FOLATE * METAFOLIN * Calcium levomefolate | C20H23CaN7O6 - PubChem
16
30/01/16, 2302 Calcium levomefolate | C20H23CaN7O6 - PubChem Page 1 of 16 https://pubchem.ncbi.nlm.nih.gov/compound/15341110#section=Top NIH U.S. National Library of Medicine National Center for Biotechnology Information D A T A B A S E Search Compounds ! PUBCHEM COMPOUND CALCIUM LEVOMEFOLATE Calcium Levomefolate " Cite this Record # Vendors $ Drug%Information & Literature ' Patents ( ( PubChem CID: 15341110 Chemical Names: Calci um levomefolate; 151533-22-1; UNII-A9R10K 3F2F; Metafolin; (S)-2-(4-(((( S)-2-Amino-5- methyl-4-oxo-3,4,5,6,7,8- hexahydropteridin-6- yl)methyl)amino)benzamido)pentanedioic acid, calcium salt; Metafolin (TN); More... Molecular Formula: C H CaNO Molecular Weight: 497.51792 g/mol InChI Key: VWBBRFHSPXRJQD-QNTKWALQSA-L UNII: A9R10K3F2F Modify Date: 2016-01-29 Create Date: 2007-02-09 20 23 7 6 ) Compound Summary for CID 15341110
Transcript of FOLATE * METAFOLIN * Calcium levomefolate | C20H23CaN7O6 - PubChem
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 1 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
NIH US National Library of Medicine National Center for Biotechnology Information
D A T A B A S E
Search Compounds
PUBCHEM COMPOUND CALCIUM LEVOMEFOLATE
Calcium Levomefolate Cite this Record
Vendors $DrugInformation amp Literature Patents
( (
PubChem CID 15341110
Chemical Names
Calcium levomefolate 151533-22-1 UNII-A9R10K3F2FMetafolin (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic
acid calcium salt Metafolin (TN) More
Molecular Formula C H CaN O
Molecular Weight 49751792 gmol
InChI Key VWBBRFHSPXRJQD-QNTKWALQSA-L
UNII A9R10K3F2F
Modify Date 2016-01-29
Create Date 2007-02-09
20 23 7 6
) Compound Summary for CID 15341110
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 2 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
Contents
1 2D Structure
2 3D Conformer
3 Names and Identifiers
4 Chemical and Physical Properties
5 Related Records
6 Chemical Vendors
7 Drug and Medication Information
8 Literature
9 Patents
10 Classification
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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Page 3 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from PubChem
1 2D Structure
+ Magnify
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8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 5 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
3 Names and Identifiers
31 Computed Descriptors
calcium(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1678-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
from PubChem
311 IUPAC Name
InChI=1SC20H25N7O6Cac1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29h2-512-1322H6-9H21H3(H2430)(H2829)(H3233)(H42123252631)q+2p-
2t12-13-m0s1
from PubChem
312 InChI
VWBBRFHSPXRJQD-QNTKWALQSA-L
from PubChem
313 InChI Key
CN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
314 Canonical SMILES
CN1[CH](CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)N[CH](CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
315 Isomeric SMILES
32 Other Identifiers
A9R10K3F2F
from FDASPL Indexing data
321 UNII
33 Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
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8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
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Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
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8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 2 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
Contents
1 2D Structure
2 3D Conformer
3 Names and Identifiers
4 Chemical and Physical Properties
5 Related Records
6 Chemical Vendors
7 Drug and Medication Information
8 Literature
9 Patents
10 Classification
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
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from PubChem
1 2D Structure
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8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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Page 5 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
3 Names and Identifiers
31 Computed Descriptors
calcium(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1678-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
from PubChem
311 IUPAC Name
InChI=1SC20H25N7O6Cac1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29h2-512-1322H6-9H21H3(H2430)(H2829)(H3233)(H42123252631)q+2p-
2t12-13-m0s1
from PubChem
312 InChI
VWBBRFHSPXRJQD-QNTKWALQSA-L
from PubChem
313 InChI Key
CN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
314 Canonical SMILES
CN1[CH](CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)N[CH](CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
315 Isomeric SMILES
32 Other Identifiers
A9R10K3F2F
from FDASPL Indexing data
321 UNII
33 Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
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Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 3 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from PubChem
1 2D Structure
+ Magnify
Search Download - Get Image
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 416
