fVIIa
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Transcript of fVIIa
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fVIIa: 1% of total FVII
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fVIIa
Anionic membrane
II IIa
Plt
V
VIII
XI
X
IX
XaIXa
Initiation
TFCafVIIa
prothrombinase
Ext tenase
VIIXa Va
Ca
Xa
VIIa
TFPI
Va
aPlt
Va
VIIIa
XIa
ATIII
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Active Platelet
TM
IX
X II
Int tenase
prothrombinasepropagation
Main path of XI
Plt
V
VIII
XI
CaVIIIa
IXaXa
CaVa
XIII VII
aPlt
Va
VIIIa
XIIIa VIIaIIa
IIa
APCIXa
VIIIa
XIa
Va
XIa
IXa
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Symptom(+) Lab (+) and Sym(-)
Screen Lab:APTT, PT and PLt
Confirmatory test
mixted aPTT; mixed PT 0 and 2 hour
If corrected (N+P < buffer+normal)
Factor deficiency
Or weak antibody
If not antibody
1. Anti phospholipid Ab ( no clincal importance) on 0 hr
2. Factor antibody ex: VIII ab ( delay titier: 2 hr more long)
(-)
(+)
See YouClinical significant???Factor
F XII deficiencyPrekallikrein deficiencyHigh-molecular-weight kinogen deficiencyMild to moderate factor VII deficiency
lpus anticoagulantsExcess citrate anticoagulant (e with HCT>60%)
vWDPlt function
In release; Scott syndromeFactor
FXIIIHeterozygous carriere of inherited coagulation diorder:
FIX deficiency Mild inherited coagulation disorder:
FXI deficiencyDysfibrinogenemiaFibrinolysis
Plasmin inhibitor deficiencyElegated of plasminogen activator
Hereditary hemorrhagic telangiectasisAllergic and other vascular purpura
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