Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.
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Transcript of Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.
![Page 1: Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.](https://reader035.fdocuments.in/reader035/viewer/2022062719/56813221550346895d987ff3/html5/thumbnails/1.jpg)
Figure SM-1: Formula developed for: (a) Acetaminophen, and (b)
Erythromycin ethylsuccinate.
a b
![Page 2: Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.](https://reader035.fdocuments.in/reader035/viewer/2022062719/56813221550346895d987ff3/html5/thumbnails/2.jpg)
Figure SM-2: Examples of EEM fluorescence spectra: (a) at pH 7.0 ± 0.1 of S-EPS from
GS-Eer, (b) with quenching effects obtained for 135 µmol/L of ACE, and (c) for 755
µmol/L of ERY. The white arrows indicate areas of interest, i.e. peaks A and B.
a
c
b
ERYpeak
A A
A
B B
![Page 3: Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.](https://reader035.fdocuments.in/reader035/viewer/2022062719/56813221550346895d987ff3/html5/thumbnails/3.jpg)
Figure SM-3: Modeling of the fluorescence data from Figure S2
(B-EPS from GS-Eer) using the Stern-Volmer model. The F0/F
curve is represented at the Ex/Em couple: 222 nm / 300 nm
(aromatic protein region) (in blue), and 277 nm / 305 nm (soluble
microbial by-product-like region) (in red).
![Page 4: Figure SM-1: Formula developed for: (a) Acetaminophen, and (b) Erythromycin ethylsuccinate.](https://reader035.fdocuments.in/reader035/viewer/2022062719/56813221550346895d987ff3/html5/thumbnails/4.jpg)
Acetaminophen (Paracetamol)
Erythromycin ethylsuccinate
CAS Number 103-90-2 1264-62-6
Formula C8H9NO2 C43H75NO16
Molecular mass (g/mol) 151.17 862.05
Density (g/cm³) 1.263 -
Melting point (°C) 169 229-224
Solubility in water (mg/mL) ()
12.78 VERY SLIGHTLY
IN WATER
pKa () 9.5 7.1
Log P 0.49 2.1
Table SM-1: Identification and characteristics of the drugs used in this study (Clarke, 1986; Tolls, 2001)