From Problem Lists to Illness Scripts...Pauci-clue differential Diagnosis ... – malaise, fatigue,...
Transcript of From Problem Lists to Illness Scripts...Pauci-clue differential Diagnosis ... – malaise, fatigue,...
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From Problem Lists to Illness Scripts
Learning and Teaching Expert Clinical Problem Solving
Catherine Lucey, MDVice Chair for EducationThe Ohio State University
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Learning Objectives
• Compare and contrast problem solving strategies used by novices and experts.
• Define and understand the tools of processing and illness scripts as they apply to clinical problem solving
• Use these concepts to help learn and teach clinical diagnosis and medical decision making
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Case-Based, Small Group Discussions
Case
Presentation? Differential
Diagnosis
Analyze
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Lessons from the Experts:
Learn in the style that you will use the knowledge
Cognitive Psychology
Georges Bordage, MD PhD
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Learner Maturation
Diagnostic Accuracy
ta Gathered
Da
Novice Expert
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Building Blocks of Problem Solving
Hypothesis Testing
Forward Thinking
Pattern Recognition
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Learner Maturation
Diagnostic Accuracy
Data Gathered
Novice Expert
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Problem Solving Maturation
Novice Expert
Pattern Recognition
thesis Testing
ward Thinking
Hypo 100%
For
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Typical Small Group Exercise
Diff Dx:CADPneumoniaPericarditisPEMusculoskeletalPleuritisGERD
Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. + SOB (-)
fevers Meds: OCPs Normal exam except tachycardic.
?
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Traditional Morning Report
Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. No fevers, no SOB. Meds: OCPs Normal exam except tachycardic.
Diff Dx:CADPneumoniaPericarditisPEMusculoskeletalPleuritisGERD
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Traditional Morning Report
Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. No fevers, no SOB. Meds: OCPs Normal exam except tachycardic.
Diff Dx:•CAD•Pneumonia•Pericarditis•PE•Musculoskeletal•Pleuritis•GERD
Hypothesis Testing
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What is Emphasized by this Process?
• Cast the net widely– Pauci-clue differential Diagnosis
• The law of clinical plausibility– “Could Be…” problem solving, undercuts
value of the clinical evaluation
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Morning Report
Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. No fevers, no SOB. Meds: OCPs Normal exam except tachycardic.
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Defining the Syndrome
Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. No fevers, no SOB. Meds: OCPs Normal exam except tachycardic.
Acute
Pleuritic
Chest Pain
Forward Thinking
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Chest pain
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Chest pain
Acute Chronic
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Acute Chronic
Chest pain
Acute
Pleuritic
Nonpleuritic
Semantic Qualifiers
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PROCESSING: the key to forward thinking
• Use of Semantic Qualifiers to Refine Symptoms – ‘Medical-ese’ facilitates recall– Binary and oppositional (either…..or)– Facilitates algorithmic thinking
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Examples: Descriptive Processing
Temporal
Qualitative
Epidemiology
Acute vs ChronicProgressive vs StableColicky vs Visceral Abdominal PainImmunocompromised
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Summative Processing
• Combining the processed descriptive terms to generate the syndrome
• Decreases the number of isolated symptoms that we must keep track of
• Prevents inappropriate focus on one aspect of the syndrome complex
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Summative Processing Examples
• Classic Syndromes:– CHF, Shock, Meningitis
• Thematic Summaries– Pulmonary Dyspnea with a nonfocal
exam– Destructive Thrombocytopenia
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Exercise: Processing
• Key Concepts: Page 3• Exercise: Page 4
• Using the information provided, practice processing the items listed on the table.
• Discuss whether the processing is descriptive or summative (or both!)
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Pattern Recognition
• The near instantaneous recognition that all (or almost all) components of a known disease are present– Rapid fire processing– Further questioning searches for the missing
elements of the disease• Accurate and Efficient
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Illness Scripts: Key to Pattern Recognition
• Disease Specific Packets of Information– Generated by reading and by experience
• Storage Strategy of Experts• Structure: fairly regimented
– Epidemiology, temporal pattern, syndrome statement
• Content: those elements which distinguish among like diseases
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Case:35 year old AA female with one day hx of sharp, left-sided chest pain, occurring at rest and worse with inspiration and coughing. (-) fevers, (+) SOB. Meds: OCPs Normal exam except tachycardic.
