Generating Spiral Waves with Different G CaL and G K1
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Generating Spiral Waves with Different GCaL and GK1
Clara N. Jasmine M.
Rachel S.Mark D.
CMACS Workshop 2013
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What do you see?
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Effects on Action Potential ICaL is a depolarizing inward
current
Affects plateau of action potential, a balancing act between depolarizing currents
Hypothesis: An increase in GCaL, increases ICaL, which will elongate the plateau
Saeneno JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol. Epub 2008 Feb 9. http://www.ncbi.nlm.nih.gov/pubmed/18336833
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Effects on Action Potential IK1, inward rectifying current,
closes at depolarization
Active during resting potential and the end of Phase 3 repolarization
Hypothesis: An increase in GK1, increases IK1, which will make the repolarization slope steeper
Saeneno JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol. Epub 2008 Feb 9. http://www.ncbi.nlm.nih.gov/pubmed/18336833
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Effects on Spiral Waves Is there more
orange in the upper right quadrant?
Is there more green as Gk1 increases?
How can we improve the testability of our hypotheses?
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Effects on Spiral Waves Is there more
orange in the upper right quadrant?
Is there more green as Gk1 increases?
How can we improve the testability of our hypotheses?
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Increased GK1
Inward Rectifier K+ conductance
Higher GK1 Leads to Dispersion
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Increased GK1
Inward Rectifier K+ conductance
Higher GK1 Leads to Dispersion
Gcal 25,Gk1 25
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Increased GK1
Inward Rectifier K+ conductance
Higher GK1 Leads to Dispersion
Gcal 25,Gk1 25 Gcal 25,Gk1 145
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Increased GK1
Higher value of GCaL
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Increased GK1
Higher value of GCaL
Gcal 145,Gk1 25
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Increased GK1
Higher value of GCaL
Gcal 145,Gk1 25 Gcal 145,Gk1 145
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Increased GCaL
L-Type Ca+2 conductance
GCaL changes pathway shape
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Increased GCaL
L-Type Ca+2 conductance
GCaL changes pathway shape
Gcal 25,Gk1 45
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Increased GCaL
L-Type Ca+2 conductance
GCaL changes pathway shape
Gcal 25,Gk1 45 Gcal 125,Gk1 45
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Increased GCaL
Higher value of GK1
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Increased GCaL
Higher value of GK1
Gcal 25,Gk1 185
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Increased GCaL
Higher value of GK1
Gcal 25,Gk1 185 Gcal 185,Gk1 185
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ConclusionIncreased GK1 Leads to a Tip Trajectory
Spread Out Over a Larger Area.
Increased GCal Plays a Role in the Shape of the Pathway Traced By the Tip.
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Acknowledgements!!!!!!1!!CMACS WorkshopProfessor GriffethProfessor FentonNSF/NIH/NASA/ABC/CIA/CUNY/LOLPeter’s PythonTNNP Mother Nature For Developing A
Complicated Heart Structure That Has Not Been Fully Understood Thus Far.
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Questions?