FRCA Primary Basic Science (2)
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Transcript of FRCA Primary Basic Science (2)
FRCA primary basic science
Question: 1 of 53
Time taken: 2 mins 18 secs
The following can be directly measured by spirometry:
True / False
vital capacity Correct
anatomical dead space Correct
residual volume Correct
total lung capacity Correct
functional residual capacity Correct
A spirometer is a device used for measuring lung volumes either directly or indirectly using dilution techniques, e.g. helium. It can also be used to calculate flow rates and the basal metabolic rate. Spirometry provides timed measurements of expired volumes from the lung and is the foundation of pulmonary function testing. Wet and dry spirometers exist, and with automated equipment it is possible to interpret more than 15 different measurements from spirometry alone. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC ratio, and the flow between 25% and 75% of the FVC are the most clinically helpful indices obtained from spirometry. The anatomical dead space is measured by Fowler’s method (single breath nitrogen washout); residual volume and total lung capacity can be measured using the body plethysmograph or helium dilution; the functional residual capacity can be measure by nitrogen washout or the helium dilution technique. It should be noted that the helium dilution technique is performed by the patient breathing air with a known concentration of helium, starting from the end of normal expiration from a SPIROMETER! The question asks which can be measured directly, thus the only correct option is vital capacity.
Question: 2 of 53
Time taken: 5 mins 22 secs
Gastrointestinal complications related to ITU therapy include:
True / False
Oesophageal erosions Correct
Diarrhoea Correct
Acute acalculous cholecystitis Correct
Increases in pancreatic lipases and amylase Correct
Haemorrhoids Correct
Erosive oesophagitis has an incidence of up to 48% in mechanically ventilated ITU patients. Causative factors include: nasogastric intubation; gastro intestinal reflux; and duodenogastric reflux of bile. Diarrhoea has a similar reported incidence and is due to a number of factors including: Enteral feeding; high feed rates; the administration of hyperosmolar feeds; and carbohydrate fermentation by small bowel bacterial colonisation. Antibiotic related diarrhoea accounts for 50% of cases. Clostridium difficile infection should be excluded in all cases of diarrhoea following antibiotic administration. Other drugs implicated in diarrhoea include H2 receptor antagonists and magnesium containing antacids. Acute acalculous cholecystitis has a reported incidence of up to 3% in ITU patients. Its development is associated with a number of risk factors including: Shock, dehydration; sepsis; multiple blood transfusions; prolonged fasting; and total parenteral nutrition (TPN). In animal models high levels of PEEP (above 15cm) of water have been shown to reduce
pancreatic blood flow and increase the serum levels of pancreatic enzymes, but the link has not been clearly demonstrated in the critically ill. There is no reported increased risk of haemorrhoids in ITU patients.
Question: 3 of 53
Time taken: 6 mins 59 secs
In cardiogenic shock complicating myocardial infarction, the following interventions are of proven clinical benefit:
True / False
The administration of positive inotropic drugs Correct
Intra aortic balloon counter pulsation Correct
Early invasive revascularisation Correct
Thrombolysis Correct
Pulmonary artery catheterisation Correct
The only intervention which has conclusively demonstrated an improvement in outcome following myocardial infarction is early invasive angioplasty or stenting. Although the other interventions may be required to produce an adequate blood pressure they have failed to demonstrate an improved outcome. In contrast to the demonstrated efficacy of thrombolysis in uncomplicated myocardial infarction, in post MI cardiogenic shock, thrombolysis may be harmful.