Acute Pleuritic Chest Pain withDyspnea in a young OCP user
TRAVEL??HEMOPTYSIS??INCREASED A-a Grad?
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Group Exercise: Illness Scripts
• Key Concepts, page 6• Exercise: pp 7-11
• Each Group should work on defining illness scripts for each set of diseases
• Use processed terms and summative statements (brief is better)
• Identify distinguishing features
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Small Group Teaching Goals
Diagnosis
Case Presentation
Chief complaint
HPI
PE
Labs
Promote Advanced Problem-Solving Strategies
Pattern Recognition>Forward Thinking>Hypothesis Testing
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Demystify the Magic
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TEACH/LEARN
• PROCESSING• ILLNESS SCRIPTS• PRIORITIZING
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CC: Headache and Confusion
• 32 yo African American woman with AIDS, CD4 = 22 presents with 4 weeks of worsening headache and fever. The headache is over her entire head, throbbing and unremitting and is associated with photophobia and a stiff neck. Over the past two weeks she has become progressively confused, and over the past two days she has stopped eating. She also complains of blurry vision and general aches and pains.
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CC: Headache and Confusion
• PMHX: AIDS on no meds (ran out), PCP Pneumonia x 2
• SHX: prior IDU, 2 kids, both healthy, no cigs, no ETOH, no drugs for one year
• MEDS: none ALL: NKDA
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Physical Exam• Papilledema,
photophobic, PERRLA
• Neuro: no focal motor deficits, unable to test sensory or cerebellar fxn
• All else normal
• VS: 103.5o ; 139/72; 100; 22;
• Lethargic obese patient, O x 1
• Dry MM, orthostatic pulse change
• Rigid Neck, + Kernigs
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SimpleProblem List
Processed Problem list
Prioritized Diff Dx
Tier I
Ib
Tier II
Tier III
Epi
Time Course
Syndrome Statement
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Step I: Simple Problem List
T = 103.5TachycardiaIntermittent lethargyDisorientationDry mucous membranesStiff neck and Kernig’sPapilledemaAIDS
Headache for 4 weeksFeverStiff neckConfusionTrouble WalkingBlurry VisionPoor PO intakeIncontinence
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Step II: Process the List
• Processing into ‘medical’ized terms facilitates recall
• Develop a precise and descriptive statement that describes this PATIENT’S illness script – narrows the diagnostic playing field
• Fewer items on the list allows for better attention
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Processed Problem List
• Epidemiology• Temporal Course of the Problem• Syndrome description
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Epidemiology
• Choose those aspects of the patient’s demographics, exposure or PMHx that set the stage for the illness
• Process the risk factors to emphasize their importance
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If the CC
And the PMHX Epidemiology
Chest Pain
Htn, DM, Stroke, PVD, Hypothyroidism
Vasculopathy
Cough AIDS, CD4 = 12, Ghanaian Native,
Profound CMI Deficit in recent immigrant
Rash Intracranial Hemorrhage, DM, COPD
Recent initiation of anti seizure medication
Fever ESRD, Htn, s/p appendectomy
Immunocompromised host with indwelling vascular device
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Temporal Processing
• Acute, Subacute, Chronic– Definition is linked to the chief complaint
• Patterns:– intermittent, waxing and waning, biphasic
illness, episodic• Stability:
– progressive, indolent, constant
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Creating a Syndrome Statement
• Descriptively process all items on the list• Eliminate nonspecific/redundant symptoms
– malaise, fatigue, transient diarrhea– tachypnea and Shortness of Breath
• Identify the most important symptom and combine it with those s/s that explain the most important symptom
• Check for completeness
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HeadacheFeverStiff NeckPhotophobiaKernig’s
Meningitis
Waxing and WaningMental Status,Disorientation
Delirium
Increased IntracranialPressure
HeadachePapilledemaLethargy
Poor PO IntakeDry Mucous Memb Volume Depletion
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Processed Problem list
