Figure S1. Preparation of the soft contact lens (A) Lenses were placed on a glass slide. (B-D) Trephination of the soft contact lens by a673 dermal biopsy punch.

D

B

C

A

Figure S2. Placement of the soft contact lens over the mouse corneaLenses were gently grasped with a non-toothed forceps while opening the eyelids of the mice by another forceps while the animals were anesthetized.

D

B

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A

Figure S3. Settings of the UV-B exposure experimentsAnimals were placed on paper towels after placing the soft contact lenses on their corneas and marking their body outlines. Mice numbers were noted on the towel so that they would be positioned in the exactly same manner on the towels throughout the experiments (A, yellow arrows). The paper towel was placed directly under the UVlamps by marking the edges of the towel in the UV-B exposure device so that the towels would be placed on the exact positions under the UV lamps each day (A, blue arrows). Right insert (B) shows anesthetized mice being exposed to UV-B radiation.

BA