically-driven cavitation of tissues and materials, assignee: University of Michigan. Inventors: Kurtz, Spooner, Miller, Williams; 21 May 2002. US Patent 6193711B1, Rapid pulsed Er:YAG laser, assignee: Coherent, Inc. Inventors: Connors, Spooner, Saunders; 27 Feb 2001. US Patents 695,000B1 6096031, 5644585, 5642370, High repetition rate erbium:YAG laser for tissue ablation, assignee: Coherent, Inc. Inventors: Mitchell, Reed, Spooner, Hmelar; 1 Jul 1997.

RELEVANT PUBLICATIONS Surface quality of human corneal lenticules after SMILE assessed using environmental scanning electron microscopy. N Ziebarth, M Lorenzo, J Chow, F Cabot, G Spooner, J Dishler, J Hjortdal, S Yoo. J Refract Surg. 2014 Jun;30(6) 388-393. Artificial Muscle Membranes Fabricated Using Ultra-Short Pulse Laser Ablation, IA Anderson, B O'Brien, T Brastivaceanu, GJR Spooner, ASME Conf. Proc. 2009, 63 (2009), Ultra-short pulsed laser tissue ablation using focused laser beam, M Jaunich, S Raje, K Mitra, M Grace, M Fahey, G Spooner, SPIE Proceedings, 2008:6854 Fluorescence Concentrator, G Spooner, J Nightingale, V Magno, Lasers in Surgery and Medicine, Vol. 39, Suppl. S19, pp, 1-14, Apr. 2007 Ultrastructural effects of an infrared handpiece on forehead and abdominal skin, B Zelickson, V Ross, D Kist, J Counters, S Davenport, G Spooner, Dermatol Surg, Vol. 32, No. 7, pp897-901, Jul 2006 Effect of infrared handpiece on forehead skin, B Zelickson, D Kist, R Sanner, J Counters, V Ross, S Davenport, G Spooner, Lasers in Surgery and Medicine, Vol. 68, Suppl. 17, pp, 22, Mar. 2005 Ophthalmic Applications of Ultrashort Pulsed Lasers, T Juhasz, G Spooner, Z Sacks, C Suárez, F Raksi, R Zadoyan, M Sarayba, R Kurtz, Proceedings of SPIE Proceedings, 2004:5340 Subsurface Photodisruption for Potential Noninvasive Glaucoma Surgery, H–L Liu, M Eibschitz–Tsimhoni, G Spooner, P Lichter, M Mourou, G Mourou, T Juhasz, Invest Ophthalmol Vis Sci 2004 45:E-Abstract 1002

Greg J Spooner, PhD/ Page 4 A study of the deterministic character of optical damage by femtosecond laser pulses and applications to nanomachining, A Joglekar, H Liu, G Spooner, E Meyerhofer, G Mourou, A Hunt, Applied Physics B – Lasers and Optics, Vol. 77, No. 1, pp 25-30, Aug 2003 Subsurface photodisruption in human sclera: wavelength dependence, Z Sacks, R Kurtz, T Juhasz, G Spooner, G Mourou, Ophthalmic Surgery, Lasers and Imaging, Vol. 34 No. 2 March/April 2003. Ultrafast lasers for intracellular microsurgery with minimum collateral damage, A Joglekar , G Spooner, E Meyhofer, A Hunt, Biophysical Journal Vol. 84, No. 2, Part 2, pp 298A, Feb 2003. Strain imaging of corneal tissue with an ultrasound elasticity microscope, K Hollman, S Emelianov, J Neiss, G Jotyan, G Spooner, T Juhasz, R Kurtz, & M O'Donnell, Cornea, vol. 21, pp. 68-73, Jan 2002. Photodisruptive laser nucleation of ultrasonic cavitation for biomedical applications, D Miller, G Spooner, A Williams, Journal of Biomedical Optics, Vol 6, no. 3; July 2001; p.351-8. The femtosecond blade: applications in corneal surgery, T Juhasz, R Kurtz, C Horvath, C Suarez, F Raksi, G Spooner, Optics and Photonics News, Jan 2002 New developments in ophthalmic applications of ultrafast lasers, G Spooner, T Juhasz, I Ratkay-Traub, G Djotyan, C Horvath, Z Sacks, G Marre, D Miller, A Williams, R Kurtz, SPIE Proceedings, 2000:3934 Optimization of parameters for photodisruptively nucleated ultrasonic cavitation in water and tissue models, G Spooner, A. Williams, D Miller, G Marre, SPIE Proceedings, 2000:3914A Subsurface photodisruption in scattering biological tissues, Z Sacks, G Spooner, G Marre, R Kurtz, T Juhasz, G Mourou, SPIE Proceedings, Saratov Fall Meeting 1999 Intrastromal corneal surgery in live animal models with femtosecond laser pulses, G Spooner, T Juhasz, R Kurtz, K Sletten, M Meunier, H Liu, C Horvath, CLEO 1999 Ophthalmic applications of femtosecond lasers, R Kurtz, G Spooner, K Sletten, K Yen, S Sayegh, F Loesel, C Horvath, H Liu, V Elner, D Cabrera, M Meunier, Z Sacks, T Juhasz, D Miller, A Williams, SPIE Proceedings, 1999:3610 Femtosecond laser corneal refractive surgery, R Kurtz, G Spooner, K Sletten, K Yen, S Sayegh, F Loesel, C Horvath, H Liu, V Elner, D Cabrera, M Meunier, Z Sacks, T Juhasz, SPIE Proceedings, 1999:3591

PROFESSIONAL American Society for Lasers in Surgery and Medicine (ASLMS), Industrial Marketing Representative, Board of Directors, 2005-2008