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ANTIBODIESMedixMAB™

FAB-FRAGMENTSMedixMAB™

ANTIGENSMedix

™

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CARDIOVASCULAR MARKERS .......................................................4Cardiac troponin I (cTnI) Cardiac troponin T (cTnT)Copeptin Creatine kinase (CK-MB)D-dimerFatty-acid-binding protein 3 (FABP3)Galectin-3Myeloperoxidase (MPO)MyoglobinN-terminal prohormone & prohormone of natriuretic peptide (NT-proBNP & proBNP)S100BST2

DIABETES & METABOLISM ...........................................................8AdiponectinAlbuminApolipoprotein A1 (ApoA1)Apolipoprotein B (ApoB)C-peptideFerritinGlycated hemoglobin (HbA1c)LactoferrinTransferrin

HORMONES ..............................................................................10Alpha subunitChorionic gonadotropin (HCG)Follicle-stimulating hormone (FSH)Growth hormone (GH)Luteinizing hormone (LH)Progesterone (PR)Prolactin (PRL)Sex hormone-binding globulin (SHBG)

INFECTIOUS DISEASES................................................................12Bocavirus (hBoV)Chlamydia trachomatisCoronavirusHepatitis B virus (HBsAg)Influenza A

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Influenza BPlasmodium falciparum HRP2Respiratory syncytial virus (RSV)

INFLAMMATION ........................................................................14Alpha 1-antitrypsin (AAT)C-reactive protein (CRP)CalprotectinInterleukin-6 (IL-6)Interleukin-8 (IL-8)LactoferrinProcalcitonin (PCT)Serum amyloid A (SAA)TransferrinTrypsinogen-2

KIDNEY MARKERS .....................................................................17Cystatin C Neutrophil gelatinase-associated lipocalin (NGAL)

SEROLOGY ................................................................................18Immunoglobulin A (IgA)Immunoglobulin E (IgE)Immunoglobulin G (IgG)Immunoglobulin M (IgM)

THYROID ..................................................................................19ThyroglobulinThyroid-stimulating hormone (TSH)Thyroxine (T4)

TUMOR MARKERS .....................................................................20Alpha-fetoprotein (AFP)Cancer antigen 15-3 (CA15-3)Cancer antigen 125 (CA125)Carbohydrate antigen 19-9 (CA19-9)Carcinoembryonic antigen (CEA)CYFRA21-1Hemoglobin (Hb)Human epididymis protein 4 (HE4) Neuron-specific enolase (NSE)Pepsinogen (PG I & II)Prostate-specific antigen (PSA)

All product specifications can be found online: www.medixbiochemica.com

* Concentration: mg/ml (+/- 10%)4

CARDIOVASCULARMARKERS PRODUCT CONC.* REF.

Cardiac troponin I (cTnI)

Troponins form a complex (Troponin C, I and T) and are involved in muscle contraction. Troponin levels can be used as a test for several different heart disorders, including myocardial infarction.

MONOCLONAL ANTIBODIES

MAB 9701 5 100129MAB 9703 5 100181MAB 9705 1 100125MAB 9707 5 100180MAB 9708 5 100523MAB 9709 5 100524

FAB-FRAGMENTFAB 9707 600000

RECOMBINANT ANTIGENcTnI antigen 610102 NEW

Cardiac troponin T (cTnT)

Troponins form a complex of three regulatory proteins (troponin C, I and T) that are integral to muscle contraction in skeletal and cardiac muscles. Serum cardiac troponin tests can be used to help diagnose several different heart disorders, especially myocardial infarction.

MONOCLONAL ANTIBODIESMAB 37XX TBD TBD

RECOMBINANT ANTIGENcTnT antigen 610101 NEW

Copeptin

is a 39-amino acid glycopeptide, cleaved from the C-terminus of pre-provasopressin (pre-proAVP). It has been suggested as a biomarker in diagnosis and prognosis of several diseases, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.

MONOCLONAL ANTIBODIESMAB 4801 TBD TBDMAB 4802 TBD TBDMAB 4804 TBD TBDMAB 4806 TBD TBD

Creatine kinase (CK-MB)

is a dimeric enzyme consisting of two subunits, which can be either B (brain type) or M (muscle type). CK-MB is used for diagnosis of myocardial infarction.

