Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)

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    Purines

    Adenine = 6-amino purine

    Guanine = 2-amino-6-oxy

    purine

    Hypoxanthine = 6-oxypurine

    Xanthine = 2,6-dioxypurine

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    Pyrimidines

    Uracil = 2,4-dioxypyrimidine

    Thymine = 2,4-dioxy-5-methyl pyrimidine

    Cytosine = 2-oxy-4-

    amino pyrimidine Orotic acid = 2,4-

    dioxy-6-carboxypyrimidine

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    Medical relevance of nucleotide

    pathwaysCritical in cancer treatment

    Hydroxyurea, anti-folates, FdUMP, 5-FU, etc

    Antiviral therapies

    acyclovir and herpes

    Important inborn errors and pathologies

    Adenosine deaminase and SCIDS

    Lesch-Nyhan Syndrome

    Hyperuricemia

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    Lesch-Nyhan syndrome

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    Orotic aciduria

    an inherited human disease caused by adeficiency in the multifunctional enzymethat catalyzes the last 2 steps in the

    pyrimidine synthesis large amounts of orotic acid in urine retarded growth and severe anemia

    treat by administration (injection) of uridineand/or cytidine

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    CLINICAL SIGNIFICANCE

    6-Mercaptopurine Inhibits PRPP Amidotransferase, IMP DHASE,Adenylsuccinate synthase

    5-Fluorouracil(FUTP) Inhibit maturation of r,m RNA(FdUMP) Inhibits thymidylate synthase

    Methotrexate Inhibits H2 folate reductase.Azaserine : Inhibits enzymes that utilize gln as N doners(Gln antagonists)6-Diazo-5-oxo-1-norleucine: (Gln antagonists)Hydroxyurea: Inhibits ribonuleotide reductase.

    3-azido-3-deoxythymidine -AZT :antiviral-chain termination(pyr analog)

    Acycloguanosine- Acyclovir: "( pur. Analog)

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NUCLEOTIDES & NUCLEIC ACIDS · Structure of Nucleotides . The purine or pyrimidine base. Pyrimidine and purine Know these! Nucleotide bases in nucleic acids are pyrimidines or purines.

NUCLEOTIDES & NUCLEIC ACIDS · Structure of Nucleotides . The purine or pyrimidine base. Pyrimidine and purine Know these! Nucleotide bases in nucleic acids are pyrimidines or purines.

Disorders of metabolism 1. purine and pyrimidine 2 ...udmp.lf1.cuni.cz/file/5668/purines pyrimidines porphyria fasting.pdf · 3. ketogenesis/ketolysis 4. Biochemistry of starvation

Disorders of metabolism 1. purine and pyrimidine 2 ...udmp.lf1.cuni.cz/file/5668/purines pyrimidines porphyria fasting.pdf · 3. ketogenesis/ketolysis 4. Biochemistry of starvation

nucleoside nucleotides - Vanderbilt University...175 342 28.1: Pyrimidines and Purines. The heterocyclic base; there are five common bases for nucleic acids (Table 28.1, p. 1166).

nucleoside nucleotides - Vanderbilt University...175 342 28.1: Pyrimidines and Purines. The heterocyclic base; there are five common bases for nucleic acids (Table 28.1, p. 1166).

36 37 38 39 AminoAcidBiosynthesis laptopNucleotide Biosynthesis purines pyrimidines Biosynthesis of secondary products of amino acids Non-essential Amino acids: These are very few

36 37 38 39 AminoAcidBiosynthesis laptopNucleotide Biosynthesis purines pyrimidines Biosynthesis of secondary products of amino acids Non-essential Amino acids: These are very few

Purines – Adenine and Guanine Pyrimidines – Cytosine and Thymine.

Purines – Adenine and Guanine Pyrimidines – Cytosine and Thymine.

27.23 Pyrimidines and Purines

27.23 Pyrimidines and Purines

Biology 2120 Reading Day Review Session - UCAE · 2019-04-30 · Purines: adenine and guanine Pyrimidines: cytosine, thymine, and uracil Replication Template Strand Daughter Strand.

Biology 2120 Reading Day Review Session - UCAE · 2019-04-30 · Purines: adenine and guanine Pyrimidines: cytosine, thymine, and uracil Replication Template Strand Daughter Strand.

mercaptoethanolquantity of purines, pyrimidines, and their derivatives was estimated from the optical density at 260 m,u of the cold PCA extract, assumingamolarextinction coefficient

mercaptoethanolquantity of purines, pyrimidines, and their derivatives was estimated from the optical density at 260 m,u of the cold PCA extract, assumingamolarextinction coefficient

Chemistry of Lipids · Chemistry of Heterocyclic Compounds Porphyrins Purines and pyrimidines Nucleosides and nucleotides. Introduction to Heterocyclic Compounds Cyclic compounds

Chemistry of Lipids · Chemistry of Heterocyclic Compounds Porphyrins Purines and pyrimidines Nucleosides and nucleotides. Introduction to Heterocyclic Compounds Cyclic compounds

REVIEW DNA Structure. Deoxyribonucleic Acid DNA Deoxyribose sugar Double helix A -2-T, C-3-G Strands are complementary Purines: A and G Pyrimidines: T.

