Genomic Selection in Dairy Cattle
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Genomic Selection in Dairy Cattle
Dr.Wuttigrai Boonkum
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Genomic Selection
• Dairy cattle most are specialised dairy breed Holstein, Jersey, Brown Swiss, Ayrshire• Some dual propose Simmental, Montbeliarde, Normande, etc• More than 80% AI from AI companies• Global exchange of genetic so international
genetic evaluation
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Genomic Selection
P = G + EGenetic evaluation or Molecular genetics
Need time and data completeAppropriated major gene only
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Genomic Selection,What does it bring us?
• Reliable breeding values at young age
– higher success rate to get top bulls
– lower costs for test proofs
– shorter generation-interval
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Reliability of breeding values
Categorie Production Type Longevity
Parent average 35% 35% 30%
GS young bull 50-55% 45-50% 40-45%
1st EBV (prog.) 80% 75% 50-65%
2nd EBV (prog.) 89% 81% 50-80%
50% reliability is realistic
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Advantages of Genomic Selection
• Increased genetic improvement (30-40%)
• Higher genetic level of test sires
• Higher genetic level of Delta embryo’s
• Wider portfolio of commercial bulls & higher level
• More outcross; less inbreeding
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Disadvantages of Genomic Selection
• New method, not fully proven or tested
• Need to genotype a sufficiently large set of animals for accurate GEBV
• Across breed accuracy low• Genotypes still costly (10,000 bath/head)
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1. การก�าหนดเป้าหมายของการป้ร�บป้ร�งพั�นธุ์��โคนม
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1. การก�าหนดเป้าหมายของการป้ร�บป้ร�งพั�นธุ์��โคนม
ผลผล�ตน้ำ���น้ำม
องค์ ประกอบน้ำ���น้ำม
ล�กษณะโค์รงร��ง
ค์ว�มสมบ�รณ พั�น้ำธุ์�
ล�กษณะก�รต��น้ำท�น้ำโรค์
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พั�นธุ์��โคนมของป้ระเทศไทย
TMZ TF
Friebrah
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3. การใช้�ระบบผสมข�ามพั�นธุ์��ท!"เหมาะสม
Dairy cattle crossbreds
Traits TF TMZ FB
Milk yield (kg/head/lactation)Milk yield (kg/head/day)Day in milk (day)First oestrus after calving (day)Calving interval (day)Number of service per conception (times)Income (baht/lactation)Production cost (baht/lactation)Milk production cost (baht/kg)Net profit (baht)
4,517.76+384.1914.39+2.92314.45+24
69.17+28415.10+722.10+0.8752,406.0129,795.39
6.3722,610.62
3,902.57+460.9113.34+4.06292.30+28
68.19+43399.90+491.70+0.8245,269.8728,032.08
7.4917,237.79
2,472.90+456.129.20+1.21
268.50+5154.23+28
363.70+431.40+0.6928,676.2424,646.17
9.914,030.07
Table 3 Comparison of average of milk yield, reproductive performance and economic returns of Thai Friesian (TF), Thai milking zebu (TMZ) and Friebrah (FB)
Source: (สดใส และค์ณะ, 2549 ก,ข)
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4. การใช้�พั�นธุ์�ศาสตร�โมเลก�ลในการป้ร�บป้ร�งพั�นธุ์��โคนม
Selection indexincluding
MA information
medium, low
Heritability
high
BLUPBLUP
TraditionalSelection indexby MT-BLUP
Pre-selectionby markerconfirmed
by MT-BLUPindex
MASSelection indexby MA-BLUP
GΔ GΔGΔ
GΔ
Figure 6 Dairy cattle improvement using BLUP and genetic marker scheme