Friedrich Miescher

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Friedrich Miescher (1844-1895) Friedrich (Fritz) Miescher was born in Basel, Switzerland. The Miescher family was well-respected and part of the intellectual elite in Basel. Friedrich's father was a physician and taught pathological anatomy; Friedrich's uncle, Wilhelm His, was a well-known embryologist. Miescher was an excellent student despite his shyness and a hearing handicap. Miescher initially wanted to be a priest, but his father opposed the idea and Miescher entered medical school. When he graduated in 1868, Miescher ruled out specialties where patient interactions were necessary because of his hearing problem. He decided to base his career on medical research. He went to the University of Tübingen to study under Felix Hoppe-Seyler in the newly established faculty of natural science. Hoppe-Seyler's laboratory was one of the first in Germany to focus on tissue chemistry. At a time when scientists were still debating the concept of "cell," Hoppe-Seyler and his lab were isolating the molecules that made up cells. Miescher was given the task of researching the composition of lymphoid cells — white blood cells. These cells were difficult to extract from the lymph glands, but they were found in great quantities in the pus from infections. Miescher collected bandages from a nearby clinic and washed off the pus. He experimented and isolated a new molecule - nuclein - from the cell nucleus. He determined that nuclein was made up of hydrogen, oxygen, nitrogen and phosphorus and there was an unique ratio of phosphorus to nitrogen. He was able to isolate nuclein from other cells and later used salmon sperm (as opposed to pus) as a source. Although Miescher did most of his work in 1869, his paper on nuclein wasn't published until 1871. Nuclein was such a unique molecule that Hoppe-Seyler was skeptical and wanted to confirm Miescher's results before publication. Miescher continued to work on nuclein for the rest of his career. He also examined the metabolic changes that occur in salmon when they spawn. In 1872, Miescher was appointed the professor of physiology at

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Friedrich Miescher

Transcript of Friedrich Miescher

Page 1: Friedrich Miescher

Friedrich Miescher (1844-1895)

Friedrich (Fritz) Miescher was born in Basel, Switzerland. The Miescher family

was well-respected and part of the intellectual elite in Basel. Friedrich's father was

a physician and taught pathological anatomy; Friedrich's uncle, Wilhelm His, was a

well-known embryologist.

Miescher was an excellent student despite his shyness and a hearing handicap.

Miescher initially wanted to be a priest, but his father opposed the idea and

Miescher entered medical school. When he graduated in 1868, Miescher ruled out

specialties where patient interactions were necessary because of his hearing

problem. He decided to base his career on medical research. He went to

the University of Tübingen to study under Felix Hoppe-Seyler in the newly

established faculty of natural science.

Hoppe-Seyler's laboratory was one of the first in Germany to focus on tissue

chemistry. At a time when scientists were still debating the concept of "cell,"

Hoppe-Seyler and his lab were isolating the molecules that made up cells.

Miescher was given the task of researching the composition of lymphoid cells —

white blood cells.

These cells were difficult to extract from the lymph glands, but they were found in

great quantities in the pus from infections. Miescher collected bandages from a

nearby clinic and washed off the pus. He experimented and isolated a new

molecule - nuclein - from the cell nucleus. He determined that nuclein was made

up of hydrogen, oxygen, nitrogen and phosphorus and there was an unique ratio of

phosphorus to nitrogen. He was able to isolate nuclein from other cells and later

used salmon sperm (as opposed to pus) as a source.

Page 2: Friedrich Miescher

Although Miescher did most of his work in 1869, his paper on nuclein wasn't

published until 1871. Nuclein was such a unique molecule that Hoppe-Seyler was

skeptical and wanted to confirm Miescher's results before publication.

Miescher continued to work on nuclein for the rest of his career. He also examined

the metabolic changes that occur in salmon when they spawn. In 1872, Miescher

was appointed the professor of physiology at theUniversity of Basel, a position

previously held by his father and then his uncle. The appointment meant more

funds and equipment for research, but it also meant that Miescher had to teach.

Although he put in a lot of time and effort, Miescher was not a good teacher. His

shyness and preoccupation with his research made it difficult for him to relate to

his students. He was a perfectionist and a workaholic, and often worked very long

hours to do the nuclein isolations.

It would be years before the role of nucleic acids were recognized. Miescher,

himself, believed that proteins were the molecules of heredity. However, Miescher

laid the groundwork for the molecular discoveries that followed. Miescher died in

1895 from tuberculosis.

Message of the Story of Ramayana

The Ramayana is not just a story, but also an educational medium to demonstrate the importance of values such as loving and respecting your family, keeping your promises, protecting the weak and so on. Use the magnum opus of Hindu mythology, the Ramayana, as a medium to teach your child about values and ethics here.

The Ramayana is one of the greatest epics of Hindu Mythology. Written by the Hindu sage Valmiki, the Ramayana is not just a story, but also an educational medium used by the ancient sages to espouse the importance of doing yourdharma (duty) in relationships. The Ramayana depicts characters that we should aspire to be like, such as the ideal father, ideal son, ideal brother, ideal leader, ideal wife, etc.

You can teach values and ethics to your child by way of storytelling. The Ramayana and Mahabharata especially, preach a lot of values that we would want our children to imbibe. Not for nothing, are they the most commonly taught epics since ancient times. Instead of simply commanding your child to respect his elders, you can use examples from his favourite epics to teach him the same.

Learn how you can use one of the greatest gems of Hindu Mythology, namely the Ramayana to teach your children moral values and ethics with the following suggestions.

Sibling Relationships

If your child has any siblings, focus on the love the brothers had for each other. Why did Lakshman, who was used to all the worldly luxuries due to a prince, decide to give all of that up voluntarily to live with his elder brother for 14 years of hardship in a forest? Because he loved his brother and could not bear the thought of having to live 14 years without him.

You can also teach your child the importance of standing up for his siblings with the example of Surpanakha. When Surpanakha was insulted by Lakshman, her brothers Khaara and Dooshan rushed to avenge her not caring of the fact that it could lead to their death. When Rama and Lakshmana did indeed

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vanquish her brothers, Surpanakha sought her other brother Ravana's aid, setting the wheels for the grand battle between Rama and Ravan, good and evil, into motion. 

In today's materialistic world where disputes between siblings are commonplace, stories like these need to be extolled and repeated time and again. Parents need to encourage their children to not only spend time with their siblings, but also stand up for each other and be there for each other when required. Such deep affection can be cultivated only when parents encourage such growth, and keep emphasizing the importance of love amongst siblings.

Differentiating between Right and Wrong

You can teach your child to choose right over wrong even when wrong may feel more right by giving him the example of Bharat, who was awarded the honour of ruling the mighty kingdom of Ayodhya. Bharat could have just accepted the throne and the absolute power and luxury that came with it but his sense of right and wrong would not permit him to do what most others would greedily do. Instead, upon learning that his mother Kaikeyi had unjustly managed to get Rama banished from Ayodhya, he immediately went into the forest to look for Rama and offer him his rightful position as ruler of Ayodhya. So great was his devotion to his brother and so strong was his desire to be fair and just, that when Rama refused to return to Ayodhya before completing his 14 years in exile, Bharat placed Rama's footwear on the throne and ruled Ayodhya in the name of Rama – as Rama’s emissary until he returned to regain his rightful position. 

This teaches your child that even if something is extremely desirable, he should only accept it if is attained in a just manner without hurting or affecting anyone else in an unfair and unjust manner.