Tradeline 2013 International Conference on College & University Science Facilities - October, Boston

Russell Chernoff Principal, Chernoff Thompson Architects

Naomi Gross Principal, Chernoff Thompson Architects

Tim Reynolds Treanor Science & Technology

Kelley Cramm Associate, Henderson Engineers Inc.

FUNDAMENTALS OF PLANNING & DESIGNOF MODERN LABS AND LAB MEP

MODULE 1 - DEFINING A LAB

MODULE 2 - GETTING STARTED/LAB PROGRAMMING

MODULE 3 - BUILDING ORGANIZATION & LAB DESIGN I

MODULE 4 - BUILDING ORGANIZATION & LAB DESIGN II

MODULE 5 - HVAC FUNDAMENTALS OF MODERN LAB DESIGN

MODULE 6 - PLUMBING AND ELECTRICAL BASICS

1 UP-FRONT PLANNING & PROJECT MANAGEMENT

MODULE 1DEFINING A LAB

1 DEFINING A LAB

P1

Types of Labs, Terminology and Factors Influencing DesignTypes of Laboratories

•Chemistry

•Bio Sciences

•Pharmacy

•Diagnostic

•Clean Room - Drug Manufacturing

•Clean Room - Materials Research

•Bioinformatics

•Biocontainment

•Animal Resource Centre

•Pilot Plant

•Physics

•Astronomy

•Aquatic

•Engineering

1 DEFINING A LAB

P2

Types of Labs, Terminology and Factors Influencing Design

Chemistry

•Exhaust large quantities of air

•Robust finishes

•Sinks

•Fume hoods

•Hazardous materials handling storage and removal

Cardiome Fume Hood

UVic Bob Wright Science Centre

1 DEFINING A LAB

P3

Chemistry Continued

•Benches

•Acid use / neutralization

•Air pressure negative to corridor

•glove box

Glove Box

Acid Tank

1 DEFINING A LAB

P4

Bio Sciences

•Sinks

•Tissue culture

•Incubators

•Fume Hoods

•Biosafety cabinets - range of types

•Benches

•Thimble

Angiotech Lab Bench

Thimble

1 DEFINING A LAB

P5

Bio Sciences Cont’d

•Differential pressures

•Autoclave (sterilizer)

•Freezers(-20˚,-80˚)

•CentrifugeAngiotech Freezer

Angiotech Centrifuge

1 DEFINING A LAB

P6

Pharmacy

•USP 797

- For sterile compounding (compounded sterile preparations CSP’s)

- Air quality control - Pressure control - Temperature

1 DEFINING A LAB

P7

Diagnostic

•Blood

•Urine

•Imaging - helium - equipment can be noisy

•Trend for one stop “shopping” in hospital environments

Diagnostic Equipment

Vancouver Hospital MRI Unit

1 DEFINING A LAB

P8

Clean Room - Drug Manufacturing (keep contamination out)

•Classification (Class 100, 1000, 10,000, etc. Iso 5, 6, 7 etc.)

•Decontamination

•Finishes impervious

•Lyopholizer

•WFI (water for injection)

•Barrier isolator

•Hepa filter

Lyopholizer

ISO 6; Local ISO 5 Barrier Isolator ISO 5

1 DEFINING A LAB

P9

Clean Room Cont’d

•Aseptic conditions

•Autoclave

•Cost

•Approach to construction - stick built - turnkey/DB

•Gowning

•cGMP

•Validation

Northern Lipids Compounding Room

Gowning

1 DEFINING A LAB

P10

Clean Room - Materials Research(keep contamination out)

•Classification (particle count)•Air pressure•Impervious Finishes•Hazardous gases•Nanotechnology•Microchips•Metal free•Vibration•Cost•Approach to Construction