REVIEW DNA Structure. Deoxyribonucleic Acid DNA Deoxyribose sugar Double helix A -2-T, C-3-G Strands are complementary Purines: A and G Pyrimidines: T.

Physiological concentrations of purines and …rasmodel.org/_downloads/7877593.pdfPhysiological concentrations of purines and pyrimidines Thomas W. Traut Department of Biochemistry

Physiological concentrations of purines and …rasmodel.org/_downloads/7877593.pdfPhysiological concentrations of purines and pyrimidines Thomas W. Traut Department of Biochemistry

Nutrition - Premier Analytical Services · Osmolality in drinks (also Milk Freezing Point Depression) Phospholipids Phytic acid Purines (total) & Pyrimidines (total) Quinine in soft

Nutrition - Premier Analytical Services · Osmolality in drinks (also Milk Freezing Point Depression) Phospholipids Phytic acid Purines (total) & Pyrimidines (total) Quinine in soft

Metabolism of purines and pyrimidines Vladimíra Kvasnicová The figure was found at (Jan 2008)

Metabolism of purines and pyrimidines Vladimíra Kvasnicová The figure was found at (Jan 2008)

Kalasalingam Academy of Research and EducationR. llavarasi, L. Muthulakshmi and S. Selvanayagam,- Synthesis and Characterization of Complexes of Rh (Il) with purines and pyrimidines",

Kalasalingam Academy of Research and EducationR. llavarasi, L. Muthulakshmi and S. Selvanayagam,- Synthesis and Characterization of Complexes of Rh (Il) with purines and pyrimidines",

Purines and pyrimidines, nucleosides, nucleotides ... · Nucleotides have a variety of roles in cellular metabolism - They are activated precursors of nucleic acids. - ATP is the

Purines and pyrimidines, nucleosides, nucleotides ... · Nucleotides have a variety of roles in cellular metabolism - They are activated precursors of nucleic acids. - ATP is the

Purines and Pyrimidines. Purine and Pyrimidine are the names of the parent compounds of two types of nitrogen- containing heterocyclic aromatic compounds.

Purines and Pyrimidines. Purine and Pyrimidine are the names of the parent compounds of two types of nitrogen- containing heterocyclic aromatic compounds.

B.Sc(MLT) Syllabus 2010 The Tamilnadu Dr.M.G.R Medical …psgohcms.ac.in/Allied Health Sciences/B.sc Syllabus2011/B... · 2011-06-17 · Introduction to hormones,purines ,pyrimidines&

B.Sc(MLT) Syllabus 2010 The Tamilnadu Dr.M.G.R Medical …psgohcms.ac.in/Allied Health Sciences/B.sc Syllabus2011/B... · 2011-06-17 · Introduction to hormones,purines ,pyrimidines&

Kodak reports to laboratories...10A SCIENCE, VOL. 120 FOR Po RESEARCH ADENYUTES, NUCLEATES, PURINES and PYRIMIDINES Adenine Sulfate Adenosine Adenosine-3-Phosphoric Acid …

Kodak reports to laboratories...10A SCIENCE, VOL. 120 FOR Po RESEARCH ADENYUTES, NUCLEATES, PURINES and PYRIMIDINES Adenine Sulfate Adenosine Adenosine-3-Phosphoric Acid …

1. B.Sc. Biotechnology (Entire)ycis.ac.in/syllabus_pdf/biotechnology/B.Sc. I... · Structure and functions of Nucleic acids, purines & pyrimidines, Nucleosides & Nucleotides, Biologically

1. B.Sc. Biotechnology (Entire)ycis.ac.in/syllabus_pdf/biotechnology/B.Sc. I... · Structure and functions of Nucleic acids, purines & pyrimidines, Nucleosides & Nucleotides, Biologically

nuclear structure nucleus: DNA & chromosomesDNA structure • Watson and Crick proposal • pyrimidines pair with purines • C-G, A-T • minor and major groove • allow place for

nuclear structure nucleus: DNA & chromosomesDNA structure • Watson and Crick proposal • pyrimidines pair with purines • C-G, A-T • minor and major groove • allow place for