MONOCLONAL ANTIBODIESMAB 7501 5 100630MAB 7502 5 100086

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All product specifications can be found online: www.medixbiochemica.com 5


D-dimer

is a small degradation product of cross-linked fibrin. D-dimer is released in the blood during fibrinolysis and it is used to diagnose pulmonary embolism and deep vein thrombosis.

MONOCLONAL ANTIBODIESMAB 1401 5 100204MAB 1402 5 100205MAB 1403 5 100228MAB 1404 5 100479MAB 1405 5 100480MAB 1406 5 100481MAB 1407 5 100482

Fatty-acid-binding protein 3 (FABP3)

is a family of carrier proteins for fatty acids and other lipophilic substances. Heart-FABP (FABP3) can be used as a diagnostic marker in the early phase of acute myocardial infarction.

MONOCLONAL ANTIBODIESMAB 2302 5 100292MAB 2303 5 100293MAB 2304 5 100294

RECOMBINANT ANTIGENFABP3 antigen 610043

Galectin-3

is a beta-galactosidase- binding lectin. The expression of galectin-3 is upregulated during inflammation. It is used in assessing the prognosis of patients diagnosed with chronic heart failure. Galectin-3 is also involved in pathological processes including cancer, fibrosis and chronic inflammation.

RECOMBINANT ANTIGENGalectin-3 antigen TBD

Myeloperoxidase (MPO)

is an enzymatic mediator of inflammatory cascades and microbial killing. Higher serum levels of MPO have been associated with cardiovascular diseases.


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Myoglobin

is an intracellular protein transporting oxygen in the cardiac and skeletal muscle cells. Myoglobin is one of the earliest biomarkers of cardiac injury.


RECOMBINANT ANTIGENMyoglobin antigen 610030

N-terminal prohormone and prohormone of natriuretic peptide (NT-proBNP & proBNP)

The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-ProBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction.

MONOCLONAL ANTIBODYMAB NT-proBNP 1306 5 100521

FAB-FRAGMENTFAB NT-proBNP 1306 600025

RECOMBINANT ANTIGENNT-proBNP antigen 610090proBNP antigen 710017 NEW

S100B

belongs to the family of dimeric calcium-binding S100 proteins. S100B is a biomarker for traumatic brain injury.

RECOMBINANT ANTIGENS100B antigen 710014 NEW

ST2

is a member of interleukin-1 receptor family. ST2 protein has two isoforms: a soluble (sST2) and membrane- bound form. Patients with heart failure and elevated sST2 protein levels in the blood are at risk for heart failure progression.

RECOMBINANT ANTIGENST2 antigen 710020 NEW


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DIABETES & METABOLISM PRODUCT CONC.* REF.

Adiponectin

is a protein hormone that modulates a number of metabolic processes that may lead to type 2 diabetes, obesity, atherosclerosis, and non-alcoholic fatty liver disease.


RECOMBINANT ANTIGENAdiponectin antigen 710013 NEW

Albumin

normally constitutes about 60% of human plasma proteins and is produced in the liver. It is important in regulating blood volume, and also serves as carriers for molecules in blood.


Apolipoprotein A1 (ApoA1)

is a major component of the high-density lipoproteins (HDL) complex. ApoA1 helps clear cholesterol from arteries. ApoA1 has been suggested as a better discrimination of coronary artery disease than HDL.


RECOMBINANT ANTIGENApoA1 antigen 710012 NEW

Apolipoprotein B (ApoB)

is the primary apolipoprotein of low-density lipoproteins (LDL), which is responsible for carrying cholesterol to tissues. High levels of ApoB can lead to plaques that cause atherosclerosis.

MONOCLONAL ANTIBODYMAB 2101 5 100261

C-peptide

is produced when proinsulin is split into insulin and C-peptide. C-peptide can be used to help determine how much insulin the patient’s pancreas is still producing.



DIABETES & METABOLISM PRODUCT CONC.* REF.