Question: 4 of 53
Time taken: 11 mins 18 secs
Computerised axial tomography scans (CT scans) of patients with traumatic head injuries:
True / False
Extradural haematomas are seen more frequently than subdural haematomas Correct opposite
Extradural haematomas are classically biconcave in shape on the scan Correct biconvex in appearance
Diffuse axonal injury is easily identified Correct
A normal scan excludes raised intracranial pressure (ICP) Correct
Evidence of intra-ventricular blood is an indication for referral to a neurosurgical unit Correct
Subdural haematomas are the commonest type of intra-cerebral haemorrhage and occur in 30% of severe head injuries. Extradural haematomas only occur in < 10% of unconscious head injured patients. On computerised axial tomography scans (CT scans) extradural haematomas are classically lenticular or biconvex in appearance, whereas subdural haematomas are classically cresenteric in shape. Diffuse axonal injury is caused by shearing forces on neurones, which subsequently leads to their death. It produces rapid unconsciousness due to its effect on the reticular activating system. Diffuse axonal injury is best demonstrated on diffusion weighted magnetic resonance imaging scans (not CT scans). Although there are classic signs relating to raised intracranial pressure (ICP) on CT scans, a normal scan does not preclude raised ICP. The presence of intraventricular blood particularly in the third and forth ventricles can block CSF drainage and predispose to the development of obstructive hydrocephalus. The decision to insert an intra-ventricular drain should be considered following referral to a neurosurgical unit.
Question: 5 of 53
Time taken: 23 mins 28 secs
Positive end expiratory pressure (PEEP):
True / False
Increases pulmonary vascular resistance Correct
Decreases extra-vascular lung water Correct
Increases dead space Correct
May contribute to barotrauma Correct
The protective effects of PEEP on the lung are limited to the oxygen sparing action Correct
Although positive end expiratory pressure (PEEP) may provide an oxygen sparing effect by reducing the intrapulmonary shunt, and increasing alveolar recruitment, it has many deleterious effects including: 1 - Decreasing cardiac output; 2 - Increasing pulmonary artery pressure due to increased pulmonary vascular resistance 3 - Increasing dead space; 4 - Increasing the distension of uninjured lung units increases the risk of barotrauma; 5 - Increasing extra-vascular lung water by decreasing pulmonary interstitial lymph drainage (although PEEP reduces oedema in left ventricular failure and in fluid overload). The protective effects of PEEP on the lung are mediated not only through its ability to decrease the inspired oxygen requirements, but also due to a reduction in repeated alveolar collapse and re-inflation. This limits the shear stress on the alveolar wall, which reduces the formation of pro-inflammatory mediators by the pulmonary vascular epithelium and alveolar macrophages.
Question: 6 of 53
Time taken: 26 mins 45 secs
Complications following an interscalene nerve block include:
True / False
Horner’s syndrome Correct
Recurrent laryngeal nerve block Correct
Subarachnoid injection Correct
Vagus nerve block Correct
Vertebral artery injection Correct
Hoarseness can occur following interscalene block due to recurrent laryngeal nerve blockade, and unless it is bilateral it is rarely significant. Diaphragmatic paralysis may also occur during an interscalene block due to phrenic nerve blockade. However, this rarely causes symptoms unless the patient has severe respiratory disease. Horner’s syndrome, subarachnoid injection and vertebral artery injection have all been reported Blockade of the vagus nerve is not a recognized complication following an interscalene block.
Question: 7 of 53
Time taken: 28 mins 46 secs
Regarding the management of burns patients:
True / False
parenteral nutrition markedly attenuates the hypermetabolic response Correct
nursing the patient in a cool environment reduces the hypercatabolic state Correct
in a patients with 60% burns, the metabolic rate is four times higher than the normal rate Correct twice the normal rate
bacterial translocation from the intestines occurs 24 hours after a burn injury Correct
high protein diets may improve survival Correct
After suffering a thermal injury, the patient rapidly becomes hypercatabolic, with an increased cardiac output and oxygen consumption. Severe burn injuries are associated with a greater hypermetabolic response. With a 60% total body surface area burn the metabolic rate is about twice the normal rate (not four times greater). Patients should be nursed in temperatures of at least 30 degrees Celsius to reduce energy expenditure (not cool environments). The resetting of hypothalamic thermoregulation results in a 1-2 degree Celsius rise in core temperature. The burned area should be covered to reduce evaporative loss of fluids. The barrier function of the intestine is lost immediately after a thermal injury, allowing the translocation of bacteria and endotoxins, which can occur within hours (not 24 hours after the burn). Early enteral feeding preserves intestinal mucosal integrity and prevents translocation of microorganisms into the circulation. Enteral nutrition is associated with a marked attenuation of the hypermetabolic response to a burn injury (not parenteral nutrition). High protein diets (with a calorie to nitrogen ratio of 100:1), may improve survival after a burn. 50% of the calories should be in the form of carbohydrate, 30% as lipids or fat and up to 20% as protein or amino acids. Despite the associated risk of infection supplementary parenteral feeding may be required.
