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From Biofuels and BeyondInspired Science to Deliver Sustainable Solutions for a Growing WorldJoel VelascoApril 2014
2Copyright © 2012 Amyris, Inc. All rights reserved.
This presentation and oral statements accompanying this presentation contain forward-
looking statements, and any statements other than statements of historical facts could be
deemed to be forward-looking statements. These forward-looking statements include, among
other things, sizes of markets that may be addressed by Amyris’s current and potential
products, Amyris’s expected product pipeline, sales volumes and average selling prices,
production volumes and costs and associated product launch timing expectations, operation
of production facilities, commercial relationships, and financial results, that involve risks and
uncertainties. These statements and other forward-looking statements that may be provided in
the presentation and/or oral statements accompanying it are based on management’s
estimates and current expectations and actual results and future events may differ materially
due to changes in Amyris’s business and various risks and uncertainties, including those
associated with any delays or failures in development, production and commercialization of
products, liquidity and ability to fund capital expenditures, Amyris’s reliance on third parties to
achieve its goals, and other risks detailed in the “Risk Factors” section of Amyris’s quarterly
report on Form 10-K filed on April 2, 2014. Amyris disclaims any obligation to update
information contained in these forward-looking statements whether as a result of new
information, future events, or otherwise.
Cautionary Note re: Forward Looking Statements
3Copyright © 2012 Amyris, Inc. All rights reserved.3Copyright © 2012 Amyris, Inc. All rights reserved.
The Renewable Fuel Standard (RFS2)
4Copyright © 2012 Amyris, Inc. All rights reserved.
RFS2 as Imagined
2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
Conventional Biofuels 10.5 12 12.6 13.2 13.8 14.4 15 15 15 15 15 15 15 15
Non-celulosic Advanced 0.1 0.2 0.3 0.5 0.75 1 1.5 2 2.5 3 3.5 3.5 3.5 4
Biomass-based Diesel 0.5 0.65 0.8 1 1 1 1 1 1 1 1 1 1 1
Celulosic Advanced NaN 0.1 0.25 0.5 1 1.75 3 4.25 5.5 7 8.5 10.5 13.5 16
3
8
13
18
23
28
33
38B
illi
on
s o
f G
allo
ns
LOWER GHG
Source: EISA of 2008, U.S. Environmental Protection Agency (RFS-2) Final Rule.
5Copyright © 2012 Amyris, Inc. All rights reserved.
RFS2 as Expected
2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
Conventional Biofuels 10.5 12 12.6 13.2 13.8 14.4 15 15 15 15 15 15 15 15
Non-celulosic Advanced 0.1 0.2 0.3 0.5 0.75 1 1.5 2 2.5 3 3.5 3.5 3.5 4
Biomass-based Diesel 0.5 0.65 0.8 1 1 1 1 1 1 1 1 1 1 1
Celulosic Advanced NaN 0.1 0.25 0.5 1 1.75 3 4.25 5.5 7 8.5 10.5 13.5 16
3
8
13
18
23
28
33
38B
illi
on
s o
f G
allo
ns
Source: EISA of 2008, U.S. Environmental Protection Agency (RFS-2) Final Rule.
Assuming current EPA approach, RFS mandated volumes only increase to the extend total gasoline
consumption increases…
Blend Wall (10% Gasoline Demand)
6Copyright © 2012 Amyris, Inc. All rights reserved.
EIA’s Gasoline and Diesel Consumption Outlook
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
2032
2033
2034
2035
2036
2037
2038
2039
2040
0
2
4
6
8
10
12
14
US
mo
tor
gas
olin
e an
d d
iese
l co
nsu
mp
tio
n
(mill
ion
barr
els
per
day)
AEO2013
AEO2007
AEO2010Gasoline
AEO2007AEO2010
AEO2013
Diesel
Source: EIA, Annual Energy Outlook 2007, Annual Energy Outlook 2010, Annual Energy Outlook 2013
7Copyright © 2012 Amyris, Inc. All rights reserved.7Copyright © 2012 Amyris, Inc. All rights reserved.
From Biofuels and Beyond
8Copyright © 2012 Amyris, Inc. All rights reserved.
Amyris: The Industrial Synthetic Biology Company
• Founded in 2003 by post-doctoral fellows from the University of California, Berkeley.
• Headquartered in the San Francisco Bay Area and with operations in Brazil.
• 390 full-time employees, of which one-third are PhDs.
• Backed by leading investors and strong partnerships with global brands.