Ferritin

binds and stores iron. It releases iron in controlled fashion normally preventing iron deficiency and iron overload in humans. The amount of ferritin in the serum is measured in relation to some chronic diseases and anemia.


Glycated hemoglobin (HbA1c)

is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. Higher levels are found in people with persistently elevated blood sugar, as in diabetes.


Lactoferrin

Lactoferrin is an antimicrobial protein, also known as lactotransferrin, which transfers iron to the cells. It is used in a faecal test to detect inflammation in the intestine. Lactoferrin levels are associated with disease severity in intestinal bowel disease (IBD).

RECOMBINANT ANTIGENLactoferrin antigen 710016 NEW

Transferrin

regulates the amount of free iron in circulation. Transferrin concentration elevates in anemia, but can be also be used to diagnose other clinical conditions.


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HORMONES PRODUCT CONC.* REF.

Alpha subunit

of LH, FSH, TSH, and HCG is identical. The biological activity of these hormones is evoked by the specific beta subunit.


Chorionic gonadotropin (HCG)

is a glycoprotein hormone produced in pregnancy and commonly utilized for early pregnancy testing. Testing for HCG may also be done when diagnosing or monitoring some tumors.

MONOCLONAL ANTIBODIESHCG beta:MAB 5004 5 100004MAB 5006 5 100005MAB 5008 5 100006MAB 5011 1 100009MAB 5014 5 100011MAB 5016 5 100013

HCG complex:MAB 5009 5 100008

HCG free beta:MAB 5012 5 100368

Follicle-stimulating hormone (FSH)

regulates the development, growth, pubertal maturation, and reproductive processes of the body. It is used to diagnose problems in the reproductive system.


Growth hormone (GH)

is a single-chain polypeptide hormone. Growth hormone is used clinically to diagnose and treat children’s growth disorders and adult growth hormone deficiency.



HORMONES PRODUCT CONC.* REF.

Luteinizing hormone (LH)

is essential for reproduction in both sexes. LH is measured to detect abnormalities in sexual development and reproductive functions.

MONOCLONAL ANTIBODIESMAB 5301 5 100016MAB 5302 1 100018MAB 5303 1 100019MAB 5304 5 100022

Progesterone (PR)

is a steroid hormone needed for normal reproduction. Progesterone levels are monitored during pregnancy and for an indication of ovarian cancer.


Prolactin (PRL)

is a peptide hormone primarily associated with lactation. Prolactin is usually measured when checking for pituitary tumors or the cause of abnormal milk production.


Sex hormone-binding globulin (SHBG)

binds to sex hormones, specifically testosterone and estradiol. Abnormally low or high SHBG levels are used to diagnose several non-physiological conditions.


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INFECTIOUS DISEASES PRODUCT CONC.* REF.

Bocavirus (hBoV)

is a member of the Parvoviridae virus family. It is a newly described human pathogen that has been associated especially with lower respiratory tract and gastrointestinal infections, predominantly in children.


Chlamydia trachomatis

is an intracellular pathogen and can cause numerous disease states in both men and women, such as urethritis, proctitis, trachoma, and infertility.


Coronavirus

is believed to cause a significant percentage of all common colds in human adults. Coronaviruses primarily infect the upper respiratory and gastrointestinal tract.

MONOCLONAL ANTIBODIESHCoV 229E: MAB 3501 5 100528MAB 3502 5 100529

HCoV OC43:MAB 3503 5 100530MAB 3504 5 100531MAB 3505 5 100532MAB 3506 5 100533

RECOMBINANT ANTIGENSHCoV OC43 N 610040HCoV NL63 N 610041HCoV HKU1 N 610042HCoV 229E N 610091 NEW

Hepatitis B virus (HBsAg)

causes liver inflammation, and chronic hepatitis B may eventually cause liver cirrhosis and liver cancer. The first detectable viral antigen to appear during infection is hepatitis B surface antigen (HBsAg).

MONOCLONAL ANTIBODIESMAB 2503 5 100351MAB 2505 5 100352MAB 2507 5 100502MAB 2508 5 100504MAB 2510 5 100568


INFECTIOUS DISEASES PRODUCT CONC.* REF.