Question: 8 of 53
Time taken: 34 mins 15 secs
When performing a caudal epidural block in a child:
True / False
hypotension is a commonly encountered problem Correct
the sacral cornua forms the lateral border of the sacral hiatus Correct
the dura extends to the lower border of L4 Correct
an intraosseous injection of local anaesthetic may cause profound hypotension Correct
the cauda equina terminates at S2 Correct
Failure of fusion of the laminae of the fifth sacral segment results in the formation of the sacral hiatus. The sacral cornua form the lateral border and the spinous process of the fourth sacral segment forms the superior border. The sacrococcygeal membrane forms the roof of the sacral hiatus (posterior sacrococcygeal ligament). The spinal cord terminates at L1/2. The cauda equina (lumbar and sacral nerve roots), which is covered by the dura, terminates at S2. Hence, the dura extends to the lower border of S2 (not L4). The filum terminale terminates at the coccyx. The complications associated with caudal anaesthesia have a low incidence and are certainly not common. However, an intraosseous injection of local anaesthetic can produce results similar to an intravascular injection, causing profound hypotension or cardiac arrest. Other complications, which are also not commonly encountered include: urinary retention, lower limb blockade, dural puncture and hypotension.
Question: 9 of 53
Time taken: 35 mins 7 secs
Damage to the cauda equina may lead to:
True / False
Urinary incontinence. Correct
Weakness of leg muscles Correct
Faecal incontinence. Correct
Sexual dysfunction Correct
Sacral analgesia. Correct
Faecal incontinence, impotence and sacral analgesia are all features of damage to the cauda equina. Weakness of the leg muscles is an early sign and abnormal leg reflexes may occur. Urinary retention rather than incontinence is seen.
Question: 10 of 53
Time taken: 38 mins 14 secs
The following are complications associated with regional techniques:
True / False
Supraclavicular block – Horner’s syndrome Correct
Interscalene block – phrenic nerve palsy Correct
Extradural block – total spinal block Correct
Spinal block – anterior spinal artery syndrome Correct
Spinal block – shivering Correct
Phrenic nerve palsy and Horner’s syndrome are seen as a result of both the supraclavicular and interscalene blocks. Failure to recognise a dural puncture or subarachnoid / subdural placement of the epidural catheter during epidural anaesthesia, exposes the patient to the risk of a total spinal. If a large volume of local anaesthetic is injected into the cerebrospinal fluid (CSF), then a total spinal block may occur with rapidly ascending motor and sensory blockade, respiratory paralysis and central apnoea. Anterior spinal artery syndrome may occur as a complication of spinal or subarachnoid block. Shivering after extradural anaesthesia is common, and is thought to be caused by differential nerve blockade, either suppressing descending inhibition of spinal reflexes, or allowing selective transmission of cold sensation. In spinal anaesthesia where the block is denser, shivering is rare.
Question: 11 of 53
Time taken: 40 mins 48 secs
Post dural puncture headache:
True / False
Can be successfully treated by epidural blood patch in over 90% of patients. Correct
Is associated with sixth cranial nerve palsy. Correct
Is a postural headache, classically over the frontal or temporal regions Correct
Occurs less often when spinal anaesthesia is performed using a Quinke needle than if a Sprotte needle is used.
