GABA Receptors and Cognition: Perspectives for Drug Development S. J. Enna, Ph.D. Summer School of...

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Principles of GABA Pharmacology -Attractive Target Because of Importance in CNS Function -Generalized Activation Decreases CNS Activity Sedation Hypnosis Cognitive Impairment -Generalized Inhibition Increases CNS Activity Anxiety Seizures -Selective Manipulation of Receptor Subtypes Are Essential for Therapeutic Benefit