Influenza A

is the most common cause of influenza, flu pandemics and most epidemics. Influenza A virus causes influenza in birds and some mammals.


Influenza B

causes also seasonal epidemics but it is only known to infect humans and seals. This limited host range is apparently responsible for the lack of Influenza B caused pandemics.


Plasmodium falciparum HRP2 (Malaria)

is a histidine-rich protein secreted by the P. falciparum parasite. HRP2 detection is widely used in the diagnosis of malaria.


RECOMBINANT ANTIGENHRP2 antigen 610081

Respiratory syncytial virus (RSV)

causes respiratory tract infections. It is the major cause of lower respiratory tract infection and hospital visits during infancy and childhood.


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INFLAMMATION PRODUCT CONC.* REF.

Alpha 1-antitrypsin (AAT)

is a glycoprotein that protect the lungs from destructive actions of blood enzymes, generally known as serum trypsin inhibitor. Disorders of this protein include AAT-deficiency, a hereditary disorder leading to a chronic uninhibited tissue breakdown.


C-reactive protein (CRP)

is a protein found in the blood and the levels rise in response to inflammation. CRP values are useful in determining disease progress or the effectiveness of treatments.

MONOCLONAL ANTIBODIESMAB 6402 5 100145MAB 6403 5 100146MAB 6404 2 100058MAB 6404 6 100061MAB 6405 5 100358MAB 6407 5 100147

FAB-FRAGMENTFAB 6404 600024

Calprotectin

belongs to the family of S100 proteins and is composed of two subunits S100A8 and S100A9. Increased concentrations are found in response to infections and inflammation.

MONOCLONAL ANTIBODIESS100A9:MAB 3401 5 100458MAB 3403 5 100460

S100A8:MAB 3404 5 100468MAB 3405 5 100469MAB 3406 5 100470

S100A8/S100A9 complex:MAB 3407 5 100618 NEW

RECOMBINANT ANTIGENS100A8/S100A9 antigen 610061 NEWS100A8 antigen 710018 NEWS100A9 antigen 710019 NEW



Interleukin-6 (IL-6)

acts as both pro-inflammatory and anti-inflammatory cytokine. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer’s Disease, cancer, and rheumatoid arthritis.


RECOMBINANT ANTIGENIL-6 antigen 710015 NEW

Interleukin-8 (IL-8)

is a chemokine which serves as a chemical signal that attracts neutrophils at the site of inflammation. IL-8 is a promising marker for many clinical conditions with inflammations.


Lactoferrin

Lactoferrin is an antimicrobial protein, also known as lactotransferrin, which transfers iron to the cells. It is used in a faecal test to detect inflammation in the intestine. Lactoferrin levels are associated with disease severity in intestinal bowel disease (IBD).

RECOMBINANT ANTIGENLactoferrin antigen 710016 NEW

Procalcitonin (PCT)

is a precursor protein of the hormone calcitonin, associated with systemic infections. In clinical diagnostics, PCT test is most often used to identify patients with sepsis.

MONOCLONAL ANTIBODIESMAB 4001 5 100561 NEWMAB 4002 5 100565 NEWMAB 4003 5 100562 NEWMAB 4004 5 100563 NEWMAB 4005 5 100564 NEWMAB 4006 5 100567 NEW

RECOMBINANT ANTIGENPCT antigen 610080 NEW

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Serum amyloid A (SAA)

is associated with HDL during inflammatory states. The blood level of SAA increases dramatically in response to tissue injury and inflammation.


RECOMBINANT ANTIGENSAA antigen 610070

Transferrin

regulates the amount of free iron in circulation. Transferrin concentration elevates in anemia, but can be also be used to diagnose other clinical conditions.


Trypsinogen-2

is the precursor form of the pancreatic enzyme trypsin. Determination of urine trypsinogen-2 is a useful test to detect acute pancreatitis and to evaluate disease severity.


RECOMBINANT ANTIGENTrypsinogen-2 antigen 610020


KIDNEY MARKERS PRODUCT CONC.* REF.