Correct
May be treated by strict bed rest Correct
Post dural puncture headache (PDPH) may be associated with nausea, vomiting, photophobia, dizziness and cranial nerve palsies, especially of the sixth cranial nerve. The PDPH is classically frontal or occipital (not temporal) and is exacerbated by standing up from the supine position, coughing or straining. Non-cutting needles e.g. Sprotte, Whitacre or Green, are said to produce a lower incidence of PDPH than cutting needles e.g. Quinke. Over 90% of patients with PDPH can be successfully treated by epidural blood patch. They also prefer to lie flat, but this does not reduce the incidence or duration of the headache following dural puncture, and bed rest is not a recognised treatment.
Question: 12 of 53
Time taken: 44 mins 3 secs
Concerning spinal (subarachnoid) anaesthesia:
True / False
Barbotage will increase the spread of the block . Correct
The spread of the local anaesthetic is greater in pregnancy. Correct
In the UK, bupivacaine with a specific gravity of 1.026 is commonly used for spinal blockade. Correct
It is contraindicated in benign intracranial hypertension . Correct
It can impair the ability to cough. Correct
Barbotage involves the repeated aspiration and reinjection of cerebrospinal fluid (CSF) into the syringe whilst injecting the hyperbaric local anaesthetic solution, which increases the spread of the block. Pregnancy increases the spread of the block due to reduced CSF volume and compressed epidural space. In the UK hyperbaric bupivacaine 0.5% (in 8% dextrose) which has a specific gravity of 1.026, is the only hyperbaric local anaesthetic licensed for use in spinal anaesthesia. Epidural and subarachnoid blocks may be safely undertaken in patients with benign intracranial hypertension. Intercostal and abdominal muscle weakness may impair active exhalation and coughing, although tidal volume and inspiratory pressure are maintained by intact diaphragmatic innervation (C3-5).
Question: 13 of 53
Time taken: 47 mins 19 secs
Lidocaine:
True / False
Is an amide local anaesthetic and contains an intermediate (-NH.CO-) chain. Correct
Is hydrolysed by plasma cholinesterase before being broken down in the liver. Correct
Has a pKa of 8.1 Correct 7.7 not 8.1
Is achiral. Correct
Transfers across the placenta less than bupivacine. Correct more than bupivacine (not less).
Lidocaine is an achiral amide local anaesthetic and contains a lipophilic aromatic group, an intermediate amide (-NH.CO-) chain and a hydrophilic group.
Amide local anaesthetics are broken down by amidases in the liver, whereas ester local anaesthetics are rapidly hydrolysed by plasma cholinesterase. The pKa of lidocaine is 7.7. In general, highly protein-bound drugs have a low umbilical vein to maternal blood ratio (uv:m). The uv:m ratio for bupivacaine is approximately 0.2; and for lidocaine and Prilocaine it is 0.5. Therefore, lidocaine transfers across the placenta more than bupivacine (not less).
Question: 14 of 53
Time taken: 48 mins 40 secs
Regarding chiral local anaesthetics:
True / False
Prilocaine and bupivacaine are chiral compounds. Correct
The S (-) enantiomer usually has higher local anaesthetic activity Correct
The S (-) enantiomer has a longer duration of local anaesthetic activity. Correct
The R (-) enantiomers may have reduced potential for toxicity when compared with the racemic drug. Correct
S (-) bupivacaine is available for clinical use. Correct
Prilocaine and bupivacaine are chiral compounds. Most ester local anaesthetics, as well as lidocaine are achiral. Individual enantiomers have approximately equal local anaesthetic activity, although R (+) bupivacine may be more potent than the S (-) enantiomer. The S (-) enantiomers produce enhanced vasoconstriction and have prolonged local anaesthetic activity; they may also be less cardiotoxic. The S (-) enantiomers (nor R) may have reduced potential for toxicity when compared with the racemic mixture of the drug. Chirocaine is the S (-) enantiomer of bupivacaine and is commercially available for clinical use.
