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![Page 1: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/1.jpg)
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Four levels of measurement
Nominal
Ordinal
Interval
Ratio
Nominal: the lowest level
Ordinal
Interval
Ratio: the highest level
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Classic Parametric Setting
For the classic ANOVA, we assume we are sampling from normally distributed populations with identical variances. From here we test the hypothesis:
H(0):μ1= μ2 = μ3 (All distributions are identical) or μ1- μ overall = 0, μ2 - μ overall = 0, μ3 - μ overall =0
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Nonparametric Setting
H(0): F0 = F2 = F4 = F6 = F8 (Identical Distributions) orF0 - H = 0, F2 - H = 0, F4 - H = 0, F6 - H = 0, F8 - H = 0where H is the overall average distribution.
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Settings for Nonparametric Tests
• When data are very non-normal (e.g. very skewed, or presence of outliers)
• If you suspect the variable is not normally distributed in the population
• When you have ordinal data and are interested in comparing distributions and their relationships.
• If other assumptions of parametric tests are violated (e.g. homogeneity of variance, ordinal
• data)
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Nonparametric Methods
• Can provide invariant results when strictly monotone transformations of the data are used.
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Gamma GT StudyNote Non Constant Variance, Outliers, and Heavily Skewed Distributions
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Gamma GT MeansOriginal data means, means of ln(x), and means of ln(ln(x)). Note reversal of treatment means. Nonparametric gives same result for all 3 ‘versions’ of the data
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Nonparametric Methods
• Absence of variability in treatment groups is admitted
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Panic 2 Study. Note skewed distributions, outliers, andzero variance at Week 10.
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Nonparametric Methods
• Can provide approximations for small sample sizes
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Nonparametric Methods
• Can be performed using SAS macros
• “Proc Mixed”
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Disadvantages - Advantages
• Lesser power relative to corresponding parametric test (when assumptions of the parametric test are met)
• When assumptions of parametric tests are not met nonparametric methods can be more powerful
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Definition of Probability ‘Distributions’
Probability Distribution Function (f): A function that assigns a probability to each possible outcome.
P(X = Some particular set of values of x) for all possible x
Cumulative Probability Distribution Function (F): A function that assigns a probability to a value less than or equal to each possible outcome.
P(X some particular value of x) for all possible x
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Empirical Distribution Function F
If we have a sample from a ‘Parent Distribution’ F, our estimate of F from the sample is the Empirical Distribution Function, denoted F hat.
iF̂
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Panic1 Study Empirical Normalized Dist. Functions
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Relative Effects P(i)The empirical distribution functions F(i), do provide information to detect differences among the different group distributions.
But there exists a summary measure that describes thelikelihood that values from one distribution tend to be greater or lesser than the overall mean distribution H. This measure is called:
the ‘Relative Effect’ for group i.
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Interpretation of Relative Effects p(i)
The relative effect p(i) quantifies the tendency of the marginal distribution F(i) with respect to the overall average distribution H.
If F(i) tends to lie in the region to the left of H then p(i) < 0.5.
If F(i) tends to lie in the region to the right of H then p(i) > 0.5.
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Calculation of Estimated Relative Effects: A function of the ranks
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The Relationship of the Distribution function F(i), p(i),
and μ (i)
a
aP
aF
H
and
pppH
FFFH
...:
...:
...:
210
210
210
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Covariance Matrix Notes:
1. A covariance matrix must have an inverse in orderto calculate many multivariate stats (Wald, Hotelling).
2. A covariance matrix of a set of variables in which onevariable has ZERO variance will not have an inverse.
3. Both of the above types of covariance matrices have a TRACE, the sum of the diagonal elements.
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Row t0 t2 t4 t6 t8
1 8 6 5 5 4 2 8 6 5 4 2 3 6 5 5 4 2 4 6 6 6 5 5 5 7 6 6 6 6 6 8 7 3 2 2 7 7 6 7 3 3 8 6 4 5 3 3 9 5 4 3 3 2 10 8 6 5 5 4 11 7 6 5 4 2 12 6 5 5 4 2 13 6 6 6 5 5 14 8 6 6 6 6 15 8 7 4 2 2 16 7 6 7 3 3
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Row t0 t2 t4 t6 t8
1 8 6 5 5 4 2 8 6 5 4 2 3 6 5 5 4 2 4 6 6 6 5 5 5 7 6 6 6 6 6 8 7 3 2 2 7 7 6 7 3 3 8 6 4 5 3 3 9 5 4 3 3 2 10 8 6 5 5 4 11 7 6 5 4 2 12 6 5 5 4 2 13 6 6 6 5 5 14 8 6 6 6 6 15 8 7 4 2 2 16 7 6 7 3 3
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Panic1 Study Empirical Normalized Dist. Functions
![Page 27: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/27.jpg)
Relative Effects P(i)The empirical distribution functions F(i), do provide information to detect differences among the different group distributions.
