Genome sequencing for animal health - input and impact
Transcript of Genome sequencing for animal health - input and impact
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Genome sequencing for animal health – input and impact
Gwenaelle DAUPHINAGAH – EMPRES
Lab Unit coordinator
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Running PCR
Obtaining genetic sequence
Analysing and sharing
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Monitoring virus distribution
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Monitoring virus genetic evolution
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Monitoring vaccine matching
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More powerful molecular epidemiology
Better design of diagnostic assays
Improved veterinary vaccination
Molecular DIVA for CapripoxvirusesCapripoxvirus Genotyping
Whole genome phylogenetic analysis of Capripoxviruses
Whole genome sequencing
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Outcomes and impact in Indonesia: Influenza Virus Monitoring Network
Informed Avian influenza control policies, including vaccination
Improved knowledge of circulating H5N1 viruses
Clear process to support decision making
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Endemic with influenza H5N1 since 2004: -3,500 poultry H5N1 outbreaks reported-1,150 Egyptian influenza H5N1isolates from poultry which sequences = deposited to the public domain
Outcomes and impact in Egypt
Phylogenetic analysis of A(H5N1) in Egypt during 2006-2014
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Conclusions• Sequence data: key component in the control and prevention of animal and zoonotic
diseases• Molecular biology used in all countries - use of sequencing is expanding – high
demand for training• Sharing of sequences of utmost importance
active in building capacities, assisting countries to apply sequencing and promoting the use and sharing of sequences