Question: 15 of 53
Time taken: 49 mins 56 secs
Field block for inguinal hernia repair:
True / False
Requires blockade of the iliohypogastric and ilioinguinal nerves Correct
Requires blockade of the subcostal nerve Correct
Requires blockade of the genital branch of the genitofemoral nerve Correct
Involves blocking dermatomes S2-S4 Correct
Prilocaine 0.5% with adrenaline is a suitable choice of local anaesthetic agent Correct
A field block for an inguinal hernia repair is ideal for high risk patients unsuited for general or spinal anaesthesia. The innervation of the inguinal region is through the ventral rami of T11 and T12 and the two upper branches of the lumbar plexus, the iliohypogastric and ilioinguinal nerves. The anterior cutaneous branch of the iliohypogastric nerve supplies the skin above the pubis and medial end of the inguinal ligament. The ilioinguinal nerve supplies the skin over the root of the penis and scrotum. The ventral ramus of the 12th thoracic or subcostal nerve sends a branch to join the first lumbar root and supplies the skin over the lower anterior abdominal wall. The genital branch of the genitofemoral nerve may supply skin in the medial part of the groin. Prilocaine 0.5% with adrenaline is a suitable choice of agent, which allows a large volume of solution to be used safely.
Question: 16 of 53
Time taken: 54 mins 29 secs
Concerning Intravenous Regional Anaesthesia (IVRA - Bier’s Block):
True / False
The use of a double cuff prevents any chance of systemic toxicity if it remains inflated for at least 20 minutes. Correct
Pre-operative starvation of patients is not necessary. Correct
Methaemoglobinaemia may be seen after IVRA using 40mls of 0.5% prilocaine Correct
Bupivacaine or prilocaine are most commonly used due to their long duration of action. Correct
Bier’s block can be performed on the lower leg for some types of ankle or foot surgery Correct
There have been reports of convulsions and systemic side effects despite a functioning double cuff. This may be due to rapid injection of local anaesthetic achieving injection pressures higher than the tourniquet occlusion pressure, resulting in systemic leakage causing high plasma levels of local aneasthetic. Interosseous leakage and poor exsanguination of the limb may also contribute to this. It is recommended that the patient is fully starved prior to IVRA or any regional block, due to the risks of systemic toxicity. Neither systemic toxicity nor methaemoglobinaemia have ever been reported at this dose of prilocaine. Bupivacaine should not be used because of the risk of cardiotoxity. Prilocaine is the recommended agent for IVRA, but lidocaine has also been used. With a tourniquet placed at mid-calf level, the technique of IVRA and dose of local anaesthetic used is identical to that of upper limb Bier’s block. IVRA of the lower limb is much less widely used and it is said that the anaesthesia is less reliable than when performed on the arm.
Question: 17 of 53
Time taken: 59 mins 29 secs
When setting initial ventilator settings in Critical Care:
True / False
an oxygen concentration of 60% should be used to avoid oxygen toxicity Correct
positive end-expiratory pressure (PEEP) should be titrated against pCO2 Correct
the pCO2 should be targeted and not the pH Correct
a tidal volume of less than 5ml per kg should be used to prevent volutrauma Correct
neuromuscular blockade may need to be used Correct
The initial oxygen concentration delivered to the patient should be 100% (or an FIO2 of 1.0) which can then be titrated down. Positive end-expiratory pressure should be titrated against pO2 (not pCO2). The minute ventilation should be used to target pH, permissive hypercapnia may be used. Tidal volumes should be about 8 ml per kg. Using tidal volumes of <5ml per kg does prevent volutrauma, but also results in hypoventilation. Many patients can be ventilated providing they are adequately sedated, which subsequently allows neuromuscular blockade to be reserved for difficult patients.
Question: 18 of 53
Time taken: 1 hrs 2 mins 3 secs
A high mixed venous oxygen saturation (SvO2) may be caused by:
True / False
sepsis Correct
anaemia Correct
hyperthermia Correct
shivering Correct
cardiogenic shock Correct
A mixed venous oxygen saturation (SvO2) >80% is considered high, and is caused by high oxygen delivery e.g. a high FiO2 and a decreased O2 demand e.g. anaesthesia, hypothermia and decrease O2 tissue uptake (as in sepsis).
