“G-DERM” BEAUTY PRODUCTS

ООО “G-Group”Bioskin Developers: Saint-Petersburg –Orenburg

2013

G-DERM- Aesthetics, Science, Basis!

Scientific Substantiation of “G-DERM Professional” Cosmetic Line Formula

• Cosmetic formulas of “G-DERM”, biosynthetic polymeric hyaluronic acid with new types of links used (See Table) obtained as the result of application of original technology.

• The result of HA preparations action depends on HA percentage and on its molecular length. The minimum concentration for moisturizing effect is 0.001%; for long-lasting deep moisturizing and lifting, HA in concentration of 0.5 – 1.5% is used.

K, см-1 Вид связей Функциональная группа

800 - 900 Преимущественно C-C валентные связи С-С

830 - 940 Симметричные и ассиметричные С-О-С валентные связи С-О-С

780 - 975 C-H связи C-H

K, cm-1 Types of links Functional group

800 - 900 Mostly C-C valent links С-С

830 - 940 Symmetrical and asymmetrical С-О-С valent links С-О-С

780 - 975 C-H links C-H

Scientific Substantiation of “G-DERM Professional” Cosmetic Line Formula

“G-DERM” formulas use the original peptide complex (regulating peptides), capable of real triggering of physiological processes of cellular cutaneous layers renovation with long-lasting cosmetic and aesthetic effect.

Peptides Chemical formula Weight

Arg-Gly-Asp C19H26N4O4 374.19541

IleAspIle C16H29N3O6 359.20564

PheArgPro C20H30N6O4 418.23285

GlnHisHis C17H24N8O5 420.18697

AlaTrpLys C20H29N5O4 403.22195

ProHisTyr C20H25N5O5 415.18557

ThrTrpTrp C26H29N5O5 491.21687

LysPheThr C19H30N4O5 394.22162

LysArgMet C17H35N7O4S 433.24712

PheCysMet C17H25N3O4S2 399.12865

IleIle C12H24N2O3 244.17869

AspLysLys C16H31N5O6 389.22743

TrpPro C16H19N3O3 301.14264

GluThr C9H16N2O6 248.10084

Desmosine C24H40N5O8 526.28769

Scientific Substantiation of “G-DERM Professional” Cosmetic Line Formula

Cosmetic skin got its name due to fantastic similarity of tissular composition of “cosmetic skin” and outer layers of human skin (Fig. 1A and 2).

Fig. 1A. Example (cosmetic skin slice) Fig. 2. Sample (natural skin slice)

Serums of “G-DERM Professional” Cosmetic Line

Interaction of “G-DERM” peptides with tissues is based on their capability to penetrate through cell membrane and activate optimal metabolism with the effect of tissue renovation. Serums “G-DERM professional” contain regulating peptides (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis).

• *Recommended hyaluronic acid concentrations in cosmetics in compliance with FDA (2010) requirements are 0.1 - 1%.• *Professional cosmetics: a) 0.5-1% (crème, gels, beauty milk, lotions, masques,

capsules and preparations for injections); b) 2.0-3.5% for creation of significant volume effects as bioimplants.

“G-DERM professional” Cosmetic Skin• Description: Elastic parchment-like skin-form masque of golden to light-brown color. Masque activator.

• Composition: hyaluronic acid, peptide complex (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis), hydrolyzate of collagen – elastin complex.

Indications: • Dewatered and very dry skin.• Gravity ptosis.• Small and deep wrinkles.• Pigmentation and hyperpigmentation.• Puffiness.• Skin after excessive solar exposure.• Dewatered and very dry skin.• Reduced skin water balance.• Rehabilitation after rapid weight saving .• Cuperosis.• Acne in the stage of regeneration (post-acne).

“G-DERM” Cosmetic Skin

• Action: • Combats photo aging and biological aging.• Moisturizes.• Whitens.• Levels skin relief.• Has powerful lifting effect for face contours.• Works at all levels of epidermis and derma.• Adds to regeneration and modeling of skin matrix, as well as to restoration of

microvasculature and triggering of metabolic processes in the derma.

Recommendations for use:• Clean facial skin.• Dilute the activator in 100 ml of warm water and plunge the

masque for 2-3 minutes.• Apply the masque with its pebbled face to the skin and expand

to avoid crinkles and air pockets.• Leave the masque for 35-50 minutes. • Give additional moisture to the masque as far as it gets

polymerized.• Moisturize and remove the tissue. • On termination of the procedure, do not wash the face. • Complete the procedure by application of finishing crème «G-

DERM».

