Free Classroom Resources from HHMI for Teaching Evolution, Part 2
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Transcript of Free Classroom Resources from HHMI for Teaching Evolution, Part 2
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Free Classroom Resources from HHMI for Teaching Evolution,
Part 2Megan Stine
[email protected] 19, 2014
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Evolution: Behind the Scenes
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Evolving Switches, Evolving Bodies
• Film guides• Virtual lab• Classroom activities:– Using Genetic Crosses to
Analyze a Stickleback Trait
– Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
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Evolving Switches, Evolving Bodies Film
• http://www.hhmi.org/biointeractive/making-fittest-evolving-switches-evolving-bodies
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Which phenotype is dominant?
• Assumption: single-gene trait, 2 alleles, normal dominance
• Cross between a marine stickleback and one from Bear Paw Lake
• Parents are homozygous• F is dominant, f is recessive
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Predict the results of the crosses
F F
f
f
Ff
Ff
Ff
Ff
Pelvic spines present:absent =
0:11:0
F f
F
f
FF
Ff
Ff
ff
Pelvic spines present:absent =
3:1 1:3
1st generation 2nd generation
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Sorting by Phenotype
With pelvic spines Without pelvic spines
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Do the data support your hypothesis?
• Sort the F1 cards:– Fish with pelvic spines– Fish without pelvic
spines
• Sort the F2 cards
• Ratio of fish with:without pelvic spines in F1?
• Ratio of fish with:without pelvic spines in F2?
1:0
3.4:1
Was our initial assumption correct? Is this a single-gene trait?
Was your hypothesis correct? Which phenotype is dominant?
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Virtual Lab
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Natural Selection in Humans
• Film guides• Classroom resources:– Nature of Science– Mendelian Genetics,
Pedigrees, and Chi-square Analysis
– How Fibers Form– Population Genetics
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Natural Selection in Humans Film
• http://www.hhmi.org/biointeractive/making-fittest-natural-selection-humans
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Mendelian Genetics Activity
• Punnett squares• Pedigree analysis• Pedigree creation• Chi-square analysis• Data prediction
• Important notes:– A is normal allele– S is sickle cell allele– AA has normal RBC
phenotype– AS has sickle cell trait– SS has sickle cell disease
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Question #1: Intro Punnett
A S
A
S
• Chance of normal RBC in high and low oxygen?
• Chance of SCD?• Chance of 3 children
with SCD?• Chance of 2 children
with sickle cell trait and 1 with SCD?
• Child without SCD, what chance he/she has trait?
AA
AS
AS
SS
1/4
1/4
1/64
1/16
2/3
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Question #6: Intro Pedigree
• Genotype of: – 1st gen male?– 2nd gen daughter?– Individual #3?
• If family moves to lowlands of E. Africa, 4/5 males will have two genetic advantages. What are they?
AS
SS
AS
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Human Evolution Click & Learn
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Teacher Guides
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Holiday Lecture Series
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Coming in Fall 2014…
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Thank you for your time and attention!
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