Gen Report Ngs Market Trends May 20142332301892

GENReports:,Market,&,Tech,Analysis,!Produced!by!Enal!Razvi,!Ph.D.!©!2014,GENengnews.com,

> Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. [email protected]!

GENReports: Market & Tech Analysis


•  The,focus,of,this,GEN,Market,&,Tech,Analysis,Report,is,to, characterize, the, next, generaBon, sequencing, (NGS),space,based,on,the,following,classes,of,data,which,we,have,been,collecBng,as,part,of,our,conBnuing,analysis,of,this,field:,

,–  Bo<om>up! Research! Trends! based! upon! an! Online! Market!

Survey! we! Conducted! on! Researchers! UJlizing! NGS! in! their!Current!Research!AcJviJes!

–  Provides! a! picture! of! the! field! as! it! exists! today! in! terms! of!applicaJon!areas!and!uJlizaJon!pa<erns—both!qualitaJve!and!quanJtaJve!trends!are!presented!

Scope!


Growth of Next-Generation Sequencing Focused

Publications

0!

1,500!

3,000!

4,500!

6,000!

1970! 1975! 1980! 1985! 1990! 1995! 2000! 2005! 2010! 2015! 2020!

Num

ber!o

f!Pub

licaJ

ons!p

er!Year!

Year!

This,ExponenBal,Growth,of,NGSKFocused,PublicaBons,in,PubMed,ANests,to,the,Expansion,

of,NGS,and,its,PenetraBon,into,Life,Science,Research,


Breakout of Researchers vis-à-vis Their

Utilization of NGS. I

Basic!Academic!Research!49%!UJlizaJon!of!

NGS!for!Discovering!Disease>associated!VariaJons/MutaJons!

32%!

Studying!Cancer!using!

NGS!18%!

Studying!Non>coding!RNAs!using!NGS!

1%!

Note,how,small,this,segment,is,

Gross,Breakout,of,Research,Efforts,in,the,NGS,Space,


Breakout of Researchers vis-à-vis Their

Utilization of NGS. II

Developing!InstrumentaJon!for!

NGS!12%!

Developing!Reagents!for!NGS!9%!

MutaJon/Variant!Discovery!using!NGS!

19%!

ComparaJve!Genome!Sequencing!using!NGS!

29%!

Sequencing!of!Clinical!Samples!using!NGS!

21%!

Discovery!of!Cancer!MutaJons/Variants!

6%!

ValidaJon!of!Cancer!MutaJons/Variants!in!

Clinical!Samples!4%!

Fine,Structure,Breakout,of,Research,Efforts,in,the,NGS,Space,


“Analyte Classes” Studied via NGS Today: Provides a

Picture of Research Efforts by Type of Nucleic Acid

Studying!Small!RNAs,!microRNAs,!or!microRNA!

biology!per!se!15%!

Studying!Small!RNAsmicroRNAs!in!Cancer!

8%!

Studying!Long!Non>coding!RNAs!6%!

Studying!mRNA!Expression!via!RNA>Seq!

33%!

Studying!SomaJc!MutaJons![in!the!genome]!

38%!

Studying!the!Genome!via!NGS!

RNA>Seq!


Technologies/Application Areas Influencing the

Research of Researchers Involved with NGS

0

10

20

30

40

50

60

70

NG

S

qPC

R

Mic

roar

rays

Mic

roflu

idic

s/La

b-on

-a-C

hip

Sam

ple

Pre

para

tion

Bio

info

rmat

ics

Can

cer

Bio

mar

kers

Exo

som

es/M

icro

vesi

cles

Epi

gene

tics

Ste

m C

ells

Which Technologies or Application Areas are Influencing your Research Currently?

Not at All

Some

A Key Focus

Arrows!Illustrate!Areas!of!Key!Research!Focus:!Note!how!Crucial!Sample!PreparaJon!and!BioinformaJcs!are!!


•  Select! Biosciences! presents! a! snapshot! of! the! NGS! space! as! it! is!translaJng!from!research!towards!the!clinic!

•  The!focus!of!this!report!is!to!frame!some!of!the!primary!market!research!data! relaJng! to! NGS! research! trends! we! have! obtained! based! on!“bo<om>up”!market!surveys!from!pools!of!researchers!involved!with!this!research!area!

•  We! note! the! percentage! breakout! between! acJviJes! focused! on!analyzing!somaJc!mutaJons!versus!RNA>Seq!

•  We! also! demonstrate! the! currently! small! contribuJon! of! small>RNA!research!acJviJes!into!the!broader!NGS!space!

•  These!data!are!crucial!in!framing!the!research!landscape!of!the!NGS!field!as!it!evolves—the!picture!from!the!research!community!

Summary and Key Takeaways

Gen Report Ngs Market Trends May 20142332301892

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