Cystatin C

is an emerging renal biomarker. It is used for the diagnosis of chronic kidney disease. Cystatin C has also been associated with an increased risk of cardiovascular disease and heart failure.

MONOCLONAL ANTIBODIESMAB 10001 5 TBDMAB 10002 5 TBDMAB 10003 5 TBDMAB 10004 5 TBDMAB 10005 5 TBD

RECOMBINANT ANTIGENCystatin C antigen 610100 NEW

Neutrophil gelatinase-associated lipocalin (NGAL)

also known as Lipocalin-2 (LCN2), is used as a biomarker of kidney injury, and has also been shown to play a role in cancer and cardiovascular events.

MONOCLONAL ANTIBODIESMAB 4202 5 100579 NEWMAB 4203 5 100580 NEWMAB 4204 5 100581 NEWMAB 4205 5 100582 NEW

RECOMBINANT ANTIGENNGAL antigen 610012

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SEROLOGY PRODUCT CONC.* REF.

Immunoglobulin A (IgA)

is an antibody which plays a critical role in mucosal immunity. IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA).


Immunoglobulin E (IgE)

plays an important role in allergy and defence against parasites. IgE is a class of antibody that has only been found in mammals.


HRP-CONJUGATED ANTIBODYHRP 8510 8510-HRP

Immunoglobulin G (IgG)

antibodies are involved in the secondary immune response. IgG is a monomeric immunoglobulin consisting of four subclasses and constituting 75% of serum immunoglobulins in humans.



Immunoglobulin M (IgM)

is involved in primary immune response. IgM is a basic antibody that first appears in response to exposure to antigen and indicates recent infection in patient’s serum.




THYROID PRODUCT CONC.* REF.

Thyroglobulin

is used in the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer.


Thyroid-stimulating hormone (TSH)

is a peptide hormone which regulates the endocrine function of the thyroid gland. Abnormal TSH levels may lead to hyperthyroidism or hypothyroidism.

MONOCLONAL ANTIBODIESMAB 5401 1 100023MAB 5403 5 100024MAB 5404 5 100026MAB 5405 1 100030MAB 5407 5 100254MAB 5408 1 100033

TSH complexMAB 5409 5 100034

FAB-FRAGMENTSFAB 5404 600020FAB 5405 600021FAB 5409 600023

Thyroxine (T4)

is the major hormone produced by the thyroid gland. Thyroxine is a prohormone and a reservoir for the active thyroid hormone (T3). Thyroxine is measured from blood to diagnose thyroid disorders.


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TUMOR MARKERS PRODUCT CONC.* REF.

Alpha-fetoprotein (AFP)

is a major plasma protein produced by fetus. AFP is measured in pregnancy as a screening test for a subset of developmental abnormalities. It is also used as a biomarker to detect a subset of tumors.


Cancer antigen 15-3 (CA15-3)

is defined by the use of two monoclonal antibodies, one specific for MUC-1 protein core and another specific for a carbohydrate epitope on the MUC-1 protein. CA15-3 is a widely used serum marker for breast cancer monitoring.

Antibodies 4401, 4402, 4403, and 4404 recognize the MUC-1 core protein of CA15-3.

MONOCLONAL ANTIBODIESMAB 4401 5 100591 NEWMAB 4402 5 100595 NEWMAB 4403 5 100583 NEWMAB 4404 5 100584 NEW

Cancer antigen 125 (CA125)

is a peptide epitope on the mucin glycoprotein MUC16. CA125 is the most widely used serum biomarker to monitor epithelial ovarian cancer. It is also used for the differential diagnosis of pelvic masses.

MONOCLONAL ANTIBODIESMAB 4601 5 100598 NEW

MAB 4602 5 100628 NEW

Carbohydrate antigen 19-9 (CA19-9)

is a tumor biomarker also called Sialyl Lewis A. Serum level measurements of CA19-9 are widely used in pancreatic cancer patients for monitoring their response to cancer treatments.

MONOCLONAL ANTIBODIESMAB 4701 5 100609 NEW

Carcinoembryonic antigen (CEA)

is normally produced during fetal development. It has been used as a tumor marker for colorectal cancer and several carcinomas.




