1. SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views

2. 3 3. 4 4. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations 5. ReadHumanGenomeinanHourfor$1000 Fluidics Biochemistry Semiconductors Gene3cs Mathema3cs Immunology 6. How will future life sciences research be funded ? 7. Strategieso+enovertakenbyEvents NeedforAgileLeadership Discoveries Product Recalls Government Policychanges Economic Crises 8. 9. 10. 11. 18 12. WGP1980-2013(%,constantprices) Diversitytoseize globalmarkets 13. EUGDP1980-2013 (%,constantprices) 14. VietnamGDP1985-2011 15. >40% WDP by 2015 IMF - adjusted for Purchasing Power Parity 16. 24 17. 25 18. 26 19. 375 bn $2.3 trillion US + $85bn per month 20. EMOTION 21. Europe Dying 4 couples to produce single great-grand child Stop Ageing 22. 75%ofallUSandUKwealthownedbythoseover65 65%healthspendisonover65s 23. ChronicCondiTonsMulTpleNeeds 100millionAmericanshavechroniccondi3ons 80%ofhealthspending 88%ofallprescrip3ons 70%ofphysicianvisits 66%Medicarecost=peoplewith5+condi3ons Almostallcausedbyonesinglefactor 24. AGE Neuro-degeneration Cancer / Heart / Stroke / Obesity Infections / Chronic wounds Joint replacement / Mobility Care of elderly at home 25. Rationing all government Health competes with ....RESEARCH Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition 26. Irrational Rationing 27. Pharma Crisis Patent expiry, pipeline length, lack innovation 28. Performance Shift in retail health care from health treatment to life enhancement 29. $15bn spend on cosmetic surgery in US (2012) 14.6 million procedures - up 5% in 12 months 6.1 million Botox treatments - up by 8% Want to look better $100 for 1.7-ounces 30. may be Want to think better............ 20%studentsinUSusememory-enhancingdrugs 31. Know more than your doctor 32. 90% in US want to view test results before their doctor Mayo Clinic 33. 2 million visits every month 34. 1trillion pagesamonth 35. Future life sciences research will be funded increasingly by emerging markets and wealthy individuals 36. 2.8bn in 2012 - 450 platforms - x2 / year 37. http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg 38. Future of Med TechHow smart innovation will transform human health Dr Patrick Dixon Chairman Global Change Ltd 39. Expect clinical medtech to feed lab medtech 40. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations 41. coatings and robots 42. Text 43. Digital Control 44. Human nerve cells growing on an integrated circuit 45. Imaging and Robotics 46. Fasterhealing 47. Positron emission tomography Magnetic nuclear resonance 48. Cloud Processing 49. $75bn endoscopy market by 2022 ($23bn 2010) 125,000 stents or carotid surgery a year in US 50. non slip tracheal implant 51. Dune device detecting cancer during operation 52. Organ support 53. Print Elastomere 54. HarvardBioscience Bioreactor Bonemarrowstemcells Polymerscaold 55. Print New Skin (Lexmar) 56. 1.75minUSwithMaculardegeneraTon 57. Device or Virus ? 58. Using high power lasers to transfer fluorophores into long-lived "off states" a non-fluorescent molecule state. Can take 2-10 minutes to develop the image fully. 59. Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in approximately 10 years. Big Data 60. Computer-aideddecisionssavelives 61. Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads 62. Tele-Monitoring Ecosystem 63. Diabetes, congestive heart failure, obstructive pulmonary 2.2 million at home > $22bn by 2015 Mobile telephony Smart Tablet 64. Future of BiotechHow biotech will change life on earth and slow ageing Dr Patrick Dixon Chairman Global Change Ltd 65. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations 66. ReadHumanGenomeinanHourfor$1000 Fluidics Biochemistry Semiconductors Gene3cs Mathema3cs Immunology 67. Genes for old age, speech, memory, criminality, depression, obesity and stable relationships 68. Genetic Prophecy 69. Danaher (Beckman Coulter) 70. Brand Trusted Natural Medicine Epigenetics impact on gene expression from environment 71. Obesity epidemic 1 in 3 babies in New York will develop adult-type diabetes - many as children Obesity costs US $100bn a year 72. Resveratol Broccoli(sulforaphane) Flavonoids Beta-carotene Anthocyanins Alpha-linoleicacid Glucosamine Chondroi3n Ginseng Garlicoil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group) Interesting Neutraceuticals 73. Can we stop ageing ? 74. Worn out Mitochondria Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine 75. Alzheimers: Souvenaid Souvenaid clinical trial Multi-nutrient drink MIT collaboration 76. Monkeysondietlivelonger After 20 years 80% alive v 50% on normal calories Less cancer, diabetes, Less heart disease, strokes Less brain decay 124 77. Metformin story 125 78. Low blood pressure and total body lift - Alteon 79. Stem Cells 80. Pigsteethgrowninsiderats Micegrownewteethfromnervecells/gumGrow New Teeth 81. Repair Heart / Brain 82. Woman with a male brain - lessons for brain repair 83. Adenovirus Infectedmousehaircells Permanentcolourchange PermanentHairColour 84. AdenoviruscontainsMath1gene Turnsyoungearcellsintohaircells Injectviruspar3clesintoinnerear NewhaircellsgrownearOrganofCor3 ResearchinGuineaPigs Cure for Deafness Or transform cells as part of organ repair 85. Adenoviral human telomerase reverse transcriptase 86. Confidential HSV1causescoldsores.WhenengineeredasSeprehvir (HSV-1716),itisharmlesstohealthy@ssue. Oncoly3cviruses Infectandkillcancertumourcells Nodamagetohealthy3ssue Evidenceofimpactinclinicaltrials Abletodelivernewgenesintocancercells Micro-dosechemo,micro-doseradiotherapy Viruses to cure cancer 87. Slow or no ageing is a reality Rockfish, Turtles, some Whales No signs of getting old Rougheyerocksh(SebastesaleuFanus)205years AldabraGiantTortoise255years Lobstersarebelievedtolive100ormoreyears OceanQuahogclam405years Some animals do not seem to age in normal way 88. 136 89. 1 in 12 in Liberia UNICEF 1in10womendieinchildbirthinsome partsofNorthernMozambique 90. 138 1.8millionsmallchildrendieeveryyearbecauseofdirtywatersupplies 91. SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views