FUROSLIMFUROSLIM IRVINGIA GABOGENESISIRVINGIA GABOGENESIS

AN ANSWER TO GROWING MENACE OF AN ANSWER TO GROWING MENACE OF

OBESITYOBESITY

OBESITYOBESITY

FUROSLIM Irvingia GabonensisTM

• AN EXTRACT OF IRVINGIA AN EXTRACT OF IRVINGIA GABOGENESIS: AFRICAN MANGOGABOGENESIS: AFRICAN MANGO• SAFELY AND SIGNIFICANTLY REDUCES SAFELY AND SIGNIFICANTLY REDUCES

BODY WEIGHT ON OVERWEIGHT AND BODY WEIGHT ON OVERWEIGHT AND OBESE SUBJECTS AND HAS FAVOURABLE OBESE SUBJECTS AND HAS FAVOURABLE IMPACT ON VARIETY OF OTHER IMPACT ON VARIETY OF OTHER METABOLIC PARAMETERS.METABOLIC PARAMETERS.

HOW FUROSLIM WORKSHOW FUROSLIM WORKS

• REVERSES LEPTIN RESISTANCE BY REVERSES LEPTIN RESISTANCE BY REDUCING PLASMA CRP LEVELSREDUCING PLASMA CRP LEVELS

• INCREASES ADIPONECTIN LEVELSINCREASES ADIPONECTIN LEVELS• INHIBITS ADIPOGENSIS INHIBITS ADIPOGENSIS • INHIBITS AMYLASEINHIBITS AMYLASE• INHIBITS INHIBITS GLYCEROL-3-PHOSPHATE GLYCEROL-3-PHOSPHATE

DEHYDROGENASEDEHYDROGENASE

FUROSLIM REVERSES LEPTINFUROSLIM REVERSES LEPTIN RESISTANCERESISTANCE

INHIBIT NYP/AgPP NEURON

REDUCED NYP/AgPP SECRETION

ACTIVATES POMC NEURON

INCREASES α MSH EXPRESSION & SECRETION

INCREASED α MSH BINDING & ACTIVATION OF

MELANOCORTIN RECEPTORS

REDUCED FOOD INTAKE

REDUCES BLOOD C-REACTIVE PROTEIN LEVELS

MORE LEPTIN IS FREELY AVAILABLE THAT CROSSES BLOOD BRAIN BARRIER

FUROSLIM INCREASES ADIPONECTIN LEVELSFUROSLIM INCREASES ADIPONECTIN LEVELS

ADIPONECTINS HAVE FOLLOWING BIOACTIVITIES

•ANTIATHEROGENIC•ANTI INFLAMMATORY•ANTI DIABETIC

INCREASES PLASMA ADIPONECTIN LEVELS

INCREASES FATTY ACID CATABOLISM (BREAKDOWN OF FATTY ACIDS)

INHIBITS ADIPOGENESIS

FUROSLIM INHIBITS EXPRESSION OF PPARFUROSLIM INHIBITS EXPRESSION OF PPARγγ EXPRESSION EXPRESSION

FUROSLIM INHIBITS AMYLASE ACTIVITYFUROSLIM INHIBITS AMYLASE ACTIVITY

REDUCES THE AMOUNT OF CARBOHYDRATES THAT WILL BE CONVERTED AND ABSORBED AS SUGAR.

FUROSLIM INHIBITS ACTIVITY OF GLYCEROL-3-PHOSPHATE FUROSLIM INHIBITS ACTIVITY OF GLYCEROL-3-PHOSPHATE DEHYDROGENASEDEHYDROGENASE

REDUCES CONVERSION OF GLYCEROL INTO TRIGLYCERIDE

FUROSLIM Irvingia GabonensisTM

• IMPROVES METABOLISMIMPROVES METABOLISM• REGULATES APETITE-REVERSES REGULATES APETITE-REVERSES

LEPTIN RESISTANCELEPTIN RESISTANCE• BLUNTS FAT STORAGEBLUNTS FAT STORAGE• DECREASES CARBOHYDRATE DECREASES CARBOHYDRATE

CONVERSION TO GLUCOSE CONVERSION TO GLUCOSE

Study Report -1 Irvingia Gabonensis a novel seed extract of the West

African plant Irvingia Gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation

Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JE.

Source-Laboratory of Nutrition and Nutritional Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon. jlngondi@yahoo.com

• CONCLUSION: Irvingia gabonensis administered 150 mg twice daily before

meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions.

Study Report- 2 The effect of Irvingia gabonensis seeds on

body weight and blood lipids of obese subjects in Cameroon

Judith L Ngondi,1 Julius E Oben, 1 and Samuel R Minka1

Lipids Health Dis. 2005; 4: 12. PMCID: PMC1168905

Published online 2005 May 25. doi: 10.1186/1476-511X-4-12

• Effect on body composition Irvingia gabonensis induced a decrease in weight

of 2.91 ± 1.48% (p < 0.0001) after two weeks and 5.6 ± 2.7% (p < 0,0001) after one month. Although the percentage of body fat was not significantly reduced with both placebo and IG, the waist circumference (5.07 ± 3.18%; p < 0.0001) and hip circumference (3.42 ± 2.12%; p < 0,0001) were significantly reduced by IG. A reduction of 1.32 ± 0.41% (p < 0.02) and 2.23 ± 1.05% (p < 0.05) was observed with the placebo after two and four weeks respectively of treatment.

• Effect on blood lipids components The plasma total cholesterol

cencentration was reduced by 39.21%, triglyerides by 44.9% (p < 0,05) and LDL by 45.58%. This was accompanied by a significant increase in HDL-cholesterol of 46.852%. The CT/HDL ratio (p < 0.05) and the blood glucose level were also reduced (32.36%; p < 0.05). No significant change was observed in the placebo group

Study report- 3 African mango:- a proprietary seed

extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight human.

Ross SM.Holist Nurs Pract. 2011 Jul-Aug;25(4):215-7. No abstract available.

PMID:21697664 [PubMed - indexed for MEDLINE]

• CONCLUSIONS This preliminary study suggests that ,a proprietary

seed extract of Irvingia gabonensis (150 mg), when taken twice per day for a 10-week period has the ability to significantly decrease body fat,body weight, and waist circumference in overweight individuals. Furthermore, Irvingia gabonensis has demonstrated favorable affects on several metabolic parameters associated with insulin resistance, a characteristic of metabolic syndrome. The authors of this study suggest that “Irvingia gabonensis may be a helpful adjunct in the management of overweight and/or obesity.”

10 WEEKS Randomize double-blind placebo controlled study on Irvingia Gabonensis extract has resulted• Weight loss : 13%• Fat loss : 18.4%• Waist Reduction : 16.2%• Cholestrol : 26%• LDL : 27%• Glucose : 22%

• Leptin : 49%• CRP :52%

Each cap contains 150 mg of Irvingia Gabonensis

Extract

WISH YOU A WISH YOU A

GOOD GOOD HEALTHHEALTH

&&

GOOD GOOD LIFELIFE