Best-in-Class Tech
Scaled Manufacturing
No Compromise® Products
AMYRIS PLANT IN BRAZIL
AMYRIS HQ IN CALIFORNIA
9Copyright © 2012 Amyris, Inc. All rights reserved.
Isoprene (C5)
F&F Molecules
FARNESENE (C15)
Living Factories Delivering Better Products
• Diesel• Jet Fuel
Fuels
• Base Oils• Finished Lubricants
Lubricants
• Polymers• Solvents and Fluids
Performance Materials
• Cosmetic Emollients• Flavor & Fragrances
Consumer Care
Amyris engineers living factories and produces renewable products
10Copyright © 2012 Amyris, Inc. All rights reserved.
From Curing Malaria to Better Fuels and ChemicalsDelivering sustainable growth for the worlds leading brands
BIOLDINGinvestment
LEADING INVESTORS
11Copyright © 2012 Amyris, Inc. All rights reserved.
Significant Addressable MarketsDiverse Production Portfolio Today with Improving Profitability
12Copyright © 2012 Amyris, Inc. All rights reserved.
Amyris Business Model: Partner-funded product collaboration pipeline, long-term annuity from sales, and industry leading gross margin
Strategic & Capability Building Partners
COLLABORATIONS RENEWABLE PRODUCTS
COLLABORATION INFLOWSExpect to continue at
$60M to $70M annually
PRODUCTION & SALESExpect to double year-on year
during the next few years
PROVIDES CASH FORR&D OpEx and CapEx
Investments in high-value Farnesene Industry leading cash gross margin
Over 15 new molecules under
contract with 1 to 3 new product
launch per year
DRIVER OF Revenue Growth
Earnings through Long-Term SupplyOperations OpEx and CapEx
Customers
13Copyright © 2012 Amyris, Inc. All rights reserved.
• Developed high-throughput strain engineering system to code and screen over 100,000 yeast strains per month at 95% lower cost.
• Generated over 600,000 unique farnesene strains in last year, surpassing 3 million strains.
• Tested over 5,000 unique strains in actual fermentation to date and now predict 200,000 liter fermentation performance from 2 liter scale tests.
• Reduced time to target isoprenoid molecule from years to months, with thousands of molecules to be accessed.
Amyris Synthetic Biology Technology PlatformThe Science of Genentech with the Engineering of Intel
Design based on Learnings
Build: Robotics & Automation
Test: 100,000 strains/month
14Copyright © 2012 Amyris, Inc. All rights reserved.
The Leading Innovator in Industrial Biotech
15Copyright © 2012 Amyris, Inc. All rights reserved.
Summary
TECHNOLOGY• Leading technology
platform capable of making 50,000 molecules.
• Engineer yeast to convert sugar into renewable hydrocarbons.
MANUFACTURING• Access to lowest cost
feedstock (sugarcane).• Lowest carbon footprint.• First plant operating with
capital light approach.
PRODUCTS• Anti-malarial drug
precursor (no profit).• No Compromise® fuels
and specialty chemicals, with initial sales ongoing.
INTEGRATED RENEWABLE PRODUCTS COMPANY
16Copyright © 2012 Amyris, Inc. All rights reserved.
For Further Reading
Visit our website at investors.amyris.com
18Copyright © 2012 Amyris, Inc. All rights reserved.
19Copyright © 2012 Amyris, Inc. All rights reserved.
• 2004 Amyris, a “virtual company” licenses back Synthetic Biology patent portfolio.
• 2005 Amyris opens with a $15M of a five-year grant from the Bill and Melinda Gates Foundation to develop anti-malarials with Synthetic Biology platform.
• 2006 Amyris takes venture capital to apply SynBio platform to hydrocarbon fuels & chemicals.
• 2007 John Melo, former president of BP’s US Fuels division
• 2007 Amyris team makes “first drops” of renewable diesel in the lab
• 2008 key technical milestones in anti-malarial drug production
– partners with Sanofi-Aventis to scale-up & commercialize anti-malarial drug
• 2008 Amyris opens Pilot Plant for fuel in Emeryville; “first gallons” of diesel
• 2009 Successful Artemisinin technology transfer to Sanofi-Aventis
• 2009 Amyris produces “first barrels” of diesel
• 2010 Partnership with Total
• 2010 IPO (AMRS)
• 2011 Begin sales of Diesel and Squalane
• 2012 Amyris produces 2 Million liters of Diesel and Squalane
• 2013 Launch Artemisinin 70-120 million malaria cures (Sanofi)
A Brief History of Amyris