Food Grade Products Pharmaceutical Grade Products€¦ · Subsidiary Company in USA Bloomage Freda...
Transcript of Food Grade Products Pharmaceutical Grade Products€¦ · Subsidiary Company in USA Bloomage Freda...
Subsidiary Company in USABloomage Freda Biopharm USA Inc.181 New Road, Suite 308, Parsippany NJ 07054TEL: +1-862-485-8343FAX: +1-973-428-4925
Bloomage Freda Biopharm JapanR. 521 Banchoheim, 1-2 Nibancho, Chiyoda-ku, Tokyo 102-0084TEL: +81-3-6256-9688FAX: +81-3-6256-9687
Shanghai OfficeTEL: +86-21-64480654FAX: +86-21-64480654
Guangzhou OfficeTEL: +86-20-36261514 FAX: +86-20-86253859
Global Distribution
SODIUM HYALURONATE
Add : No.678 Tianchen St., High - Tech Development Zone,Jinan,China 250101Tel:+86 531 82685998 Fax:+86 531 82685988www.bloomagefreda.com E-mail:[email protected] Jun. 2018, Bloomage Freda Biopharm
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Sodium Hyaluronate
Sodium Hyaluronate
Gamma Aminobutyric Acid
Molecular Weight
200 kDa ~ 600 kDaCustomized molecular weight for your application
200 kDa ~ 600 kDa1,000 kDa ~1,500 kDa
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Applications
Used as ingredient in food or health food
Injection Grade
Sodium Hyaluronate
Medical Grade
Sodium Hyaluronate
Intrinsic Viscosity m³/kg
Measured Value
1.6~2.2
2.7~3.6
Measured Value
1.2~2.8
2.7~3.6
0.5~1.0
Applications
For parenteral preparations, including intra-articular and intra-ocular preparations, such as OVD,intra-articular injections, intradermal injections for aesthetic correction, anti-adhesive products, etc.
For parenteral preparations or oral preparations not including intra-articular and intra-ocular preparations. It can be used in eye drops,contact lens solutions, topical preparations for wound or burn healing, medical lubricants, etc.
Product Code
HA-EP2
HA-EP1.8 (DMF & CEP & KDMF)
HA-EP3.0 (DMF & CEP & KDMF)
HA-EP1
HA-E2.0 (DMF)
HA-E3.0 (DMF)
HA-P-0.5 (DMF)
Pharmaceutical Grade Products
Food Grade Products
HyatrueTM
Product Name
Product Name
HAPLEX®
HAPLEX®Plus
GabarelaxTM
Product List
Product Name Molecular Weight Benefits
HA-THM
HA-T
HA-TLM
HA-TLM 20-40
HA-TLM 3-5
HA-Oligo
HA-TL
HA-TLLM
Applications
应用
HybloomTM
miniHATM
COMPANY HISTORY
Bloomage Freda Biopharm Co.,Ltd. was established in 1998 by Bloomage International Investment Group Inc.
and it’s national high-tech enterprises.For the past 20 years, the company has focused its efforts on
R&D,production and sales of Sodium Hyaluronate (HA), and has become one of the world's leading
manufacturers. The applications and specifications of HA vary by product and are divided into Pharmaceutical,
Cosmetic, and Food grades.
Certification
Pharmaceutical Grade Sodium Hyaluronate
Cosmetic Grade Sodium Hyaluronate & Aminobutyric Acid
Food GradeSodium Hyaluronate & Gamma Aminobutyric Acid
China GMP
ECOCERTCOSMOS HALAL KOSHER
DMF CEP
High Molecular Weight Sodium Hyaluronate
Sodium Hyaluronate
Low Molecular Weight Sodium Hyaluronate
Low Molecular Weight Sodium Hyaluronate
Hydrolyzed Hyaluronic Acid
Oligo Hyaluronic Acid
Sodium Hyaluronate 1% Solution
Low Molecular Weight Sodium Hyaluronate 1% Solution
≥1,800kDa
1,000kDa ~ 1,800kDa
10kDa ~ 1,000kDa
200kDa ~ 400kDa
37 kDa~56 kDa
<10kDa
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<10kDa
MoisturizingLubricity and film-forming effects Increase emulsion stabilityNutrition deliveryPrevent and repair skin damageAnti-aging
Skin care products: cream, emulsion, essence, lotion, gel, facial mask, etc.
Makeup products:lipstick, eye shadow, foundation, etc.
Cleansing products:facial cleaner, body wash, etc.
Hair care products: shampoo, hair conditioner, styling gel, hair restorer, etc.