Question: 19 of 53
Time taken: 1 hrs 4 mins 17 secs
IgE:
True / False
Is present in plasma in the same concentration as IgG Correct
Is increased acutely in an asthmatic attack Correct
Crosses the normal placenta Correct No
Is increased in the serum of atopic individuals Correct
Is involved in type 2 hypersensitivity Correct type I hypersensitivity reaction (not 2).
IgG is the predominant form of immunoglobulin in plasma at a concentration around 10,000 times greater than IgE. IgG crosses the placenta to confer immunity to the fetus ( not IgE). IgE is involved in arming mast cells and basophils. IgE causes mast cells to release vasoactive amines, such as histamine, producing an inflammatory response which can result in a type I hypersensitivity reaction (not 2). IgE is responsible for allergen-mediated diseases such as anaphylaxis, asthma and atopy. Total serum IgE is frequently increased in those with atopy, but serum IgE does not rise acutely during an asthmatic attack.
Question: 20 of 53
Time taken: 1 hrs 5 mins 55 secs
Magnesium:
True / False
causes vascular smooth muscle relaxation Correct
is predominantly an intracellular cation Correct
is a tocolytic Correct
potentiates deep tendon reflexes Correct
is used as an anticonvulsant Correct
Magnesium is largely an intracellular cation, present mainly in bone and skeletal muscle. Only 1% is in the ECF and normal plasma level are 0.75 – 1.05 mmol/l. Its effect can be described as antagonising the actions of calcium. Magnesium sulphate is used in pre-eclampsia as an anticonvulsant but it also relaxes vascular smooth muscle, causing vasodilatation thus lowering the mean arterial blood pressure. It is also an effective tocolytic drug helping to decrease uterine contractions. It acts at the neuromuscular junction decreasing acetylcholine release thus neuromuscular function is weakened. Therapeutic plasma levels of magnesium are 2.0 - 3.5 mmol/l, but side effects may occur above 4.0 mmol/l. Increasing plasma levels of magnesium cause deep tendon reflexes to gradually diminished until they become absent. Thus tendon reflexes are frequently used as a bed-side measurement of hypermagnesaemia.
Question: 21 of 53
Time taken: 1 hrs 7 mins 34 secs
Regarding a LASER:
True / False
Is an acronym for Light Amplification of Stimulated Ejection of Radiation. Correct Emission
Produces multichromatic light. Correct monochromatic
Requires a pair of mirrors at opposite ends of a optical cavity containing the lasing medium Correct
The wavelength is determined by the stimulating current Correct The lasing medium notthe current
The lasing medium can be gaseous or crystalline. Correct
Is an acronym for Light Amplification of Stimulated Emission of Radiation. A Laser produces a highly directional beam of coherent (monochromatic) electromagnetic radiation. Photons of energy produced from energised atoms in the lasing medium are reflected back and forth many times between the mirrors amplifying their number. The lasing medium determines the wavelength of electromagnetic radiation emitted. The lasing medium is most commonly gaseous but may be crystalline.
Question: 22 of 53
Time taken: 1 hrs 9 mins 21 secs
Regarding polycythaemia:
True / False
It may be caused by smoking. Correct
There is a reduced risk of DVT. Correct
There is often splenic enlargement Correct
There is an increased risk of myocardial infarction. Correct
Gastrointestinal haemorrhage may occur. Correct
Polycythaemia is an increase in the concentration of red blood cells above the normal level. Polycythaemia may be primary, secondary (chronic hypoxia stimulates erythropoetin), relative (reduced plasma volume, normal red cell mass) or inappropriate (inappropriate erythropoetin production). Polycythaemia leads to increased blood viscosity and sluggish blood flow, resulting in increased risk of myocardial infarction, stroke, ischaemic limbs and DVT. Approximately 75% of patients will have splenic enlargement. Peptic ulceration is common in polycythaemia rubra vera (primary). Haemorrhagic lesions may be a feature of the condition, especially of the GI tract.
