Genscript overview 030110[1]
Transcript of Genscript overview 030110[1]
Your Innovation Partner in Drug Discovery!
Introducing GenScript
March 2010
Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
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Presentation Overview
The Biology CRO
About GenScript
Service Overview
Your Reliable Partner
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
About GenScript
Founded in 2002 >800 employees Headquarters in Piscataway, NJ, USA Facilities and branches:
New Jersey, USA Nanjing, China
Paris, France
Osaka, Japan
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Fast Growing Company
Organic Growth Since Inception
2002 2003 2004 2005 2006 2007 2008
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
The largest provider of custom gene synthesis services in the U.S. We offer the best antibody service guarantee in the industry We provide small- and large-molecule one-stop biology CRO services for early drug
discovery and development Local access and 24-hour customer support ISO 9001:2000-certified and full client IP protection We offer advanced bioinformatics tools and IT infrastructure for value-added services Customers include top pharmaceutical companies, major biotech firms, and research
institutions in over 70 countries Seasoned science and business management teams
Key Facts About GenScript
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
INVESTORS
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Most respected VC in the world Funded Genentech, Google, Amazon, Pacific Biosciences, etc Invested in > 300 IT , life science, and biotech companies
Leading independent advisory company Top boutique investment banking firm in China Clients include Sinopec, Jiangsu Lihua, Masterrind, Medical Systems
In Search of the Next Big Idea
Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Comprehensive Biology Services
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Gene Synthesis
— Any gene you desire!Synthesize genesOptimumGeneTM Codon OptimizationLarge-Scale Gene Synthesis
Cloning
—Any construct you want to build! PCR Cloning/SubcloningGenPoolTM ORF CloningKI & KO Vector ConstructionCustom vector construction
Mutagenesis
— Any variant from your design!Mutagenesis Service Site-Directed Mutagenesis LibrariesSequential Permutation Scanning LibrariesRandomized and Degenerated Libraries
Plasmid Preparation
— Any amount to fit your plan!Flexible Scale: 100 μg to 1,000 mgLow Endotoxin Levels: <5 EU/mg
Largest Gene Synthesis Supplier in USA
Transforming Molecular Biology
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
GenScript One Stop Protein Services
Gene Services•Largest gene synthesis supplier in US•Comprehensive portfolio of molecular biology services:
Codon Optimization
Cloning
Vector Construction
Mutagenesis
Plasmid Preparation
etc.
Gene Services•Largest gene synthesis supplier in US•Comprehensive portfolio of molecular biology services:
Codon Optimization
Cloning
Vector Construction
Mutagenesis
Plasmid Preparation
etc.
Protein Services•Expression (E.coli, yeast, insect, mammalian)•Purification•Production of biologically functional protein•Large capacity for scale-up (fermentation, protein production from stable cell lines)
Protein Services•Expression (E.coli, yeast, insect, mammalian)•Purification•Production of biologically functional protein•Large capacity for scale-up (fermentation, protein production from stable cell lines)
Antibody Services•pAb production•mAb production•Hybridoma development
Antibody Services•pAb production•mAb production•Hybridoma development
Assay Services•Assay development & validation (GPCR, ion channel, enzyme)•Compound screening & profiling
Assay Services•Assay development & validation (GPCR, ion channel, enzyme)•Compound screening & profiling
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Custom Peptide Synthesis Services
Custom Peptide Synthesis Services
Standard Peptide Synthesis
High complexity and purityLong peptides up to 200 aaHigh success rate ≥ 95%
Peptide Libraries
Rapid parallel platformCompetitive prices Guaranteed deliveryFlexible screening tools
Cosmetic Peptides
FlexPeptideTM technologyComprehensive documents
Batch size from mg to 2 kgPeptides up to 50 aa
Recombinant Peptides
Flexible technologyVariety of modifications Any length, any sequence, any scale
Non-GMP Peptides
GMP Peptides
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Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
pAb Services
Affinity-Purified pAbPhospho-Specific pAb
Express AntibodyTM ServicesSpecies: rabbit, goat/sheep, chicken, mouse, rat, etc
mAb services
MonoExpressTM Antibody Services mAb Production ServicesMost Popular: Phospho-Specific pAb Package
Large Scale Antibody Production Services
Additional Services
Ab ModificationAb PurificationAb CharacterizationCell Line StoragePeptide Synthesis Services
Immunoassay Development Services for Drug Discovery & Clinical Studies
Guaranteed Antibody Services
Custom pAb and mAb ServicesCatalog antibodiesExpress servicesBest guaranty in the industry
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Leading the industry standard on antibody guarantee …
Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
In house Project Design
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Antibody Affinity Maturation
Stable Cell Line Generation
Antibody Production
Bioprocess Development
Antibody Affinity Maturation
Stable Cell Line Generation
Antibody Production
Bioprocess Development
Antibody DrugAntibody DrugDevelopment CenterDevelopment Center
Target Validation
Industry-scale Antibody Drug Development
Immunon-Immunon-izationization
Hybridoma Selection Maturation Production Target Validation
Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Antibody Drug Development CenterProtein
Antigen productionMolecular Biology
Library constructionmAb sequencing
Antibody EngineeringAffinity maturationAntibody humanizationAnti-idiotype antibody generationEpitopic mapping
Antibody ProductionHybridomaProtein purification
Bioprocess DevelopmentTransient and stable expression in flexible scales
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Comprehensive Antibody Drug Development
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Transient Gene Expression and Protein Production
Proprietary technology Serum free 293 and CHO suspension systems Rapid protein and mAb production up to grams
Stable Cell Line Development and Protein Production
Proprietary expression system High flexibility with parental cell types State-of-the-Art facilities Record proven on-time delivery
Process Development and Transfer
— We pay attention to every single detail
BioProcess Services
Stable cell developmentBioreactors and WAVE-bag technologyIndustry Scale Protein Production
Custom Solution Bioprocess Services
Your Innovation Partner in Drug Discovery!
Our Innovation
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Gene-on-DemandTM gene synthesis technology - best and most economic gene synthesis
FlexChemTM ligation technology - peptide synthesis up to 200 amino acids
CloneEZTM seamless cloning technology - state-of-art cloning into any vector at any site
Nanotechnology for adjuvant mixing - induction of enhanced immune response
Diversified expression systems - bacteria, yeast, insect cells, and mammalian cells
T-MaxTM adjuvant - increased titer of at least ten times, and reduced cost
FoldingArtTM technology - refold rate of 95% for inclusion bodies and proteins (virus expression)
OptimumAntigenTM antigen design - optimized antigen design
293TGETM system - most efficient transient expression system
OptimumGeneTM codon optimization technology - optimized gene expression
Innovative technologies for enhanced services
Your Innovation Partner in Drug Discovery!
YOUR RELIABLE PARTNER
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Business Model
Your Reliable Partner
Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!
Confidentiality agreement for each contract project
Secure online information transfer
Account specific document management
Strict access control for dedicated research areas
ClientClient
ClientClient
Your Reliable Partner IP protection is crucial to a sustainable partnership between
pharmaceutical clients and GenScript
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Your Innovation Partner in Drug Discovery!
Thank you!Thank you!
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Nicole Niu, Ph.D.
Regional Sales Manager
GenScript USA Inc.
120 Centennial Ave, Piscataway, NJ 08854, USA
Tel: 732-885-9188 x 155 Fax: 732-210-0262
Email: [email protected]
Your Innovation Partner in Drug Discovery!