Recommended usage:0.1%-0.5%
HA-Oligo Degraded by Hyaluronidase
Transdermal absorptionDeep moisturizingRepair damaged cellsScavenge free radicalsAnti-aging
Product Name Benefits Applications Recommended Usage
1 HA
2 HA Derivatives
3 Other Fermentation Products
HyacrossTM
Hyaluronic Acid Elastomer
HymagicTM-AcHASodium Acetylated Hyaluronate
HymagicTM-4D
HyacolorTM
Oil-dispersed Sodium Hyaluronate
cationHATM
Substantive Sodium Hyaluronate
Excellent protective film with long-lasting moisturizing effect Smooth and not sticky feelingIncrease skin elasticity and reduces roughness
High affinity & adsorption Superb moisturizationRepair skin barrierImprove skin elasticity
Accurately targeting different skin layers, synergistic moisturizing
High content of HAUnique HA microsphere technologyPerfect transdermal absorptionExcellent lip-plumping, repairing, moisturizing
High substantivity Reduce the irritation caused by SAA Improve the barrier function of the skin & scalpGood compatibility
Skin care products
Skin care products
skin care&hair care product
Specially for lip care products & make-up products
Specially for rinse-off products
1%-5%
0.01%-0.1%
1%~10%
0.1%-2%
0.5%-1%
Product Name Benefits Applications Recommended Usage
GabacareTM BL98TAminobutyric Acid
HyafactorTM-NAGAcetyl Glucosamine
HyafactorTM-PGASodium Polyglutamate
Bioyouth™-BriceBrown Rice Ferment Filtrate
Reduce wrinkles and smooth skinRepair the damaged skinPromote the synthesis of HA and collagen
Promote HA synthesis and scavenge free radicalsNatural exfoliating regulator Whiten and moisturize effects
Promote the accumulation of NMFsReduce the degradation of HAEnhance moisturizing capacity and elasticity of skinInhibition of melanin production
Repairing skin barrierAnti-oxidant and delaying skin agingSignificant whitening
Skin care & Hair care products Make-up products
Skin care products
Skin care products
Skin care & rinse-off product
0.05%-0.3%
0.5%-2%
0.05%-1%
0.5%-4%
Cosmetic Grade Products
1990s
1998
2001
2002
2004
2005
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
Chief Scientist Dr. Guo Xueping initiated the research on producing HA by bio-fermentation technology
�e company Shandong Freda Biochem Co., Ltd. was established and launched the production of Cosmetic Grade HA by fermentation
Bloomage International Investment Group invested in the company�e company passsed ISO 9001 Quality Management System Certi�cation
Dr. Guo received Wu Jieping Medical Research Award & Paul Janssen Pharmaceutical Research Award for his great contributions to the HA industryProduction line of HA for Pharmaceutical Excipient use passed the inspection by China FDA Achieved the National approval license for Eye Drop Grade HA used as a Pharmaceutical Excipient
�e company moved into the new location in the development zone of Jinan City
HAPLEX was approved as a New Dietary Ingredient in ChinaBecame the �rst holder of the production license for HA as a New Dietary Supplement in China
Injection Grade HA new workshop was established and trial production was successful
Company name changed into Shandong Freda Biopharm Co., Ltd.
Achieved the National approval license for Eye Drop Grade HA used as an API Obtained the China GMP certi�cateObtained the CEP and DMF certi�cation for Injection Grade HAminiHATM - the world �rst Oligo HA by enzymatic degradation was successfully launched
Successfully passed the on-site inspection by US FDACompany name changed into Bloomage Freda Biopharm Co., Ltd. Subsidiary company Bloomage Freda Biopharm USA Inc. was established in New Jersey
Achieved the National approval license for Injection Grade HA used as an APIObtained the KDMF registration certi�cate for Injection Grade HAHyacolorTM(Oil-dispersed HA) was successfully launchedObtained the 2013 China Personal Care & Cosmetics Innovation Award for miniHATM
New anti-wrinkle ingredient GabacareTM BL98T(Aminobutyric Acid) was successfully launchedObtained the 2014 China Personal Care & Cosmetics Innovation Award for HyacolorTM
New factory was put into operationObtained the Japan MF registration certi�cate for Medical Grade HA
New food ingredient GabarelaxTM was successfully launchedNew cosmetic ingredients HyacrossTM(Hyaluronic Acid Elastomer) & cationHATM(Substantive Sodium Hyaluronate) were successfully launchedObtained the 2015 China Personal Care & Cosmetics Innovation Award for GabacareTMBL98T and cationHATM
New cosmetic ingredients HyafactorTM-NAG(Acetyl Glucosamine) & HyafactorTM-PGA(Sodium Polyglutamate) were successfully launchedObtained the Russian registration certi�cate for Pharmaceutical Grade HAObtained the CEP registration certi�cate for Medical Grade HAHAPLEX® Plus with clinical e�cacy data was successfully launchedBloomage Freda Biopharm Japan was established in Tokyo
Obtained the COSMOS certi�cation for Cosmetic Grade HA and GabacareTM BL98THymagicTM(Sodium Acetylated Hyaluronate ) was successfully launched