Gen pathology finals pictures
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Transcript of Gen pathology finals pictures
Finals Pictures
Examples of Malformations
A. Polydactyly (one or more extra digits) and syndactyly (fusion of digits)B. Cleft lip (may be with or without associated cleft palate)C. Lethal malformation (midface structures are fused or ill-formed); external
dysmorphogenesis associated with severe internal anomalies such as maldevelopment of the brain and cardiac defects
Disruption by an amniotic
band
Disruptions (Amniotic Bands)
Oligohydramnios sequence
Flattened facial features and deformed right foot (talipes equinovarus)
Thalidomide Babies
Fetal macrosomia in Gestational Diabetes
Trisomy 21 (Down’s Syndrome)
Trisomy 18 (Edward’s Syndrome)
• unusually small head
• back of the head is prominent
• ears are malformed and low-set
• mouth and jaw are small (may also have a cleft lip or cleft palate
• hands are clenched into fists, and the index finger overlaps the other fingers
• Clubfeet (or rocker bottom feet) and toes may be webbed or fused
Trisomy 13 (Patau Syndrome)
Hyaline Membrane Disease
This is hyaline membrane disease due to
prematurity and lack of surfactant
production from type II pneumonocytes
within the immature lung. Note the thick
pink membranes lining the alveolar
spaces.
Necrotizing enterocolitis (NEC)
Necrotizing enterocolitis (NEC)
The plain abdominal film shows air in the portal vein, air in the bowel walls, and a large
pneumoperitoneum [subdiaphragmatic free air, perihepatic free air, double wall sign (blue
arrows), triangle sign (green arrows), and falciform ligament (red arrow)].
Pneumatosis
instestinalis
(air within
the intestinal
walls)
Hydrops Fetalis (non-immune)
Generalized edema from fluid collection in the soft tissues
results in hydrops fetalis. Causes: Most common are "non-
immune" types that include infections, congestive failure (from
anemia or cardiac abnormalities), and congenital anomalies.
Immune hydrops, from maternal antibody formed against fetal
red blood cells, is not common when Rh immune globulin is
employed in cases of potential Rh incompatibility.
Cystic hygroma (in fetus w/ Turner’s syndrome)
Kernicterus
Congenital Capillary Hemangioma
At birth At 2 years
After spontaneous regression
Capillary Hemangioma
RBC-filled capillaries
Lymphangioma
Dilated lymphatic channels
Teratoma
Mucus-secreting glands, cartilage, bone
Neuroblastoma
Acute Myeloid Leukemia
BM expansion
Wilms Tumor, kidney
Wilms tumor of the kidney (lobulated white-tan mass), many are associated with genetic defects on
chromosome 11.
Children present with abdominal enlargement from the mass effect.
nests and sheets of dark blue cells at the left
with compressed normal renal parenchyma
at the right
Carbon monoxide poisoning
Cherry-red discoloration of the skin
Asbestosis
Asbestos fiber
Asbestos fibers coated with iron
Tan-white pleural plaques
Lead Toxicity
Arsenic poisoning
Dental fluorosis
Tetracycline-stained teeth
Effects of Smoking
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Liver cirrhosis in chronic alcoholism (left)Esophageal varices associated with liver cirrhosis (right)
Stevens-Johnson Syndrome
SJS is defined as detachment of less
than 10% of the body surface area
Marasmus vs. Kwashiorkor
Anorexia Nervosa
Bulimia nervosa
Bitot’s spot in Vit. A deficiency
Rickets
Scurvy
Riboflavin deficiency
Chickenpox vs. Shingles
Mumps
Measles
Herpes Simplex
Cytomegalovirus
Blueberry-muffin babyOwl-eye inclusions in the lung tissue
Epstein-Barr virus
Dengue
Herman's rash – islands of white in a sea of red
Human Papilloma Virus
Cervical Cancer
Poliomyelitis
Strep throat
Diphtheria
Gram-negative intracellular diplococci
Tetanus
Opisthotonus
(severe spastic paralysis)
Syphilis (chancre)
Entamoeba histolytica(cause of amoebiasis)
Giardia lamblia(Giardiasis)
Trichomonas vaginalis(Trichomoniasis)
“Strawberry cervix" - cervical mucosa
reveals punctate hemorrhages with
accompanying vesicles or papules
Ascaris lumbricoides(Giant intestinal roundworm)
cause of Ascariasis
Enterobius vermicularis
Female worms leave the rectum during the
night and deposit eggs on the perianal
skin, producing pruritus.
Tapeworm
Schistosomiasis
Candida albicans(Candidiasis-oral thrush)
Yeast cells Pseudohyphae
Ringworm
Tinea corporis
Tinea cruris
Ameloblastoma
Pleomorphic Adenoma
Warthin’s Tumor
Mucoepidermoid Carcinoma
Adenoid Cystic Carcinoma
Aneurysm
Atherosclerotic aneurysm of
the aorta (large "bulge“ just
above the aortic bifurcation).
Prone to rupture when they
reach about 6 to 7 cm in size.
Felt on PE as a pulsatile mass
in the abdomen.
Arteriovenous malformation (AVM)
Atrial Septal Defect (ASD)
Ventricular Septal Defect (VSD)
Patent Ductus Arteriosus (PDA)
Tetralogy of Fallot (TOF)
Transposition of the Great Arteries
GOODLUCK!