General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work....
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Transcript of General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work....
![Page 1: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/1.jpg)
General Shape of a Smooth Muscle Cell
"Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - https://commons.wikimedia.org/wiki/File:Smooth_muscle_tissue.jpg#/media/File:Smooth_muscle_tissue.jpg
![Page 2: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/2.jpg)
Smooth Muscle Motor Units?
"1029 Smooth Muscle Motor Units" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC BY 3.0 via Commons - https://commons.wikimedia.org/wiki/File:1029_Smooth_Muscle_Motor_Units.jpg#/media/File:1029_Smooth_Muscle_Motor_Units.jpg
![Page 3: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/3.jpg)
Contraction Patterns in Smooth Muscles
Phasic (quick, SkMus-like) and tonic contractions
![Page 4: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/4.jpg)
EC Coupling in Smooth Muscle
![Page 5: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/5.jpg)
Thin and Thick Filament Arrangements in Smooth Muscle
![Page 6: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/6.jpg)
"1028 Smooth Muscle Contraction" by OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013.. Licensed under CC BY 3.0 via Commons - https://commons.wikimedia.org/wiki/File:1028_Smooth_Muscle_Contraction.jpg#/media/File:1028_Smooth_Muscle_Contraction.jpg
"Actin myosin filaments" by Boumphreyfr - Own work. Licensed under CC BY-SA 3.0 via Commons - https://commons.wikimedia.org/wiki/File:Actin_myosin_filaments.png#/media/File:Actin_myosin_filaments.png
Contraction in Smooth Muscle -- Overview
![Page 7: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/7.jpg)
Caldesmon
![Page 8: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/8.jpg)
Caldesmon In Relaxed Fibers
![Page 9: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/9.jpg)
Regulation of Smooth Muscle Contraction
Thick Filament Regulation (on myosin light chain):
-- Modulation by MLCK/MLCP
-- Other Mechanisms
Thin Filament Regulation (?):
-- Does caldesmon have a regulatory role?
-- Other mechanisms
![Page 10: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/10.jpg)
Calcium and the Control of MLCK Leading to Control of the Myosin Light Chain
![Page 11: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/11.jpg)
Contracted Smooth Muscle
![Page 12: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/12.jpg)
There is Always a Reverse Process:
MLCP phosphatase is inhibited by a Ca++ dependent pathway (but in any case, its maximum activity is lower than MLCK)
![Page 13: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/13.jpg)
SM Contraction and Relaxation: Ca++ and the Regulation of Phosphorylation of the Myosin Light Chain
![Page 14: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/14.jpg)
Regulation via the PKC Pathway
![Page 15: General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - Smooth_muscle_tissue.jpg#/me.](https://reader036.fdocuments.in/reader036/viewer/2022081516/5697bf8e1a28abf838c8cf50/html5/thumbnails/15.jpg)
Latch Mechanism?