1. Dr Patrick Dixon Chairman Global Change Ltd SustainAgility How smart innovation, biotech and agile leadership will transform human health

2. 5 C-Brace 3. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations 4. Strategieso+enovertakenbyEvents NeedforAgileLeadership Discoveries Product Recalls Government Policychanges Economic Crises 5. ClicktoeditMastertextstyles 19 6. AGILITY means more than one strategy 7. How will future life sciences research be funded ? 8. WGP1980-2013(%,constantprices) Diversitytoseize globalmarkets 9. EUGDP1980-2013 (%,constantprices) 10. VietnamGDP1985-2011 11. >40% WDP by 2015 IMF - adjusted for Purchasing Power Parity 12. 27 13. 28 14. 29 15. 32 16. ClicktoeditMastertextstyles 17. ClicktoeditMastertextstyles 18. 375 bn $2.3 trillion US + $85bn per month 19. Text 20. Digital Control 21. Human nerve cells growing on an integrated circuit 22. The future is about EMOTION 23. 300 million move to cities in China and 475 million to cities in Africa by 2025 24. 1 billion over 60 year olds in 10 years 25. most are women 26. Europe Dying 4 couples to produce single great-grand child Stop Ageing 27. 75%ofallUSandUKwealthownedby thoseover65-butmanyneedtowork 28. OlderMoney 65% health budget on those over 65 29. 66% of over 50s in Asia by 2050 81 million now over 60 in India 30. Chronic Conditions Multiple Needs 100 million Americans have chronic conditions 80% of health spending 88% of all prescriptions 70% of physician visits 66% Medicare cost = people with 5+ conditions Almost all caused by one single factor 31. 65% health spend on those over 65 AGE 32. Health Challenges Neurodegeneration eg Avonex Cancer / Obesity /Chronic wounds Infections eg Ceftolozane/tazobactam Joint replacement long term Care elderly at home 33. Patent Expiry 3000 Canadian Pharma Patents 2003-11 34. $75bn endoscopy market by 2022 ($23bn 2010) 35. 125,000 stents or carotid surgery a year in US 36. Cloud Processing 37. Positron emission tomography Magnetic nuclear resonance 38. Imaging and Robotics 39. Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in Big Data 40. Product scanning means safety Computer-aided decisions save lives and time 41. Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads 42. Home Care 43. Tele-Monitoring Ecosystem 44. Diabetes, congestive heart failure, obstructive pulmonary 2.2 million at home > $22bn by 2015 Mobile telephony 45. swallow smart pill relays info about gut sensor-enabled tablets check if medication taken Smart Tablet Startups 46. EU 8bn in UK alone Independent Living 47. Mobility Comfort Support Safety 48. Faster healing 49. 82 Med Tech most med tech rapidly obsolete 50. Know more than your doctor 51. 90% in US want to view test results before their doctor Mayo Clinic 52. 2 million visits every month 53. 1trillion pagesa month 54. Read Human Genome in an Hour Fluidics Biochemistry Semiconductors Genetics Mathematics Immunology Robotics 55. Home Tele-Monitoring 56. Virtual Medicine 57. Irrational Rationing 58. Rationing all government Health competes with .... Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition 59. Irrational Rationing 60. Transurethral resection Laser destruction Microwave destruction Heat destruction Da Vinci robot Competition 61. Patient campaigns / Google Legal / IT linked decisions Financial incentives Patient experience /quality life Local skills / experience Appropriate infrastructure Impact on rationing 62. Performance Shift in retail health care from health treatment to life enhancement 63. $15bn spend on cosmetic surgery in US (2012) 14.6 million procedures - up 5% in 12 months 6.1 million Botox treatments - up by 8% Want to look better 64. may be Want to think better 20% students in US use memory-enhancing drugs 65. Can we stop ageing ? 