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 5 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
3 Names and Identifiers
31 Computed Descriptors
calcium(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1678-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
from PubChem
311 IUPAC Name
InChI=1SC20H25N7O6Cac1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29h2-512-1322H6-9H21H3(H2430)(H2829)(H3233)(H42123252631)q+2p-
2t12-13-m0s1
from PubChem
312 InChI
VWBBRFHSPXRJQD-QNTKWALQSA-L
from PubChem
313 InChI Key
CN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
314 Canonical SMILES
CN1[CH](CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)N[CH](CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
315 Isomeric SMILES
32 Other Identifiers
A9R10K3F2F
from FDASPL Indexing data
321 UNII
33 Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 416
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 5 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
3 Names and Identifiers
31 Computed Descriptors
calcium(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1678-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
from PubChem
311 IUPAC Name
InChI=1SC20H25N7O6Cac1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29h2-512-1322H6-9H21H3(H2430)(H2829)(H3233)(H42123252631)q+2p-
2t12-13-m0s1
from PubChem
312 InChI
VWBBRFHSPXRJQD-QNTKWALQSA-L
from PubChem
313 InChI Key
CN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
314 Canonical SMILES
CN1[CH](CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)N[CH](CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
315 Isomeric SMILES
32 Other Identifiers
A9R10K3F2F
from FDASPL Indexing data
321 UNII
33 Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
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8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 5 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
3 Names and Identifiers
31 Computed Descriptors
calcium(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1678-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
from PubChem
311 IUPAC Name
InChI=1SC20H25N7O6Cac1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29h2-512-1322H6-9H21H3(H2430)(H2829)(H3233)(H42123252631)q+2p-
2t12-13-m0s1
from PubChem
312 InChI
VWBBRFHSPXRJQD-QNTKWALQSA-L
from PubChem
313 InChI Key
CN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
314 Canonical SMILES
CN1[CH](CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)N[CH](CCC(=O)[O-])C(=O)[O-][Ca+2]
from PubChem
315 Isomeric SMILES
32 Other Identifiers
A9R10K3F2F
from FDASPL Indexing data
321 UNII
33 Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 6 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 levomefolate calcium
2 metafolin
3 N-(4-(((2-amino-145678-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acidcalcium salt
4 safyral
from MeSH
331 MeSH Synonyms
from PubChem
1 Calcium levomefolate
2 151533-22-1
3 UNII-A9R10K3F2F
4 Metafolin5 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-345678-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedi
6 Metafolin (TN)
7 Levomefolate calcium
8 LMCA
9 Levomefolate (calcium)
10 L-5-Methyltetrahydrofolate calcium
332 Depositor-Supplied Synonyms
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 716
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 7 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
4 Chemical and Physical Properties
Molecular Weight 49751792 gmol
Molecular Formula C H CaN O
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 497133572 gmol
Monoisotopic Mass 497133572 gmol
Topological Polar Surface Area 204 A^2
Heavy Atom Count 34
Formal Charge 0
Complexity 854
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
from PubChem
41 Computed Properties
20 23 7 6
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 816
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 8 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
5 Related Records
Medications (3) Literature (7) 3D Structure (6) Bioactivities (7) Patents (27)
from PubChem
51 Related Compounds with Annotation
Leucovorin levomefolate calcium levomefolate calcium
Parent Compound Levomefolic acid (CID 444412)
from PubChem
52 Parent Compound
Same Connectivity 7 records
Same Stereo 2 records
Same Isotope 6 records
Same Parent Tautomer 97 records
Same Parent Connectivity 95 records
Same Parent Stereo 23 records
Same Parent Isotope 87 records
Same Parent Exact 20 records
Mixtures Components andNeutralized Forms
2 records
Similar Compounds 1075 records
from PubChem
53 Related Compounds
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 916
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 9 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
54 Substances
Same 26 records
from PubChem
541 Related Substances
Chemical Vendors (17)
Governmental Organizations (2)
Journal Publishers (3)
Research and Development (2)
Subscription Services (4)
from PubChem
542 Substances by Category
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1016
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 10 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
VendorSupplier Purchasable Chemical PubChem SID
MedChemexpress MCE HY-17383 163621061
Boerchem BC254573 249582900
ChemMol30112957 126627110
