GFR & I'ts Regulation
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Transcript of GFR & I'ts Regulation
GFR & IT’S Regulation
By:-Dr.Pradeep Sharma
PG ( Res.)SMS ,medical college.jaipur
GOOD MORNING
GFR & IT’S REGULATION
Glomerular filtration rate (GFR) is the measure that describes the total
amount of filtrate formed by all the renal corpuscles in both kidneys per
minute.
• Glomerular filtration is first step of urine formation.
• It’s begin with filtration of large amounts of fluid through glomerular capillaries in to Bowman’s capsule.
• Glomerular capillaries are impermeable to proteins, cellular elements including RBC’s
• Filtered fluid through glomerular capillaries called glomerular filtrate.
• Some LMWS ( like calcium, fatty acids ) are not freely filtered, because of partilally bound to plasma proteins
• Glomerular filtration rate (GFR) is equal to the Clearance Rate when any solute is freely filtered and is neither reabsorbed nor secreted by the kidneys.
Urine concentration * Urine flow• GFR = Plasma concentration
Estimation of GFR
1) Measurement using inulin/ sinistrin ( most accurate) 2) Measurement with radioactive tracers (Chromium- 51 and 99 m- T) 3) Creatinine-based approximations of GFR. ( most clinically used)
U cr * VCcr = P crExample: A person has a plasma creatinine
concentration of 0.01 mg/ml and in 1 hour produces 60ml of urine with a creatinine concentration of 1.25 mg/mL.
REGULATION OF GFR
Renal blood flow & GFR
• 1) Auto regulation• 2) Neural (autonomic ) regulation• 3)Hormonal regulation• 4) RAAS (renin-angiotensin- aldosteron
system)
THANK YOU