Methodic of “Matrix therapeutic remodeling”

“G-DERM” Cosmetic Skin

Indications for use:

• Plastics of investing tissues defects.

• Cutaneous cellular layers rehabilitation after beauty procedures (peeling, dermal abrasion, etc.)

• For cellular technologies as the matrix for cultivation of “invitro” eukaryotic cells.

Method of use during after-peeling rehabilitation:

Step 1. Asepsis and antisepsis of traumatic surface

• Step 2. Laying of the material on the treated surfaces

• Step 3. Formation of biological crust: 15-20 minutes.

• Step 4. Observation over after-peeling area until complete cuticularization.

Method of after-peeling bioplastical regenerationwith “G-DERM professional” cosmetic skin preparations

Two-Component Peeling

Description:

Light gel consistency, transparent, odorless, with inclusions in the form of air bubbles.

Composition

Polymer crystal (100-200 МКМ), 1,8% hyaluronic acid, silver colloid solution, phosphate mixture, distilled water.

Indications: Wrinkles and crow’s feet.

Dry cutaneous covering .• Reduction of cutaneous tissue tension.• Age-related changes.• Reduced lifting.• Cuperosis.• Pigmentation and hyperpigmentation.• Gravity ptosis.

1,8% Hyaluronic acid buffer system, Polymer crystals.

Two-Component PeelingAction:

• Loosening of epidermis.

• Mechanical driving in of hyaluronic acid into deeper skin layers (moisturizing)

• Leveling of cutaneous covers color.

• Removal of light aging and pigmentation effects.

• Heating of cutaneous covers before "G-DERM“ Cosmetic Skin” application.

Abrasive peeling procedure:• Peeling is prepared before the procedure.• Abrasive peeling preparation technology: add 1 ml of abrasive (sachet 2) to one part of

peeling gel 5 ml (sachet 1), stir for 2.5 min.• Apply prepared peeling on clean face, neck and décolleté area skin, rub in peeling for 3-4

minutes along massage lines• Remove remainders of abrasive peeling using wet cleansing tissue.

Bi-Ampoules

• Description:

• Colorless transparent gel. 1,5% destructurized hyaluronic acid "G-DERM" (DS), ampoules (10х2 ml.); Serum of peptide complex "G-DERM" (PS), ampoules (10х2 ml).

Composition:

• DS Hyaluronic acid, colloid silver solution, distilled water. PS peptide complex (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis), hyaluronic acid, distilled water.

Indications:• Dry cutaneous covering.• Reduced cutaneous tissue tension.• Age-related skin changes.• Reduced lifting.• Cuperosis.• Pigmentation and hyperpigmentation.• Gravity ptosis.

Sterile, suitable for mesorollers

Bi-Ampoules

Action:

• Triggers skin rejuvenation processes at cellular level.

• procedure becomes painless and does not require rehabilitation period

• Free penetration of hyaluronic acid into core skin layers

• Creation of strong intercellular matrix due to epidermal cells renovation

• Retention of hyaluronic acid in intercellular matrix for a maximum possible period

• Correction of problem zones of face, neck and décolleté area skin

Methodic of “Matrix therapeutic remodeling”

Method of use: • Prepare the electroporation device (low-frequency laser)

observing recommended operating mode • Open the ampoule of “1.5% destructurized DS acid” and

apply evenly on face zones• Move the nozzle along the zones• Duration of procedure: 10 minutes• Open ampoule of “Serum of РS peptide complex” and

apply evenly on face zones• Move the nozzle along the zones• Duration of procedure: 10 minutes• Apply finishing “G-DERM professional” cream

See detailed procedure on http://g-derm.ru

Patches around Eyes Description:

Elastic plates of oval elongated form of golden to light-brown color (2 pcs.), 10 pcs. in the packing.

Composition:

Hyaluronic acid, peptide complex (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis), hydrolyzate of collagen-elastin complex.

Indications: Dark circles of any genesis.• Swollen lower lid.• Puffiness.• Dewatered skin.• Skin damaged by solar exposure• Photo and biological skin aging.• Faint skin.• Pigmentation and hyperpigmentation.Action:• Combats photo aging and biological aging.• Moisturizes.• Whitens.• Levels skin relief.• Has powerful lifting effect.• Works at all levels of epidermis and derma.