Epi:35 yo woman withT cell immunodefTime course:ChronicSyndrome:MeningitisDeliriumICHSecondary VolDepletion
Tier 1
Tier 2
Tier 3
1b
HeadacheFeverStiff neckConfusionTrouble WalkingBlurry VisionPoor PO intakeIncontinence
T = 103.5TachycardiaIntermittent lethDisorientationDry MMStiff neck and PapilledemaAIDS
OriginalProblem List
Prioritized Diff Dx
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Step III: Prioritized DDX
• The processed problem list describes the patient’s ILLNESS SCRIPT
• Goal: Search for a disease which has an ILLNESS SCRIPT that matches the patient’s
• Tools: Pattern Recognition > Forward Thinking > Hypothetico-deductive
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Prioritization of Differential
• Learner Must describe classic pattern of any diagnosis offered
• The extent of match between patient’s presentation and classic determines priority
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Rationale
• Emphasizes that diagnostic power of the carefully done and analyzed clinical exam
• Stresses compare and contrast thinking• Prioritizes management• Closes the loop
– illustrates the value of pertinent positive and negatives from the HPI.
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Prioritizing Differential Diagnosis
• Tier I Diagnosis:– Disease illness script matches the patient’s illness script
almost perfectly
• Tier II Diagnosis:– Patient is missing key features of the disease– Disease does not explain prominent features of patient’s
presentation
• Tier III Diagnosis:– single or pauci clue match
IB: A critical addition
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Demystifying Pre test Probability
• Tier I Diagnosis: 75% pretest probability– Disease illness script matches the patient’s illness script
almost perfectly
• Tier II Diagnosis: 30-50 % pretest probability– Patient is missing key features of the disease– Disease does not explain prominent features of patient’s
presentation
• Tier III Diagnosis: < 30% pretest probability– single or pauci clue match
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Prioritized Diff Dx
Epi:35 yo woman withT cell immunodef
Time course:Chronic
Syndrome:MeningitisDeliriumICHSecondary VolDepletion
Headache for FeverStiff neckConfusionTrouble WalkBlurry VisionPoor PO intakeIncontinence
T = 103.5TachycardiaIntermittent DisorientationDry MMStiff neck andPapilledemaAIDS
Processed Problem list
OriginalProblem List
I. Cryptococcal MeningTuberculous MeningHistoplasm. Mening
1b Bact. Mening.
II ToxoplasmosisCNS Lymphoma
III. SarcoidosisCNS SLEPseudotumor Cerebri
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Group Exercise: Case Dissection
• Key Concepts: page 12• Exercise: pp 13-15• Create a processed problem list for
the case described on page 13.• Identify illness scripts and then
prioritize the ddx for this case using the diagnoses listed on page 15.
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Step IV. Teaching and Learning Issues
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Wrong Answers?--Coach
• Encourage Autocorrection• What does that disease typically look like?
– Use structured processed problem list format• How does that compare with this patient?• Stress Key and Rejecting Features
– What would have to be present to make this a Tier I diagnosis?
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No Patterns? Recommend Alternate Strategies
• Goal:Generate diagnostic ideas and then • Evaluate: using illness scripts • Forward Thinking
– Categories of thrombocytopenia• Pathophysiology/Anatomy
– How is edema formed?• Category Chase
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Evaluative Benefits
Process allows window into the black box of thinking
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Wrong Answer?
• Step I: inattentiveness• Step II: processing problem; syndrome
recognition• Step III:
– Factual knowledge (incorrect illness scripts)– Lack of understanding of Key features (correct
illness scripts, can’t match)
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Compare and Contrast Illness ScriptsSyndrome
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Compare and Contrast Illness ScriptsSyndrome
Distinguishing Features
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Compare and Contrast Illness ScriptsSyndrome
Distinguishing Features
Key Features