More CD4 for less.

FLOWCARETM PLG CD4 SYSTEMFor centralized lab testing

BR-9796B

5-DAY SAMPLE UTILITY.

SIMPLIFIED, AFFORDABLE TESTING.

AUTOMATION FOR FAST,ACCURATE RESULTS.

SINGLE PLATFORM STANDARDIZATION.

%CD4 FOR PEDIATRICS.

GLOBAL SERVICE AND SUPPORT.

AUTOMATED SOLUTION.For high-volume CD4 measurement demands, Beckman Coulter’sTQ-PrepTM and PrepPlusTM provide best-in-class solutions for fullyautomated,“walk-away” sample preparation. By reducing variability,system-wide efficiency is enhanced. And our closed-tube samplingmethod prevents accidental biohazard exposure.

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FlowCARE. EXTENDING SIMPLE AND AFFORDABLE CD4 TESTING

TO 5 DAYS POST-DRAW.

SINGLE PLATFORM STANDARDIZATION.By utilizing Flow-CountTM Fluorospheresin every sample, the preparation step iscontrolled, helping to ensure standardized,high-quality and repeatable results.

“With many years in the field, I saw the need for aHIV/AIDs test that’s both accurate and cost-effective.

By applying scientific knowledge in a new way, we found it.And now, the PLG CD4 test is bringing

better care to millions of patients worldwide.”–Professor Debbie Glencross

The FlowCARE PLG CD4 concept was developedby Professor Debbie Glencross at the University of theWitwatersrand and the South African National HealthLaboratory Services (NHLS) in Johannesburg,South Africa, and is licensed exclusively worldwideby Beckman Coulter. This innovative approach wasadopted in response to the urgent need forsimple, rapid, accurate and low cost CD4results in centralized laboratories monitoring large numbers of HIV patients.

For more detailed information on the PLG CD4 method, visit www.plgCD4.net

%CD4 FOR PEDIATRICS.Accurate %CD4 values are particularly important in young patients,where clinical milestones can be masked by usingabsolute CD4 counts alone.2 By delivering both %CD4 and absolute CD4 counts in just minutes, the FlowCARE Systemgives healthcare workers critical information needed for confident treatment decisions across all age groups.

5-DAY SAMPLE TESTING WINDOW.The FlowCARE System provides accurate percent and absolute CD4 values on patient specimens for up to 5 daysafter collection.This simple but effective flow cytometry-based technique uses pre-optimized reagents to providehighly reliable results for all age groups, including pediatrics.These unique capabilities allow blood to be drawn frommore remote locations, a greater number of patients to be screened, and test repeats to be dramatically reduced.

SIMPLIFIED, AFFORDABLE TESTING.By focusing on the most essential parameters for monitoring HIV therapies, FlowCARE PLG CD4 drastically reducesthe cost, complexity and time previously required by labor-intensive processes. For the first time, busy labs have access to an affordable, high-performance HIV monitoring solution that also offers standardization and simplicity.And its efficient operation helps lower overall costs. Combined with a less expensive methodology, fewer repeats,expandable menus and cross-platform reagents, FlowCARE is taking high-volume CD4 testing to new places.

The Panel on Clinical Practices for theTreatment of HIV Infections has determined that a patient’s CD4 count is the singlemost important consideration in deciding to initiate antiretroviral therapy, as well as in monitoring subsequent response.1

Moreover, comparing baseline and recent CD4 counts offers the strongest predictor of disease progression and patient mortality.1

Recognizing the enormous worldwide need for better access to this important data, we’ve leveraged our automation leadershipand extensive resources to provide high-volume labs with a simple, accurate, and highly cost-effective CD4 monitoring solution.

THE BECKMAN COULTER ADVANTAGE – RENOWNED GLOBAL SERVICE AND SUPPORT.To help you get the most out of your Beckman Coulter instruments, our award-winning service and support resources are always ready for on-line or on-site assistance worldwide.With an extensive number of skilled applications scientists and engineers readily available to customers,we make it easy to achieve optimum results.

1. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. October 29, 2004. Developed by the Panel on ClinicalPractices for the Treatment of HIV Infection convened by the Department of Health and Human Services (DHHS).

2. Guidelines for the Use of Antiretroviral Agents in Pediatric HIV-Infection. November30, 2004. Developed by the Working Group on AntiretroviralTherapy and Medical Management of HIV-Infected Children convened by the National Resource Center at the Francois-Xavier Bagnoud Center,UMDNJ. The Health Resources and Services Administration (HRSA); and the National Institutes of Health (NIH).

PUTTING THE POWER OF SCIENCE WHERE IT’S NEEDED MOST.

Leading the charge against the ravaging effects of the worldwide HIV/AIDS epidemic, we’vemobilized worldwide resources, leveraged decades of scientific leadership, and collaboratedclosely with customers and partners to offer an integrated family of breakthroughCD4 monitoring solutions. Count on our CARE Systems to simplify and accelerate CD4monitoring, and contribute to more affordable healthcare worldwide. For more information,please contact your local Beckman Coulter representative, email flowcare@beckman.comor visit our web site at www.beckmancoulter.com/flowcare

ORDERING INFORMATION

FlowCARETM PLG CD4 SYSTEMPart No. Description Status Size627808 FlowCARE PLG CD4 Reagent Kit IVD 300 tests

Supporting Products7546999 IMMUNOPREPTM Reagent Kit IVD 300 tests6605359 Flow-CheckTM Fluorospheres IVD 3 vials,10mL/vial7547053 Flow-CountTM Fluorospheres IVD 200 tests8546859 IsoFlowTM Sheath Fluid IVD 10 L8546930 COULTER CLENZ® Cleaning Agent IVD 5L6607077 IMMUNO-TROLTM Cells IVD 60 tests6607098 IMMUNO-TROLTM Low Control Cells IVD 60 tests2523749 Test tubes 250/bag

Ask about our comprehensive line of CD4 monitoring solutions.

FlowCARETM PLGCD4 Reagent Kit

COULTER® Manual CD4 Count Kit

Africa/Middle East/Eastern Europe: Switzerland, Nyon (41) 22 994 0707. Australia, Gladesville (61) 2 9844 6000. Brazil (011) 5511) 4154-5815 Sao Paulo; (011) (5521) 2445-2358Rio de Janeiro. Canada, Mississauga (1) 905 819 1234. China, Beijing (86) 10 6515 6028. France, Villepinte (33) 1 49 90 90 00. Germany, Krefeld (49) 2151 33 35. Hong Kong (852) 2814 7431, 2814 0481. India, Mumbai (91) 22 30805000. Italy, Milan (39) 02 953921. Japan, Tokyo (81) 3 6745-4704. Latin America (1) (305) 380 4709. Mexico, Mexico City (011) (5255) 5605-7770. Netherlands, Mijdrecht (31) 297 230630. Puerto Rico (1) 787-747-3335 Singapore (65) 6339 3633.South Africa, Johannesburg (27) 11 805 2014. Sweden, Bromma (46) 8 564 85 900. Switzerland, Nyon 0800 850 810. Taiwan, Taipei (886) 2 2378 3456. Turkey, Istanbul (90) 216 309 1900. UK, High Wycombe (44) 01494 441181. USA, Miami, FL (1) 800 526 3821, Option 7.

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