FOLDING MOLECULAR BIOLOGY
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Transcript of FOLDING MOLECULAR BIOLOGY
Function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy and Powerful technology of single cell RNA sequencing to track the genetic development of a human and a mouse
Embryo
Molecular Biology
LEIDY JOHANA HINCAPIÉ RESTREPO
MEDICINE STUDENT 3RD SEMESTER
INTRODUCTION
•Regulated:•Promoters
located in the beginning of genes.
•Enhancers which may be located as far as thousands of base pairs away from the gene they regulate.
Gene transcription
•RNA sequence.
Diagnostic technique
Function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy
GENE TRANSCRIPTION
PROMOTER DNA sequence where the RNA polymerase binds.1. Initiation.2. Elongation.3. Termination.
Function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy
• Promoters located in the beginning of genes.
• Enhancers which may be located as far as thousands of base pairs away from the gene they regulate.
• A new enhancer in macrophages.Regulated
• The activation from transcription factor binding to histone acetylation.
• eRNA transcription.
Function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy
H3K4me1/2
long-term epigenetic changes in cells.Information about the function of this new type of RNA.
OBSERVATION
I think it is extremely important to advance new forms of treatment for genetic diseases and other damage to cellular RNAs sequences.
Powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse Embryo
Powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse Embryo
Single cell RNA sequencing
Determine the precise nature of the total gene transcripts.
Determine all of the genes that are actively expressed in a cell.
• It is a much more comprehensive analysis than was achievable before.
• The technique requires a very minimal amount of sample material just one cell.
Powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse Embryo
• Genetic diagnosis BRCA1 y BRCA2.• Reproductive medicine.
Powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse Embryo
OBSERVATION
Gives us a better notion of how the expression is Given genica since the beginning of the cell division and how you can help in the diagnosis of genetic mutations.
• Identifying genetic damage to improve the quality of life of patients and in the case of breast cancer.
MEDICAL UTILITY
• University of California - Los Angeles (2013, July 31). Scientists analyze genetic makeup of human and mouse embryos in amazing detail. (On Line). ScienceDaily.
• University of Eastern Finland (2013, August 13). Enhancer RNAs may open new avenues for gene therapy. (On Line). ScienceDaily. Retrieved August 24.
• MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7 ed. Medellín: UPB. Fac. de Medicina, 2012. 85 - 91 p.
BIBLIOGRAPHY