But there exists a summary measure that describes thelikelihood that values from one distribution tend to be greater or lesser than the overall mean distribution H. This measure is called:
the ‘Relative Effect’ for group i.
![Page 28: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/28.jpg)
Interpretation of Relative Effects p(i)
The relative effect p(i) quantifies the tendency of the marginal distribution F(i) with respect to the overall average distribution H.
If F(i) tends to lie in the region to the left of H then p(i) < 0.5.
If F(i) tends to lie in the region to the right of H then p(i) > 0.5.
![Page 29: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/29.jpg)
Calculation of Estimated Relative Effects: A function of the ranks
![Page 30: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/30.jpg)
The Relationship of the Distribution function F(i), p(i),
and μ (i)
a
aP
aF
H
and
pppH
FFFH
...:
...:
...:
210
210
210
![Page 31: Four levels of measurement Nominal Ordinal Interval Ratio 4 Nominal: the lowest level 4 Ordinal 4 Interval 4 Ratio: the highest level.](https://reader035.fdocuments.in/reader035/viewer/2022062500/56649d835503460f94a69154/html5/thumbnails/31.jpg)
Panic1 Empirical Normalized Distributions F(i)
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Panic1 Estimated Relative Effects for P(i) and 95% CI’s
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data panic1;input patient t1-t5;array t{5} t1-t5;do i=1 to 5; week=(i-1)*2; score=t{i};output; end;drop i t1-t5;datalines;1 8 6 5 5 4 2 8 6 5 4 2 3 6 5 5 4 2 4 6 6 6 5 5 5 7 6 6 6 6 6 8 7 3 2 2 7 7 6 7 3 3 8 6 4 5 3 3 9 5 4 3 3 2 10 8 6 5 5 4 11 7 6 5 4 2 12 6 5 5 4 2 13 6 6 6 5 5 14 8 6 6 6 6 15 8 7 4 2 2 16 7 6 7 3 3 ;run;
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Obs patient week score 1 1 0 8 2 1 2 6 3 1 4 5 4 1 6 5 5 1 8 4 6 2 0 8 7 2 2 6 8 2 4 5 9 2 6 4 10 2 8 2 . . . . . . . . . . . . 71 15 0 8 72 15 2 7 73 15 4 4 74 15 6 2 75 15 8 2 76 16 0 7 77 16 2 6 78 16 4 7 79 16 6 3 80 16 8 3
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%include 'E:\nonparametric\SAS Macros\ld_f1.sas';
%ld_f1(data=panic1, var=score, time=week, subject=patient, var_pt=_no_, time_pt=_no_); run;
%include 'E:\nonparametric\SAS Macros\ld_ci.sas';
%ld_ci(data=panic1, var=score, time=week, subject=patient, alpha=0.05); run;
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LD_1F --- subjects x T
T: fixed, subjects: random
SAS-data-filename: panic1
response-variable: score
Class Level Information
CLASS LEVELS
T WEEK 5
Total number of observations 80
Total number of subjects 16
Number of missing values 0
RTE = relative treatment Effects
Nobs = Number of observations (do not count
the repeated measurements within the cells)
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Source Time Rank means Nobs RTE
week 0 66.094 16 .81992
week 2 50.500 16 .62500
week 4 41.281 16 .50977
week 6 25.625 16 .31406
week 8 19.000 16 .23125
The SAS System 10
17:29 Friday, October 3, 2003
----------------------------------------------------------
Statistics df1 df2 p-value
Wald Chi^2(df1) 126.69 4.0000 . .00000
Hotelling F(df1,df2) 25.339 4.0000 12.000 .00001
Anova Chi^2(df1)/df1 36.937 2.2341 . .00000
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The SAS System 11
17:29 Friday, October 3, 2003
LD_CI
Bias-Estimation and Confidence-Intervals for Relative Effects
SAS-Data-Filename: panic1
Response-Variable: score Observations: 80
Group-Variable: _none_ Groups: 1
Time-Variable: week Timepoints: 5
Subject-Variable patient Subjects: 16
Relative Effects, Biases, Variances and Confidence-Limits (alpha=0.05)
Time RE Bias Variance lower upper
0 .81992 .00284 .00768 .76566 .85379
2 .62500 -.0008 .01571 .56079 .68278
4 .50977 .00310 .02512 .43271 .58610
6 .31406 -.0018 .00800 .27316 .36061
8 .23125 -.0033 .01597 .18033 .30524