66. Brand Trusted Natural 67. Obesity Epidemic 1 in 3 newborn babies in NewYork will develop diabetes Obesity costs US $100bn a year 68. Interesting Neutraceuticals Resveratol Broccoli (sulforaphane) Flavonoids Beta-carotene Anthocyanins Alpha-linoleic acid Glucosamine Chondroitin Ginseng Garlic oil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group) 69. Click to edit Master text styles 116 $100 for 1.7-ounces 70. Alzheimers: Souvenaid Souvenaid clinical trial Multi-nutrient drink MIT collaboration 71. Worn out Mitochondria Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine 72. Adenovirus Infected mouse hair cells Permanent colour change Permanent Hair Colour 73. Treatment which restores and maintains the youthful elasticity of hardened arteries and helps wrinkled skin. Global sales? Low blood pressure and total body lift Alteon 74. Pigs teeth grown inside rats Mice grow new teeth from nerve cells / gum tissue Grow New Teeth 75. Repair of heart or brain damage following coronary / stroke using adult stem cells Repair Heart / Brain 76. Stem cells Compete or Co-operate 77. Near-perfect repair of heart or brain damage following coronary / stroke 78. Your Brain Can Repair 79. Monkeys on diet live longer After 20 years - 80% alive v 50% on normal calories Less cancer, diabetes, heart disease, strokes, brain decay 126 80. Slow or no ageing is a reality Rockfish, Turtles, some Whales No signs of getting old Rougheye rockfish (Sebastes aleutianus) 205 years Aldabra Giant Tortoise 255 years Lobsters are believed to live 100 or more years Ocean Quahog clam 405 years Some animals do not seem to age in normal way 81. Summary - Pharma and Ageing Many new opportunities See through older eyes Connect with emotion Timing is everything Events + decisions Performance - wellness Diagnostics Home monitoring Neutraceuticals Save treatment costs Improve mobility Prolong independence Ageing remedies with real evidence will be tomorrows blockbusters 82. Genetic Prophecy 83. Genes for old age, speech, memory, criminality, depression, obesity and stable relationships 84. Danaher (Beckman Coulter) 85. Fluidics Biochemistry Semiconductors Genetics Mathematics Immunology Robotics Read genome in 2 hours for $5,000 86. Using sound and microuidics to separate cells 87. Stem Cells 88. Brain Can Repair Itself Daily 89. Positron emission tomography Magnetic nuclear resonance 90. Cloud processing huge investment 91. Imaging and Robotics 92. $75bn endoscopy market by 2022 ($23bn 2010) 93. Dune device detecting cancer during operation 94. 125,000 stents or carotid surgery a year in US 95. non slip tracheal implant 96. 3d print 97. Organ support 98. Print Elastomere 99. Harvard Bioscience Bioreactor Bone marrow stem cells Polymer scaffold 100. Print New Skin (Lexmar) 101. Negative Pressure Healing 102. 14 times oxygen levels in wound tissue Hyperbaric Oxygen 103. Adenoviral human telomerase reverse transcriptase 104. coatings and robots 105. Build Nanotech Robots 106. Adenoviral human telomerase reverse transcriptase Heal Old Wounds 107. Mobility Comfort Support Safety 108. ` 109. eSight 110. Device or Virus 111. 2.8bn in 2012 - 450 platforms - x2 / year 112. Emerging markets Emerging Markets 113. 1 in 10 women die giving birth in parts of Northern Mozambique 1 in 12 in Liberia UNICEF 114. 179 115. 180 116. Adenovirus contains Math1 gene Turns young ear cells into hair cells Inject virus particles into inner ear New hair cells grow near Organ of Corti Research in Guinea Pigs Cure for Deafness ? 117. Confidential HSV1causescoldsores. Whenengineeredas Seprehvir(HSV-1716),itis harmlesstohealthy@ssue. Oncolytic viruses Infect and kill cancer tumour cells No damage to healthy tissue Evidence of impact in clinical trials Able to deliver new genes into cancer cells Micro-dose chemo, micro-dose radiotherapy Viruses to cure cancer ? 118. Reolysin - 28% improvement in response to chemo in head and neck cancer Early Phase III 185 Viruses to cure cancer ? 119. Emerging markets 120. 1 in 12 in Liberia UNICEF 1 in 10 women die in childbirth in some parts of Northern Mozambique 121. 188 1.8 million small children die every year because of dirty water supplies 122. 189 123. globalchange.com - slides and videos SustainAgility How smart innovation and agile leadership will transform human health