CYFRA21-1

is a fragment of Cytokeratin 19. Serum CYFRA21-1 has been used as a tumor marker of different origins and especially in non-small cell lung cancer.

MONOCLONAL ANTIBODIESMAB 1602 5 100220MAB 1603 5 100221MAB 1604 5 100222MAB 1605 5 100223MAB 1608 5 100518MAB 1610 5 100519MAB 1611 5 100520

Hemoglobin (Hb)

is the iron-containing oxygen-transport metalloprotein in the red blood cells. Hemoglobin carries oxygen from the lungs to the body tissue. Changes from the normal values usually indicate abnormalities, such as anemia.


Human epididymis protein 4 (HE4)

also known as WAP four-disulfide core domain protein 2, is a 124 amino acid long protease inhibitor. Serum HE4 is often measured together with CA125 to monitor progression of epithelial ovarian cancer after treatment.

MONOCLONAL ANTIBODIESMAB 4501 5 100589 NEWMAB 4502 5 100592 NEWMAB 4503 5 100608 NEWMAB 4505 5 100593 NEWMAB 4506 5 100594 NEW

Neuron-specific enolase (NSE)

has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma.


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Pepsinogen (PG I & II)

is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount also into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities.

MONOCLONAL ANTIBODIESPG I MAB 8003 5 100120PG I MAB 8009 1 100093PG I MAB 8015 5 100143PG I MAB 8016 1 100095

PG II MAB 8101 5 100097PG II MAB 8102 1 100098PG II MAB 8103 5 100121

HRP-CONJUGATED ANTIBODIESHRP 8003 8003-HRPHRP 8102 8102-HRP

RECOMBINANT ANTIGENSPG I antigen 610000PG II antigen 610001

Prostate-specific antigen (PSA)

is a protein produced by the cells of the prostate gland. PSA is often elevated in the presence of prostate cancer and in other prostate disorders. Free PSA is a form of PSA that does not become attached to other blood proteins. Decreased levels of free PSA may indicate prostate cancer.

MONOCLONAL ANTIBODIES

MAB 8301 5 100102MAB 8311 1 100103MAB 8312 5 100139

Free PSAMAB 8313 5 100488

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CARDIOVASCULAR MARKERS:

cTnI antigen ref. 610102cTnT antigen ref. 610101 FABP3 antigen ref. 610043Galectin-3 antigen ref. TBDMyoglobin antigen ref. 610030NT-proBNP antigen ref. 610090proBNP antigen ref. 710017S100B antigen ref. 710014ST2 antigen ref. 710020 DIABETES & METABOLISM:

Adiponectin antigen ref. 710013ApoA1 antigen ref. 710012Lactoferrin antigen ref. 710016 INFECTIOUS DISEASES:

HCoV OC43 N antigen ref. 610040HCoV NL63 N antigen ref. 610041HCoV HKU1 N antigen ref. 610042HCoV 229E N antigen ref. 610091HRP2 antigen ref. 610081

INFLAMMATION:

S100A8/S100A9 antigen ref. 610061S100A8 antigen ref. 710018 S100A9 antigen ref. 710019IL-6 antigen ref. 710015 Lactoferrin antigen ref. 710016 PCT antigen ref. 610080SAA antigen ref. 610070Trypsinogen-2 antigen ref. 610020 KIDNEY MARKERS:

Cystatin C antigen ref. 610100NGAL antigen ref. 610012 TUMOR MARKERS:

PG I antigen ref. 610000PG II antigen ref. 610001

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ANTIGENSMedix

™

THE COLLECTION OF

IS GROWING STRONGLY!

MEDIX BIOCHEMICA– THE ORIGINAL MANUFACTURER • Over 30 years of monoclonal antibody technology expertise.• The preferred partner for a number of the world’s leading IVD

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Copyright © 06/2017 Medix Biochemica. All rights reserved. MedixMAB and MedixAntigens are trademarks or registered tradermars of Medix Biochemica. Medix Biochemica reserves the right to make changes and improvements to any of the products described in this document without prior notice.

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