- stick built - turnkey/DB

•Gowning

SFU TASC II 4D

UVic Bob Wright Science Centre Clean Room

1 DEFINING A LAB

P11

US FED STD 209F Clean Room Standards

Classmaximum particles/ft3

ISO equivalent≥0.1 µm ≥0.2 µm ≥0.3 µm ≥0.5 µm ≥5 µm

1 35 7 3 1 ISO 3

10 350 75 30 10 ISO 4

100 750 300 100 ISO 5

1,000 1,000 7 ISO 6

10,000 10,000 70 ISO 7

100,000 100,000 700 ISO8

1 DEFINING A LAB

P12

Bioinformatics

•Computer intensive

•Fume hood

•Benches

•Freezers

•Heat loads to spaces

•If truly dry lab possible air recirculation

Kinexus

1 DEFINING A LAB

P13

Biocontainment (keep contamination in)

•Risk Assessment

•Level 1, Level 2, Level 3, Level 4

•Biological safety cabinets - Class I - Vent to atmosphere - Class II - Type A1, A2, B1, B2 - Class III

•Air differential, pressurization

•Decontamination (decon)

•Water

•Waste

•Air seal integrity, tightness, construction impact

•Anteroom

iCapture at St. Paul’s Hospital

1 DEFINING A LAB

P14

Holding Room

Ventilated CagesCorridor

Animal Resource Centre

•Holding rooms

•Cagewash

•Autoclave

•Bioexclusion (barrier)

•Bioinclusion

•Cage change station

•Allergens

•Clean / Dirty

•Ventilated cages

•Anteroom

1 DEFINING A LAB

P15

Pilot Plant

•Manufacturing on small scale

- Pharmaceuticals - Food products - Equipment prototypes - Process for scale up to full manufacturing

1 DEFINING A LAB

P16

Physics

•Nuclear and Particle

- Beamlines - Magnets - Cryogenics for superconducting magnets (helium)

- Thick concrete walls - Radiation shielding - Remote handling - Contamination/decontamination - Active Sumps - Vibration - Settlement

TRIUMF ISAC 1

TRIUMF Beamline

1 DEFINING A LAB

P17

•Conventional Physics Lab

- Benches (possibly movable) - Ceiling supported structural rails - Ceiling power, data drops - Optical table - Lasers - Light control - Vibration

Laser Lab

1 DEFINING A LAB

P18

UVic Bob Wright Observatory

UVic Bob Wright Observatory UVic Bob Wright Astronomy Lab

Astronomy

•Vibration

•Sky access for viewing

•Air obstructions

•Temperature in dome

•Benches

•Lighting

1 DEFINING A LAB

P19

Aquatic

•Tanks

•Water recirculation

•Wet environment

•Biosecurity

•Shore facilities

VIU International Centre for Sturgeon Studies

1 DEFINING A LAB

P20

Engineering•Special structural

elements eg. strong walls, strong floors

•Conventional benches but flexible

•Can be computer intensive, especially electrical engineering

•The building as a research and teaching tool

1 DEFINING A LAB

P21

Engineering•Direct-outdoor access

•High headroom spaces

•Diverse services requirements - chemicals/fumehoods - power, data - compressed air - exotic gases, some highly toxic - potential clean room environments - floor mounted equipment - vibration producing and vibration sensitive

- lasers and imaging

1 DEFINING A LAB

P22

Design for Teaching•Sightlines

- Attendee to Presenter & viewing material presented

- Eye contact - Overview of activities

•Presentation wall / display

1 DEFINING A LAB

P23

•Flexibility

- Varied layout options - Combine lab and collaboration space

•Transparency

- Science on display - Connect public space with science activities

Design for Teaching/Collaboration

1 DEFINING A LAB

P24

•Technology

- projectors - screens - data drops - power - smart boards - outside the classroom

Design for Teaching

1 DEFINING A LAB

P25

Storage•Much needed especially with multiple

research programs

•Separate rooms are good only if efficiently planned with shelving

•Storage options within lab space provide easy access, can reduce need for dedicated rooms

•Requires easy access

•Destination for items needed, not parking for junk