Question: 23 of 53
Time taken: 1 hrs 12 mins 58 secs
Regarding hyperventilation:
True / False
it may cause an increase in the blood pH Correct
it may occur following cerebral injury Correct
it raises the pCO2 of arterial blood Correct
it decreases the pO2 of arterial blood Correct
it decreases concentration of ionised calcium Correct
Hyperventilation is associated with a respiratory alkalosis that will raise the blood pH, lower arterial pCO2 and may elevate the arterial pO2 (not decrease). Cerebral injury may initially precipitate hyperventilation, although depressed respiration and hypoventilation is the predominant feature. The raised pH reduces ionised calcium concentrations, which is why tetany can occur in association with hyperventilation.
Question: 24 of 53
Time taken: 1 hrs 13 mins 59 secs
Immunoglobulins:
True / False
Contain antigen-binding sites derived solely from the light chains Correct
Contain Fc regions derived solely from the heavy chains. Correct
Are chiefly of IgA class at mucosal surfaces. Correct
Are produced by T lymphocytes as well as B lymphocytes Correct
IgE confers protection against parasitic worms. Correct
The antigen binding sites on immunoglobulins are composed of the hypervariable regions of both heavy and light chains which together make the complementarity determining region (CDR) of the antibody. The Fc is made up of two H chains, linked by disulphide bonds. IgA (actually IgA2), constitutes the major antibody in secretions, and bathes mucosal surfaces. IgA1 is mainly confined to the serum. Only B lymphocytes are capable of synthesising antibodies, as are plasma cells. Worm antigens are constantly being released, and attach to specific IgE antibody that in turn has attached to mast cells by their receptor for IgE. Interactions with IgE results in mediator release by the mast cell, one effect of which is contraction of smooth muscle, which is intended to expel the parasite from the gut.
Question: 25 of 53
Time taken: 1 hrs 16 mins 10 secs
Regarding acquired (adaptive) immunity:
True / False
Immunological recognition is an important component. Correct
Antibody is produced by T cells. Correct
Recognition of antigen by B cells is mediated by antibody. Correct
Antibodies produced in response to infection recognise more than one epitope on the surface of the invading micro-
organisms. Correct
Elimination of intracellular micro-organisms is dependent on antigen. Correct
The B cell receptor is an immunoglobulin of the same specificity as the one the cell is programmed to make. Antigen binding to this leads to B cell activation and antibody production. The elimination of intracellular micro-organisms is cell mediated and depends on affected cells displaying particular antigens at their cell surface allowing the killing of the cell by antigen-specific cytotoxic T-cells. Antibodies produced in response to infection recognise more than one epitope on the surface of the invading micro-organisms.
Question: 26 of 53
Time taken: 1 hrs 17 mins 41 secs
Cryoglobulins:
True / False
cause red cell agglutination at 4°C Correct
are a cause of arterial thrombi Correct
are seen in mycoplasma pneumonia Correct
are seen in subacute bacterial endocarditis Correct
are associated with hepatitis B and C Correct
Cryoglobulins are immunoglobulins that reversibly precipitate below 10°C, they are not cold agglutinins. They may cause:
hyperviscosity and vasculitis, Raynauds, arterial thrombi, gangrene, retinal haemorrhages. Three tyes exist: Type 1 are
usually IgM/IgG (monoclonal) which are seen in Waldenstrom's, lymphoproliferative disease; Type II (monoclonal IgM
rheumatoid factor plus polyclonal IgG) are seen in bacterial endocarditis, Hepatitis C, Hepatitis B, Epstein-Barr, and CMV;
Type III (polyclonal IgM rheumatoid factor plus polyclonal IgG) are seen in spirochaetal disease, coccidiomycosis, malaria,
SLE, rheumatoid, Sjogrens, scleroderma and mixed essential cryoglobulinaemia. Cold agglutinins cause red cell
agglutination at 4°C and may be seen in mycoplasma pneumonia.
