Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)
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Transcript of Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)
![Page 1: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/1.jpg)
Gaucher Disease: Bone Imaging
![Page 2: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/2.jpg)
DXA (Dual-Energy X-ray Absorptiometry)
![Page 3: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/3.jpg)
DXA Spine Image and Test Results
![Page 4: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/4.jpg)
DXA Hip Image and Test Results
![Page 5: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/5.jpg)
Absorptiometry
![Page 6: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/6.jpg)
BMD ↓
BMD ↓
BMD ↓
DXA: Trabecular Bone Change
![Page 7: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/7.jpg)
BMD ↓
BMD ↓
BMD ↓
DXA: Cortical Bone Change
![Page 8: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/8.jpg)
1
2
MeasurementSlice
Computed Tomography
![Page 9: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/9.jpg)
Whole-body CT Scan With Vertebra
![Page 10: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/10.jpg)
Close-up of Vertebra
![Page 11: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/11.jpg)
Forearm CT Scan
![Page 12: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/12.jpg)
Image of Radius and Ulna
![Page 13: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/13.jpg)
TBD ↓
TBD ↓
TBD ↔
Quantitative Computed Tomography (QCT): Trabecular Bone Change
![Page 14: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/14.jpg)
CBD ↓
CBD ↔
CBD ↔
QCT: Cortical Bone Change
![Page 15: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/15.jpg)
Possible Conditions for Bone Loss
Resorption ↑ Formation ↔
Resorption ↔
Formation ↓
Resorption ↑
Formation ↓
Negative Balance
![Page 16: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/16.jpg)
Follow-up Measurements
1 2 3
Measurement
0.5
0.6
0.7
0.8
BM
D [
g/c
m2 ]
![Page 17: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)](https://reader035.fdocuments.in/reader035/viewer/2022062314/56649e7b5503460f94b7c297/html5/thumbnails/17.jpg)
Significant Differences
1 2
Measurement Point
0.60
0.65
0.70
0.75
0.80
0.85
BM
D [
g/c
m2]
2.8 sd(p>95%)
sd