Finishing Face Cream Description:

•Yellow emulsion with slight pleasant odor of “Milk fantasy” perfume composition.

Composition:

•Peptide complex, hyaluronic acid, emulsion wax, lime flowers oily extract, shea butter, chamomile flowers oily extract, cosmetic stearine, allantoin, lanoline, D-panthenol, perfume composition, distilled water.

Indications:

•Protection against environmental impacts

•Protection against UV-rays and restoration of hydro-lipid mantle

after beauty procedures.

Action:

•Moisturizes.

•Nourishes face skin.

•Protects against adverse environmental impact

Bi-ComplexDescription:

Colorless gels, may have inclusions in the form of air bubbles. Polymeric 20 ml tubes. Two tubes in the packing

Composition:

Hyaluronic acid, collagen-elastin complex, colloid silver solution, distilled water; peptide complex (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis), hyaluronic acid, colloid silver solution, distilled water.

Indications:• Combating age-related changes.• Skin withering.• Skin rehabilitation after UV-solar exposure• After-peeling rehabilitationAction:• Moisturizes face skin.• Eliminates exfoliation .• Adds to rehabilitation of epidermal cells • Triggers and stimulates perturbed cells rejuvenation processes• Has powerful rejuvenating action.• Restores balance and natural collagen synthesis.• Inhibits skin aging. • Has intense lifting effect . • Increases cells activity. • Improves state of epidermal microvasculature.• Makes skin blooming healthily .

Facial Cream MousseDescription:

White emulsion with slight pleasant odor of :”Milk cream” perfume composition

Composition:

Hyaluronic acid, collagen – elastin complex, lime flowers oily extract, phytowax, cosmetic stearin, allantoin, lanolin, perfume composition, distille

Indications:• Dry and very sensible skin.• Wrinkles and crow’s feet.• Age-related changes.• Skin after stress and faint skin

Action:• Moisturizes.• Nourishes.• Removes fatigue. • Protects against negative environmental impact. • Reinforces barrier and protective skin functions• Allows reduction of allergic reactions

Serum for Skin around EyesDescription:

Light gel consistence, transparent and odorless, with inclusions in the form of air bubbles. “Ampoule” vacuum dispenser with steel roller.

Composition:

Hyaluronic acid, colloid silver solution, distilled water.

Indications:• Dewatered skin.• Dark circles of any genesis.• Swollen lower lid.• Puffiness.• Skin damaged by solar exposure.• Hyperpigmentation.• Faint skin.• Photo and biological skin aging.Action: Lymph drainage effect.• Has strong lifting effect• Moisturizes skin and condenses skin matrix• Increases epidermal capillary activity• Ensures high grade of nutrients penetration into deep epidermal

layers.• Renders skin elastic.• Levels complexion.

Crème Gel for Skin around EyesDescription:

White emulsion with slight pleasant odor of “Kensoki” lotus perfume composition.

Composition:

Peptide complex (Desmosine, TrpPro, PheCysMet, ProHisTyr, GlnHisHis), hyaluronic acid, collagen-elastin complex, thyme oily extract, perfume composition, emulsion wax, lanolin, distilled water.

Indications:• Dry and sensible skin.• Age-related skin changes.• Hyperpigmentation.• Wrinkles and crow’s feet.• “Tobacco” wrinkles around lips .

Action:• Moisturizes and nourishes skin around eyes.• Has strong lifting effect.• Increases cellular activity, which allows bringing their

state to the earlier age group.• Eliminates swell in paraorbital area.• Opens look due to consolidation of upper and lower lid

skin matrix.

“Skin Radiance” Day Face Crème GelDescription:

White emulsion with slight pleasant odor of “Milk Fantasy” perfume composition

Composition:

Peptide complex, hyaluronic acid, emulsion wax, laminaria hydroalcoholic extract, allantoin, “Milk fantasy” perfume composition, concentrated colloid silver solution, waterless lanolin, distilled water.

Indications:Is intended for deep and long-lasting skin moisturizing and efficient protection against aggressive environmental factors.Action:• Increases cellular energy potential• Moisturizes.• Protection against adverse factors.• Is the ideal basis for makeup.• Ensures high hydration level• Smoothes small lines• Increases skin elasticity and tension.• Softly and carefully peels off old tissues.• Stimulates growth of new cells.• Levels complexion.

Thank you for your attention!