Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations...

31
András Falus Semmelweis University Dept. GCI Do-Re-Mi November 5. 2013. Genetic and epigenetic regulation of the immune response

Transcript of Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations...

Page 1: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

And

rás

Falu

s

Sem

mel

wei

s U

nive

rsity

Dep

t. G

CI

Do-

Re-

Mi

Nov

embe

r 5. 2

013.

Gen

etic

and

epi

gene

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egul

atio

n of

the

imm

une

resp

onse

Page 2: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage
Page 3: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 4: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 5: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 6: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 7: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 8: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 9: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 10: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage
Page 11: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 12: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 13: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 14: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage
Page 15: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 16: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

Orn

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in J

, Dau

benm

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, Wei

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Page 17: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

2006

.

Page 18: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 19: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 20: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 21: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 22: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

DC

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Page 23: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 24: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

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Page 25: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

T-ly

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Page 26: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

An

epig

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mis

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s,

plea

se e

mai

l: jo

urna

ls.p

erm

issi

ons@

oupj

ourn

als.

org

Page 27: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

Met

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Page 28: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

A Pi

varc

si20

13

Page 29: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

Net

wor

k M

edic

ine

Bar

abás

i, N

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ngla

nd J

ourn

al o

f Med

icin

e (2

007)

Page 30: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

Gen

omic

s-ep

igen

omic

s

•H

ered

ity (g

enet

ics)

is ir

reve

rsib

le

•Eg

igen

etic

cha

nges

are

rev

ersi

ble

LIFE

STYL

E!!!

Page 31: Genetic and epigenetic regulation of the immune response ... · GWAS analysis of SNP associations in asthma by Bayes informatics tool Csorba et al, PlosOne, 2013 DC, monocyte/macrophage

http

://w

ww.

face

book

.com

/edu

vita

l.net