49403385 126663711
DiscoveryGate 15341110 97190108
Aurora Fine Chemicals LLC A24113118 300447141
AKos Consulting amp Solutions AKOS025117256 249871234
Hangzhou APIChem Technology AC-7457 92723019
Chembo KB-251147 172900794
Molepedia M90777144P 252432412
MolPort MolPort-035-758-319 249684093
Founder Pharma FD30153 250214259
Finetech Industry Limited FT-0670776 164761574
Shenzhen Nexconn Pharmatechs Ltd L-5-Methyltetrahydrofolate calcium 193126302
AN PharmaTech AN-765 223660064
Alsachim 4854 253659201
Ark Pharm Inc AK110246 163409224
from PubChem
6 Chemical Vendors
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1116
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 11 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
7 Drug and Medication Information
71 FDA Orange Book
Prescription Drug Products 1 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name BEYAZ
ApplicantBAYER HLTHCARE (Application Number N022532 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
Prescription Drug Products 2 of 2
Drug Ingredient DROSPIRENONE ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM
Proprietary Name SAFYRAL
ApplicantBAYER HLTHCARE (Application Number N022574 Patents 57983386441168 6958326 7163931 8617597 )
from FDA Orange Book
711 Prescription Drug Products
Drug Labels for Ingredients 1 of 1
Label Information Total 24 labels
Drug Ingredient LEVOMEFOLATE CALCIUM
NDC Code(s)
NDC Code(s)
0642-0075-30 0642-0077-90 0642-0093-01 0642-0093-30 0642-0094-03
0642-0094-30 0642-0120-03 0642-0120-90 0781-4075-15 0781-4075-52 total 42
Packagers
AvKARE Inc Bayer HealthCare Pharmaceuticals Inc CENTRIXPHARMACEUTICAL INC Everett Laboratories Inc Medicap laboratoriesInc Method Pharmaceuticals LLC Sandoz Inc Trigen Laboratories IncVirtus Pharmaceuticals Virtus Pharmaceuticals LLC
from DailyMed
72 Drug Labels for Ingredients
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1216
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 12 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
8 Literature
from PubChem
81 NLM Curated PubMed Citations
All NLM Curated PubMed Citations
Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1316
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 13 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
9 Patents
1 to 1 of 1
Patent Submitted Granted
STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE[US2012263762]
2010-08-11 2012-10-18
from PubChem
91 Depositor-Supplied Patent Identifiers
Relevance
FDA Orange Book Patents 1 of 5
Patent 5798338
Expiration Jul 10 2015
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 2 of 5
Patent 8617597
Expiration Feb 8 2030
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 3 of 5
Patent 6441168
Expiration Apr 17 2020
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONE
ETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
92 FDA Orange Book Patents
12 3
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1416
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 14 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
from FDA Orange Book
FDA Orange Book Patents 4 of 5
Patent 7163931
Expiration Mar 3 2022
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
FDA Orange Book Patents 5 of 5
Patent 6958326
Expiration Dec 20 2021
Applicant BAYER HLTHCARE
Drug ApplicationN022574 (Prescription Drug SAFYRAL Ingredients DROSPIRENONEETHINYL ESTRADIOL LEVOMEFOLATE CALCIUM )
from FDA Orange Book
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1516
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 15 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
10 Classification
101 Ontologies
1 to 1 of 1 4 List View 5 Tree View
from MeSH
1011 MeSH Tree
levomefolate calcium
1 to 5 of 5 4 List View 5 Tree View
from WIPO
1012 WIPO IPC
A61K31519 - ortho- or peri-condensed with heterocyclic rings
A61K3156 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems Derivatives
A61K914 - Particulate form eg powders
A61P1518 - Feminine contraceptives
A61P302 - Nutrients eg vitamins minerals
0 RefineAnalyze Download
0 RefineAnalyze Download
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
8152019 FOLATE METAFOLIN Calcium levomefolate | C20H23CaN7O6 - PubChem
httpslidepdfcomreaderfullfolate-metafolin-calcium-levomefolate-c20h23can7o6-pubchem 1616
300116 2398309802Calcium levomefolate | C20H23CaN7O6 - PubChem
Page 16 of 16httpspubchemncbinlmnihgovcompound15341110section=Top
1 FDA Orange BookPatent6958326httpwwwfdagovDrugsInformationOnDrugsucm129662htmhttpwwwfdagovDrugsInformationOnDrugsucm129662htm
2 DailyMedLEVOMEFOLATE CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUMhttpdailymednlmnihgovdailymedsearchcfmlabeltype=allampquery=LEVOMEFOLATE+CALCIUM
3 FDASPL Indexing datahttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htmhttpwwwfdagovForIndustryDataStandardsStructuredProductLabelingucm377913htm
4 PubChemData deposited in or computed by PubChemhttpspubchemncbinlmnihgov httpspubchemncbinlmnihgov
5 MeSH levomefolate calciumhttpwwwncbinlmnihgovmesh67569381 httpwwwncbinlmnihgovmesh67569381MeSH Treehttpwwwnlmnihgovmeshmeshhomehtml httpwwwnlmnihgovmeshmeshhomehtml
6 WIPOInternational Patent Classification 2014httpwwwwipointclassificationsipc httpwwwwipointclassificationsipc
11 Information Sources