Question: 27 of 53
T cells:
True / False
survive for two weeks Correct
possess surface immunoglobulin Correct
secrete IL-2 when activated Correct
secrete immunoglobulin Correct
recognise native antigen. Correct
T cells have characteristic surface glycoproteins and their own form of receptors. Helper T cells recognise foreign antigens in association with HLA class II antigens on presenting cells. Survival of T cells varies from several weeks to the lifetime of an individual, such as the T cells in thymus. They secrete IL-2 when activated. B-lymphocytes express immunoglobulins on their surface and secrete immunoglobulins (not T cells).
Question: 28 of 53
Time taken: 1 hrs 21 mins 38 secs
A pre-operative 12 lead ECG is required in the following patients:
True / False
a 40-year-old female with essential hypertension Correct
a 30-year-old male for an inguinal hernia repair Correct
a healthy 45-year-old male who smokes 20 cigarettes per day Correct
an obese 35-year-old male with exercise induced dyspnoea Correct
a 50-year-old female with a permanent pacemaker for a knee replacement Correct
As a rule all patients over the age of 40 require a 12 lead ECG preoperatively, even if a history of cardio-respiratory disease is absent. Hypertension can cause left ventricular hypertrophy which can be identified on the ECG by a large R wave in V6 and large S wave in V1 (combination greater than 35 mm). Patients with permanent cardiac pacemakers always require a preoperative 12 lead ECG, in addition to a pacemaker check 6 months prior to elective surgery. Useful information can be obtained from the ECG about the type of pacemaker and its programming. Dyspnoea may be secondary to cardiac rather than respiratory disease making an ECG essential. The usual speed of recording of an ECG is 25 mm per second and the calibration is 1 milivolt per cm.
Question: 29 of 53
Time taken: 1 hrs 23 mins 4 secs
Regarding urine or urine production:
True / False
urine production is normally about 1 ml per kg per day Correct
oliguria is defined as urine production of less than 0.5 ml per kg per hour Correct
large doses of intravenous propofol may turn the urine green Correct
the pigments urochrome and uroerythrin give urine its yellow colour Correct
urine normally contains bilirubin Correct
Urine is coloured yellow by the pigments urochrome and uroerythrin, but it darkens on standing due to the oxidation of urobilinogen to urobilin. Abnormal constituents of urine include glucose, ketones, bilirubin, erythrocytes, large numbers of leucocytes and casts. The urine of patients on longterm sedation using propofol is frequently coloured green. Normal urine output in temperate climates is 800 – 2500 ml per day, which is about 1 ml/kg per hour. Despite the concentrating ability of the kidney, a minimum of 500 ml/day is required to eliminate the urea and other electrolytes. Oliguria is defined as a urine production < 0.5 ml/kg per hour (approx less than 50mls), and may indicate hypovolaemia or renal failure.
Question: 30 of 538118
Hypothermia:
True / False
is a core temperature of less than 34°C Correct less than 35°C
is rarely seen in children as they have a higher basal metabolic rate Correct
can cause atrial fibrillation Correct
can cause J waves on the ECG Correct
is commonly associated with alcohol intoxication Correct
Hypothermia is defined as a core temperature of less than 35°C. Children have a relatively large body surface area to weight ratio and even thought they have a higher basal metabolic rate, they are very susceptible to hypothermia. Alcohol and anaesthetic gases cause vasodilatation thus increase heat loss. As the core temperature continues to fall the cardiac rhythm becomes increasingly unstable, sinus bradicardia tends to give way to atrial fibrillation followed by ventricular fibrillation and finally asystole. In hypothermic patients, J waves are frequently seen on the ECG.
Question: 31 of 53
Time taken: 1 hrs 27 mins 52 secs
8117
Hypercalcaemia is associated with:
True / False
hypoparathyroidism Correct
thiazide diuretics Correct
hyperthyroidism Correct
sarcoidosis Correct
adrenocortical insufficiency Correct
Hypercalcaemia is commonly caused by hyperparathyroidism and malignant tumours (especially bone secondaries). Less common causes include milk-alkali syndrome, hyperthyroidism, sarcoidosis, adrenocortical insufficiency, immobilization and thiazide diuretics.